Dr. John Newsted

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Michigan State University
College of Veterinary Medicine
Animal Science
Adjunct Associate ProfessorAppointed: 2000

Mailing Address

Michigan State University
218 Nat. Food Safety Toxicol. Center
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 381-1434
Fax: (517) 381-1435
newsted@msu.edu

Qualifications

Ph.D., Michigan State University, Environmental Toxicology, 1991.
M.S., Michigan Technological University, Aquatic Biology, 1985.
B.S., Michigan State University, Limnology, 1978.

Expertise and Research Interests

1. Movement and fate of trace contaminants in aquatic ecosystems. Current focus on fluorochemicals and halogenated aromatic hydrocarbons such as PCBs, PCDFs, PCDDs.
2. Development and use of in vivo and in vitro molecular/biochemical markers of the effect of xenobiotics on the reproduction, growth and development of aquatic organisms.
3. Development of novel genetic methods to examine and profile potential exposure of aquatic organisms to complex classes of chemicals. Methods include microarray technologies, differential display, real time PCR, SSH-PCR.
4. Development of nonlethal methods to examine potential exposure and effect of environmental organisms to chemical and environmental stress.
5. Use of bioassessment techniques to examine ecosystem health in aquatic environments.

Keywords

COS Keywords:

Biochemical Markers, Biological Markers, Environmental Health, Food Safety, Wildlife.

Additional Terms:

Aquatic Toxicology, Biochemical Markers, Environmental Risk Assessment, Wildlife Toxicology.

Memberships

American Fisheries Society
International Association for Great Lakes Research
Society of Environmental Toxicology and Chemistry

Previous Positions

1993-2000, Professor, University of Massachusetts Amherst, College of Natural Resources and the Environment, Conservation and Natural Resources
1991-1993, Senior Toxicologist, Eli Lilly and Company, Environmental Toxicology

Funding Received

  • STAR Program: Chemical Induced Changes in Gene Expression Patterns Using A Small Fish Model: A Systems Approaxch, $750,000, 2004 to 2007.
  • Environmental Protection Agency (EPA): Optimization of an Assay Using H295R Cell Line to Identify Chemical Modulators of Steroidogenesis and Aromatase Activity, $602,871, 2004 to 2008.
  • Environmental Protection Agency (EPA): Use of the H295R Human Adrenocarcinoma Line for Screening for Effects of Compounds on Steroidogenesis, $341,000, 2002 to 2004.

