Dr. Kelly Smith

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University of Washington
School of Medicine
Pathology
Assistant ProfessorAppointed: 2002

Mailing Address

University of Washington Medical Center
Department of Pathology
HSB E504, Box 357470
1959 NE Pacific St.
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-0820
Fax: (206) 598-4928
Mobile: (206) 383-6465
Pager: (206) 986-4956
kelsmith@u.washington.edu

Qualifications

M.D., University of Iowa, 1996.
Ph.D., University of Iowa, 1996.

Expertise and Research Interests

Immunology, Innate Immunity, Pathology, Inflammation, Infectious Diseases, Inflammatory Disorders, Kidney Disease, Cardiovascular Disease

Keywords

COS Keywords:

Health and Medicine, Immune System Disorders, Immunology, Infectious Diseases or Agents, Inflammation, Kidney Disease, Pathology.

Additional Terms:

Immunology.

Memberships

American Society of Investigational Pathology
American Society of Nephrology
College of American Pathologists
Renal Pathology Society

Honors and Awards

2000-2003, Career Development Award, National Institutes of Health (NIH)
1991, Alpha Omega Alpha, Alpha Omega Alpha Honor Medical Society
1988-1996, Medical Scientist Training Program, National Institutes of Health (NIH)
1985, Graduated with Distinction, University of Wisconsin-Madison
1981-1984, Dean's Honor List, University of Wisconsin-Madison

