Dr. John P. Kirwan

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Cleveland Clinic Foundation
Digestive Disease Institute
Gastroenterology & Hepatology
StaffAppointed: 2006
Cleveland Clinic Foundation
Lerner Research Institute
Pathobiology
StaffAppointed: 2006
Cleveland Clinic Foundation
Lerner College of Medicine of Case Western Reserve University
Molecular Medicine
Associate ProfessorAppointed: 2006
Case Western Reserve University
School of Medicine
Physiology and Biophysics
Associate ProfessorAppointed: 2003
Case Western Reserve University
School of Medicine
Nutrition
Associate ProfessorAppointed: 1999
Professional Headshot of John P. Kirwan

Mailing Address

Cleveland Clinic
Lerner Research Institute
9500 Euclid Avenue / NE40
Cleveland, Ohio 44195
United States

Contact Information

Phone: (216) 444-3412
Fax: (216) 636-1493
Pager: 22532
kirwanj@ccf.org

Qualifications

Visiting Scientist, University of California, San Diego, Molecular Biology, 2004.
Postdoctoral Fellow, Washington University in St. Louis, Applied Physiology/Aging/Metabolism, 1991.
Ph.D., Ball State University, Bioenergetics, 1987.
M.Sc., University of Massachusetts Amherst, 1983.
B.A., University of Limerick, 1980.

Expertise and Research Interests

The Kirwan Lab conducts clinical translational research in age and obesity related insulin resistance and type 2 diabetes.

Aging and Insulin Resistance:
Our current research is focused on examining how exercise and nutrition alter disease risk associated with insulin resistance, obesity, and type 2 diabetes in older adults. We are conducting an NIH funded clinical trial to determine how aerobic exercise training and nutrition interventions, including high and low glycemic diets, may reverse insulin resistance. These studies are designed to investigate the physiological and cellular mechanisms by which alterations in life-style factors such as exercise and nutrition can improve metabolic control and body composition in older men and women.

Exercise and Insulin Resistance in Skeletal Muscle:
Exercise training is typically associated with enhanced insulin sensitivity and is used as a first line treatment for age-related diseases such as type 2 diabetes. We have shown that heightened insulin sensitivity is mediated by increased post-receptor insulin signaling, specifically at the distal steps of the insulin/PI 3-kinase signaling cascade that leads to GLUT-4 translocation and glucose uptake. It should be stated that the majority of human studies, including our own, have been performed on young healthy individuals. We are currently examining whether the same holds true for older adults with impaired glucose tolerance or type 2 diabetes.

Fatty Liver Disease and Insulin Resistance:
There is a growing body of evidence that an accumulation of fat in vital organs outside of the adipose tissue depots may be one of the driving mechanisms behind the development of insulin resistance and type 2 diabetes. This accumulation is particularly problematic in the liver, because it may contribute to hepatic insulin resistance, and hyperglycemia. Recent clinical data suggests that up to 70% of patients with type 2 diabetes have sufficient accumulation of fat in the liver to warrant diagnosis of nonalcoholic fatty liver disease (NAFLD), a disease that may advance to steatosis, fibrosis, cirrhosis and death. We are currently exploring the use of Magnetic Resonance Imaging (MRI) and spectroscopy techniques to non-invasively and comprehensively characterize hepatic lipids. We plan to use these tools in intervention studies in patients with NAFLD and NASH with the goal of identifying effective treatment strategies for reversing and preventing steatosis.

Obesity and Insulin Resistance:
Obesity is a major contributing factor to insulin resistance and type 2 diabetes. Bariatric surgery is a widely used therapy for those with a BMI greater than 40, or a BMI >35 in the presence of significant comorbidities. Certain bariatric surgery procedures are associated with remission of diabetes, and this may occur within days after surgery. We are currently examining the effects of various GI surgical procedures on insulin resistance, insulin secretion and hepatic glucose output in human and animal studies. We are measuring gut hormones that may have modulating effects on glucose metabolism with the goal of identifying new therapeutic targets for the treatment of obesity, insulin resistance and type 2 diabetes.

