Jason W. Chien

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Fred Hutchinson Cancer Research Center
Pulmonary and Critical Care Medicine
Clinical Research
Assistant MemberAppointed: 2005
Seattle Cancer Care Alliance
Pulmonary Function Testing Laboratory
Medical DirectorAppointed: 2004
University of Washington
School of Medicine
Pulmonary and Critical Care Medicine
Assistant ProfessorAppointed: 2004
Professional Headshot of Jason W. Chien

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North
Suite D5-280
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-4860
Fax: (206) 667-5899
jchien@fhcrc.org

Qualifications

M.S., University of Washington, Genetic Epidemiology, 2005.
M.D., University of Medicine and Dentistry of New Jersey, Medicine, 1994.
B.A., University of Michigan, 1989.

Expertise and Research Interests

Clinical, molecular, and genetic epidemiology is my main area of expertise. Since year 2000, my laboratory has focused on conducting translational research that spans from the characterization of clinical phenotypes using standard epidemiologic methods to the identification of genetic variants that predispose to the development of these phenotypes, and translating these findings into potential biomarkers that can be used to identify individuals at risk for developing these phenotypes. Our genetic epidemiologic studies are based upon high-throughput whole gene screens of candidate pathways using a tagSNP approach, and in the near future, will expand to whole genome screens. Specific phenotypes occurring after hematopoietic stem cell transplantation that we are currently studying include airflow obstruction (bronchiolitis obliterans), idiopathic pneumonia syndrome, Gram-negative bacteremia, invasive fungal infection, cytomegalovirus infection, and community acquired respiratory viral infection. Our research has also recently expanded to include tobacco related respiratory diseases. Specifically, we have taken similar research approaches toward identifying genetic and molecular markers that will identify individuals who are at risk for developing chronic obstructive pulmonary disease and lung cancer.

These studies have led to molecular genetic studies in the laboratory that include complete sequencing of candidate genes for discovery novel functional mutations, transfection and mutagenesis studies to determine the function of novel mutations, and molecular assays to characterize the intermediate phenotypes resulting from these mutations.

Other Expertise

Clinically, I am an expert in the management of noninfectious pulmonary complications, the most common of which are hematopoietic stem cell transplant related airflow obstruction, otherwise known as bronchiolitis obliterans syndrome (BOS), and bronchiolitis obliterans organizing pneumonia (BOOP).

I am also the director of the Lung Cancer Early Detection and Prevention Clinic at the Seattle Cancer Care Alliance. This is a clinic dedicated to the health of current and former smokers, focusing on the prevention and early detection of the most common tobacco related lung diseases such as COPD, emphysema, chronic bronchitis, and lung cancer.

Industrial Relevance

I have developed and validated the "PAM score" (Pretransplant Assessment of Mortality Score), which is accessible as a simple caluclator by all clinicians via the website "http://cdsweb.fhcrc.org/pam/". This score provides information with regard to the mortality risk a patient is likely to experience if he or she undergoes an allogeneic hematopoietic stem cell transplant (HCT). The scoring algorithm was developed and validated using clinical data from over 2800 allogeneic transplants performed from 1990 to 2002 at the Seattle Cancer Care Alliance/Fred Hutchinson Cancer Research Center. Five validation cohorts from our Center were used to assess the performance of this predictor tool: 1990 to1997 cohort, 1997 to 2002 cohort, all chronic myeloid leukemia patients, all acute myeloid leukemia patients, and all myelodysplastic syndrome patients. The analyses found that this tool can predict the mortality risk of a patient considering allogeneic HCT with reasonably high accuracy. The details of the methods and results are described in our March 2006 Annals of Internal Medicine publication.

Keywords

COS Keywords:

Biomarkers, Bone Marrow Transplantation, Cancer Genetics, Cell Transplantation, Clinical Research Or Studies, Critical Care, Epidemiology, Infectious Diseases Or Agents, Lung Cancer, Molecular Epidemiology, Mutagenesis, Pulmonary Diseases, Respiratory Diseases, Stem Cells, Surgery.

