Harvey J. Kliman |
|
Yale University School of Medicine Obstetrics & Gynecology Reproductive and Placental Research Unit Research ScientistAppointed: 1991 |  |
Mailing Address300 George Street Reproductive and Placental Research Unit Suite 8100, Dept. of Ob/Gyn New Haven, Connecticut 06520United States | Contact InformationPhone: (203) 785-3854 Fax: (203) 387-6422 harvey.kliman@yale.edu http://info.med.yale.edu/obgyn/kliman/ |
Qualifications
M.D., University of Chicago, 1981.
Ph.D., University of Chicago, 1981.
B.S., Syracuse University, 1974.
Expertise and Research Interests
Implantation Research:
Implantation is a major hurdle for successful human reproduction. During most attempts of assisted reproductive technology (ART), fewer than 10% of embryos successfully implant. Abnormalities in the process of implantation may underlie infertility in many women, and undermine the effectiveness of ART. Predictors of implantation potential are needed, both to better understand the causes of infertility in women and to improve the efficacy and reliability of embryo transfer. Despite almost two decades of ART, the precise molecular mediators of human implantation remain unknown. As a corollary to this problem, no molecular markers exist to adequately predict whether implantation will occur during any given ART cycle. My research team hypothesized that the dynamic changes in the endometrium throughout the menstrual cycle require the coordinated expression of specific steroid-modulated molecules. Recently we have identified an epitope on MUC1, the major endometrial mucin, which varies throughout the menstrual cycle. This epitope was first identified in endometrial epithelial cell Golgi because of its strong reactivity with IgG antibodies in numerous murine ascites, hence the designation MAG (mouse ascites Golgi). In donor oocyte recipients, MAG appears on the endometrial surface at the time of embryo transfer in women who ultimately become pregnant, but is absent in donor recipients who fail repeatedly to become pregnant. We have also demonstrated that cyclin E and p27 parallel the normal and abnormal expression of MAG in endometrial biopsies. We are investigating MAG, cyclin E and p27 as markers of endometrial receptivity in order to differentiate implantation-receptive endometrium from non-receptive endometrium in donor oocyte andunexplained infertility patients. The results of these studies should provide new information about the significance of MAG mucin/MUC1, cyclin E and p27 expression in clinical settings where high rates of normal implantation are desired.
Placental Responseto Inflammation:
It is well known that more than a third of all preterm births are associated with labor initiated by acute chorioamnionitis. Not only does chorioamnionitis have severe consequences for the fetus through the initiation of pretermdelivery, but chorioamnionitis is followed by a 20% greater-than-expected frequency of neurologic abnormalities at 7 years of age. Chorioamnionitis appears to be deleterious to the fetus because the inflammatory process induces villous edema. We have hypothesizedthat villous edema makes the fetus hypoxic by compressing fetal blood vessels inside the villi and by increasing the diffusion barrier for oxygen between the maternal and fetal circulations. Our laboratory is developing methods to assess the presence andtiming of villous edema—both pre- and postpartum—and the cytokines responsible for formation of villous edema.
Structural Defects in the Placenta Suggest the Presence of Genetic Defects in the Fetus:
The placenta grows much like a tree. Just as tree growth patterns can be mathematically modeled using fractal equations, the placenta also follows a simple algorithm for its growth. The cellular basis of the placental growth pattern is the dynamic relationship between cytotrophoblast replication and differentiation towards syncytiotrophoblast. We have identified an abnormal growth pattern of the trophoblast layers which appears to be associated with genetic defects in the fetus: trophoblast invaginations. We are collecting histologic datafrom elective andspontaneous terminations, genetic analysis and ultrasound studies to elucidate the correlation between placental structural abnormalities and genetic defects.
