Prof. Douglas B. Kell

(Reading, Writing, Speaking)

BBSRC: A LOT MORE THAT YOU CAN READ IN OASIS, to .
Development of bacterial strains improved in bioreductions (Co-investigator), Science and Engineering Research Council (SERC), 81,587, Oct 1990-Sep 1993
Biotransformations in mixed organic solvents (Grant Value Holder), BBSRC, 119,060, Nov 1991-Nov 1994
Rapid analysis of multiple determinands using pyrolysis mass spectrometry and neural networks, BBSRC, 218,944, May 1992-Nov 1995
Whole cell biosensors based on nonlinear dielectricity, BBSRC, 156,320, Oct 1992-Oct 1995
The exploitation of dielectric spectroscopy in fermenter control, Science and Engineering Research Council (SERC), 83,701, Jan 1991-Dec 1993
Metabolic control analysis using neural networks: a means of obtaining parameters by measuring variables (Grant Value Holder), Wellcome Trust, Oct 1991-Oct 1993
On line dielectric spectroscopic methods for controlling fermentations in real time, BBSRC, 174,964, Jan 1994-Jan 1997
Biotechnological exploitation of flow cytometric cell sorting (Grant Value Holder), BBSRC, 141,872, Jul 1993-Jul 1996
Quantification of microbial productivity via multiangle light scattering and supervised learning (Grant Value Holder), BBSRC, 159,772, Mar 1995-Mar 1997
User orientated simulation/optimisation system for the rational improvement of biotechnological processes (Grant Value Holder), BBSRC, 113,284, Oct 1994-Oct 1997
A Fourier transform infrared (FTIR) based metabolic microscope for biotechnology, BBSRC (Grant Value Holder), 284,720, Sep 1995-Feb 1999
Pheromones and the resuscitation of dormant microorganisms (Grant Value Holder), BBSRC, 189,571, Feb 1996-Feb 1999
Rapid analysis of multiple determinands using ultrasensitive, dispersive Raman spectroscopy and supervised learning (Grant Value Holder), BBSRC, 492,607, Jun 1996-Jul 1999
User orientated simulation/optimisation system for the rational improvement of biotechnological processes (Grant Value Holder), BBSRC, 117,847, Oct 1994-Oct 1997
A Fourier transform infrared (FTIR) based metabolic microscope for biotechnology (Grant Value Holder), BBSRC, 299,814, Sep 1995-Feb 1999
Explanatory analysis of complex vibrational spectra using genetic programming of fuzzy rules (Grant Value Holder), Engineering and Physical Sciences Research Council (EPSRC), 94,159, Sep 1997-Aug 1999

