Dr. Farrah Kheradmand

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The Texas A&M Health Science Center
Baylor College of Medicine
Medicine Pulmonary
Associate Professor

Mailing Address

Pulmonary Department
Baylor College of Medicine
One Baylor Plaza, BCMC 520B
Houston, Texas 77030
United States

Contact Information

Phone: (713) 798-8622
Fax: (713) 798-3619
farrahk@bcm.tmc.edu

Qualifications

M.D., George Washington University, Medicine, 1989.

Expertise and Research Interests

Research Interest/ Ongoing Research:

My research is focused on understanding the role of innate and adaptive immune cells in the pathogenesis of obstructive lung diseases in particular, in human COPD and in asthma. Our ongoing research has elucidated the critical role that is played by several members of the matrix metalloproteinase (MMP) family in lung inflammation. We have made several seminal observations in the field of allergic airway inflammation and COPD that include identifying the distinct contributions of MMP2 and MMP9 in regulating clearance of allergic inflammatory cells in the lung. In addition to work on experimental asthma, my laboratory has successfully established human translational research studies in COPD and emphysema. Our recent studies have shown the critical role for T cells and Th1 cytokines and chemokines in particular, gamma interferon and CXCL-10 (IP-10), in upregulation of MMP12 that is linked to the development of COPD and emphysema. Our human translational studies aim to dissect the more proximal molecular and cellular events that lead to the pro-elastolytic lung environment induced by tobacco smoke. Our published studies are among the first to suggest an adaptive immune basis to human COPD/emphysema.

Keywords

COS Keywords:

Allergy, Asthma, Inflammation, Pulmonary Diseases.

Additional Terms:

Allergic Inflammation, Asthma, Lung Development, Matrix, Matrix Degrading Enzymes, copd/emphysema.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Farsi (Persian): (Fluent, Fluent, Fluent)

Memberships

American Medical Association
American Society for Clinical Investigation
American Thoracic Society

Previous Positions

1995-1999, Fellow with Dr. Zena Werb, University of California, San Francisco, Anatomy and Radiobiology
1992-1994, Cardiovascular research fellow with Dr. Michael Matthay, University of California, San Francisco
1982-1985, Graduate studies and research with Dr. Phyllis Kind, George Washington University, Immunology

Funding Received

  • National Institutes of Health (NIH): The role of proteases in experimental asthma, Sep 30, 1999 to Aug 31, 2003.
  • National Institutes of Health (NIH): The epithelial-mesenchymal interaction in lung development, Sep 1, 1997 to Dec 31, 2002.
  • National Institutes of Health (NIH): Viral Induced T cell responses in COPD exacerbation, 2005 to 2010.
  • alpha one foundation: Regulation of Elastolysis by Immune cells in emphysema, 2005 to 2007.
  • National Institutes of Health (NIH): Immune Modulators of Inflammation in Severe COPD, 2002 to 2007.
  • National Institutes of Health (NIH): The Role of Proteases in Experimental Asthma, 1999 to 2010.
  • American Lung Association (ALA)National Award: Alveolar epithelial repair and role of fibronection and integrins, 1995 to 1997.