Implantation is a major hurdle for successful human reproduction. During most attempts of assisted reproductive technology (ART), fewer than 10% of embryos successfully implant. Abnormalities in the process of implantation may underlie infertility in many women, and undermine the effectiveness of ART. Predictors of implantation potential are needed, both to better understand the causes of infertility in women and to improve the efficacy and reliability of embryo transfer. Despite almost two decades of ART, the precise molecular mediators of human implantation remain unknown. As a corollary to this problem, no molecular markers exist to adequately predict whether implantation will occur during any given ART cycle. My research team hypothesized that the dynamic changes in the endometrium throughout the menstrual cycle require the coordinated expression of specific steroid-modulated molecules. Recently we have identified an epitope on MUC1, the major endometrial mucin, which varies throughout the menstrual cycle. This epitope was first identified in endometrial epithelial cell Golgi because of its strong reactivity with IgG antibodies in numerous murine ascites, hence the designation MAG (mouse ascites Golgi). In donor oocyte recipients, MAG appears on the endometrial surface at the time of embryo transfer in women who ultimately become pregnant, but is absent in donor recipients who fail repeatedly to become pregnant. We have also demonstrated that cyclin E and p27 parallel the normal and abnormal expression of MAG in endometrial biopsies. We are investigating MAG, cyclin E and p27 as markers of endometrial receptivity in order to differentiate implantation-receptive endometrium from non-receptive endometrium in donor oocyte andunexplained infertility patients. The results of these studies should provide new information about the significance of MAG mucin/MUC1, cyclin E and p27 expression in clinical settings where high rates of normal implantation are desired.
Placental Responseto Inflammation:
It is well known that more than a third of all preterm births are associated with labor initiated by acute chorioamnionitis. Not only does chorioamnionitis have severe consequences for the fetus through the initiation of pretermdelivery, but chorioamnionitis is followed by a 20% greater-than-expected frequency of neurologic abnormalities at 7 years of age. Chorioamnionitis appears to be deleterious to the fetus because the inflammatory process induces villous edema. We have hypothesizedthat villous edema makes the fetus hypoxic by compressing fetal blood vessels inside the villi and by increasing the diffusion barrier for oxygen between the maternal and fetal circulations. Our laboratory is developing methods to assess the presence andtiming of villous edema—both pre- and postpartum—and the cytokines responsible for formation of villous edema.
Structural Defects in the Placenta Suggest the Presence of Genetic Defects in the Fetus:
The placenta grows much like a tree. Just as tree growth patterns can be mathematically modeled using fractal equations, the placenta also follows a simple algorithm for its growth. The cellular basis of the placental growth pattern is the dynamic relationship between cytotrophoblast replication and differentiation towards syncytiotrophoblast. We have identified an abnormal growth pattern of the trophoblast layers which appears to be associated with genetic defects in the fetus: trophoblast invaginations. We are collecting histologic datafrom elective andspontaneous terminations, genetic analysis and ultrasound studies to elucidate the correlation between placental structural abnormalities and genetic defects.
Other Expertise
I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.
Academic Experience:
Awards, Honors and Membership in Honorary Societies:
1971-74 Regents Scholarship Award, New York State
1971-74 Honors Department, Syracuse University
1974 Graduated Summa Cum Laude (Biology), Syracuse University
1974 Phi Beta Kappa Election
1974 Phi Kappa Phi Honor Society Election
1975-81 Insurance Medical Scientist Scholar
1980 Sigma XiElection
1984 Special Citation, Microscopic Category, ASCP/Kodak Medical Photography Competition.
1985-6 Clinical Research Grant, Diabetes Research and Education Foundation
1985-88 Clinical Investigator Award, NICHD, NIA
1988-9 McCabe Award
1989-90 University Research Foundation Award
1990-1 Medical Center and University BRSG Awards
1991-2 Andrew Mellon Fellowship Award
1993-5 Shannon Award, NICHD, NIH
Principal Investigator of Grants:
1. Steroidogenesis in the human trophoblast. NIH 1 KO8 HD00715-01, 12/85-12/88, $187,000
2. Clinical Research Grant, Diabetes Research and Education Foundation, 1985-6, $10,000
3. McCabe Award, 9/88-9/89, $15,000
4. University Research Foundation Award, 7/89-6/90, $7,000
5. Medical Center BRSG Award, 7/90-6/91, $10,000
6. University BRSG Award, 7/90-6/91, $8,000
7. TUN: Purification and Characterization, Ares-Serono, 12/91-11/93, $67,000
8. MAG: MAG Mucin, Abbott Laboratories, 4/92-93, $15,000
9. Leukocyte chemoattractants in endometriosis, 1R55HD30501-01A1, 9/30/93-9/29/95, $100,000
10. MAG Mucin Diagnostic, Centocor, Inc., 7/1/95-6/30/96, $46,150
11. MAG Mucin and Endometrial Receptivity, 12/01/96-01/31/00, NICHD, $793,498, pending
Study Sections:
Biochemical Endocrinology (AHR-M1) Study Section, 11/92
Reproductive Endocrinology (AHR-B1) Study Section, 3/94
Reproductive Endocrinology (AHR-B1) Study Section, 7/94
Division of Scientific Review, NICHD, Site Visit, 4/96
Academic Committees at the University of Pennsylvania:
1984-91 Member, Tissue Committee
1986 Member, Endocrinology Curriculum Review Committee
1987-91 Member, Committee on Studies Involving Human Beings
1988-90 Member, Computers in Medical Education
1990-91 Chairman, Education Subcommittee of the University Information Resource Management Committee
Academic Committees at Yale University:
1993-95 Member, Library Committee, School of Medicine
1993-95 Member, Committee on Computers in Medical Education
Search Committees at Yale University:
1992 Member, Search for Director, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology
1992 Member, Search for Director, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology
1992-3 Member, Pathology Residents Recruitment Committee
Community Activities:
1991- Member, Board of Education, B'nai Jacob, Woodbridge
1993- Member, Publicity Committee, B'nai Jacob, Woodbridge
1995- Presidential Couple, Connecticut Jewish Marriage Encounter
Teaching and Clinical Responsibilities at Yale University:
Perinatal/Placental Pathology Activities:
Placental and Perinatal Pathology Program Director, 1991-95
Perinatal-Placental Review Conference (weekly), 1991-95
Reproductive Endocrinology Review Conference (weekly), 1991-95
Ob/Gyn Resident Pathology Review Series (biweekly), 1991-95
Perinatal Morbidity and Mortality Conference (monthly), 1991-95
Maternal-Fetal Medicine Lecture Series (biannual), 1991-95
Norwalk/Danbury Teaching Lectures (annual), 1991-
Medical Center Teaching:
Pathology Residents: Gestational Pathology (daily), 1991-95
Pathology Residents: Perinatal Autopsy Service (daily), 1991-95
Quinnipiac College Pathologists' Assistant Program Instructor (daily), 1991-95
Pathology 100 Laboratory Instructor, 1991-95
Pathology 100 Tutorial Leader, 1991-95
Pathology of Placenta and Fetus, Pathology 100, 1991-
Implantation and Placenta Formation, Reproductive Biology 280b, 1991-
Ob/Gyn 3rd year Clerkship, Reproductive BiologyCourse (6 times/y), 1991-
Graduate Students, Fellows, Medical and Undergraduate Trainees:
Graduate Students:
L-C Kao, Department of Pathology, University of Pennsylvania, ''Trophoblast Interactions with Extracellular Matrix Proteins'';
S Caltabiano, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Role of GnRH in Trophoblast hCG Synthesis and Secretion''
Medical Fellows:
MA Feinman, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Role of cAMP in Trophoblast Differentiation'';
L Schwartz, Department of Obstetrics and Gynecology, Yale School of Medicine, ''Mouse Ascites Golgi (MAG) Mucin Expression And Regulation By Progesterone In The Rat'';
M Cunningham, Department of Surgery, Yale School of Medicine, ''Interleukin-8 Secretion by Trophoblasts in Response to Endotoxin'';
M Nachtigall, Department of Obstetrics and Gynecology, Yale School of Medicine, ''Role of Leukemia Inhibitory Factor in Trophoblast Differentiation and Implantation'';
Tony Asis, Department of Obstetrics and Gynecology, Yale School of Medicine, ''EPO and CRH Expression in Normal and Stressed Placentas''
Post-Doctoral Fellows:
R Feinberg, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Plasminogen Activator Inhibitor Expression in Invading Trophoblasts''
X Li, Department of Obstetrics and Gynecology, Korea, ''Degradation Pathways of hCG in the Chorionic Villous''
K-S Lee, Department of Obstetrics and Gynecology, Pusan National University, Korea, ''Degradation Pathways of hCG in the Chorionic Villous Core''
Senior Medical Thesis Advisor:
E Buchanan, Medical Student Research Fellow of the American Heart Association, Department of Pathology, University of Pennsylvania, ''Urokinase Receptor: A Modulatorfor Trophoblast Invasion?''
