Dr. Jack R. Harkema

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Michigan State University
College of Veterinary Medicine
Pathobiology and Diagnostic Investigation
University Distinguished ProfessorAppointed: 1994
Professional Headshot of Jack R. Harkema

Mailing Address

212 Food Safety and Toxicology Building
Department of Pathobiology and Diagnostic Investigation
National Food Safety & Toxicology Center
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 353-8627
Fax: (517) 353-9902
harkemaj@msu.edu

Qualifications

Ph.D., University of California, Davis, Comparative Pathology, 1985.
D.V.M., Michigan State University, Veterinary Medicine, 1980.
M.S., Michigan State University, Mammalian Physiology, 1977.
B.S., Calvin College, Biology, Chemistry, 1975.

Expertise and Research Interests

Dr. Harkema's primary research interests are in the understanding of the cellular and molecular mechanisms responsible for the pathogenesis of airway injury, adaptation, and repair after exposure to inhaled toxicants in outdoor and indoor environments. His laboratory is investigating the roles of inflammatory cells and their mediators in the pathogenesis of airway epithelial alterations(e.g.,apoptosis,necrosis,hyperplasia, metaplasia)in both the upper and lower respitory tract after exposure (and co-exposure) to various inhaled xenobiotic agents (e.g., particulate matter, ozone, endotoxin, mycotoxins). His research also focuses on identifying biological factors (e.g.,genetics, age, pre-existing disease) responsible for increasing airway susceptibility to toxicant-induced injury. The long-range goal of these studies are to understand the basic mechanisms of airway cell injury and repair in order to better prevent or treat the adverse effects of airborne pollutants.

Keywords

COS Keywords:

Air Pollution, Animal Physiology or Morphology, Asthma, Blood Diseases, Cardiology, Cardiopulmonary Chest Medicine, Cardiovascular System, Food Safety, Immunohistochemistry, Inflammation, Mammalogy, Messenger RNA, Pathobiology, Pathogenesis, Pathology, Pharmacology, Pulmonary Diseases, Respiratory Diseases, Toxicology, Veterinary Medicine.

Additional Terms:

Air Pollution, Airborne Particulate Matter, Airway Epithelium, Airway Mucus, Animal Models of Human Respiratory Disease, Asthma, Chronic Bronchitis, Endotoxin, Food Safety, Hepatic Toxicology, Immunohistochemistry, Inhalation Toxicology, Messenger RNA, Metaplasia, Morphometry, Mucin-specific Gene Expression, Nasal Toxicology, Organic Dusts, Ozone, Pulmonary Toxicology, Toxicologic Pathology.

Memberships

American Association for the Advancement of Science
American College of Veterinary Pathologists
American Thoracic Society
American Veterinary Medical Association
Phi Zeta
Society of Toxicologic Pathologists
Society of Toxicology

Honors and Awards

2006, Distinguished Faculty Award, College of Veterinary Medicine, Michigan State University
2003, University Distinguished Professor Michigan State University
2001, Pfizer Award for Research Excellence, Pfizer, Michigan State University, Animal Health
1987, New Investigator Award, Inhalation Specialty Section of the Society of Toxicology

Previous Positions

1986-1994, Pathologist and Program Manager, Inhalation Toxicology Research Institute, Albuquerque, Lovelace Respiratory Research Institute, Pathogenesis Program
1982-1985, NIEHS Training Grant Recipient, University of California, Davis, School of Veterinary Medicine, Pathology

Funding Received

  • California National Primate Research Center: Toxicity of Satratoxin G from the Black Mold Stachybotrys chartarum in the Nose and Brain of the Rhesus Monkey, 2006 to 2007.
  • National Institutes of Health (NIH): Environmental, Microbial, and Mammalian Biomolecular Responses to AHR Ligands (Michigan State University Superfund Basic Research Program), 2006 to 2011.
  • United States Department of Energy (DOE): Tri-City Concentrated Ambient Particle Study, 2005 to 2009.
  • Environmental Protection Agency (EPA): Southern California Particulate Center, 2005 to 2010.
  • Environmental Protection Agency (EPA): Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment RFA Estrogen Elicited Gene Expression Network Elucidation in the Rat Uterus, 2004 to 2007.
  • NIH/National Center for Complementary and Alternative Medicine: Translational Research Center for CAM Therapy of Asthma, 2004 to 2009.
  • National Institutes of Health (NIH): Mechanisms of Species-Dependent Environmental Lung Injury, 2003 to 2011.
  • Health Effects Institute (HEI): Fine Airborne Particles and Allergic Airway Disease, 2003 to 2006.
  • National Institutes of Health (NIH): Inflammation and Drug Idiosyncrasy, 2003 to 2007.
  • Environmental Protection Agency (EPA): Effects of Airborne Particles on Allergic Airway Disease, 2001 to 2006.
  • Michigan Life Sciences Corridor Fund: Biomarkers of Air Pollution-Related Diseases, 2000 to 2004.
  • Health Effects Institute: Effects of Inhaled Urban Air Particulates on Normal and Hypersecretory Airways in Rats, 1999 to 2001.
  • International Carbon Black Association: Carbon black-induced lung tumors in the rat: Pathology, 1999 to 2001.
  • National Institutes of Health (NIH): Effects of O3/Endotoxin co-exposure on airway epithelium, 1998 to 2001.