Industrial Relevance

Clinical trials
Obesity
Weight loss
Body composition
Diabetes
Dietary supplements
Dietary composition
Glycemic index
Metabolism

Keywords

COS Keywords:

Biophysics, Body Composition, Diabetes, Exercise, Gastroenterology, Geriatrics, Gerontology, Inflammation, Insulin, Kinesiology, Nutrition or Dietetics, Obesity, Pathobiology, Physiology, Pregnancy, Reproductive Biology, Sports Medicine.

Additional Terms:

Age Difference, Aging, Calorimetry, Diet, Exercise, Fatty Acid Metabolism, Gestational Diabetes, Glucose Clamp Technique, Glucose Metabolism, Glucose Tolerance Test, Hormone Regulation Control Mechanism, Human Middle Age, Human Old Age, Human Subject, Insulin, Obesity, Reducing Diet, Striated Muscle, Weight Loss.

Languages

(Reading, Writing, Speaking)

Irish Gaelic: (Functional, Functional, Functional)
Spanish: (Basic, Basic, None)

Memberships

American Association for the Advancement of Science
American College of Sports Medicine
American Diabetes Association
American Physiological Society
American Society for Nutritional Sciences
Gerontological Society of America
Obesity Society

Honors and Awards

2008, Clinical & Translational Science Collaborative Pilot Funding Award, National Institutes of Health (NIH), Case Western Reserve University, Insulin Resistance and Fatty Liver Disease
1995, National Research Service FIRST Award, NIH-NIA, Pennsylvania State University, Aging/Diet/Exercise/Metabolism
1991, Fellow of the American College of Sports Medicine, American College of Sports Medicine
1989, National Research Training Award, NIH, Washington University in St. Louis, Physiology/Metabolism/Aging
1982, Research Grant-in-Aid Award, Sigma Xi, University of Massachusetts Amherst, Exercise Biochemistry

Previous Positions

2004-2006, Associate Professor, Case Western Reserve University, School of Medicine, Department of Medicine, Schwartz Center for Nutrition and Metabolism
1999-2004, Associate Professor, Case Western Reserve University, School of Medicine, Reproductive Biology
1995-1999, Director, Pennsylvania State University, Muscle Core Laboratory
1993-1999, Assistant Professor, Pennsylvania State University, Noll Physiological Research Center, Physiology
1991-1993, Director, University of Limerick, National Coaching and Training Center, Irish Government Elite Athlete Program
1987-1991, Post-Doctoral Fellow, Washington University in St. Louis, School of Medicine, Medicine, Applied Physiology

Funding Received

  • Nestle International: Effects of Diet on Energy Expenditure and Body Composition, 2009 to 2010.
  • National Institutes of Health (NIH): Insulin Resistance: Detection of Hepatocellular Lipid Sub-Species by Magnetic Resonance Spectroscopy, 2008 to 2010.
  • National Institutes of Health (NIH), AG12834: Age, Exercise, Diet: Effects on Insulin Resistance, 2003 to 2010.
  • Diabetes Association of Greater Cleveland: Use of Exercise to Identify Mechanisms Responsible for Insulin Resistance in Type 2 Diabetes, 2001 to 2003.
  • General Mills Corp.: Fiber Content and Glycemic Index of Select Breakfast Foods, 1999 to 2000.
  • NIH NIA Minority Predoctoral Supplement Award to AG12834: Age, Exercise, Diet: Effects on Glucose/Fatty Acid Cycle, 1998 to 1999.
  • Robard Corporation: Effects of a High Protein Diet on Weight Loss, Body Composition and Energy Expenditure in Obese Men and Women, 1997 to 1999.
  • NIH NCRR MO1 RR10732: Muscle Core Laboratory, 1995 to 1999.
  • National Institutes of Health (NIH), AG12834: Age, Exercise, Diet: Effects on Glucose/Fatty Acid Cycle, 1995 to 2003.
  • Penn State University - Interdisciplinary Seed Grant: Effects of Resistance Exercise on Insulin Action in Older Men and Women, 1994 to 1995.