Undergraduate Senior Thesis Advisor:
S Wu, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Effect of ECM on Trophoblast Endocrine Function'';
K Ahn, Yale College, Yale University, ''Identification of Endometrial Tissue in Menstrual and Peritoneal Fluid: Precursor for Endometriosis?''
Summer Student Advisor:
J Wetmore, Yale College, Yale University, ''Endometrial MAG Mucin Expression in Normal and Infertile Patients'';
L Gordon, Yale College, Yale University, ''Endometrial Receptivity and MAG Mucin Expression''
Reviewer of Manuscripts for the following Journals:
American Journal of Obstetrics and Gynecology
American Journal of Pathology
Biology of Reproduction
Cancer Research
Development
Developmental Biology
In Vitro
Journal of Clinical Investigation
Journal of Developmental Physiology
Laboratory Investigation
Placenta
Trophoblast Research
International Workshops Organized
October 10, 1988 ''Trophoblast Differentiation in Tissue Culture,'' 11th Rochester Trophoblast Conference, Rochester, NY;
September 28, 1989 ''Trophoblast Cells in Culture,'' III European Placental Group Meeting, Paris, France;
October 2, 1992 ''Models of Implantation: Trophoblast Endometrium Interactions,'' 12th Rochester Trophoblast Conference,
Academic Experience:
Awards, Honors and Membership in Honorary Societies:
1971-74 Regents Scholarship Award, New York State
1971-74 Honors Department, Syracuse University
1974 Graduated Summa Cum Laude (Biology), Syracuse University
1974 Phi Beta Kappa Election
1974 Phi Kappa Phi Honor Society Election
1975-81 Insurance Medical Scientist Scholar
1980 Sigma XiElection
1984 Special Citation, Microscopic Category, ASCP/Kodak Medical Photography Competition.
1985-6 Clinical Research Grant, Diabetes Research and Education Foundation
1985-88 Clinical Investigator Award, NICHD, NIA
1988-9 McCabe Award
1989-90 University Research Foundation Award
1990-1 Medical Center and University BRSG Awards
1991-2 Andrew Mellon Fellowship Award
1993-5 Shannon Award, NICHD, NIH
Principal Investigator of Grants:
1. Steroidogenesis in the human trophoblast. NIH 1 KO8 HD00715-01, 12/85-12/88, $187,000
2. Clinical Research Grant, Diabetes Research and Education Foundation, 1985-6, $10,000
3. McCabe Award, 9/88-9/89, $15,000
4. University Research Foundation Award, 7/89-6/90, $7,000
5. Medical Center BRSG Award, 7/90-6/91, $10,000
6. University BRSG Award, 7/90-6/91, $8,000
7. TUN: Purification and Characterization, Ares-Serono, 12/91-11/93, $67,000
8. MAG: MAG Mucin, Abbott Laboratories, 4/92-93, $15,000
9. Leukocyte chemoattractants in endometriosis, 1R55HD30501-01A1, 9/30/93-9/29/95, $100,000
10. MAG Mucin Diagnostic, Centocor, Inc., 7/1/95-6/30/96, $46,150
11. MAG Mucin and Endometrial Receptivity, 12/01/96-01/31/00, NICHD, $793,498, pending
Study Sections:
Biochemical Endocrinology (AHR-M1) Study Section, 11/92
Reproductive Endocrinology (AHR-B1) Study Section, 3/94
Reproductive Endocrinology (AHR-B1) Study Section, 7/94
Division of Scientific Review, NICHD, Site Visit, 4/96
Academic Committees at the University of Pennsylvania:
1984-91 Member, Tissue Committee
1986 Member, Endocrinology Curriculum Review Committee
1987-91 Member, Committee on Studies Involving Human Beings
1988-90 Member, Computers in Medical Education
1990-91 Chairman, Education Subcommittee of the University Information Resource Management Committee
Academic Committees at Yale University:
1993-95 Member, Library Committee, School of Medicine
1993-95 Member, Committee on Computers in Medical Education
