Dr. Norbert E. Kaminski

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Michigan State University
College of Veterinary Medicine
Center for Integrative Toxicology
DirectorAppointed: 2004
Michigan State University
College of Human Medicine
Pharmacology and Toxicology
ProfessorAppointed: 1999
Professional Headshot of Norbert E. Kaminski

Mailing Address

315 Food Safety and Toxicology Bldg.
Center for Integrative Toxicology
Michigan State University
East Lansing, Michigan 48824-1302
United States

Contact Information

Phone: (517) 353-3786
Fax: (517) 432-3218
kamins11@msu.edu

Qualifications

Ph.D., North Carolina State University, Toxicology and Physiology, 1985.
M.S., North Carolina State University, Toxicology, 1981.
B.A., Loyola University Chicago, Chemistry, 1978.

Expertise and Research Interests

Pharmacology/Toxicology
Immune Suppression
Immune Regulation by Endogenous Cannabinoids
Immunotoxicology of Dioxins
Respiratory Hypersensitivity
Immune Modulation by Transforming Growth Factor Beta
Immunopharmacology of Cannabinoids

Keywords

COS Keywords:

Antibodies, Biomarkers, Cell Culture, Disease Model, Electroblotting, Environment (Health Or Safety Or Medical), Environmental Health, Environmental Medicine, Environmental Toxicology, Enzyme Linked Immunosorbent Assay, Enzymes, Flow Cytometry, Growth Factors, Immunosuppression, Interleukins, Liver Disorders, Liver Functions, Lymphocytes, Macrophage, Messenger RNA, Pharmacology, Receptors, Tissue Culture, Toxicology.

Additional Terms:

ADP Ribosylation, Adenylate Cyclase, Airway Hypersensitivity, Antibody Formation, B Cells, B Lymphocyte, Biomarker, Cannabinoid Receptor, Cannabinoids, Cannabinol, Carbon Tetrachloride, Cell Population Study, Chemical Structure Function, Cyclic AMP, Dioxin, Disease Model, Drug Tolerance, Environmental Toxicology, Enzyme Activity, Enzyme Inhibitor, Flow Cytometry, G Protein, Gene Induction Repression, Gene Regulation, Hepatotoxicant, Human Tissue, Immunomodulator, Immunopharmacology, Immunosuppression, Immunotoxicology, Interleukin, Liver Cell, Liver Metabolism, Liver Toxic Disorder, Lymphocyte Proliferation, Macrophage, Marijuana Abuse, Messenger RNA, Mixed Lymphocyte Reaction Test, Northern Blotting, PCBs, Protein Kinase A, Psychopharmacologic Agent, Receptor Binding, Receptor Coupling, Receptor Expression, Spleen, Stereoisomer, T Cells, T Lymphocyte, Tissue Cell Culture, Transforming Growth Factor beta.

Memberships

American Association of Immunologists
American Society of Pharmacology and Experimental Therapeutics
International Cannabinoid Research Society
International Life Sciences Institute-Health and Environmental Sciences Institute
Society of Toxicology
Society on Neuroimmune Pharmacology

Previous Positions

1993-1995, Assistant Professor, Michigan State University, Veterinary Medicine and Human and Osteopathic Medicine, Pharmacology/Toxicology and Pathology
1988-1993, Assistant Professor, Medical College of Virginia, Pharmacology and Toxicology