Publications

  • Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE (Jan 2008) Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress. Abstract
  • Buchweitz JP, Karmaus PW, Williams KJ, Harkema JR, Kaminski NE (Dec 2007) Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of {Delta}9-tetrahydrocannabinol. Abstract
  • Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, Boucher RC (Dec 2007) Development of Chronic Bronchitis and Emphysema in {beta}ENaC Overexpressing Mice. Abstract
  • Buchweitz JP, Karmaus PW, Harkema JR, Williams KJ, Kaminski NE (Nov 2007) Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice., The Journal of pharmacology and experimental therapeutics, 323 (2), 675-83 Abstract
  • Pestka JJ, Yike I, Dearborn DG, Ward MD, Harkema JR (Nov 2007) Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building-Related Illness: New Insights into a Public Health Enigma. Abstract
  • Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR (Nov 2007) Comparative Toxicogenomic Examination of the Hepatic Effects of PCB126 and TCDD in Immature, Ovariectomized C57BL/6 Mice. Abstract
  • Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB (Oct 2007) gamma-Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Abstract
  • Islam Z, Amuzie CJ, Harkema JR, Pestka JJ (Aug 2007) Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure., Toxicological sciences : an official journal of the Society of Toxicology, 98 (2), 526-41 Abstract
  • Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R (Jul 2007) Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice., Journal of virology, 81 (14), 7410-23 Abstract
  • Wagner JG, Harkema JR (May 2007) Rodent models of allergic rhinitis: relevance to human pathophysiology., Current allergy and asthma reports, 7 (2), 134-40 Abstract
  • Li M, Harkema JR, Cuff CF, Pestka JJ (Feb 2007) Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection., Toxicological sciences : an official journal of the Society of Toxicology, 95 (2), 412-26 Abstract
  • Keeler GJ, Morishita M, Wagner JG, Harkema JR (2007) Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan., Toxicologic pathology, 35 (1), 15-22 Abstract
  • Carey SA, Minard KR, Trease LL, Wagner JG, Garcia GJ, Ballinger CA, Kimbell JS, Plopper CG, Corley RA, Postlethwait EM, Harkema JR, Einstein DR (2007) Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques., Toxicologic pathology, 35 (1), 27-40 Abstract
  • Buchweitz JP, Harkema JR, Kaminski NE (2007) Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice., Toxicologic pathology, 35 (3), 424-35 Abstract
  • Birmingham NP, Parvataneni S, Hassan HM, Harkema J, Samineni S, Navuluri L, Kelly CJ, Gangur V (2007) An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut., International archives of allergy and immunology, 144 (3), 203-10 Abstract
  • Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, Zacharewski TR (Dec 2006) Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice., Toxicological sciences : an official journal of the Society of Toxicology, 94 (2), 398-416 Abstract
  • Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G (Dec 2006) A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black., Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 48 (12), 1265-78 Abstract
  • Deming D, Sheahan T, Heise M, Yount B, Davis N, Sims A, Suthar M, Harkema J, Whitmore A, Pickles R, West A, Donaldson E, Curtis K, Johnston R, Baric R (Dec 2006) Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants., PLoS medicine, 3 (12), e525 Abstract
  • Li M, Harkema JR, Islam Z, Cuff CF, Pestka JJ (Nov 2006) T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis., Toxicology and applied pharmacology, 217 (1), 76-85 Abstract
  • Lugo J, Harkema JR, deFeijter-Rupp H, Bartner L, Boruta D, Robinson NE (Sep 2006) Airway inflammation is associated with mucous cell metaplasia and increased intraepithelial stored mucosubstances in horses., Veterinary journal (London, England : 1997), 172 (2), 293-301 Abstract
  • Farraj AK, Harkema JR, Kaminski NE (Jul 2006) Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice., Toxicological sciences : an official journal of the Society of Toxicology, 92 (1), 321-8 Abstract
