Dr. Joe William Ramos

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University of Hawaii
Cancer Research Center University of Hawaii
Natural Products
Assistant ProfessorAppointed: 2004
Professional Headshot of Joe William Ramos

Mailing Address

651 Ilalo Street
BSB 231E
Honolulu, Hawaii 96813
United States

Contact Information

Phone: (808) 564-5843
Fax: (808) 587-0742
jramos@crch.hawaii.edu
http://www.crch.org/Faculty/jramos

Qualifications

Postdoctoral, Scripps Research Institute, Vascular Biology, 2000.
Ph.D., University of Virginia, Cell Biology, 1996.
B.A., University of Virginia, Biology, 1989.

Expertise and Research Interests

Our mission is to understand the regulation of cell signaling pathways. We are particularly focused on the affects of a protein called PEA-15 on the MAP kinase and apoptotic pathways. Because of the fundamental nature of this work it has applications to a number of pathological states including breast cancer, diabetes, brain cancer and leukemia.

Future Research

We are beginning to investigate the use of natural products derived from organisms indigenous to Hawaii to affect tumor cell growth and metastasis.

Keywords

COS Keywords:

Apoptosis, Cancer Biology, Cell Biology, Cell Proliferation, Natural Products, Vascular Biology.

Additional Terms:

Apoptosis, Cancer Biology, Cell Adhesion, Cell Signaling, Development, Integrins, MAP Kinase, Natural Products, PEA-15, Proliferation, Rsk2.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Spanish: (Basic, Basic, Functional)

Memberships

American Association for the Advancement of Science
American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
Cancer Institute of New Jersey

Honors and Awards

1999, Short Term Travel Award, Leukemia Society of America
1992, ASCB Predoctoral Student Travel Award, American Society for Cell Biology, Cell Biology

Previous Positions

2000-2004, Assistant Professor, Rutgers, The State University of New Jersey, FAS, Cell Biology and Neuroscience
1998-2000, Research Assistant, Scripps Research Institute, Vascular Biology
1995-1997, Post-doctoral Fellow, Scripps Research Institute, Vascular Biology
1989-1995, Graduate Student, University of Virginia, School of Medicine, Cell Biology

Funding Received

  • National Institutes of Health (NIH): Regulation of Cell Adhesion and Signaling, $1,292,595, Jul 1, 2002 to 2008.
  • Johnson and Johnson Foundation: Discovery Grant, $20,000, Jul 2001 to Jun 2003.
  • American Cancer Society (ACS): Cell Signaling and Adhesion, $847,000, Jan 1, 2002 to 30, 2002.
  • California Cancer Research Project: Career Developement Award, $198,000, Jan 1, 1999 to Sep 1, 2000.
  • Hawaii Community Foundation: PEA-15 Control of Cell Survival in Breast Cancer, $50,000, 2006 to 2008.
  • Leukemia Society of America: Fellowship, 1998 to 2000.
  • National Institutes of Health (NIH): NRSA, 1997 to 1998.

Publications

  • Ramos JW (2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells., The international journal of biochemistry & cell biology, 40 (12), 2707-19 Abstract
  • Pastorino S, Ramos JW (Jan 2008) Glioma: challenges and new insights in the development of effective therapies., Hawaii medical journal, 67 (1), 20-3, 25 Abstract
  • Vaidyanathan H, Opoku-Ansah J, Pastorino S, Renganathan H, Matter ML, Ramos JW (Dec 2007) ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15., Proceedings of the National Academy of Sciences of the United States of America, 104 (50), 19837-42 Abstract
  • Renault-Mihara F, Beuvon F, Iturrioz X, Canton B, De Bouard S, Léonard N, Mouhamad S, Sharif A, Ramos JW, Junier MP, Chneiweiss H (Dec 2006) Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism., Molecular biology of the cell, 17 (12), 5141-52 Abstract
  • Matter ML, Ramos JW (2006) Expression cloning of signaling proteins regulated by cell adhesion., Methods in molecular biology (Clifton, N.J.), 341, 155-65 Abstract
  • Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW (Sep 2005) Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD., The Biochemical Journal, 390 (Pt 3), 729-35 Abstract
  • Sur R, Ramos JW (Apr 2005) Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation., The Biochemical Journal, 387 (Pt 2), 315-24 Abstract
  • Ramos JW (Mar 2005) Cancer research center hotline: PEA-15 phosphoprotein: a potential cancer drug target., Hawaii Medical Journal, 64 (3), 77-80 Abstract
  • Chou FL, Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg MH, PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation, The Journal of Biological Chemistry, 278(52), 52587-97, Dec 2003 Abstract
  • Vaidyanathan H, Ramos JW, RSK2 activity is regulated by its interaction with PEA-15, Journal of Bioligical Chemistry, 278(34), 32367-72, August 2003 Abstract
  • Hill JM, Vaidyanathan H, Ramos JW, Ginsberg MH, Werner MH, Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain, The Embo Journal, 21(23), 6494-504, December 2002 Abstract
  • Ramos JW, Ginsberg M, Expression cloning strategies for the identification of adhesion molecules, Methods in Cell Biology, 69, 209-21, 2002 Abstract
  • Matter ML, Ginsberg MH, Ramos JW, Identification of cell signaling molecules by expression cloning, Science's Stke [electronic Resource] : Signal Transduction Knowledge Environment., 2001(103), PL9, October 2001 Abstract
  • Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H, PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase, Developmental Cell, 1(2), 239-50, August 2001 Abstract
  • Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA, Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them, Journal of Biological Chemistry, 275(45), 35224-32, November 2000 Abstract
  • Ramos JW, Hughes PE, Renshaw MW, Schwartz MA, Formstecher E, Chneiweiss H, Ginsberg MH, Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism, Molecular Biology of the Cell, 11(9), 2863-72, September 2000 Abstract
  • Fenczik, CA, Ramos, JW, Ginsberg MH, Expression cloning of proteins that modify integrin activation, Signaling Through Cell Adhesion Molecules, Jun-Lin Guan ed(CRC Press), 235-243, 1999
  • Ramos JW, Kojima TK, Hughes PE, Fenczik CA, Ginsberg MH, The death effector domain of PEA-15 is involved in its regulation of integrin activation, Journal of Biological Chemistry, 273(51), 33897-900, December 1998 Abstract
  • Fenczik CA, Sethi T, Ramos JW, Hughes PE, Ginsberg MH, Complementation of dominant suppression implicates CD98 in integrin activation, Nature, 390(6655), 81-5, November 1997 Abstract
  • Ramos JW, Whittaker CA, DeSimone DW, Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation, Development (cambridge, England), 122(9), 2873-83, September 1996 Abstract
  • Ramos JW, DeSimone DW, Xenopus embryonic cell adhesion to fibronectin: position-specific activation of RGD/synergy site-dependent migratory behavior at gastrulation, Journal of Cell Biology, 134(1), 227-40, July 1996 Abstract
  • Alfandari D, Ramos J, Clavilier L, DeSimone DW, Darribere T, The RGD-dependent and the Hep II binding domains of fibronectin govern the adhesive behaviors of amphibian embryonic cells, Mechanisms of Development, 56(1-2), 83-92, May 1996 Abstract
  • Danker K, Hacke H, Ramos J, DeSimone D, Wedlich D, V(+)-fibronectin expression and localization prior to gastrulation in Xenopus laevis embryos, Mechanisms of Development, 44(2-3), 155-65, December 1993 Abstract

Profile Details

Last Verified: 10/3/2008

COS Expertise ID #960080
Reference this profile directly: http://myprofile.cos.com/jramos