Dr. A. Daniel Jones

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Michigan State University
Biochemistry & Molecular Biology and Chemistry
ProfessorAppointed: 2005

Mailing Address

212 Biochemistry
Dept. of Biochemistry & Molecular Biology
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-7126
Fax: (517) 353-9334
jonesar4@msu.edu

Qualifications

Ph.D., Pennsylvania State University, Chemistry, 1984.
B.S., Harvey Mudd College, Chemistry, 1976.

Expertise and Research Interests

Mass spectrometry, separations, and analytical chemistry
Analytical strategies for metabolomics and metabolite profiling
High-throughput techniques for discovery of bioactive natural products
Reactive metabolites in signaling and toxicity
Chemical ecology
Plant-insect and plant-pathogen interactions

Keywords

COS Keywords:

Analytical Chemistry, Chemical Sciences, Mass Spectrometry, Natural Products, Proteomics, Toxicology, Xenobiotics.

Additional Terms:

Lipidomics, Mass Spectrometry, Metabolomics, Peptidomics.

Memberships

American Chemical Society
American Society for Mass Spectrometry
American Society of Plant Biologists
Metabolomics Society

Honors and Awards

1996-1996, James H. Meyer Distinguished Achievement Award, University of California, Davis, University of California, Davis

Previous Positions

1998-2005, Senior Scientist, Pennsylvania State University, Science, Eberly, Chemistry
1990-1993, Assistant Adjunct Professor, University of California, Davis, School of Veterinary Medicine, Molecular Biosciences
1989-1998, Academic Administrator and Director, University of California, Davis, Facility for Advanced Instrumentation
1984-1984, Visiting Assistant Professor, Harvey Mudd College, Chemistry
1984-1989, Assistant Research Spectroscopist and Acting Director, University of California, Davis, Facility for Advanced Instrumentation

Patents

Inhibition of Glutathione Transferase by Haloenol Lactones, Patent Number: 6103665, 2000, Institution-owned, United States.
Inhibition of Glutathione Transferase by Haloenol Lactones, Patent Number: 5767147, 1998, Institution-owned, United States.
Inhibition of Glutathione Transferase by Haloenol Lactones, Patent Number: 6495370, Institution-owned, United States.

Funding Received

  • National Institutes of Health (NIH): Advancing Drug Development from Medicinal Plants using Transcriptomics and Metabolomics, $2,875,000, 2009 to 2011.
  • National Institutes of Health (NIH): IL-2 Suppression by Endocannabinoid Activation of PPAR-gamma (subcontract from MSU), $94,500, 2008 to 2010.
  • Michigan Universities Commercialization Initiative: Reducing mycotoxin contamination in stored grain and nuts, 80,000, 2008 to 2010.
  • National Science Foundation (NSF): MRI: Acquisition of Metabolite Profiling Mass Spectrometry Instrumentation for MSU, $467,365, 2006 to 2008.
  • National Science Foundation (NSF): GEPR: Building and Operating a Chemical Factory: Glandular Trichomes of Solanum Species (co-PI), $3,696,295, 2006 to 2009.
  • Michigan Economic Development Corporation: Application of Laser-based Molecular Scalpel Technology for Proteomic and Metabolomic Analysis (co-PI), $1,229,365, 2006 to 2009.
  • MSU Foundation (Strategic Partnership Grant program): Plant Metabolic Engineering for Feedstock Production (co-PI), $880,000, 2006 to 2009.
  • MSU Foundation (Strategic Partnership Grant program): Cellulose Biorefining to Ethanol: Developing Generic Technology Platforms (co-PI), $836,981, 2006 to 2009.