  • Farraj AK, Harkema JR, Kaminski NE (Jul 2006) Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice., Toxicological sciences : an official journal of the Society of Toxicology, 92 (1), 321-8 Abstract
  • Islam Z, Harkema JR, Pestka JJ (Jul 2006) Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain., Environmental health perspectives, 114 (7), 1099-107 Abstract
  • Sirivelu MP, MohanKumar SM, Wagner JG, Harkema JR, MohanKumar PS (Jun 2006) Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease., Environmental health perspectives, 114 (6), 870-4 Abstract
  • Crockett ET, Galligan JJ, Uhal BD, Harkema J, Roth R, Pandya K (Feb 2006) Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists., 6 (1), 3 Abstract
  • Harkema JR, Carey SA, Wagner JG (2006) The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium., Toxicologic pathology, 34 (3), 252-69 Abstract
  • Hyde DM, Harkema JR, Tyler NK, Plopper CG (2006) Design-based sampling and quantitation of the respiratory airways., Toxicologic pathology, 34 (3), 286-95 Abstract
  • Morishita MKG, Keeler GJ, Wagner JG, Harkema JR (2006) Source identification of ambient PM2 5 during summer inhalation exposure studies in Detroit, MI, Atmospheric Environ, 40, 3823-3834
  • Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G (Dec 2005) Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology., Toxicological sciences : an official journal of the Society of Toxicology, 88 (2), 614-29 Abstract
  • Kwekel JC, Burgoon LD, Burt JW, Harkema JR, Zacharewski TR (Nov 2005) A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling., Physiological genomics, 23 (3), 327-42 Abstract
  • Harkema JR, Wagner JG (Jul 2005) Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: enhancement of toxicant-induced airway injury., Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 57 Suppl 1, 129-41 Abstract
  • Harkema JR, Wagner JG (Jul 2005) Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: enhancement of toxicant-induced airway injury., Exp Toxicol Pathol, 57 Suppl 1, 129-41 Abstract
  • Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, Zacharewski TR (Jun 2005) Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity., Toxicological sciences : an official journal of the Society of Toxicology, 85 (2), 1048-63 Abstract
  • Harris JF, Fischer MJ, Hotchkiss JR, Monia BP, Randell SH, Harkema JR, Tesfaigzi Y (Apr 2005) Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium., Am J Respir Crit Care Med, 171 (7), 764-72 Abstract
  • Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E (Aug 2004) Effects of concentrated ambient particles on normal and hypersecretory airways in rats., Res Rep Health Effects (120), 1-68; discussion 69- Abstract
  • Farraj AK, Harkema JR, Kaminski NE (Jun 2004) Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice., Toxicol Sci, 79 (2), 315-25 Abstract
  • Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC (May 2004) Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice., Nat Med, 10 (5), 487-93 Abstract
  • Tesfaigzi Y, Harris JF, Hotchkiss JA, Harkema JR (Feb 2004) DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS., Am J Physiol Lung Cell Mol Physiol, 286 (2), L268-74 Abstract
  • Yee SB, Harkema JR, Ganey PE, Roth RA, The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide, Toxicological Sciences : an Official Journal of the Society of Toxicology., 74(2), 457-69, August 2003 Abstract
  • Wagner JG, Van Dyken SJ, Wierenga JR, Hotchkiss JA, Harkema JR, Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways, Toxicological Sciences : an Official Journal of the Society of Toxicology., 74(2), 437-46, August 2003 Abstract
  • Farraj AK, Harkema JR, Jan TR, Kaminski NE, Immune responses in the lung and local lymph node of a/j mice to intranasal sensitization and challenge with adjuvant-free ovalbumin, Toxicologic Pathology, 31(4), 432-47, 2003 Abstract
  • Gavett SH, Haykal-Coates N, Highfill JW, Ledbetter AD, Chen LC, Cohen MD, Harkema JR, Wagner JG, Costa DL, World trade center fine particulate matter causes respiratory tract hyperresponsiveness in mice, Environmental Health Perspectives, 111(7), 981-91, June 2003 Abstract