Publications

  • Haus JM, Solomon TP, Marchetti CM, Edmison JM, Gonzalez F, Kirwan JP (2010) Free faty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance, J Clin Endocrinol Metab, 95 (1), 323-7
  • Radelli T, Farrell KA, Huston-Presley L, Amini SB, Kirwan JP, McIntyre HD, Catalano PM (2009) Estimates of insulin sensitivity using glucose and c-peptide from the HAPO glucose tolerance test, Diabetes Care
  • Kashyap SR, Daud S, Kelly KR, Gastaldelli A, Win H, Brethauer S, Kirwan JP, Schauer PR (2009) Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes, Int J Obes
  • Navaneethan SD, Kelly KR, Sabbagh F, Schauer PR, Kirwan JP, Kashyap SR (2009) Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery, Obes Surg
  • Solomon TP, Haus JM, Kelly KR, Cook MD, Riccardi M, Rocco M, Kashyap SR, Barkoukis H, Kirwan JP (Nov 2009) Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans., The American journal of clinical nutrition, 90 (5), 1222-9 Abstract
  • McIntyre HD, Chang AM, Callaway LK, Cowley DM, Dyer AR, Radaelli T, Farrell KA, Huston-Presley LP, Amini SB, Kirwan JP, Catalano PM (2009) Hormonal and metabolic factors assoicated with variations in insulin sensitivity in human pregnancy, Diabetes Care
  • Kirwan JP, Barkoukis H, Brooks LM, Marchetti CM, Stetzer BP, Gonzalez F (Oct 2009) Exercise Training and Dietary Glycemic Load May Have Synergistic Effects on Insulin Resistance in Older Obese Adults., Annals of nutrition & metabolism, 55 (4), 326-333 Abstract
  • Kelly KR, Kashyap SR, O'Leary VB, Major J, Schauer PR, Kirwan JP (Oct 2009) Retinol-binding Protein 4 (RBP4) Protein Expression Is Increased in Omental Adipose Tissue of Severely Obese Patients., Obesity (Silver Spring, Md.) Abstract
  • Kelly KR, Williamson DL, Fealy CE, Kriz DA, Krishnan RK, Huang H, Ahn J, Loomis JL, Kirwan JP (Sep 2009) Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans., Metabolism: clinical and experimental Abstract
  • Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO (Jul 2009) Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus., American journal of physiology. Endocrinology and metabolism, 297 (1), E151-6 Abstract
  • González F, Rote NS, Minium J, Kirwan JP (Jul 2009) Evidence of proatherogenic inflammation in polycystic ovary syndrome., Metabolism: clinical and experimental, 58 (7), 954-62 Abstract
  • Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP (Jun 2009) Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans., American journal of physiology. Endocrinology and metabolism Abstract
  • Haus JM, Solomon TP, Marchetti CM, O'Leary VB, Brooks LM, Gonzalez F, Kirwan JP (Jun 2009) Decreased visfatin after exercise training correlates with improved glucose tolerance., Medicine and science in sports and exercise, 41 (6), 1255-60 Abstract
  • Kelly KR, Brooks LM, Solomon TP, Kashyap SR, O'Leary VB, Kirwan JP (Jun 2009) The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity., American journal of physiology. Endocrinology and metabolism, 296 (6), E1269-74 Abstract
  • Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, Kirwan JP (Feb 2009) Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance., Diabetes, 58 (2), 337-343 Abstract
  • Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP (Jan 2009) Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial., The journals of gerontology. Series A, Biological sciences and medical sciences, 64 (1), 90-5 Abstract
  • Solomon TP, Marchetti CM, Krishnan RK, Gonzalez F, Kirwan JP (Aug 2008) Effects of aging on basal fat oxidation in obese humans., Metabolism: clinical and experimental, 57 (8), 1141-7 Abstract
  • Solomon TP, Sistrun SN, Krishnan RK, Del Aguila LF, Marchetti CM, O'Carroll SM, O'Leary VB, Kirwan JP (May 2008) Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults., Journal of applied physiology (Bethesda, Md. : 1985), 104 (5), 1313-9 Abstract