Funding Received

  • PO1 DA09789: Immune Regulation by Endogenous Cannabinoids, $210,180, 9/15/95 to 8/31/98.
  • National Institutes of Health (NIH) RO1 ES02520: Characterization of Toxic Effects of TCDD on B-cells, $614,769, 7/1/94 to 3/31/98.
  • Dow Chemical Company: Dow Chemical Company SPHERE Grant, $50,000, 4/2/98 to 3/31/99.
  • National Institute on Drug Abuse: CB1/CB2-dependent and -independent T Cell Modulation, RO1 DA07908, $875,000, 4/1/02 to 3/31/07.
  • National Institutes of Health (NIH) RO1 DA07908: The Role of a Cannabinoid Receptor in Immunosuppression, $414,364, 4/01/92 to 3/31/96.
  • P01 P42ES04911-11: Activation of AhR-Dependent & -Independent Signaling Cascades in Immune Cell Dysfunction., $865,313, 4/01/00 to 3/31/06.
  • National Institute of Environmental Health Sciences.: Environmental, Microbial, and Mammalian Biomolecular Responses to the AhR Ligands. RFA P42 ES04911, $16,068,481, 2006 to 2011.
  • National Institute of Environmental Health Sciences.: Characterization of the Pathways Linking Ah Receptor Activation with Altered B Cell Differentiation Using an Integrated Experimental and Computational Modeling Approach. Sub-Project of RFA P42 ES04911, $1,061,826, 2006 to 2011.
  • National Institute on Drug Abuse (NIDA): IL-2 Suppression by Endocannabinoid Action of PPARgamma. R01 DA020402-01, $1,125,000, 2005 to 2010.
  • National Institute of Environmental Health Sciences.: Impairment of B cell Differentiation by TCDD. R01 ES002520-20A1, $1,068,750, 2005 to 2010.
  • National Institutes of Health (NIH): Health Hazards from Groundwater Contamination: Hepatotoxicant-Induced Immune Suppression Through TGF-ß Release. P42ES04911-08, $65,625, 1996 to 1999.
  • National Institute on Drug Abuse (NIDA): A Lymphoid Model to Study Cannabinoid-Induced Tolerance., RO1 DA09171, $339,602, 1994 to 1997.
  • RO1 ES02520: Role of AhR Expression in B-cell Inhibition by TCDD., $828,388, 12/1/98 to 11/31/03.
  • American Chemical Council: Cytokine Gene Expression is an Accurate Predictor of Allergen-Induced Respiratory Hypersensitivity., $333,108, 09/01/99 to 04/31/04.
  • RO1 DA12740-01: Repression of T-cell Activation by Endocannabinoids., $460,591, 07/01/99 to 11/30/03.
  • RO1 DA07908: Cannabinoid Immune Suppression by Altered Gene Expression., $610,700, 04/01/96 to 03/31/01.