  • Jan TR, Farraj AK, Harkema JR, Kaminski NE, Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice, Toxicology and Applied Pharmacology, 188(1), 24-35, April 2003 Abstract
  • Lugo J, Stick JA, Peroni J, Harkema JR, Derksen FJ, Robinson NE, Safety and efficacy of a technique for thoracoscopically guided pulmonary wedge resection in horses, American Journal of Veterinary Research, 63(9), 1232-40, September 2002 Abstract
  • Wagner JG, Hotchkiss JA, Harkema JR, Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats, Toxicological Sciences : an Official Journal of the Society of Toxicology., 67(2), 284-94, June 2002 Abstract
  • Wagner JG, Harkema JR, Roth RA, Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat, Shock (augusta, Ga.), 17(2), 151-8, February 2002 Abstract
  • Harkema JR, Wagner JG, Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways, Novartis Foundation Symposium, 248, 181-97; discussion 1, 2002 Abstract
  • Jefcoat AM, Hotchkiss JA, Gerber V, Harkema JR, Basbaum CB, Robinson NE, Persistent mucin glycoprotein alterations in equine recurrent airway obstruction, American Journal of Physiology. Lung Cellular and Molecular Physiology, 281(3), L704-12, September 2001 Abstract
  • Wagner JG, Hotchkiss JA, Harkema JR, Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations, Environmental Health Perspectives, 109 Suppl 4, 591-8, August 2001 Abstract
  • Wiethoff AJ, Harkema JR, Koretsky AP, Brown WE, Identification of mucosal injury in the murine nasal airways by magnetic resonance imaging: site-specific lesions induced by 3-methylindole, Toxicology and Applied Pharmacology, 175(1), 68-75, August 2001 Abstract
  • Wagner JG, Van Dyken SJ, Hotchkiss JA, Harkema JR, Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium, Toxicological Sciences : an Official Journal of the Society of Toxicology., 60(2), 338-47, April 2001 Abstract
  • Moss OR, Gross EA, James RA, Janszen DB, Ross PW, Roberts KC, Howard AM, Harkema JR, Calderon-Garciduenas L, Morgan KT, Respiratory tract toxicity in rats exposed to Mexico City air, Research Report (health Effects Institute), 1-24; discussion 25-, March 2001
  • Wiley JA, Cerwenka A, Harkema JR, Dutton RW, Harmsen AG, Production of interferon-gamma by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology, American Journal of Pathology, 158(1), 119-30, Jan 2001 Abstract
  • Martinez-Mier G, Toledo-Pereyra LH, Bussell S, Gauvin J, Vercruysse G, Arab A, Harkema JR, Jordan JA, Ward PA, Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury, Transplantation, 70(10), 1431-7, November 2000 Abstract
  • Cho HY, Hotchkiss JA, Bennett CB, Harkema JR, Neutrophil-dependent and neutrophil-independent alterations in the nasal epithelium of ozone-exposed rats, American Journal of Respiratory and Critical Care Medicine, 162(2 Pt 1), 629-36, August 2000 Abstract
  • Yee SB, Kinser S, Hill DA, Barton CC, Hotchkiss JA, Harkema JR, Ganey PE, Roth RA, Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline, Toxicology and Applied Pharmacology, 166(3), 173-85, August 2000 Abstract
  • Zhou HR, Harkema JR, Hotchkiss JA, Yan D, Roth RA, Pestka JJ, Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs, Toxicological Sciences : an Official Journal of the Society of Toxicology., 53(2), 253-63, February 2000 Abstract
  • Cho HY, Hotchkiss JA, Harkema JR, Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats, Toxicological Sciences, 51(1), 135-45, September 1999 Abstract
  • Cho HY, Hotchkiss JA, Harkema JR, Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats., Toxicological Sciences, 51(1), 135-45, September 1999 Abstract
  • Cho HY, Hotchkiss JA, Bennett CB, Harkema JR, Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium., Toxicology and Applied Pharmacology, 158(2), 92-102, 15 Jul 1999 Abstract
  • Cho HY, Hotchkiss JA, Bennett CB, Harkema JR, Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium, Toxicology and Applied Pharmacology, 158(2), 92-102, July 1999 Abstract
  • Fanucchi MV, Harkema JR, Plopper CG, Hotchkiss JA, In vitro culture of microdissected rat nasal airway tissues, American Journal of Respiratory Cell and Molecular Biology, 20(6), 1274-85, June 1999 Abstract