Publications

  • Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE (Oct 2009) Sulindac metabolism and synergy with tumor necrosis factor-{alpha} in a drug-inflammation interaction model of idiosyncratic liver injury., The Journal of pharmacology and experimental therapeutics, 331 (1), 114-21 Abstract
  • Koo AJ, Gao X, Jones AD, Howe GA (Sep 2009) A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis., The Plant journal : for cell and molecular biology, 59 (6), 974-86 Abstract
  • DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ (May 2009) Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2., Molecular pharmacology, 75 (5), 1005-13 Abstract
  • Kahlon DK, Lansdell TA, Fisk JS, Hupp CD, Friebe TL, Hovde S, Jones AD, Dyer RD, Henry RW, Tepe JJ (Feb 2009) Nuclear Factor-kappaB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds., Journal of medicinal chemistry, 52 (5), 1302-1309 Abstract
  • Kalcic CL, Gunaratne TC, Jones AD, Dantus M, Reid GE (Jan 2009) Femtosecond laser-induced ionization/dissociation of protonated peptides., Journal of the American Chemical Society, 131 (3), 940-2 Abstract
  • Balan V, da Costa Sousa L, Chundawat SP, Vismeh R, Jones AD, Dale BE (May 2008) Mushroom spent straw: a potential substrate for an ethanol-based biorefinery., Journal of industrial microbiology & biotechnology, 35 (5), 293-301 Abstract
  • Mansfield MA, Jones AD, Kuldau GA (Mar 2008) Contamination of fresh and ensiled maize by multiple penicillium mycotoxins., Phytopathology, 98 (3), 330-6 Abstract
  • Chung HS, Koo AJ, Gao X, Jayanty S, Thines B, Jones AD, Howe GA (Mar 2008) Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory., Plant physiology, 146 (3), 952-64 Abstract
  • Butler PJ, Dong C, Snyder AJ, Jones AD, Sheets ED (2008) Bioengineering and Bioinformatics Summer Institutes: meeting modern challenges in undergraduate summer research., CBE life sciences education, 7 (1), 45-53 Abstract
  • Lu B, Xu C, Awai K, Jones AD, Benning C (Dec 2007) A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import., The Journal of biological chemistry, 282 (49), 35945-53 Abstract
  • Gu L, Jones AD, Last RL (Nov 2007) LC-MS/MS assay for protein amino acids and metabolically related compounds for large-scale screening of metabolic phenotypes., Analytical chemistry, 79 (21), 8067-75 Abstract
  • Denkenberger KA, Bowers RA, Jones AD, Mueller KT (Aug 2007) NMR studies of the thermal degradation of a perfluoropolyether on the surfaces of gamma-alumina and kaolinite., Langmuir : the ACS journal of surfaces and colloids, 23 (17), 8855-60 Abstract
  • Turich, C., Freeman, K. H., Bruns, M. A., Conte, M., Jones, A. D., Wakeham, S. G. (2007) Lipids of marine Archaea: patterns and provenance in the water-column and sediments, Geochimica et Cosmochimica Acta, 71, 3272-3291
  • Mansfield MA, Archibald DD, Jones AD, Kuldau GA (Apr 2007) Relationship of sphinganine analog mycotoxin contamination in maize silage to seasonal weather conditions and to agronomic and ensiling practices., Phytopathology, 97 (4), 504-11 Abstract
  • Last RL, Jones AD, Shachar-Hill Y (Feb 2007) Towards the plant metabolome and beyond., Nature reviews. Molecular cell biology, 8 (2), 167-74 Abstract
  • Martin AN, Farquar GR, Jones AD, Frank M (2007) The non-destructive identification of solid over-the-counter medications using single particle aerosol mass spectrometry., Rapid communications in mass spectrometry : RCM, 21 (22), 3561-8 Abstract
  • Ishmael SS, Ishmael FT, Jones AD, Bond JS (Dec 2006) Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer., The Journal of biological chemistry, 281 (49), 37404-15 Abstract