Search Committees at Yale University:
1992 Member, Search for Director, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology
1992 Member, Search for Director, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology
1992-3 Member, Pathology Residents Recruitment Committee
Community Activities:
1991- Member, Board of Education, B'nai Jacob, Woodbridge
1993- Member, Publicity Committee, B'nai Jacob, Woodbridge
1995- Presidential Couple, Connecticut Jewish Marriage Encounter
Teaching and Clinical Responsibilities at Yale University:
Perinatal/Placental Pathology Activities:
Placental and Perinatal Pathology Program Director, 1991-95
Perinatal-Placental Review Conference (weekly), 1991-95
Reproductive Endocrinology Review Conference (weekly), 1991-95
Ob/Gyn Resident Pathology Review Series (biweekly), 1991-95
Perinatal Morbidity and Mortality Conference (monthly), 1991-95
Maternal-Fetal Medicine Lecture Series (biannual), 1991-95
Norwalk/Danbury Teaching Lectures (annual), 1991-
Medical Center Teaching:
Pathology Residents: Gestational Pathology (daily), 1991-95
Pathology Residents: Perinatal Autopsy Service (daily), 1991-95
Quinnipiac College Pathologists' Assistant Program Instructor (daily), 1991-95
Pathology 100 Laboratory Instructor, 1991-95
Pathology 100 Tutorial Leader, 1991-95
Pathology of Placenta and Fetus, Pathology 100, 1991-
Implantation and Placenta Formation, Reproductive Biology 280b, 1991-
Ob/Gyn 3rd year Clerkship, Reproductive BiologyCourse (6 times/y), 1991-
Graduate Students, Fellows, Medical and Undergraduate Trainees:
Graduate Students:
L-C Kao, Department of Pathology, University of Pennsylvania, ''Trophoblast Interactions with Extracellular Matrix Proteins'';
S Caltabiano, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Role of GnRH in Trophoblast hCG Synthesis and Secretion''
Medical Fellows:
MA Feinman, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Role of cAMP in Trophoblast Differentiation'';
L Schwartz, Department of Obstetrics and Gynecology, Yale School of Medicine, ''Mouse Ascites Golgi (MAG) Mucin Expression And Regulation By Progesterone In The Rat'';
M Cunningham, Department of Surgery, Yale School of Medicine, ''Interleukin-8 Secretion by Trophoblasts in Response to Endotoxin'';
M Nachtigall, Department of Obstetrics and Gynecology, Yale School of Medicine, ''Role of Leukemia Inhibitory Factor in Trophoblast Differentiation and Implantation'';
Tony Asis, Department of Obstetrics and Gynecology, Yale School of Medicine, ''EPO and CRH Expression in Normal and Stressed Placentas''
Post-Doctoral Fellows:
R Feinberg, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Plasminogen Activator Inhibitor Expression in Invading Trophoblasts''
X Li, Department of Obstetrics and Gynecology, Korea, ''Degradation Pathways of hCG in the Chorionic Villous''
K-S Lee, Department of Obstetrics and Gynecology, Pusan National University, Korea, ''Degradation Pathways of hCG in the Chorionic Villous Core''
Senior Medical Thesis Advisor:
E Buchanan, Medical Student Research Fellow of the American Heart Association, Department of Pathology, University of Pennsylvania, ''Urokinase Receptor: A Modulatorfor Trophoblast Invasion?''
Undergraduate Senior Thesis Advisor:
S Wu, Department of Obstetrics and Gynecology, University of Pennsylvania, ''Effect of ECM on Trophoblast Endocrine Function'';
K Ahn, Yale College, Yale University, ''Identification of Endometrial Tissue in Menstrual and Peritoneal Fluid: Precursor for Endometriosis?''