  • Fanucchi MV, Harkema JR, Plopper CG, Hotchkiss JA, In vitro culture of microdissected rat nasal airway tissues., American Journal of Respiratory Cell and Molecular Biology, 20(6), 1274-85, June 1999 Abstract
  • Zhou HR, Harkema JR, Yan D, Pestka JJ, Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol), Journal of Toxicology and Environmental Health, 57(2), 115-36, May 1999 Abstract
  • Vesely KR, Schelegle ES, Stovall MY, Harkema JR, Green JF, Hyde DM, Breathing pattern response and epithelial labeling in ozone-induced airway injury in neutrophil-depleted rats, American Journal of Respiratory Cell and Molecular Biology, 20(4), 699-709, April 1999 Abstract
  • Vesely KR, Hyde DM, Stovall MY, Harkema JR, Green JF, Schelegle ES, Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats, Journal of Applied Physiology, 86(3), 951-62, March 1999 Abstract
  • Harkema JR, Hotchkiss JA, Barr EB, Bennett CB, Gallup M, Lee JK, Basbaum C, Long-lasting effects of chronic ozone exposure on rat nasal epithelium, American Journal of Respiratory Cell and Molecular Biology, 20(3), 517-29, March 1999 Abstract
  • Longphre M, Zhang L, Harkema JR, Kleeberger SR, Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF, Journal of Applied Physiology, 86(1), 341-9, Jan 1999 Abstract
  • Fanucchi MV, Hotchkiss JA, Harkema JR, Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium, Toxicology and Applied Pharmacology, 152(1), 1-9, September 1998 Abstract
  • Tesfaigzi J, Hotchkiss JA, Harkema JR, Expression of the Bcl-2 protein in nasal epithelia of F344/N rats during mucous cell metaplasia and remodeling, American Journal of Respiratory Cell and Molecular Biology, 18(6), 794-9, June 1998 Abstract
  • Tesfaigzi J, Hotchkiss JA, Harkema JR, Expression of the Bcl-2 protein in nasal epithelia of F344/N rats during mucous cell metaplasia and remodeling., American Journal of Respiratory Cell and Molecular Biology, 18(6), 794-9, 1998 Abstract
  • Hotchkiss JA, Hilaski R, Cho H, Regan K, Spencer P, Slack K, Harkema JR, Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium., American Journal of Respiratory Cell and Molecular Biology, 18(1), 91-9, 1998 Abstract
  • Roth RA, Harkema JR, Pestka JP, Ganey PE, Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?, Toxicology and Applied Pharmacology, 147(2), 300-11, December 1997 Abstract
  • Kleeberger SR, Levitt RC, Zhang LY, Longphre M, Harkema J, Jedlicka A, Eleff SM, DiSilvestre D, Holroyd KJ, Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice, Nature Genetics, 17(4), 475-8, December 1997 Abstract
  • Harkema JR, Hotchkiss JA, Griffith WC, Mucous cell metaplasia in rat nasal epithelium after a 20-month exposure to ozone: a morphometric study of epithelial differentiation, American Journal of Respiratory Cell and Molecular Biology, 16(5), 521-30, May 1997 Abstract
  • Harkema JR, Catalano PJ, Hotchkiss JA, Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XII: Atrophy of bone in nasal turbinates, Research Report / Health Effects Institute, 1-19; discussion 21-, April 1997 Abstract
  • Brown AP, Harkema JR, Schultze AE, Roth RA, Ganey PE, Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration, Shock, 7(3), 186-92, March 1997 Abstract
  • Hotchkiss J A, Harkema J R, Johnson N F, Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone., Toxicology and Applied Pharmacology, 143(1), 75-82, March 1997 Abstract
  • Harkema JR, Barr EB, Hotchkiss JA, Responses of rat nasal epithelium to short- and long-term exposures of ozone: image analysis of epithelial injury, adaptation and repair, Microscopy Research and Technique, 36(4), 276-86, February 1997
  • Snipes MB, Harkema JR, Hotchkiss JA, Bice DE, Neutrophil involvement in the retention and clearance of dust intratracheally instilled into the lungs of F344/N rats, Experimental Lung Research, 23(1), 65-84, 1997 Abstract
  • Tesfaigzi J, Th'ng J, Hotchkiss J A, Harkema J R, Wright P S, A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia., American Journal of Respiratory Cell and Molecular Biology, 14(5), 478-86, May 1996 Abstract
  • Longphre M, Zhang LY, Harkema JR, Kleeberger SR, Mass cells contribute to O3-induced epithelial damage and proliferation in nasal and bronchial airways of mice, Journal of Applied Physiology, 80(4), 1322-30, April 1996 Abstract