  • Friedman JE, Kirwan JP, Jing M, Presley L, Catalano PM (Mar 2008) Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum., Diabetes, 57 (3), 606-13 Abstract
  • Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW (Nov 2007) Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse., The Journal of biological chemistry, 282 (45), 32844-55 Abstract
  • González F, Rote NS, Minium J, O'leary VB, Kirwan JP (Oct 2007) Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia., Obesity (Silver Spring, Md.), 15 (10), 2436-44 Abstract
  • O'Leary VB, Jorett AE, Marchetti CM, Gonzalez F, Phillips SA, Ciaraldi TP, Kirwan JP (Jul 2007) Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults., American journal of physiology. Endocrinology and metabolism, 293 (1), E421-7 Abstract
  • Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE (Jul 2007) Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes., Diabetes care, 30 Suppl 2, S112-9 Abstract
  • Barkoukis H, Marchetti CM, Nolan B, Sistrun SN, Krishnan RK, Kirwan JP (2007) A high glycemic meal suppresses the postprandial leptin response in normal healthy adults., Annals of nutrition & metabolism, 51 (6), 512-8 Abstract
  • Volek JS, Silvestre R, Kirwan JP, Sharman MJ, Judelson DA, Spiering BA, Vingren JL, Maresh CM, Vanheest JL, Kraemer WJ (Dec 2006) Effects of chromium supplementation on glycogen synthesis after high-intensity exercise., Medicine and science in sports and exercise, 38 (12), 2102-9 Abstract
  • O'Connor AM, Pola S, Ward BM, Fillmore D, Buchanan KD, Kirwan JP (Jun 2006) The gastroenteroinsular response to glucose ingestion during postexercise recovery., American journal of physiology. Endocrinology and metabolism, 290 (6), E1155-61 Abstract
  • O'Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP (May 2006) Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat., Journal of applied physiology (Bethesda, Md. : 1985), 100 (5), 1584-9 Abstract
  • González F, Rote NS, Minium J, Kirwan JP (Apr 2006) Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome., The Journal of clinical endocrinology and metabolism, 91 (4), 1508-12 Abstract
  • González F, Rote NS, Minium J, Kirwan JP (Mar 2006) In vitro evidence that hyperglycemia stimulates tumor necrosis factor-alpha release in obese women with polycystic ovary syndrome., The Journal of endocrinology, 188 (3), 521-9 Abstract
  • González F, Minium J, Rote NS, Kirwan JP (Feb 2006) Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during hyperglycemia., Metabolism: clinical and experimental, 55 (2), 271-6 Abstract
  • González F, Rote NS, Minium J, Kirwan JP (Jan 2006) Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome., The Journal of clinical endocrinology and metabolism, 91 (1), 336-40 Abstract
  • Kim J, Saidel GM, Kirwan JP, Cabrera ME (2006) Computational model of glucose homeostasis during exercise., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 1, 311-4 Abstract
  • Gonzalez F, Minium J, Rote NS, Kirwan JP (Sep 2005) Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome., The Journal of Clinical Endocrinology and Metabolism, 90 (9), 5336-42 Abstract
  • Kalinski MI, Kirwan JP (2005) Adaptation of the signal transduction system of different skeletal muscles during exercise, Medicina Sportiva, 9
  • Kirwan JP, Varastehpour A, Jing M, Presley L, Shao J, Friedman JE, Catalano PM, Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling, The Journal of Clinical Endocrinology and Metabolism, 89(9), 4678-84, Sep 2004 Abstract
  • Kirwan JP, del Aguila LF, Insulin signalling, exercise and cellular integrity, Biochemical Society Transactions, 31(Pt 6), 1281-5, Dec 2003 Abstract
  • Krishnan RK, Evans WJ, Kirwan JP, Glucose clearance is delayed after hyperglycemia in healthy elderly men, Journal of Nutrition, 133(7), 2363-6, July 2003 Abstract