Previous Positions

2000, Acting Instructor, University of Washington, School of Medicine, Pathology

Publications

  • Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A (Jul 2005) The evolution of vertebrate Toll-like receptors, Proceedings of the National Academy of Sciences of the United States of America., 102 (27), 9577-82
  • Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A (Jun 2005) Evasion of Toll-like receptor 5 by flagellated bacteria, Proceedings of the National Academy of Sciences of the United States of America., 102 (26), 9247-52
  • Limaye AP, Smith KD, Cook L, Groom DA, Hunt NC, Jerome KR, Boeckh M (Mar 2005) Polyomavirus nephropathy in native kidneys of non-renal transplant recipients, American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons., 5 (3), 614-20
  • Bergman MA, Cummings LA, Barrett SL, Smith KD, Lara JC, Aderem A, Cookson BT (Mar 2005) CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles, Infection and Immunity, 73 (3), 1350-6
  • Stolovitzky GA, Kundaje A, Held GA, Duggar KH, Haudenschild CD, Zhou D, Vasicek TJ, Smith KD, Aderem A, Roach JC (Feb 2005) Statistical analysis of MPSS measurements: application to the study of LPS-activated macrophage gene expression, Proceedings of the National Academy of Sciences of the United States of America., 102 (5), 1402-7
  • Smith KD, Bolouri H (Feb 2005) Dissecting innate immune responses with the tools of systems biology, Current Opinion in Immunology, 17 (1), 49-54
  • Kowalewska J, Yuan S, Sustento-Reodica N, Nicosia RF, Smith KD, Davis CL, Alpers CE (Jan 2005) IgA nephropathy with crescents in kidney transplant recipients, American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 45 (1), 167-75
  • Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (Dec 2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron, Nature, 432 (7019), 917-21
  • Ogushi K, Wada A, Niidome T, Okuda T, Llanes R, Nakayama M, Nishi Y, Kurazono H, Smith KD, Aderem A, Moss J, Hirayama T, Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells, The Journal of Biological Chemistry, 279(13), 12213-9, Mar 2004 Abstract
  • Aderem A, Smith KD, A systems approach to dissecting immunity and inflammation, Seminars in Immunology, 16(1), 55-67, Feb 2004 Abstract
  • Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A, Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility, Nature Immunology, 4(12), 1247-53, Dec 2003 Abstract
  • Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A, A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease, The Journal of Experimental Medicine, 198(10), 1563-72, Nov 2003 Abstract
  • Means TK, Hayashi F, Smith KD, Aderem A, Luster AD, The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells, Journal of Immunology (baltimore, Md. : 1950), 170(10), 5165-75, May 2003 Abstract
  • Smith KD, Wrenshall LE, Nicosia RF, Pichler R, Marsh CL, Alpers CE, Polissar N, Davis CL, Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use, Journal of the American Society of Nephrology : Jasn, 14(4), 1037-45, Apr 2003 Abstract
  • Smith KD, Ozinsky A, Toll-like receptor-5 and the innate immune response to bacterial flagellin, Current Topics in Microbiology and Immunology, 270, 93-108, 2002 Abstract
  • Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A, The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Nature, 410(6832), 1099-103, April 2001 Abstract
  • Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A, The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors, Proceedings of the National Academy of Sciences (USA), 97(25), 13766-71, December 2000 Abstract
  • Ozinsky A, Smith KD, Hume D, Underhill DM, Co-operative induction of pro-inflammatory signaling by Toll-like receptors, Journal of Endotoxin Research, 6(5), 393-6, 2000 Abstract
  • Underhill DM, Ozinsky A, Smith KD, Aderem A, Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages, Proceedings of the National Academy of Sciences (USA), 96(25), 14459-63, 1999 Abstract
  • Shi Y, Smith KD, Lutz CT, TAP-independent MHC class I peptide antigen presentation to alloreactive CTL is enhanced by target cell incubation at subphysiologic temperatures, Journal of Immunology, 160(9), 4305-12, May 1998 Abstract
  • Kurago ZB, Lutz CT, Smith KD, Colonna M, NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR NK cells by HLA-B7 variants and target cells, Journal of Immunology, 160(4), 1573-80, February 1998 Abstract
  • Shi Y, Smith KD, Kurilla MG, Lutz CT, Cytotoxic CD8 T cells recognize EBV antigen but poorly kill autologous EBV-infected B lymphoblasts: immunodominance is elicited by a peptide epitope that is presented at low levels in vitro, Journal of Immunology, 159(4), 1844-52, August 1997 Abstract
  • Smith KD, Huczko E, Engelhard VH, Li YY, Lutz CT, Alloreactive cytotoxic T lymphocytes focus on specific major histocompatibility complex-bound peptides, Transplantation, 64(2), 351-9, July 1997 Abstract
  • Smith KD, Lutz CT, Alloreactive T cell recognition of MHC class I molecules: the T cell receptor interacts with limited regions of the MHC class I long alpha helices, Journal of Immunology, 158(6), 2805-12, March 1997 Abstract
  • Smith KD, Kurago ZB, Lutz CT, Conformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system, Immunologic Research, 16(3), 243-59, 1997 Abstract
  • Vigna JL, Smith KD, Lutz CT, Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove, Journal of Immunology, 157(10), 4503-10, November 1996 Abstract
  • Li YY, Smith KD, Shi Y, Lutz CT, Alloreactive anti-HLA-B7 cytolytic T cell clones use restricted T cell receptor genes, Transplantation, 62(7), 954-61, October 1996 Abstract
  • Smith KD, Mace BE, Valenzuela A, Vigna JL, McCutcheon JA, Barbosa JA, Huczko E, Engelhard VH, Lutz CT, Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies, Journal of Immunology, 157(6), 2470-8, September 1996 Abstract
  • Smith KD, Lutz CT, Peptide-dependent expression of HLA-B7 on antigen processing-deficient T2 cells, Journal of Immunology, 156(10), 3755-64, May 1996 Abstract
  • Smith KD, Epperson DF, Lutz CT, Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation, Immunogenetics, 43(1-2), 27-37, 1996 Abstract
  • Zarling AL, Smith KD, Lutz CT, Lee DR, Correction of the HLA-Cw3 genomic sequence tentatively identifies it as HLA-Cw*0304, Immunogenetics, 44(1), 82-3, 1996 Abstract
  • McCutcheon JA, Gumperz J, Smith KD, Lutz CT, Parham P, Low HLA-C expression at cell surfaces correlates with increased turnover of heavy chain mRNA, Journal of Experimental Medicine, 181(6), 2085-95, June 1995 Abstract
  • Kurago ZB, Smith KD, Lutz CT, NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells, Journal of Immunology, 154(6), 2631-41, March 1995 Abstract
  • Lutz CT, Smith KD, Greazel NS, Mace BE, Jensen DA, McCutcheon JA, Goeken NE, Bw4-reactive and Bw6-reactive antibodies recognize multiple distinct HLA structures that partially overlap in the alpha-1 helix, Journal of Immunology, 153(9), 4099-110, November 1994 Abstract
  • McCutcheon JA, Smith KD, Valenzuela A, Aalbers K, Lutz CT, HLA-B*0702 antibody epitopes are affected indirectly by distant antigen residues, Human Immunology, 36(2), 69-75, February 1993 Abstract
  • Smith KD, Valenzuela A, Vigna JL, Aalbers K, Lutz CT, Unwanted mutations in PCR mutagenesis: avoiding the predictable, Pcr Methods and Applications, 2(3), 253-7, February 1993 Abstract
  • Knight WB, Sem DS, Smith K, Miziorko HM, Rendina AR, Cleland WW, Phosphorylated thiosugars: synthesis, properties, and reactivity in enzymatic reactions, Biochemistry, 30(20), 4970-7, 1991 Abstract

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Last Verified: 7/26/2006

COS Expertise ID #863977
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