  • Gordon T, Harkema JR, Mucous cell metaplasia in the airways of rats exposed to machining fluids, Fundamental and Applied Toxicology, 28(2), 274-82, December 1995 Abstract
  • Gordon T, Harkema JR, Cotton dust produces an increase in intraepithelial mucosubstances in rat airways, American Journal of Respiratory and Critical Care Medicine, 151(6), 1981-8, June 1995 Abstract
  • Hotchkiss JA, Evans WA, Chen BT, Finch GL, Harkema JR, Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium, Toxicology and Applied Pharmacology, 131(2), 316-24, April 1995 Abstract
  • Catalano P J, Chang L Y, Harkema J R, Kaden D A, Last J A, Mellick P W, Parks W C, Pinkerton K E, Radhakrishnamurthy B, Ryan L M, et al, Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XI: Integrative Summary., Research Report / Health Effects Institute, 1-54; discussion 55-, April 1995 Abstract
  • Steiger D, Hotchkiss J, Bajaj L, Harkema J, Basbaum C, Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin., American Journal of Respiratory Cell and Molecular Biology, 12(3), 307-14, March 1995 Abstract
  • Henderson RF, Driscoll KE, Harkema JR, Lindenschmidt RC, Chang IY, Maples KR, Barr EB, A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats, Fundamental and Applied Toxicology, 24(2), 183-97, February 1995 Abstract
  • Harkema JR, Mauderly JL, Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part V: Effects on pulmonary function, Research Report / Health Effects Institute, 3-17; discussion 19-, November 1994 Abstract
  • Harkema JR, Morgan KT, Gross EA, Catalano PJ, Griffith WC, Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part VII: Effects on the nasal mucociliary apparatus, Research Report / Health Effects Institute, 3-26; discussion 27-, November 1994 Abstract
  • Hyde DM, Bolender RP, Harkema JR, Plopper CG, Morphometric approaches for evaluating pulmonary toxicity in mammals: implications for risk assessment, Risk Analysis, 14(3), 293-302, June 1994 Abstract
  • Singh G, Harkema JM, Mayberry AJ, Chaudry IH, Severe depression of gut absorptive capacity in patients following trauma or sepsis, Journal of Trauma, 36(6), 803-8; discussion 80, June 1994 Abstract
  • Last JA, Gelzleichter TR, Harkema J, Hawk S, Consequences of prolonged inhalation of ozone on Fischer-344/N rats: collaborative studies. Part I: Content and cross-linking of lung collagen, Research Report / Health Effects Institute, 1-29; discussion 31-, April 1994 Abstract
  • Ubels JL, Harkema JR, The rabbit lacrimal gland in vitamin A deficiency, Investigative Ophthalmology and Visual Science, 35(3), 1249-53, March 1994 Abstract
  • Gordon T, Harkema JR, Effect of inhaled endotoxin on intraepithelial mucosubstances in F344 rat nasal and tracheobronchial airways, American Journal of Respiratory Cell and Molecular Biology, 10(2), 177-83, February 1994 Abstract
  • Harkema JR, Hotchkiss JA, In vivo effects of endotoxin on DNA synthesis in rat nasal epithelium, Microscopy Research and Technique, 26(5), 457-65, December 1993 Abstract
  • Last JA, Gelzleichter T, Harkema J, Parks WC, Mellick P, Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats, Toxicology, 84(1-3), 83-102, November 1993 Abstract
  • Hotchkiss JA, Stam MA, Harkema JR, Platelet activating factor stimulates rapid mucin secretion in rat nasal airways in vivo, Experimental Lung Research, 19(5), 545-57, 1993 Abstract
  • Harkema JR, Plopper CG, Hyde DM, St. George JA, Wilson DW, Dungworth DL, Response of macaque bronchiolar epithelium to ambient concentrations of ozone, American Journal of Pathology, 143(3), 857-66, September 1993 Abstract
  • Gerde P, Muggenburg B A, Sabourin P J, Harkema J R, Hotckiss J A, Hoover M D, Henderson R F, Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. II. The conducting airways., Toxicology and Applied Pharmacology, 121(2), 319-27, August 1993 Abstract
  • Harkema JR, Hotchkiss JA, Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways, Toxicology Letters, 68(1-2), 251-63, May 1993 Abstract
  • Henderson RF, Hotchkiss JA, Chang IY, Scott BR, Harkema JR, Effect of cumulative exposure on nasal response to ozone, Toxicology and Applied Pharmacology, 119(1), 59-65, March 1993 Abstract