Publications

  • Strause, K.D., Zwiernik, M.J., Im, S.H., Bradley, P.W., Mosely, P.P., Kay, D.P., Park, C.S., Jones, P.D., Blankenship, A.L., Newsted, J.L., Giesy, J.P. (2007) Risk assessment of great horned owls (Bubo virginianus) exposed to polychlorinated biphenyls and DDT along the Kalamazoo River, Michigan USA, Environ. Toxicol. Chem., 26, 1386-1398
  • Hecker, M., Hollert, H., Cooper, R., Vinggaard, A.M., Akahori, Y., Murphy, M., Nellemann, M., Higley, E.R., Newsted, J.L., Wu, R., Lam, P., Laskey, J., Timm, G., Giesy, J.P. (2007) The OECD validation program of the H295R steroidogenic assay for the identification of in vitro inhibitors and inducers of testosterone and estradiol production. Phase 2: inter-laboratory pre-validation studies, Environ. Sci. Pollut. Res., 14, 23-30
  • Newsted, J.L., Coady, K.K., Beach, S.A., Gallagher, S., Giesy, J.P. (2007) Effects of perfluorooctane sulfonate (PFOS) on mallard (Anas platyrhynchus) and bobwhite quail (Colinus virginianus) when chronically exposed via the diet, Environ. Toxicol. Pharmacol., 23, 1-9
  • Neigh, A.M., Zwiernik, M.L., Bradley, P.W., Kay, D.P., Jones, P.D., Rupert, C.A., Blankenship, A.L., Newsted, J.L., Giesy, J.P. (2007) Reproductive success of passerine exposed to PCBs through the terrestrial food web of the Kalamazoo River, Ecotox. Environ. Safety, 66, 107-118
  • Hecker, M., Newsted, J.L., Murphy, M.B., Higley, E.B., Tompsett, A.R., Jones, P.D., Wu, R., Giesy, J.P. (2006) Human adrenocarcinoma (H295R) cell systems for rapid testing of chemical effects of steroidogenesis, Toxicol. Applied Pharmacol., 217 (114), 124
  • Gracia, T., Hilsherova, K., Jones, P.D., Newsted, J.L., Zhang, X., Sanderson, T.S., Yu, R., Wu, R., Giesy, J.P. (2006) Assessment of the effects of chemical mixtures on the expression of ten steroidogenic genes in the H295R cell line, Ecotox. Environ. Safety, 65, 293-305
  • Neigh, A.M., Zwiernik, M.J., Blankeship, A.L., Bradley, P.W., Kay, D.P., MacCarroll, M.A., Park, C.S., Jones, P.D., Millsap, S.D., Newsted, J.L., Giesy, J.P. (2006) Exposure and multiple lines of evidence assessment of risk for PCBs found in the diets of passerine birds at the Kalamazoo River superfund site, Human Ecol. Risk Assess., 12, 924-946
  • Murphy, M.B., Hecker, M., Coady, K.K., Tompsett, A.R., Jones, P.D., Newsted, J.L., Wong, H.L., du Preez, L.H., Solomon, K.R., Carr, J.A., Smith, E.E., Kendall, R.J., van der Kraak, G., Giesy, J.P. (2006) Sediment TCDD-EQs and EROD and MROD activities in ranid frogs from agricultural and non-agricultural sites in Michigan (USA), Arch. Environ. Contam. Toxicol., 51, 467-477
  • Rostkowski, P., Yamashita, N., So, M.K., Taniyasu, S., Lam, P.K.S., Falandysz, J., Lee, K.T., Kim, S.K., Im, S.H., Newsted, J.L., Jones, P.D., Kannan, K., Giesy, J.P. (2006) Perfluorinated compounds in streams of the Shihwa Industrial Zone and Lake Shihwa, South Korea, Environ. Toxicol. Chem., 25, 2374-2380
  • Blaha, L., Hilsherova, K., Mazurova, E., Hecker, M., Jones, P.D., Newsted, J.L., Bradley, P.W., Gracia, T., Horka, I., Holoubek, I., Giesy, J.P. (2006) Alterations of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects, Environ. Intern., 32, 749-757
  • Neight, A.M., Zwiernik, M.J., Bradley, P.W., Kay, D.P., Jones, P.D., Holem, R.R., Blankenship, A.L., Strause, K.D., Newsted, J.L., Giesy, J.P. (2006) Accumulation of polychlorinated biphenyls from foodplain soils by passerine birds, Environ. Toxicol. Chem., 25, 1503-1511
  • Newsted, J.L., Beach, S.A., Gallagher, S., Giesy, J.P. (2006) Pharmacokinetics and acute lethality of perfluorooctane sulfonate (PFOS) to the mallard and northern bobwhite, Arch. Environ. Contam. Toxicol., 50, 411-420
  • Neigh, A.M., Zwiernik, M.J., MacCarroll, M.A., Newsted, J.L., Blankenship, A.L., Jones, P.D., Kay, D.P., Giesy, J.P. (2006) Productivity of tree swallows (Tachycineta bicolor) exposed to PCBs at the Kalamazoo River Superfund site, J. Toxicol. Environ. Health, Part A, 69, 395-415
  • Neigh, A.M., Zwiernik, M.J., Bradley, P.W., Kay, D.P., Park, C.S., Jones, P.D., Newsted, J.L., Blankenship, A.L., Giesy, J.P. (2006) Tree swallow (Tachycineta bicolor) exposure to polychlorinated biphenyls at the Kalamazoo River superfund site, Environ. Toxicol. Chem., 25, 428-437
