Dr. Johnny Tang |
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Case Western Reserve University School of Medicine Ophthalmology Assistant ProfessorAppointed: 2007 |
Mailing AddressDepartment of Ophthalmology and Visual Sciences University Hospitals Case Medical Center 11100 Euclid Avenue LKSD 4115 Cleveland, Ohio 44106-5068United States | Contact Information |
Qualifications
M.D., State University of New York Health Science Center at Brooklyn, 1999.
B.S., State University of New York at Binghamton, 1994.
Expertise and Research Interests
I am a fellowship trained vitreoretinal surgeon, uveitis specialist and retinal electrophysiologist. Through my clinical and basic science work, I have recognized the importance of converging mechanisms that account for a myriad of seemingly different clinical entities. For example, it was always thought that age-related macular degeneration (AMD), a leading cause of blindness in individuals and veterans over the age of 60 in the developed word, was an acquired disease and that there was no way to predict which patients will develop the disease.
Recent discoveries have identified genetic and in particular inflammatory mechanisms as potential causes. These findings indicate that a cure for such a complex retinal disease as AMD will require a well rounded approach and will demand a thorough understanding of basic science, immunology, genetics, retinal physiology and surgical anatomy.
I have become chiefly interested in the role that retinoid flow has on a wide variety of retinal diseases including inherited retinal dystrophies and age-related macular degeneration. Retinoid flow is the most fundamental aspect of human vision, without it, sight cannot take place. Being fundamental, the retinoid cycle this is a wonderful place to look for answers to solve our most challenging questions regarding disease mechanisms and to look for treatments. My laboratory is interested in understanding cone physiology, how abnormalities in retinoid flow leads to disease states, developing improved ocular drug-delivery devices, strategies for treatment and creating improved animal models.
Recent discoveries have identified genetic and in particular inflammatory mechanisms as potential causes. These findings indicate that a cure for such a complex retinal disease as AMD will require a well rounded approach and will demand a thorough understanding of basic science, immunology, genetics, retinal physiology and surgical anatomy.
I have become chiefly interested in the role that retinoid flow has on a wide variety of retinal diseases including inherited retinal dystrophies and age-related macular degeneration. Retinoid flow is the most fundamental aspect of human vision, without it, sight cannot take place. Being fundamental, the retinoid cycle this is a wonderful place to look for answers to solve our most challenging questions regarding disease mechanisms and to look for treatments. My laboratory is interested in understanding cone physiology, how abnormalities in retinoid flow leads to disease states, developing improved ocular drug-delivery devices, strategies for treatment and creating improved animal models.
Future Research
Our future research goals are:
1) Gain insights into the biochemical basis and delineate the biochemical underpinnings between rod and cone cell phototransduction.
2) Acquire more knowledge about phototransduction in the retina.
These goals will improve further understanding of events in hormonal signaling, cellular communication and immune regulation.
1) Gain insights into the biochemical basis and delineate the biochemical underpinnings between rod and cone cell phototransduction.
2) Acquire more knowledge about phototransduction in the retina.
These goals will improve further understanding of events in hormonal signaling, cellular communication and immune regulation.
Industrial Relevance
Studies in retinoid pathways functions have direct relevance for developing targeted therapies for inherited and acquired retinal dystrophies and degenerations.
Keywords
COS Keywords:
Genetic Diseases, Ophthalmology, Retinitis Pigmentosa.Additional Terms:
Genetic Diseases, Ophthalmology, Retinitis Pigmentosa.Languages
(Reading, Writing, Speaking)
English: (Fluent, Fluent, Fluent)
Spanish: (Functional, Functional, Functional)
Memberships
American Academy of Ophthalmology
American Medical Association
Association for Research in Vision and Ophthalmology
Cleveland Ophthalmologic Society
International Society for Clinical Electrophysiology of Vision
Ohio Ophthalmologic Society
Society for Clinical Trials
Honors and Awards
Phi Beta Kappa,
State University of New York at Binghamton
Previous Positions
2005-2007, Fellow,
Retina Specialists of Boston,
Harvard Medical School
2005-2007, Instructor,
Harvard University,
Harvard Medical School
2005-2007, Clinical Assistant Professor,
Massachusetts General Hospital
2005-2007, Research Fellow,
Schepens Eye Research Institute,
Harvard Medical School
2003-2005, Fellow,
National Institute of Health (NIH),
National Eye Institute,
Ophthalmic Gentics and Visual Function Branch
2000-2003, Resident,
New York University,
Ophthalmology
Funding Received
- United States Department of Health and Human Services (DHHS): Career Development Award 2, 2008 to 2011.
Publications
- Tang J, Stevens RA, Okada AA, Chin M, Nussenblatt RB, Chan CC (Jan 2008) Association of antiretinal antibodies in acute annular outer retinopathy., Archives of ophthalmology, 126 (1), 130-2
- Tang J, Weiter JJ (Aug 2007) Branch retinal artery occlusion after injection of a long-acting risperidone preparation., Annals of internal medicine, 147 (4), 283-4
- Tang J, Foster C.S. (2007) Age-related macular degeneration: Emerging treatments and concepts, Contemporary Ophthalmology, 6, 1-6
- Tang J, Gokhale PA, Brooks SE, Blain D, Brooks BP (Apr 2006) Increased corneal thickness in patients with ocular coloboma., Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, 10 (2), 175-7
- Mruthyunjaya P, Wirostko WJ, Chandrashekhar R, Stinnett S, Lai JC, Deramo V, Tang J, Dev S, Postel EA, Connor TB, Fekrat S (Mar 2006) Central retinal vein occlusion in patients treated with long-term warfarin sodium (Coumadin) for anticoagulation., Retina (Philadelphia, Pa.), 26 (3), 285-91
- Tang J, Tsilou E, Caruso RC, Rubin B, Gahl WA (Jan 2005) Bilateral staphylomas in a patient with Hermansky-Pudlak syndrome., Retina (Philadelphia, Pa.), 25 (1), 99-100
- Tang J (2003) Ophthalmic pearls: Treating traumatic hyphemas, EyeNet: An Official Publication of the American Academy of ophthalmology, 28-29
- Tang J, Salzman IJ, Sable MD (Aug 2003) Traumatic cataract formation after vigorous ocular massage., Journal of cataract and refractive surgery, 29 (8), 1641-2
- Tang J, Rodgers IR, Basham KL, Goh J (Aug 2003) Rare case of exuberant benign lymphoid hyperplasia involving the conjunctiva, caruncle, and plica in a child with tonsilar enlargement., Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, 7 (4), 293-4
- Tang J, Lutwick L.I. (1998) The rash is gone but the malady lingers on: An atypical presentation of juvenile rheumatoid arthritis, Infections in Medicine, 15 (11), 752-754, 777
- K.J. Reddy, B.W. Soper, J. Tang, R. L. Bradley (1996) Phenotypic variation in exopolysaccharide production in the marine, aerobic nitrogen-fixing unicellular cyanobacterium Cyanothece sp., World Journal of Microbiology and Biotechnology, 12 (4), 311-318
- Tang J, Shaken Baby Syndrome: An update on ophthalmologic manifestations, International ophthalmology clinics, In Press
Profile Details
Last Updated: 2/28/2008
COS Expertise ID #1288359
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