  • Hotchkiss JA, Kennel SJ, Harkema JR, A rat monoclonal antibody specific for murine type 1 pneumocytes, Experimental and Molecular Pathology, 57(3), 235-46, December 1992 Abstract
  • Harkema JR, Hotchkiss JA, In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways. Quantitative histochemistry, American Journal of Pathology, 141(2), 307-17, August 1992 Abstract
  • Hotchkiss JA, Harkema JR, Endotoxin or cytokines attenuate ozone-induced DNA synthesis in rat nasal transitional epithelium, Toxicology and Applied Pharmacology, 114(2), 182-7, June 1992 Abstract
  • Thomassen DG, Harkema JR, Sun JD, Stephens ND, Griffith WC, The role of ozone in tracheal cell transformation, Research Report / Health Effects Institute, 1-19; discussion 21-, April 1992 Abstract
  • Lewis J L, Rhoades C E, Bice D E, Harkema J R, Hotchkiss J A, Sylvester D M, Dahl A R, Interspecies comparison of cellular localization of the cyanide metabolizing enzyme rhodanese within olfactory mucosa., Anatomical Record, 232(4), 620-7, April 1992 Abstract
  • Harkema JR, Jones SE, Naydan DK, Wilson DW, An atypical neuroendocrine tumor in the lung of a beagle dog, Veterinary Pathology, 29(2), 175-9, March 1992 Abstract
  • Nikula K J, Sabourin P J, Frietag B C, Birdwhistell A J, Hotchkiss J A, Harkema J R, Biochemical and morphologic responses of rat nasal epithelia to hyperoxia., Fundamental and Applied Toxicology, 17(4), 675-83, November 1991 Abstract
  • Harkema JR, Hotchkiss JA, In vivo effects of endotoxin on nasal epithelial mucosubstances: quantitative histochemistry, Experimental Lung Research, 17(4), 743-61, 1991 Abstract
  • Henderson RF, Harkema JR, Hotchkiss JA, Boehme DS, Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz, Toxicology and Applied Pharmacology, 109(1), 127-36, June 1991 Abstract
  • Thomassen DG, Harkema JR, Stephens ND, Griffith WC, Preneoplastic transformation of rat tracheal epithelial cells by ozone, Toxicology and Applied Pharmacology, 109(1), 137-48, June 1991 Abstract
  • Hotchkiss JA, Harkema JR, Henderson RF, Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats, Experimental Lung Research, 17(3), 589-600, 1991 Abstract
  • Harkema JR, Comparative aspects of nasal airway anatomy: relevance to inhalation toxicology, Toxicologic Pathology, 19(4 Pt 1), 321-36, 1991 Abstract
  • Sabourin PJ, Nikula KJ, Birdwhistell AJ, Freitag BC, Harkema JR, Biochemical and morphologic response of nasal epithelia to hyperoxia, Advances in Experimental Medicine and Biology, 283, 813-6, 1991 Abstract
  • Harkema JR, Comparative pathology of the nasal mucosa in laboratory animals exposed to inhaled irritants, Environmental Health Perspectives, 85, 231-8, April 1990 Abstract
  • Johnson NF, Hotchkiss JA, Harkema JR, Henderson RF, Proliferative responses of rat nasal epithelia to ozone, Toxicology and Applied Pharmacology, 103(1), 143-55, March 1990 Abstract
  • Bond JA, Harkema JR, Henderson RF, Mauderly JL, McClellan RO, Wolff RK, The role of DNA adducts in diesel exhaust-induced pulmonary carcinogenesis, Progress in Clinical and Biological Research, 340C, 259-69, 1990 Abstract
  • Gillett NA, Gerlach RF, Muggenburg BA, Harkema JR, Griffith WC, Mauderly JL, Relationship between collateral flow resistance and alveolar pores in the aging beagle dog, Experimental Lung Research, 15(5), 709-19, September 1989 Abstract
  • Hotchkiss JA, Harkema JR, Sun JD, Henderson RF, Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats, Toxicology and Applied Pharmacology, 98(2), 289-302, April 1989 Abstract
  • Wolff RK, Bond JA, Sun JD, Henderson RF, Harkema JR, Griffith WC, Mauderly JL, McClellan RO, Effects of adsorption of benzo[a]pyrene onto carbon black particles on levels of DNA adducts in lungs of rats exposed by inhalation, Toxicology and Applied Pharmacology, 97(2), 289-99, February 1989 Abstract
  • Harkema JR, Hotchkiss JA, Henderson RF, Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: quantitative histochemistry, Toxicologic Pathology, 17(3), 525-35, 1989 Abstract
  • Hotchkiss JA, Harkema JR, Kirkpatrick DT, Henderson RF, Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure, Experimental Lung Research, 15(1), 1-16, 1989 Abstract