  • Wang Y, Scherperel G, Roberts KD, Jones AD, Reid GE, Yan H (Oct 2006) A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase., Journal of the American Chemical Society, 128 (40), 13216-23 Abstract
  • Chen H, Jones AD, Howe GA (May 2006) Constitutive activation of the jasmonate signaling pathway enhances the production of secondary metabolites in tomato., FEBS letters, 580 (11), 2540-6 Abstract
  • Lamé MW, Jones AD, Wilson DW, Segall HJ (Nov 2005) Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells., Proteomics, 5 (17), 4398-413 Abstract
  • Bell DS, Cramer HM, Jones AD (Nov 2005) Rational method development strategies on a fluorinated liquid chromatography stationary phase: mobile phase ion concentration and temperature effects on the separation of ephedrine alkaloids., Journal of chromatography. A, 1095 (1-2), 113-8 Abstract
  • Manda, K., Hammer, E., Mikolasch, A., Niedermayer, T., Dec, J., Jones, A. D., Benesi, A. J., Schauer, F., Bollag, J.-M. (2005) Laccase-induced cross-coupling of 4-aminobenzoic acid with 2,5-dihydroxy-N-(2-hydroxyethyl)benzamide and 2,5-dihydroxybenzoic acid methyl ester, Journal of Molecular Catalysis B: Enzymatic, 35 (4-6), 86-92
  • Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S, Characterization of a Deletion Allele of a Sorghum Myb Gene, Yellow Seed1 Showing Loss of 3-deoxyflavonoids, Plant Science, 169(3), 542-552, Sep 2005
  • Bell DS, Jones AD, Solute Attributes and Molecular Interactions Contributing to "U-shape" Retention on a Fluorinated High-performance Liquid Chromatography Stationary Phase, Journal of Chromatography a, 1073(1-2), 99-109, 6 May 2005
  • Strynar M, Dec J, Benesi A, Jones AD, Fry RA, Bollag JM, Using 19F NMR Spectroscopy to Determine Trifluralin Binding to Soil., Environmental Science & Technology, 38(24), 6645-55, Dec 2004 Abstract
  • Coleman CS, Stanley BA, Jones AD, Pegg AE, Spermidine/spermine-N-1-acetyltransferase-2 (SSAT2) Acetylates Thialysine and Is Not Involved in Polyamine Metabolism, Biochemical Journal, 384(1), 139-148, 15 Nov 2004
  • Repeta DJ, Hartman NT, John S, Jones AD, Goericke R, Structure Elucidation and Characterization of Polychlorinated Biphenyl Carboxylic Acids As Major Constituents of Chromophoric Dissolved Organic Matter in Seawater., Environmental Science & Technology, 38(20), 5373-8, Oct 2004 Abstract
  • Frigaard NU, Maresca JA, Yunker CE, Jones AD, Bryant DA, Genetic Manipulation of Carotenoid Biosynthesis in the Green Sulfur Bacterium Chlorobium Tepidum., Journal of Bacteriology, 186(16), 5210-20, Aug 2004 Abstract
  • Boddu J, Svabek C, Sekhon R, Gevens A, Nicholson RL, Jones AD, Pedersen JF, Gustine DL, Chopra S, Expression of a Putative Flavonoid 3'-hydroxylase in Sorghum Mesocotyls Synthesizing 3-deoxyanthocyanidin Phytoalexins, Physiological and Molecular Plant Pathology, 65(2), 101-113, Aug 2004
  • Manica DP, Lapos JA, Jones AD, Ewing AG, Analysis of the Stability of Amino Acids Derivatized With Naphthalene-2,3-dicarboxaldehyde Using High-performance Liquid Chromatography and Mass Spectrometry., Analytical Biochemistry, 322(1), 68-78, Nov 2003 Abstract
  • Ramamurthy B, Jones AD, Larsson L, Glutathione reverses early effects of glycation on myosin function, American Journal of Physiology. Cell Physiology, 285(2), C419-24, August 2003 Abstract
  • Li LC, Bedinger PA, Volk C, Jones AD, Cosgrove DJ, Purification and characterization of four beta-expansins (Zea m 1 isoforms) from maize pollen, Plant Physiology, 132(4), 2073-85, August 2003 Abstract
  • Dubey AK, Baker CS, Suzuki K, Jones AD, Pandit P, Romeo T, Babitzke P, CsrA regulates translation of the Escherichia coli carbon starvation gene, cstA, by blocking ribosome access to the cstA transcript, Journal of Bacteriology, 185(15), 4450-60, August 2003 Abstract