  • Catalano PM, Kirwan JP, Haugel-de Mouzon S, King J, Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus, Journal of Nutrition, 133(5 Suppl 2), 1674S-1683S, May 2003 Abstract
  • Krishnan RK, Evans WJ, Kirwan JP, Impaired substrate oxidation in healthy elderly men after eccentric exercise, Journal of Applied Physiology (bethesda, Md. : 1985), 94(2), 716-23, February 2003 Abstract
  • Kirwan JP, Hauguel-De Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, Catalano PM, TNF-alpha is a predictor of insulin resistance in human pregnancy, Diabetes, 51(7), 2207-13, July 2002 Abstract
  • Catalano PM, Kirwan JP, Clinical utility and approaches for estimating insulin sensitivity in pregnancy, Seminars in Perinatology, 26(3), 181-9, June 2002 Abstract
  • Kirwan JP, Jing M, Modulation of insulin signaling in human skeletal muscle in response to exercise, Exercise and Sport Sciences Reviews, 30(2), 85-90, April 2002 Abstract
  • Warrington G, Ryan C, Murray F, Duffy P, Kirwan JP, Physiological and metabolic characteristics of elite tug of war athletes, British Journal of Sports Medicine, 35(6), 396-401, December 2001 Abstract
  • Kirwan JP, Krishnan RK, Weaver JA, Del Aguila LF, Evans WJ, Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia, American Journal of Physiology. Endocrinology and Metabolism, 281(6), E1137-43, December 2001 Abstract
  • Avram AM, Patel V, Taylor HC, Kirwan JP, Kalhan S, Euglycemic clamp study in clozapine-induced diabetic ketoacidosis, The Annals of Pharmacotherapy, 35(11), 1381-7, November 2001 Abstract
  • Kirwan JP, Huston-Presley L, Kalhan SC, Catalano PM, Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus, Diabetes Care, 24(9), 1602-7, September 2001 Abstract
  • Kirwan JP, O'Gorman DJ, Cyr-Campbell D, Campbell WW, Yarasheski KE, Evans WJ, Effects of a moderate glycemic meal on exercise duration and substrate utilization, Medicine and Science in Sports and Exercise, 33(9), 1517-23, September 2001 Abstract
  • Catalano PM, Kirwan JP, Maternal factors that determine neonatal size and body fat, Current Diabetes Reports, 1(1), 71-77, August 2001
  • Kirwan JP, Cyr-Campbell D, Campbell WW, Scheiber J, Evans WJ, Effects of moderate and high glycemic index meals on metabolism and exercise performance, Metabolism: Clinical and Experimental, 50(7), 849-55, July 2001 Abstract
  • O'Gorman DJ, Del Aguila LF, Williamson DL, Krishnan RK, Kirwan JP, Insulin and exercise differentially regulate PI3-kinase and glycogen synthase in human skeletal muscle, Journal of Applied Physiology, 89(4), 1412-9, October 2000 Abstract
  • del Aguila LF, Krishnan RK, Ulbrecht JS, Farrell PA, Correll PH, Lang CH, Zierath JR, Kirwan JP, Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle, American Journal of Physiology. Endocrinology and Metabolism, 279(1), E206-12, July 2000 Abstract
  • Kirwan JP, del Aguila LF, Hernandez JM, Williamson DL, O'Gorman DJ, Lewis R, Krishnan RK, Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle, Journal of Applied Physiology, 88(2), 797-803, February 2000 Abstract
  • O'Gorman, D.J., A. Hunter, C. McDonnacha, and J.P. Kirwan, Validity of field tests to evaluate endurance capacity in competitive and international level sports participants, Journal of Strength and Conditioning Research, 14(1), 62-67, 01 Jan 2000
  • del Aguila LF, Claffey KP, Kirwan JP, TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells, American Journal of Physiology, 276(5 Pt 1), E849-55, May 1999 Abstract
  • Krishnan RK, Hernandez JM, Williamson DL, O'Gorman DJ, Evans WJ, Kirwan JP, Age-related differences in the pancreatic beta-cell response to hyperglycemia after eccentric exercise, American Journal of Physiology, 275(3 Pt 1), E463-70, September 1998 Abstract
  • Kirwan JP, O'Gorman D, Evans WJ, A moderate glycemic meal before endurance exercise can enhance performance, Journal of Applied Physiology, 84(1), 53-9, Jan 1998 Abstract