  • Wolff RK, Griffith WC, Henderson RF, Hahn FF, Harkema JR, Rebar AH, Eidson AF, McClellan RO, Effects of repeated inhalation exposures to 1-nitropyrene, benzo[a]pyrene, Ga2O3 particles, and SO2 alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histo, Journal of Toxicology and Environmental Health, 27(1), 123-38, 1989 Abstract
  • Mauderly JL, Bechtold WE, Bond JA, Brooks AL, Chen BT, Cuddihy RG, Harkema JR, Henderson RF, Johnson NF, Rithidech K, et al, Comparison of 3 methods of exposing rats to cigarette smoke, Experimental Pathology, 37(1-4), 194-7, 1989 Abstract
  • Bond JA, Wolff RK, Harkema JR, Mauderly JL, Henderson RF, Griffith WC, McClellan RO, Distribution of DNA adducts in the respiratory tract of rats exposed to diesel exhaust, Toxicology and Applied Pharmacology, 96(2), 336-46, November 1988 Abstract
  • Sun JD, Pickrell JA, Harkema JR, McLaughlin SI, Hahn FF, Henderson RF, Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis, Experimental and Molecular Pathology, 49(2), 254-66, October 1988 Abstract
  • Wolff RK, Barr EB, Bond JA, Eidson AF, Griffith WC, Hahn FF, Harkema JR, Henderson RF, Mitchell CE, Rothenberg SJ, et al, Factors affecting possible carcinogenicity of inhaled nitropyrene aerosols, Research Report / Health Effects Institute, 1-36, August 1988 Abstract
  • Harkema JR, Hotchkiss JA, Harmsen AG, Henderson RF, In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry, American Journal of Pathology, 130(3), 605-15, March 1988 Abstract
  • Bond JA, Harkema JR, Russell VI, Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs, Drug Metabolism and Disposition: the Biological Fate of Chemicals, 16(1), 116-24, 1988 Abstract
  • Harkema JR, Plopper CG, Hyde DM, Wilson DW, St. George JA, Wong VJ, Nonolfactory surface epithelium of the nasal cavity of the bonnet monkey: a morphologic and morphometric study of the transitional and respiratory epithelium, American Journal of Anatomy, 180(3), 266-79, November 1987 Abstract
  • Harkema JR, Plopper CG, Hyde DM, St. George JA, Wilson DW, Dungworth DL, Response of the macaque nasal epithelium to ambient levels of ozone. A morphologic and morphometric study of the transitional and respiratory epithelium, American Journal of Pathology, 128(1), 29-44, July 1987 Abstract
  • Harkema JR, Plopper CG, Hyde DM, St. George JA, Dungworth DL, Effects of an ambient level of ozone on primate nasal epithelial mucosubstances. Quantitative histochemistry, American Journal of Pathology, 127(1), 90-6, April 1987 Abstract
  • Harkema JR, Plopper CG, Hyde DM, St. George JA, Regional differences in quantities of histochemically detectable mucosubstances in nasal, paranasal, and nasopharyngeal epithelium of the bonnet monkey, Journal of Histochemistry and Cytochemistry, 35(3), 279-86, March 1987 Abstract
  • Fowler ME, Gillespie D, Harkema J, Lymphosarcoma in a llama, Journal of the American Veterinary Medical Association, 187(11), 1245-6, December 1985 Abstract
  • Rao GA, Larkin EC, Harkema JR, Dungworth DL, Changes in lipids of lung lavage in monkeys after chronic exposure to ambient levels of ozone, Toxicology Letters, 29(2-3), 207-14, December 1985 Abstract
  • Rao GA, Larkin EC, Harkema JR, Dungworth DL, Changes in the levels of polyunsaturated fatty acids in the lung and lecithin cholesterol acyl transferase activity in plasma of monkeys exposed to ambient levels of ozone, Toxicology Letters, 24(2-3), 125-9, 1985 Abstract
  • Harkema JR, Mauderly JL, Gregory RE, Pickrell JA, A comparison of starvation and elastase models of emphysema in the rat, The American Review of Respiratory Disease, 129(4), 584-91, April 1984 Abstract
  • Harkema JR, Mauderly JL, Hahn FF, The effects of emphysema on oxygen toxicity in rats, The American Review of Respiratory Disease, 126(6), 1058-65, December 1982 Abstract
  • Harkema JR, Mason MJ, Kusewitt DF, Pickrell JA, Cholecystotomy as treatment for obstructive jaundice in a dog, Journal of the American Veterinary Medical Association, 181(8), 815-6, October 1982 Abstract
  • Harkema JR, Robinson NE, Scott JB, Cardiovascular, acid-base, electrolyte, and plasma volume changes in ponies developing alimentary laminitis, American Journal of Veterinary Research, 39(5), 741-4, May 1978 Abstract

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