Publications

  • Rao, GR, Kaminski, NE, Induction of intracellular calcium elevation by Delta9-Tetrahydrocannabinol in T cells involves TRPC1 channels, Journal of Leukocyte Biology, 79(1), 202-213, 2006
  • Rao, GR Kaminski, NE, Cannabinoid-mediated elevation of intracellular calcium: A structure-activity relationship, Journal of Pharmacology and Experimental Therapeutics, 317(2), 820-829, 2006
  • Farraj, AK, Harkema, JR, Kaminski, NE, Topical application versus intranasal instillation: A qualitative comparison of the effect of the route of sensitization on Trimellitic Anhydride induced allergic rhinitis in A/J Mice, Toxicology, 92, 321-328, 2006
  • Rockwell, CE Kaminski, NE, Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator activated receptor gamma independently of cannabinoid receptors 1 and 2, Molecular Pharmacology, 70, 101-111, 2006
  • Kaplan, BLF, Ouyang, Y, Rockwell, CE, Rao, GK Kaminski, NE, 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2, Toxicology and Applied Pharmacology, 77(6), 966-974, 2005
  • Kaplan, BLF, Ouyang, Y, Herring, A, Yea, SS, Razdan, R Kaminski, NE, Inhibition of leukocyte function and interleukin-2 (IL-2) gene expression by 2-methylarachidonyl- (2'-fluoroethyl) amide, a stable congener of the endogenous cannabinoid receptor ligand anandamine, Toxicology and Applied Pharmacology, 205(2), 107-115, 2005
  • Wang, Y, Kaminski, NE Wang, DH, VR1-mediated depressor effects during high-salt intake role of anandamide, Hypertension, 46, 986-991, 2005
  • Sulentic, CEW, Zhang, W, Na, YJ Kaminski, NE, 2,3,7,8-tetrachlorodibenzo-p-dioxin, an exogenous modulator of the 3'a immunoglobulin heavy chain enhancer, Journal of Pharmacology and Experimental Therapeutics, 309, 71-78, 2004
  • McKarns, SC, Schwartz, RH Kaminski, NE, Smad3 is essential for TGF-B1 to suppress IL-2 production and T cell receptor-induced proliferation, but not IL-2-induced proliferation, Journal of Immunology, 172, 4275-4284, 2004
  • Farraj, AK, Harkema, JR, Kaminski, NE, Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not dinitrochlorobenzene or oxazolone in A/J mice, Toxicological Science, 79, 315-325, 2004
  • Rao, GK, Zhang, W Kaminski, NE, Cannabinoid receptor-mediated regulation of intracellular calcium by Delta9-tetrahydrocannabinol in T cells, Journal of Leukocyte Biology, 75, 884-892, 2004
  • Sulentic, CEW, Kang, JS, Na, YJ Kaminski, NE, Interactions at a dioxin responsive Element (DRE) and an overlapping kB site within the hs4 domain of the 3'a immunoglobulin heavy chain enhancer, Toxicology, 200, 235-246, 2004
  • Rockwell, CE Kaminski, NE, A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes, Journal of Pharmacology and Experimental Therapeutics, 311, 683-690, 2004
  • Boverhof, DR, Tam, E, Harney, AS, Crawford, RB, Kaminski, NE Zacharewski, TR, 2,3,7,8-tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling-2 in murine B-cells, Molecular Pharmacology, 66(6), 1662-1667, 2004
  • Kaplan BL, Rockwell CE, Kaminski NE, Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes, Journal of Pharmacology and Experimental Therapeutics, 306(3), 1077-85, September 2003 Abstract
  • Kaminski N (Sep 2003) Microarray analysis of idiopathic pulmonary fibrosis., American Journal of Respiratory Cell and Molecular Biology, 29 (3 Suppl), S32-6 Abstract
  • Jan TR, Farraj AK, Harkema JR, Kaminski NE, Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice, Toxicology and Applied Pharmacology, 188(1), 24-35, April 2003 Abstract
  • Li J, Kaminski NE, Wang DH, Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor, Hypertension, 41(3 Pt 2), 757-62, March 2003 Abstract
  • Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Crawford RB, Kaminski NE, Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line, International Journal of Cancer., 104(1), 12-8, March 2003 Abstract
  • Suh J, Kang JS, Yang KH, Kaminski NE, Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls, Toxicology and Applied Pharmacology, 187(1), 11-21, February 2003 Abstract
  • Crawford RB, Sulentic, CEW, Yoo, BS, Kaminski, NE, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the regulation and posttranslational modification of p27kip1 in lipopolyssacharide-activated B cells., Toxicological Science, 75, 333-342, 2003
