Joy G. Ghosh

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Boston University
School of Medicine
Psychiatry
Post-doctoral fellowAppointed: 2007
Professional Headshot of Joy G. Ghosh

Mailing Address

670 Albany Street
Suite 420
Boston, Massachusetts 02118
United States

Contact Information

Phone: (617) 414-8366
Mobile: (206) 399-8915
joyghosh@msn.com

Qualifications

Ph.D., University of Washington, Biomolecular Structure and Design and Biological Structure, 2006.
Certificate, University of Washington, Technology and Corporate Entrepreneurship, 2005.
B.S., University of Texas at Austin, Biochemistry, 2000.

Expertise and Research Interests

Neurodegenerative diseases
Heat shock proteins
Chaperones
Protein unfolding, misfolding and aggregation
Cataracts
Alzheimer's disease
Parkinson's disease

Future Research

Neurodegenerative diseases
Protein unfolding
Amyloidosis
Aging

Industrial Relevance

Consulting: Completed comprehensive valuation analysis for EMIT Technologies, LLC. for Venture Capital financing (2004).

Keywords

COS Keywords:

Alzheimer's Disease, Biochemistry, Proteins, Neurodegenerative Diseases, Parkinson's Disease, Surgery.

Additional Terms:

Chaperones, Neurodegenerative Diseases, Protein Misfolding and Aggregation.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Hindi: (Fluent, Fluent, Fluent)
French: (Fluent, Functional, Functional)
Bengali: (Basic, Basic, Fluent)

Memberships

American Society for Cell Biology
Association for Research in Vision and Ophthalmology
Cell Stress Society International
International Biopharmaceutical Association
International Society for Eye Research
Society for Neuroscience

Honors and Awards

2004, National Venture Capital Investment Competition, Kenan-Flagler Business School, University of North Carolina at Chapel Hill, Investments and Venture Capital

Previous Positions

2007-2007, Research Fellow, Harvard University, Medical School/Brigham and Women's Hospital, Surgery
2006-2007, Postdoctoral Fellow, University of Washington, School of Medicine, Biological Structure, Biomolecular Structure and Design
2000-2006, Pre-doctoral Research Associate, University of Washington, School of Medicine, Biological Structure

Patents

Intellipeptides as therapeutics for protein misfolding diseases, Patent Number: 625364, 2004, Institution, United States of America.

Publications

  • Ghosh JG, Houck SA, Clark JI (2007) Interactive sequences in the molecular chaperone, human alphaB crystallin modulate the fibrillation of amyloidogenic proteins., Int J Biochem Cell Biol., In Press
  • Ghosh JG, Houck SA, Clark JI (2007) Interactive Domains in the Molecular Chaperone Human alphaB Crystallin Modulate Microtubule Assembly and Disassembly., PLoS ONE, 2, e498
  • Ghosh JG, Shenoy Jr. AK, Clark JI (2007) Interactions between Important Regulatory Proteins and Human alphaB Crystallin., Biochemistry, 46 (21), 6308-17
  • Ghosh JG, Houck SA, Clark JI (2007) Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments., Int J Biochem Cell Biol., 39 (10), 1804-15
  • Ghosh JG, Shenoy Jr. AK, Clark JI (2007) Interactions between important regulatory proteins and the stress response protein, human crystallin., World Conference of Stress
  • Ghosh JG, Houck SA, Doneanu CE, Clark JI (2006) The beta4-beta8 groove is an ATP-interactive site in the alpha crystallin core domain of the small heat shock protein, human alphaB crystallin., J Mol Biol., 364 (3), 364-75
  • Ghosh JG, Shenoy Jr. AK, Clark JI (2006) N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates., Biochemistry, 45 (46), 13847-54
  • Ghosh JG, Estrada MR, Clark JI (2006) Structure-Based Analysis of the beta8 Interactive Sequence of Human alphaB Crystallin, Biochemistry, 45 (32), 9878-86
  • Emerson RO, Sage EH, Ghosh JG, Clark JI (2006) Chaperone-like activity revealed in the matricellular protein SPARC, Journal of Cellular Biochemistry, 45 (32), 701-5
  • Ghosh JG, Estrada MR, Houck SA, Clark JI (2006) The function of the beta3 interactive domain in the small heat shock protein and molecular chaperone, human alphaB crystallin, Cell Stress Chaperones, 11 (2), 187-97
  • Liu L, Ghosh JG, Clark JI, Jiang S (2006) Studies of alphaB crystallin subunit dynamics by surface plasmon resonance, Analytical Biochemistry, 350 (2), 186-95
  • Ghosh JG, Estrada MR, Clark JI (2006) Identification of the chaperone sites in alphaB crystallin using protein pin arrays., Molecular Chaperones & the Heat Shock Response
  • Ghosh JG, Estrada MR, Clark JI (2005) Interactive Domains for Chaperone Activity in the Small Heat Shock Protein, Human alphaB Crystallin, Biochemistry, 44 (45), 14854-69
  • Ghosh JG, Clark JI (2005) Insights into the domains required for dimerization and assembly of human alphaB crystallin, Protein Science, 14 (3), 684-95
  • Ghosh JG, Estrada MR, Clark JI (2004) Interaction sites in human alphaB crystallin mediate multiple functions., ARVO, Investigative Ophthalmology & Visual Science, U346-U346 pages
  • Ghosh JG, Estrada MR, Clark JI (2004) Identification of the chaperone sites in human alphaB crystallin using protein pin arrays and homology modeling., XVI International Congress of Eye Research
  • Ghosh JG, Clark JI (2003) Identification of the functional domains of human alphaB crystallin using protein pin arrays and homology modeling., ARVO, Investigative Ophthalmology & Visual Science, U410-U410 pages
  • Ghosh JG, Gloria S, Clark JI (2002) Analyzing the proteins of the mouse lens using laser capture microdissection (LCM), ARVO, Investigative Ophthalmology & Visual Science, U1001-U1001 pages

Profile Details

Last Updated: 1/15/2008

COS Expertise ID #1180104
Reference this profile directly: http://myprofile.cos.com/joyghosh