  • Williamson DL, Kirwan JP, A single bout of concentric resistance exercise increases basal metabolic rate 48 hours after exercise in healthy 59-77-year-old men, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 52(6), M352-5, November 1997 Abstract
  • Bourey RE, Kohrt WM, Kirwan JP, Staten MA, King DS, Holloszy JO, Relationship between glucose tolerance and glucose-stimulated insulin response in 65-year-olds, Journal of Gerontology, 48(4), M122-7, July 1993 Abstract
  • Kirwan JP, Kohrt WM, Wojta DM, Bourey RE, Holloszy JO, Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women, Journal of Gerontology, 48(3), M84-90, May 1993 Abstract
  • Maughan RJ, Goodburn R, Griffin J, Irani M, Kirwan JP, Leiper JB, MacLaren DP, McLatchie G, Tsintsas K, Williams C, et al, Fluid replacement in sport and exercise--a consensus statement, British Journal of Sports Medicine, 27(1), 34-5, March 1993 Abstract
  • Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO, Insulin resistance in aging is related to abdominal obesity, Diabetes, 42(2), 273-81, February 1993 Abstract
  • Coggan AR, Kohrt WM, Spina RJ, Kirwan JP, Bier DM, Holloszy JO, Plasma glucose kinetics during exercise in subjects with high and low lactate thresholds [see comments], Journal of Applied Physiology, 73(5), 1873-80, November 1992 Abstract
  • Kirwan JP, Hickner RC, Yarasheski KE, Kohrt WM, Wiethop BV, Holloszy JO, Eccentric exercise induces transient insulin resistance in healthy individuals, Journal of Applied Physiology, 72(6), 2197-202, June 1992 Abstract
  • Kirwan JP, Bourey RE, Kohrt WM, Staten MA, Holloszy JO, Effects of treadmill exercise to exhaustion on the insulin response to hyperglycemia in untrained men, Journal of Applied Physiology, 70(1), 246-50, January 1991 Abstract
  • Kirwan JP, Costill DL, Flynn MG, Neufer PD, Fink WJ, Morse WM, Effects of increased training volume on the oxidative capacity, glycogen content and tension development of rat skeletal muscle, International Journal of Sports Medicine, 11(6), 479-83, December 1990 Abstract
  • Flynn MG, Costill DL, Kirwan JP, Mitchell JB, Houmard JA, Fink WJ, Beltz JD, D'Acquisto LJ, Fat storage in athletes: metabolic and hormonal responses to swimming and running, International Journal of Sports Medicine, 11(6), 433-40, December 1990 Abstract
  • Bourey RE, Coggan AR, Kohrt WM, Kirwan JP, King DS, Holloszy JO, Effect of exercise on glucose disposal: response to a maximal insulin stimulus, Journal of Applied Physiology, 69(5), 1689-94, November 1990 Abstract
  • Kirwan JP, Costill DL, Houmard JA, Mitchell JB, Flynn MG, Fink WJ, Changes in selected blood measures during repeated days of intense training and carbohydrate control, International Journal of Sports Medicine, 11(5), 362-6, October 1990 Abstract
  • Dengel DR, Flynn MG, Costill DL, Kirwan JP (Sep 1989) Determinants of success during triathlon competition., Research Quarterly for Exercise and Sport, 60 (3), 234-8 Abstract
  • Houmard JA, Kirwan JP, Flynn MG, Mitchell JB (Feb 1989) Effects of reduced training on submaximal and maximal running responses., International Journal of Sports Medicine, 10 (1), 30-3 Abstract
  • Kirwan JP, Costill DL, Mitchell JB, Houmard JA, Flynn MG, Fink WJ, Beltz JD (Dec 1988) Carbohydrate balance in competitive runners during successive days of intense training., Journal of Applied Physiology (bethesda, Md. : 1985), 65 (6), 2601-6 Abstract
  • Horswill CA, Costill DL, Fink WJ, Flynn MG, Kirwan JP, Mitchell JB, Houmard JA (Dec 1988) Influence of sodium bicarbonate on sprint performance: relationship to dosage., Medicine and Science in Sports and Exercise, 20 (6), 566-9 Abstract
  • Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA (Jun 1988) Physiological responses to successive days of intense training in competitive swimmers., Medicine and Science in Sports and Exercise, 20 (3), 255-9 Abstract