Additional Terms:

Airways Diseases, Bone Marrow Transplant, COPD, Genetic Epidemiology, Hematopoietic Stem Cell Transplant, Lung Cancer, Pulmonary Complications.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Chinese, Mandarin: (None, None, Fluent)

Memberships

American Society of Hematology
American Society of Human Genetics
American Thoracic Society

Honors and Awards

2004-2007, Dr. George Santos Scholar for the Amy Strelzer Manasevit Research Award, National Marrow Donor Program
2002-2005, American Lung Association of Washington Clinical Research Award, American Lung Association
2002-2007, NHLBI K23 Career Development Award, NHLBI

Previous Positions

2003-2005, Associate, Fred Hutchinson Cancer Research Center, Pulmonary and Critical Care Medicine, Clinical Research
2002-2004, Acting Instructor, University of Washington, School of Medicine, Pulmonary and Critical Care Medicine
2002-2003, Research Associate, Fred Hutchinson Cancer Research Center, Clinical Research Division, Pulmonary and Critical Care Medicine, Clinical Research
1999-2002, Fellow, University of Washington, School of Medicine, Pulmonary and Critical Care Medicine
1997-1999, Fellow, Case Western Reserve University, School of Medicine, Infectious Diseases
1997-1999, Co-Investigator, Case Western Reserve University, School of Medicine, Center for Drug Research
1996-1998, Clinical Instructor, Case Western Reserve University, School of Medicine, Surgery, Life Flight
1995-1997, Resident, Case Western Reserve University, School of Medicine, Internal Medicine
1994-1995, Intern, Case Western Reserve University, School of Medicine, Internal Medicine