  • Beach, S.A., Newsted, J.L., Coady, K., Giesy, J.P. (2006) Ecotoxicological evaluation of perfluorooctane sulfonate (PFOS), Rev. Environ. Contam. Toxicol., 186, 133-174
  • Newsted, J.L., Jones, P.D., Coady, K., Giesy, J.P. (2005) Derivation of avian toxicity reference values (TRVs) for perfluorooctane sulfonate (PFOS), Environ. Sci. Technol., 39, 9357-9362
  • Kay, D.P., Blankenship, A.L., Coady, K.K., Neigh, A.M., Zwiernik, M.J., Millsap, S.D., Strause, K.C., Park, C., Bradley, P., Newsted, J.L., Jones, P.D., Giesy, J.P. (2005) Differential accumulation of PCB congeners in the aquatic food web at the Kalamazoo River Superfund site, Environ. Sci. Technol., 39, 5964-5974
  • Blankenship, A.L., Zwiernik, M.J., Coady, K.K., Kay, D.P., Newsted, J.L., Bradley, P.W., Neigh, A.M., Giesy, J.P. (2005) Differential accumulation of PCB congeners in the terrestrial food web of the Kalamazoo River Superfund site, Environ. Toxicol. Chem., 39, 5954-5974
  • Jones, P.D., Newsted, J.L., Henningsen, G., Slocomb, J., Giesy, J.P. (2005) Distribution of PCDDs and PCDFs in soil collected from the Denver Front Range: Principle components analysis of diffuse sources, Environ. Sci. Pollut. Res., 12, 189-198
  • Zhang, X., Yu, R., Jones, P.D., Newsted, J.L., Gracia, T., Hecker, M., Hilscherova, K., Sanderson, J.T., Wu, R., Giesy, J.P. (2005) Quantitative RT-PCR methods for evaluating toxicant-induced effects of steroidogenesis using the H295R cell line, Environ. Sci. Technol., 39, 2777-2785
  • Hu, W., Jones, P.D., De Coen, W., Newsted, J.L., Giesy, J.P. (2005) Comparison of gene expression methods to identify gene responses to perfluorooctane sulfonic acid, Environ. Toxicol. Pharmacol., 19, 153-160
  • Hilscherova, K., Jones, P.D., Gracia, T., Newsted, J.L., Zhang, X., Sanderson, J.T., Yu, R.M.K., Wu, R.S.S., Giesy, J.P. (2004) Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR, Toxicol. Sci., 81, 78-89
  • Newsted, J.L. (2004) The effect of light, temperature and pH on the degradation of phenol by the green alga, Selenastrum capricornutum, Ecotoxicol. Environ. Safety, 59, 237-243
  • Hu, W-Y, Jones, P.D, DeCoen, W, King, L, Fraker, P, Newsted, J.L, Giesy, J.P., Alterations in cell membrane properties caused by perfluorinated compounds, Comparative Biochemistry and Physiology Part C, 135, 77-88, 2003
  • Jones, P.D., Hu, W., De Coen, W., Newsted, J.L., Giesy, J.L. (2003) Binding of perfluorinated chemicals to serum proteins, Environ. Toxicol. Chem., 22, 2639-2649
  • Newsted JL, Nakanishi J, Cousins I, Werner K, Giesy JP, Predicted distribution and ecological risk assessment of a 'segregated' hydrofluorrother in the Japanese environment, Environmental Science and Technology, 36(22), 4761-9, November 2002 Abstract
  • Giesy JP, Jones PD, Kannan K, Newsted JL, Tillitt DE, Williams LL, Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female, Aquatic Toxicology (amsterdam, Netherlands), 59(1-2), 35-53, September 2002 Abstract
  • Kannan K, Newsted J, Halbrook RS, Giesy JP, Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United States, Environmental Science and Technology, 36(12), 2566-71, June 2002 Abstract
  • Jones PD, Kannan K, Newsted JL, Tillitt DE, Williams LL, Giesy JP, Accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rainbow trout (Onchorhynchus mykiss) at environmentally relevant dietary concentrations, Environmental Toxicology and Chemistry / Setac, 20(2), 344-50, February 2001 Abstract
  • Newsted, J.L, Giesy, J.P., Epidermal growth factor receptor-protein kinase interactions in hepatic membranes of rainbow trout (Oncorhynchus mykiss), Fish Physiology and Biochemistry, 22/3, 181-189, 2000
  • Newsted, J.L, Giesy, J.P, Ankley, G.T, Tillitt, D.E, Crawford, R.A, Gooch, J.W, Jones, P.D, Denison, M.S., Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout, Enviromental Toxicology and Chemistry, 14, 861-871, 1995

Profile Details

Last Updated: 1/4/2009

COS Expertise ID #302894
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