  • Farraj, AK, Harkema, JR, Jan, TR, Kaminski, NE, Immune responses in the lung and local lymph node of A/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin., Experimental Therapeutics, 31, 432-447, 2003
  • Faubert Kaplan, BL, Kaminski, NE, Inhibition of ERK MAPK by Cannabinoids in PMA/Io-Stimulated Mouse Splenocytes, International Immunopharmacology, 31(10-11), 1503-1510, 2003
  • McKarns, SC, Letterio, JJ, Kaminski, NE, Concentration-Dependent Bifunctional Effect of TGF-B1 on Immunoglobulin Production: A Role for Smad3 in IgA Production, International Immunopharmacology, 31, 1761-1774, 2003
  • Yoo, BS, Boverhoff, DR, Shnaider, D, Crawford RB, Zacharewski, TR Kaminski, NE, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the regulation of Pax5 in lipopolysaccharide -activated B cells, Toxicological Science, 77(2), 272-279, 2003
  • Faubert Kaplan, BL, Rockwell, CE Kaminski, NE, Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes, Journal of Pharmacology and Experimental Therapeutics, 306, 1077-1085, 2003
  • Suh J, Jeon YJ, Kim HM, Kang JS, Kaminski NE, Yang KH, Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells, Toxicology and Applied Pharmacology, 181(2), 116-23, June 2002 Abstract
  • Jan TR, Rao GK, Kaminski NE, Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity, Molecular Pharmacology, 61(2), 446-54, February 2002 Abstract
  • Jan TR, Kaminski NE, Role of mitogen-activated protein kinases in the differential regulation of interleukin-2 by cannabinol, Journal of Leukocyte Biology, 69(5), 841-9, May 2001 Abstract
  • Li X, Kaminski NE, Fischer LJ, Examination of the immunosuppressive effect of delta9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes, International Immunopharmacology, 1(4), 699-712, April 2001 Abstract
  • Herring AC, Faubert Kaplan BL, Kaminski NE, Modulation of CREB and NF-kappaB signal transduction by cannabinol in activated thymocytes, Cellular Signalling, 13(4), 241-50, April 2001 Abstract
  • Sulentic CE, Holsapple MP, Kaminski NE, Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway, Journal of Pharmacology and Experimental Therapeutics, 295(2), 705-16, November 2000 Abstract
  • McKarns SC, Kaminski NE, TGF-beta 1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3 epsilon mAb- and CD28 mAb-activated splenocytes and thymocytes, Immunopharmacology, 48(2), 101-15, July 2000 Abstract
  • Faubert BL, Kaminski NE, AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun., Journal of Leukocyte Biology, 67(2), 259-66, 2000 Abstract
  • Yea SS, Yang KH, Kaminski NE, Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells, Journal of Pharmacology and Experimental Therapeutics, 292(2), 597-605, February 2000 Abstract
  • Ouyang Y, Kaminski NE, Phospholipase A2 inhibitors p-bromophenacyl bromide and arachidonyl trifluoromethyl ketone suppressed interleukin-2 \(IL-2\) expression in murine primary splenocytes., Archives of Toxicology, 73(1), 1-6, February 1999 Abstract
  • Kaminski NE, Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds., Toxicology Letters, 102-103, 59-63, 28 Dec 1998 Abstract
  • Marcus RS, Holsapple MP, Kaminski NE, Lipopolysaccharide activation of murine splenocytes and splenic B cells increased the expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator, Journal of Pharmacology and Experimental Therapeutics, 287(3), 1113-8, December 1998 Abstract
  • Sulentic CE, Holsapple MP, Kaminski NE, Aryl hydrocarbon receptor-dependent suppression by 2,3,7, 8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells, Molecular Pharmacology, 53(4), 623-9, April 1998 Abstract
  • Ouyang Y, Hwang SG, Han SH, Kaminski NE, Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells, Molecular Pharmacology, 53(4), 676-83, April 1998 Abstract
  • Ouyang Y, Hwang SG, Han SH, Kaminski NE, Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells., Molecular Pharmacology, 53(4), 676-83, 1998 Abstract
  • Herring AC, Koh WS, Kaminski NE, Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid., Biochemical Pharmacology, 55(7), 1013-23, 1 1998 Abstract
  • Kaminski NE, Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors., Journal of Neuroimmunology, 83(1-2), 124-32, 15 1998 Abstract
  • Kaminski NE, Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors, Journal of Neuroimmunology, 83(1-2), 124-32, March 1998 Abstract