  • Costill DL, Flynn MG, Kirwan JP, Houmard JA, Mitchell JB, Thomas R, Park SH (Jun 1988) Effects of repeated days of intensified training on muscle glycogen and swimming performance., Medicine and Science in Sports and Exercise, 20 (3), 249-54 Abstract
  • Beltz JD, Costill DL, Thomas R, Fink WJ, Kirwan JP (1988) Energy demands of interval training for competitive swimming, J Swimming Research, 4 (3), 5-9
  • Flynn MG, Costill DL, Kirwan JP, Fink WJ, Dengel DR (Dec 1987) Muscle fiber composition and respiratory capacity in triathletes., International Journal of Sports Medicine, 8 (6), 383-6 Abstract
  • Costill DL, Fink WJ, Flynn M, Kirwan J (Nov 1987) Muscle fiber composition and enzyme activities in elite female distance runners., International Journal of Sports Medicine, 8 Suppl 2, 103-6 Abstract
  • Neufer PD, Costill DL, Fielding RA, Flynn MG, Kirwan JP (Oct 1987) Effect of reduced training on muscular strength and endurance in competitive swimmers., Medicine and Science in Sports and Exercise, 19 (5), 486-90 Abstract
  • Kirwan JP, Costill DL, Kuipers H, Burrell MJ, Fink WJ, Kovaleski JE, Fielding RA (Jul 1987) Substrate utilization in leg muscle of men after heat acclimation., Journal of Applied Physiology (bethesda, Md. : 1985), 63 (1), 31-5 Abstract
  • Neufer PD, Costill DL, Flynn MG, Kirwan JP, Mitchell JB, Houmard J (Mar 1987) Improvements in exercise performance: effects of carbohydrate feedings and diet., Journal of Applied Physiology (bethesda, Md. : 1985), 62 (3), 983-8 Abstract
  • Graves JE, Clarkson PM, Litchfield PL, Kirwan JP (1987) Serum creatine kinase isoenzymes CK-MB following isometric exercise, J Cardiopulmonary Rehab, 7, 451-7
  • Jang KT, Flynn MG, Costill DL, Kirwan JP, Houmard JA, Mitchell JB, D'Acquisto LJ (1987) Energy balance in competitive swimmers and runners, J Swimming Research, 3 (1), 19-23
  • Fielding RA, Costill DL, Fink WJ, King DS, Kovaleski JE, Kirwan JP (1987) Effects of pre-exercise carbohydrate feedings on muscle glycogen use during exercise in well-trained runners., European Journal of Applied Physiology and Occupational Physiology, 56 (2), 225-9 Abstract
  • Graves JE, Clarkson PM, Litchfield P, Kirwan JP, Norton JP (1987) Serum creatine kinase activity following repeated bouts of isometric exercise with different muscle groups., European Journal of Applied Physiology and Occupational Physiology, 56 (6), 657-61 Abstract
  • Neufer PD, Costill DL, Fink WJ, Kirwan JP, Fielding RA, Flynn MG (Dec 1986) Effects of exercise and carbohydrate composition on gastric emptying., Medicine and Science in Sports and Exercise, 18 (6), 658-62 Abstract
  • Costill DL, Rayfield F, Kirwan J, Thomas R (1986) A computer based system for the measurement of force and power during front crawl swimming, J Swimming Research, 2 (1), 16-9
  • Kirwan JP, Clarkson PM, Graves JE, Litchfield PL, Byrnes WC (1986) Levels of serum creatine kinase and myoglobin in women after two isometric exercise conditions., European Journal of Applied Physiology and Occupational Physiology, 55 (3), 330-3 Abstract
  • Norton JP, Clarkson PM, Graves JE, Litchfield PL, Kirwan JP (1985) Serum creatine kinase activity and body composition in males and females, Human Biology, 57 (4), 591-8
  • Clarkson PM, Litchfield P, Graves J, Kirwan J, Byrnes W (1985) Serum creatine kinase activity following forearm flexion isometric exercise, Eur J Appl Physiol, 53, 368-71
  • Costill DL, Kovaleski J, Porter D, Kirwan J, Fielding R, King D (1985) Energy expenditure during front crawl swimming: predicting success in middle-distance events, Int J Sports Med, 6, 266-70

Profile Details

Last Updated: 1/22/2010

COS Expertise ID #537894
Reference this profile directly: http://myprofile.cos.com/kirwanj94