  • Lame MW, Jones AD, Wilson DW, Segall HJ, Protein Targets of 1,4-benzoquinone and 1,4-naphthoquinone in Human Bronchial Epithelial Cells., Proteomics, 3(4), 479-95, Apr 2003 Abstract
  • Johnson TW, Naithani S, Stewart Jr C, Zybailov B, Jones AD, Golbeck JH, Chitnis PR, The MenD and MenE Homologs Code for 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylate Synthase and O-succinylbenzoic Acid-CoA Synthase in the Phylloquinone Biosynthetic Pathway of Synechocystis Sp. PCC6803, Biochimica Et Biophysica Acta-Bioenergetics, 1557(1-3), 67-76, 6 Mar 2003
  • Park S, Meyer M, Jones AD, Yennawar HP, Yennawar NH, Nixon BT, Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain, The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 16(14), 1964-6, December 2002 Abstract
  • Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD, Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors, Journal of Medicinal Chemistry, 45(25), 5576-93, December 2002 Abstract
  • Schrick B, Blough JL, Jones AD, Mallouk TE, Hydrodechlorination of Trichloroethylene to Hydrocarbons Using Bimetallic Nickel-iron Nanoparticles, Chemistry of Materials, 14(12), 5140-5147, Dec 2002
  • Park S, Zhang H, Jones AD, Nixon BT, Biochemical evidence for multiple dimeric states of the Sinorhizobium meliloti DctD receiver domain, Biochemistry, 41(36), 10934-41, September 2002 Abstract
  • Vu BC, Jones AD, Lecomte JT, Novel histidine-heme covalent linkage in a hemoglobin, Journal of the American Chemical Society, 124(29), 8544-5, July 2002 Abstract
  • Lin Y, Dueker SR, Jones AD, Clifford AJ, A parallel processing solid phase extraction protocol for the determination of whole blood folate, Analytical Biochemistry, 301(1), 14-20, February 2002 Abstract
  • Sakuragi Y, Zybailov B, Shen G, Jones AD, Chitnis PR, van der Est A, Bittl R, Zech S, Stehlik D, Golbeck JH, Bryant DA, Insertional inactivation of the menG gene, encoding 2-phytyl-1,4-naphthoquinone methyltransferase of Synechocystis sp. PCC 6803, results in the incorporation of 2-phytyl-1,4-naphthoquinone into the A(, Biochemistry, 41(1), 394-405, January 2002 Abstract
  • Ramamurthy B, Hook P, Jones AD, Larsson L, Changes in myosin structure and function in response to glycation, The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 15(13), 2415-22, November 2001 Abstract
  • Alley SC, Trakselis MA, Mayer MU, Ishmael FT, Jones AD, Benkovic SJ, Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme, Journal of Bioligical Chemistry, 276(42), 39340-9, October 2001 Abstract
  • Johnson TW, Zybailov B, Jones AD, Bittl R, Zech S, Stehlik D, Golbeck JH, Chitnis PR, Recruitment of a foreign quinone into the A1 site of photosystem I. In vivo replacement of plastoquinone-9 by media-supplemented naphthoquinones in phylloquinone biosynthetic pathway mutan, Journal of Bioligical Chemistry, 276(43), 39512-21, October 2001 Abstract
  • Scott CP, Abel-Santos E, Jones AD, Benkovic SJ, Structural requirements for the biosynthesis of backbone cyclic peptide libraries, Chemistry & Biology, 8(8), 801-15, August 2001 Abstract
  • Mester T, Ambert-Balay K, Ciofi-Baffoni S, Banci L, Jones AD, Tien M, Oxidation of a tetrameric nonphenolic lignin model compound by lignin peroxidase, Journal of Bioligical Chemistry, 276(25), 22985-90, June 2001 Abstract
  • Cuiffi JD, Hayes DJ, Fonash SJ, Brown KN, Jones AD, Desorption-ionization mass spectrometry using deposited nanostructured silicon films, Analytical Chemistry, 73(6), 1292-5, March 2001 Abstract

Profile Details

Last Updated: 10/2/2009

COS Expertise ID #1088979
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