  • Morris DL, Jeong HG, Jordan SD, Kaminski NE, Holsapple MP, Characterization of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in B6C3F1 and DBA/2 mice following single and repeated exposures., Archives of Toxicology, 72(3), 157-68, 1998 Abstract
  • Crawford RB, Holsapple MP, Kaminski NE, Leukocyte activation induces aryl hydrocarbon receptor up-regulation, DNA binding, and increased Cyp1a1 expression in the absence of exogenous ligand, Molecular Pharmacology, 52(6), 921-7, December 1997 Abstract
  • Koh WS, Crawford RB, Kaminski NE, Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by delta9-tetrahydrocannabinol (delta9-THC): a putative mechanism of cannabinoid-induced immu, Biochemical Pharmacology, 53(10), 1477-84, May 1997 Abstract
  • Jeon YJ, Han SH, Yang KH, Kaminski NE, Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines, Toxicology and Applied Pharmacology, 144(1), 27-35, May 1997 Abstract
  • Schatz AR, Lee M, Condie RB, Pulaski JT, Kaminski NE, Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system, Toxicology and Applied Pharmacology, 142(2), 278-87, February 1997 Abstract
  • Koh WS, Jeon YJ, Herring AC, Kaminski NE, Transient CRE- and kappa B site-binding is cross-regulated by cAMP-dependent protein kinase and a protein phosphatase in mouse splenocytes., Life Sciences, 60(6), 425-32, 1997 Abstract
  • Williams CE, Crawford RB, Holsapple MP, Kaminski NE, Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes, Biochemical Pharmacology, 52(5), 771-80, September 1996 Abstract
  • Koh WS, Lee M, Yang KH, Kaminski NE, Expression of functional glucagon receptors on lymphoid cells, Life Sciences, 58(9), 741-51, 1996 Abstract
  • Lee M, Yang KH, Kaminski NE, Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes, Journal of Pharmacology and Experimental Therapeutics, 275(2), 529-36, November 1995 Abstract
  • Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, et al, Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochemical Pharmacology, 50(1), 83-90, June 1995 Abstract
  • Koh WS, Yang KH, Kaminski NE, Cyclic AMP is an essential factor in immune responses, Biochemical and Biophysical Research Communications, 206(2), 703-9, January 1995 Abstract
  • Koh WS, Yang KH, Jeong TC, Delany B, Kaminski NE, 2-Acetylaminofluorene inhibits the activation of immune responses by blocking cell cycle progression at G1 phase, Archives of Toxicology, 69(5), 350-6, 1995 Abstract
  • Kaminski NE, Koh WS, Yang KH, Lee M, Kessler FK, Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism, Biochemical Pharmacology, 48(10), 1899-908, November 1994 Abstract
  • Delaney B, Strom SC, Collins S, Kaminski NE, Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1, Toxicology and Applied Pharmacology, 126(1), 98-107, May 1994 Abstract
  • Delaney B, Kaminski NE, Induction of serum borne immunomodulatory factors in B6C3F1 mice by carbon tetrachloride. Exposure to carbon tetrachloride produces an increase in B-cell number and function, Toxicology, 88(1-3), 201-12, March 1994 Abstract
  • Delaney B, Kaminski NE, High concentrations of interleukin-2 selectively suppress T-cell dependent humoral immune responses, Immunopharmacology, 26(2), 119-27, 1993 Abstract
  • Schatz AR, Koh WS, Kaminski NE, Delta 9-tetrahydrocannabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function, Immunopharmacology, 26(2), 129-37, 1993 Abstract
  • Kaminski NE, Holsapple MP, A functional characterization of macrophage alterations in casein-treated B6C3F1 mice, Immunopharmacology, 24(3), 229-40, 1992 Abstract
  • Schatz AR, Kessler FK, Kaminski NE, Inhibition of adenylate cyclase by delta 9-tetrahydrocannabinol in mouse spleen cells: a potential mechanism for cannabinoid-mediated immunosuppression, Life Sciences, 51(6), PL25-30, 1992 Abstract
  • Kaminski NE, Jordan SD, Page D, Kim BS, Holsapple MP, Suppression of humoral immune responses by dialkylnitrosamines: structure-activity relationships, Fundamental and Applied Toxicology, 12(2), 321-32, February 1989 Abstract
  • Kaminski NE, Jordan SD, Holsapple MP, Suppression of humoral and cell-mediated immune responses by carbon tetrachloride, Fundamental and Applied Toxicology, 12(1), 117-28, January 1989 Abstract
  • Kaminski NE, Holsapple MP, Inhibition of macrophage accessory cell function in casein-treated B6C3F1 mice, Journal of Immunology, 139(6), 1804-10, September 1987 Abstract

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