• Kell DB, Metabolomics and systems biology: making sense of the soup, Current Opinion in Microbiology, 7(3), 296-307, Jun 2004
• Woodward AM, Rowland JJ, Kell DB, Fast automatic registration of images using the phase of a complex wavelet, The Analyst, 129(6), 542-52, Jun 2004
• Twist CR, Winson MK, Rowland JJ, Kell DB, Single-nucleotide polymorphism detection using nanomolar nucleotides and, Analytical Biochemistry, 327(1), 35-44, Apr 2004
• Johnson HE, Broadhurst D, Kell DB, Theodorou MK, Merry RJ, Griffith GW, High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics, Applied and Environmental Microbiology, 70(3), 1583-92, Mar 2004
• Kell DB, Oliver SG, Here is the evidence, now what is the hypothesis? The complementary roles, Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology., 26(1), 99-105, Jan 2004
• King RD, Whelan KE, Jones FM, Reiser PG, Bryant CH, Muggleton SH, Kell DB, Oliver SG, Functional genomic hypothesis generation and experimentation by a robot scientist, Nature, 427(6971), 247-52, Jan 2004
• Vaidyanathan S, Broadhurst DI, Kell DB, Goodacre R, Explanatory optimization of protein mass spectrometry via genetic search, Analytical Chemistry, 75(23), 6679-86, Dec 2003
• Allen J, Davey HM, Broadhurst D, Heald JK, Rowland JJ, Oliver SG, Kell DB, High-throughput classification of yeast mutants for functional genomics using metabolic footprinting, Nature Biotechnology, 21(6), 692-6, Jun 2003
• Taylor CF, Paton NW, Garwood KL, Kirby PD, Stead DA, Yin Z, Deutsch EW, Selway L, Walker J, Riba-Garcia I, Mohammed S, Deery MJ, Howard JA, Dunkley T, Aebersold R, Kell DB, Lilley KS, Roepstorff P, Yates JR 3rd, Brass A, Brown AJ, Cash P, Gaskell SJ, Hubb, A systematic approach to modeling, capturing, and disseminating proteomics experimental data, Nature Biotechnology, 21(3), 247-54, Mar 2003
• Mukamolova GV, Kaprelyants AS, Kell DB, Young M, Adoption of the transiently non-culturable state--a bacterial survival, Advances in Microbial Physiology, 47, 65-129, 2003
• Pritchard L, Kell DB, Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis, European Journal of Biochemistry / Febs, 269(16), 3894-904, Aug 2002
• Ellis DI, Broadhurst D, Kell DB, Rowland JJ, Goodacre R, Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning, Applied and Environmental Microbiology, 68(6), 2822-8, June 2002
• Shleeva MO, Bagramyan K, Telkov MV, Mukamolova GV, Young M, Kell DB, Kaprelyants AS, Formation and resuscitation of 'non-culturable' cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase, Microbiology (reading, England), 148(Pt 5), 1581-91, May 2002
• Vaidyanathan S, Kell DB, Goodacre R, Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification, Journal of the American Society for Mass Spectrometry, 13(2), 118-28, February 2002
• Day JP, Kell DB, Griffith GW, Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry, Applied and Environmental Microbiology, 68(1), 37-45, January 2002
• Vaidyanathan S, Winder CL, Wade SC, Kell DB, Goodacre R, Sample preparation in matrix-assisted laser desorption/ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins, Rapid Communications in Mass Spectrometry : Rcm, 16(13), 1276-86, 2002
• Raamsdonk LM, Teusink B, Broadhurst D, Zhang N, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, van Dam K, Oliver SG, A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations, Nature Biotechnology, 19(1), 45-50, Jan 2001
• Kell DB, Young M, Bacterial dormancy and culturability: the role of autocrine growth factors, Current Opinion in Microbiology, 3(3), 238-43, June 2000
• Kell DB, Screen idols: faster, smaller, cheaper and smarter, Trends in Biotechnology, 18(5), 186-7, May 2000
• Davies ZS, Gilbert RJ, Merry RJ, Kell DB, Theodorou MK, Griffith GW, Efficient improvement of silage additives by using genetic algorithms, Applied and Environmental Microbiology, 66(4), 1435-43, April 2000
• Kell DB, King RD, On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning., Trends in Biotechnology, 18(3), 93-8, 2000
• Woodward AM, Davies EA, Denyer S, Olliff C, Kell DB, Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating, Bioelectrochemistry, 51(1), 13-20, February 2000
• Yardley JE, Todd R, Nicholson DJ, Barrett J, Kell DB, Davey CL, Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra, Bioelectrochemistry, 51(1), 53-65, February 2000
• Goodacre R, Shann B, Gilbert RJ, Timmins EM, McGovern AC, Alsberg BK, Kell DB, Logan NA, Detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier transform infrared spectroscopy, Analytical Chemistry, 72(1), 119-27, 2000
• Shaw AD, Winson MK, Woodward AM, McGovern AC, Davey HM, Kaderbhai N, Broadhurst D, Gilbert RJ, Taylor J, Timmins EM, Goodacre R, Kell DB, Alsberg BK, Rowland JJ, Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics, Advances in Biochemical Engineering/biotechnology, 66, 83-113, 2000
• McGovern AC, Ernill R, Kara BV, Kell DB, Goodacre R, Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to alpha 2-in, Journal of Biotechnology, 72(3), 157-67, 1999
• Mukamolova GV, Kormer SS, Kell DB, Kaprelyants AS, Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor, Archives of Microbiology, 172(1), 9-14, July 1999
• Woodward AM, Gilbert RJ, Kell DB, Genetic programming as an analytical tool for non-linear dielectric spectroscopy, Bioelectrochemistry and Bioenergetics, 48(2), 389-96, May 1999
• Kell DB, Revolutionary ideas come round again, Nature, 397(6721), 644, 1999
• Davey HM, Jones A, Shaw AD, Kell DB, Variable selection and multivariate methods for the identification of microorganisms by flow cytometry, Cytometry, 35(2), 162-8, 1999
• Jones A, Young D, Taylor J, Kell DB, Rowland JJ, Quantification of microbial productivity via multi-angle light scattering and supervised learning, Biotechnology and Bioengineering, 59(2), 131-43, 1998
• Goodacre R, Timmins EM, Burton R, Kaderbhai N, Woodward AM, Kell DB, Rooney PJ, Rapid identification of urinary tract infection bacteria using hyperspectral whole-organism fingerprinting and artificial neural networks, Microbiology, 144 ( Pt 5), 1157-70, May 1998
• Mukamolova GV, Yanopolskaya ND, Kell DB, Kaprelyants AS, On resuscitation from the dormant state of Micrococcus luteus, Antonie Van Leeuwenhoek, 73(3), 237-43, April 1998
• Taylor J, Goodacre R, Wade WG, Rowland JJ, Kell DB, The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species, Fems Microbiology Letters, 160(2), 237-46, 1998
• Kell DB, Kaprelyants AS, Weichart DH, Harwood CR, Barer MR, Viability and activity in readily culturable bacteria: a review and discussion of the practical issues, Antonie Van Leeuwenhoek, 73(2), 169-87, February 1998
• Goodacre R, Rooney PJ, Kell DB, Discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks, Journal of Antimicrobial Chemotherapy, 41(1), 27-34, Jan 1998
• Davey HM, Kell DB, Fluorescent brighteners: novel stains for the flow cytometric analysis of microorganisms, Cytometry, 28(4), 311-5, 1997
• Mukamolova G V, Kaprelyants A S, Young D I, Young M and Kell, D B, A bacterial cytokine, Proc Natl Acad Sci, 95, 8916-8921, 1998
• Oliver S G, Winson, M K, Kell D B and Baganz F, Systematic functional analysis of the yeast genome, Trends Biotechnol, 16, 373-378, 1998
• On the molecular dielectric properties of biological systems, Saccharomyces cerevisiae, Bioelectrochem, Bioenerg, 24, 83-100, 1990, (with A M Woodward)
• The principles and potential of electrical admittance spectroscopy: an introduction, 429-470, Biosensors, Oxford University Press, 1987, (editors A P F Turner, I Karube and G S Wilson)
• The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology, Phys Med Biol, 1987, 32, 933-970, (with R Pethig)
• A FULL LIST IS AVAILABLE AT http://gepasi.dbs.aber.ac.uk/dbk/pubs.htm