Publications

  • Barrios RJ (2006) Asthma: pathology and pathophysiology, Arch Pathol Lab Med, 130 (4), 447-51
  • Corry DB (2006) Control of Allergic Airway Inflammation Through Immunomodulation, J Allergy Clin Immunol
  • Zhao L (2006) Identification of P311 as a Potential Gene Regulating Alveolar Generation, Am J of Resp Cell and Mol Biol
  • Kamat A.A (2006) The Role of Relaxin in Endometrial Cancer, Cancer Biology & Therapy
  • Corry D., Kheradmand F (2006) Encyclopedia of Respiratory Medicine
  • Xu J, Park P.W., Kheradmand F., and Corry D.B (2005) Endogenous Attenuation of Allergic Lung Inflammation by Syndecan-1, Journal of Immunology
  • Corry DB and Kheradmand F. (2005) The future of asthma therapy: integrating clinical and experimental studies, Immunol Res
  • Grumelli S, Corry, D, Song LZ, Song L, Green L, Huh J, Espada R, Hacken J, Lewis D, Kheradmand F. (2004) An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease., Public Library of Science Medicine
  • Lee S-H, Kiss A, Kheradmand F, Qian Y, Xu J, Song L-Z, Prince JE, Corry DB (2004) A method for quantitation of secreted airway mucin, J Allergy Clin Immunol
  • Corry D.B., Kiss A. , Song L.Z., Song L., Xu J., Lee S. H., Werb Z., and Kheradmand F.. (2004) Overlapping and Independent Contributions of MMP2 and MMP9 to Lung Allergic Inflammatory Cell Egression Through Decreased CC Chemokines, FASEB J
  • Yang T, Koch P, Kheradmand F, Overbeek P. (2004) Epidermal detachment, desmosomal dissociation and destabilization of corneodesmosin in Spink5-/- mice, Genes and Development
  • Prince J, Kheradmand F, Corry DB. (2003) Immunological Lung Disease., J Allergy and Clin. Immunol
  • Lee S-H, Prince J, Rais M, Kheradmand F, Shardonofsky F, Lu H, Smith CY, Beaudet AL, Soong L, Corry DB. (2003) Differential Requirement for CD18 in T effector homing, Nature Medicine
  • Kheradmand F., Werb Z (2002) Shedding light on sheddases: role in growth and development., BioEssays
  • Kheradmand F., Rishi K., Werb Z. (2002) Signaling through the Egf receptor controls lung morphogenesis by regulating MT1-MMP-mediated activation of gelatinase A/MMP2, J Cell Science
  • Kheradmand F., Rishi K., Corry, D. (2002) Environmental Contributions to the Allergic Asthma Epidemic., Environmental Health perspectives
  • Corry D, Rishi K., Kanelis, J Kiss A., Song L., Xu J., Feng L, Werb Z., Kheradmand F. (2002) Decreased Allergic Lung Inflammatory Cell Egression and Increased Susceptibility to Asphyxiation in MMP-2-deficiency, Nature Immunology
  • Corry D, Kheradmand F. (2002) The interleukin 4 signaling pathway in asthma therapy, Am J Respir Med
  • Kheradmand F, Kiss A, Rishi K, Kolattukudy PE, Xu J, and Corry DB. (2002) A protease activated pathway essential for Th2 development and allergic lung disease., J Immunology
  • Werner E., Kheradmand F., Isberg R. & Z. Werb (2001) Phagocytosis mediated by Yersinia invasin induces collagenase-1expression in rabbit synovial fibroblasts through a pro-inflammatory cascade, J Cell Science
  • Corry DB, Kheradmand F, Induction and regulation of the IgE response, Nature, 402(6760 Suppl), B18-23, November 1999 Abstract
  • Kheradmand F, Werner E, Tremble P, Symons M, Werb Z, Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change, Science, 280(5365), 898-902, May 1998 Abstract
  • Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA, Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury, Chest, 111(3), 652-6, March 1997 Abstract
  • Kheradmand F., Wiener-Kronish J, and Corry DB., Preoperative assessment of the patient with severe lung disease, Clinics in Chest Medicine, 18, 483-494, 1997
  • Kheradmand F., Werb Z., Proteinases and anti-proteinases in matrix remodeling, Primer on the Rheumatic Diseases, 11th Edition, 1997
  • Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA, Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro, American Journal of Physiology, 271(5 Pt 1), L844-53, November 1996 Abstract
  • Folkesson HG, Kheradmand F, Matthay MA, The effect of salt water on alveolar epithelial barrier function, American Journal of Respiratory and Critical Care Medicine, 150(6 Pt 1), 1555-63, December 1994 Abstract
  • Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA, Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model, American Journal of Physiology, 267(6 Pt 1), L728-38, December 1994 Abstract
  • Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS, Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels, Proceedings of the National Academy of Sciences (USA), 91(11), 4970-4, May 1994 Abstract
  • Matthay MA, Folkesson HG, Campagna A, Kheradmand F, Alveolar epithelial barrier and acute lung injury, New Horizons, 1(4), 613-22, November 1993 Abstract
  • Corry D., Kheradmand F., Interluekin 13 (IL-13)., , Encyclopedia of Respiratory Medicine. (bookchapter)
  • Kheradmand F., Corry D., Chemokines, CXC: CXCL10(IP-10)., , Encyclopedia of Respiratory Medicine (bookchapter)

Profile Details

Last Updated: 7/24/2006

COS Expertise ID #858295
Reference this profile directly: http://myprofile.cos.com/kheradmand