Publications

  • Chien JW, Boeckh MJ, Hansen JA, Clark JG (Dec 2007) Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. Abstract
  • Chien JW, Au DH, Barnett MJ, Goodman GE (Dec 2007) Spirometry, rapid FEV1 decline, and lung cancer among asbestos exposed heavy smokers., COPD, 4 (4), 339-46 Abstract
  • Hansen JA, Petersdorf EW, Lin MT, Wang S, Chien JW, Storer B, Martin PJ (Nov 2007) Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes. Abstract
  • Parimon T, Chien JW, Bryson CL, McDonell MB, Udris EM, Au DH (Apr 2007) Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease., American journal of respiratory and critical care medicine, 175 (7), 712-9 Abstract
  • Erard V, Chien JW, Kim HW, Nichols WG, Flowers ME, Martin PJ, Corey L, Boeckh M (Jun 2006) Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses., The Journal of infectious diseases, 193 (12), 1619-25 Abstract
  • Couriel D, Carpenter PA, Cutler C, Bolaños-Meade J, Treister NS, Gea-Banacloche J, Shaughnessy P, Hymes S, Kim S, Wayne AS, Chien JW, Neumann J, Mitchell S, Syrjala K, Moravec CK, Abramovitz L, Liebermann J, Berger A, Gerber L, Schubert M, Filipovich AH, Weisdorf D, Schubert MM, Shulman H, Schultz K, Mittelman B, Pavletic S, Vogelsang GB, Martin PJ, Lee SJ, Flowers ME (Apr 2006) Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 (4), 375-96 Abstract
  • Chien JW, Zhao LP, Hansen JA, Fan WH, Parimon T, Clark JG (2006) Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation, Blood, 107 (5), 2200-2207
  • Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW, Turner ML, Akpek G, Gilman A, McDonald G, Schubert M, Berger A, Bross P, Chien JW, Couriel D, Dunn JP, Fall-Dickson J, Farrell A, Flowers ME, Greinix H, Hirschfeld S, Gerber L, Kim S, Knobler R, Lachenbruch PA, Miller FW, Mittleman B, Papadopoulos E, Parsons SK, Przepiorka D, Robinson M, Ward M, Reeve B, Rider LG, Schulman H, Schultz KR, Weisdorf D, Vogelsang GB (2006) Measuring Therapeutic Response in Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group Report, Biol Blood Marrow Transplant, 12 (3), 252-266
  • Parimon T, Au DH, Martin PJ, Chien JW (Mar 2006) A risk score for mortality after allogeneic hematopoietic cell transplantation., Annals of internal medicine, 144 (6), 407-14 Abstract
  • Chien JW (2006) Impact of pretransplant pulmonary function on post-transplant outcomes, Curr Opin Organ Transplant, 11, 62-68
  • Parimon T, Madtes DK, Au DH, Clark JG, Chien JW (Aug 2005) Pretransplant lung function, respiratory failure, and mortality after stem cell transplantation, American Journal of Respiratory and Critical Care Medicine, 172 (3), 384-90
  • Chien JW, Maris MB, Sandmaier BM, Maloney DG, Storb RF, Clark JG (Apr 2005) Comparison of lung function after myeloablative and 2 Gy of total body irradiation-based regimens for hematopoietic stem cell transplantation, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 11 (4), 288-96
  • Chien JW, Madtes DK, Clark JG (Mar 2005) Pulmonary function testing prior to hematopoietic stem cell transplantation, Bone Marrow Transplantation, 35 (5), 429-35
  • Watkins TR, Chien JW, Crawford SW (2005) Graft versus host associated pulmonary disease and other idiopathic pulmonary complications after hematopoietic stem cell transplants, Sem Resp Crit Care Med, 26, 482-489
  • Yadavalli GK, Chien JW (2005) Interleukin 12 and interferon-gamma synthetic deficiency is associated with dendritic cell cytopenia after cardiac surgery, SHOCK, 24, 26-33
  • Filipovich A, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Prezpiorka D, Couriel D, Cowen E, Dinndorf P, Et Al (2005) National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and staging working group report, Biol Blood Marrow Transplant, 11, 945-956
  • Chien JW, Martin PJ, Flowers ME, Nichols WG, Clark JG (Apr 2004) Implications of early airflow decline after myeloablative allogeneic stem cell transplantation, Bone Marrow Transplantation, 33 (7), 759-64
  • Chien JW, Martin PJ, Gooley TA, Flowers ME, Heckbert SR, Nichols WG, Clark JG (Jul 2003) Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation, American Journal of Respiratory and Critical Care Medicine, 168 (2), 208-14
  • Chien JW, Salata RA (2002) Infections in the Immunocompromised Host, Expert Guide to the Management of Common Infectious Diseases, Philadelphia, American College of Physicians, 737-760 pages (bookchapter)
  • Chien JW, Johnson JL (2002) Viral Respiratory Infections, Expert Guide to the Management of Common Infectious Diseases, 1st Edition, Philadelphia, American College of Physicians, 535-563 pages (bookchapter)
  • Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW, Hansen JA, Clark JG (2001) Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 7 (7), 384-7
  • Chien JW, Johnson JL (Mar 2000) Viral pneumonias. Epidemic respiratory viruses, Postgraduate Medicine, 107 (3), 41-2, 45-7, 51-2
  • Chien JW, Ciufo R, Novak R, Skowronski M, Nelson J, Coreno A, McFadden ER Jr (Mar 2000) Uncontrolled oxygen administration and respiratory failure in acute asthma, Chest, 117 (3), 728-33
  • Chien JW, Johnson JL (Feb 2000) Viral pneumonias. Infection in the immunocompromised host, Postgraduate Medicine, 107 (2), 67-70, 73-4, 77-80
  • Chien JW, Johnson JL (Jan 2000) Viral pneumonias. Multifaceted approach to an elusive diagnosis, Postgraduate Medicine, 107 (1), 67-72; quiz 258
  • Chien JW, Kucia ML, Salata RA (Jan 2000) Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 30 (1), 146-51
  • Chien JW, Valdez H, McComsey G, McClernon D, St Clair M, Lederman MM (Aug 1999) Presence of mutation conferring resistance to lamivudine in plasma and cerebrospinal fluid of HIV-1-infected patients, Journal of Acquired Immune Deficiency Syndromes (1999), 21 (4), 277-80
  • Chien JW, Johnson JL (Sep 1998) Paradoxical reactions in HIV and pulmonary TB, Chest, 114 (3), 933-6
  • Chien JW (Jul 1998) Making the most of blood cultures. Tips for optimal use of this time-honored test, Postgraduate Medicine, 104 (1), 119-24, 127

Profile Details

Last Verified: 1/22/2008

COS Expertise ID #1220756
Reference this profile directly: http://myprofile.cos.com/jwchien1968