Summer Student Advisor:
J Wetmore, Yale College, Yale University, ''Endometrial MAG Mucin Expression in Normal and Infertile Patients'';
L Gordon, Yale College, Yale University, ''Endometrial Receptivity and MAG Mucin Expression''
Reviewer of Manuscripts for the following Journals:
American Journal of Obstetrics and Gynecology
American Journal of Pathology
Biology of Reproduction
Cancer Research
Development
Developmental Biology
In Vitro
Journal of Clinical Investigation
Journal of Developmental Physiology
Laboratory Investigation
Placenta
Trophoblast Research
International Workshops Organized
October 10, 1988 ''Trophoblast Differentiation in Tissue Culture,'' 11th Rochester Trophoblast Conference, Rochester, NY;
September 28, 1989 ''Trophoblast Cells in Culture,'' III European Placental Group Meeting, Paris, France;
October 2, 1992 ''Models of Implantation: Trophoblast Endometrium Interactions,'' 12th Rochester Trophoblast Conference,
Keywords
COS Keywords:
Embryology, Human Reproduction Or Fertility, Implants, Infertility, Placenta, Pregnancy.Additional Terms:
Endometrium, Infertility, Placenta, Pregnancy.Languages
(Reading, Writing, Speaking)
Hebrew: (Basic, Basic, Basic)
Memberships
American Society for Cell Biology
American Society of Clinical Pathologists
American Society of Reproductive Medicine
Canadian Academy of Pathologists
European Trophoblast Group
Sigma Xi, The Scientific Research Society
Society for Maternal-Fetal Medicine
Society of Gynecological Investigation
United States Academy of Pathologists
Previous Positions
Fellow, University of Pennsylvania
1981-1985, Hospital of the University of Pennsylvania, Resident, Pathology
1985-1987, University of Pennsylvania, Research Associate
1987-1991, University of Pennsylvania, Assistant Professor
1991-1995, Yale University, Assistant Professor
Patents
Methods of diagnosing and monitoring endometrial glandular development,
Patent Number: 6733962,
2004,
United States of America.
Fertility Determination with Transforming Growth Factor Beta,
Patent Number: 676727,
1998,
University of Pennsylvani,
Australia.
Fertility Determination with Transforming Growth Factor Beta,
Patent Number: 5693479,
1997,
Institution-owned,
United States of America.
Therapeutic and Diagnostic Applications of Mouse Ascites Golgi (MAG) Manipulation,
Patent Number: 5599680,
1997,
University of Pennsylvani,
United States.
Therapeutic and Diagnostic Applications of Tropho-Uteronectin (TUN) Manipulation, U.S. Patent No. 5,276,017, 90/94, institution-owned
Fertility Regulation with Transforming Growth Factor Beta, U.S. Patent No. 5,395,825, 92/95, institution-owned
Antibodies Specific for Oncofetal Fibronectin, U.S. Patent No. 5,523,229, 93/96, institution-owned
Funding Received
- Leukocyte chemoattractants in endometriosis, National Institutes of Health (NIH), $100,000, 9/93-9/95
- MAG Mucin Diagnostic, Centocor, Inc., $45,000, 7/95-6/96
Publications
- Sarno JL, Kliman HJ, Taylor HS, HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium:
Formation of Multimeric Complexes on HOXA10 Target
Genes., The Journal of Clinical Endocrinology and Metabolism, 90(1), 522-8, Jan 2005
- Rejniak KA, Kliman HJ, Fauci LJ, A Computational Model of the Mechanics of Growth of the Villous
Trophoblast Bilayer., Bulletin of Mathematical Biology, 66(2), 199-232, Mar 2004
- Than NG, Pick E, Bellyei S, Szigeti A, Burger O, Berente Z, Janaky T, Boronkai A, Kliman H, Meiri H, Bohn H, Than GN, Sumegi B, Functional Analyses of Placental Protein 13/galectin-13., European Journal of Biochemistry / Febs, 271(6), 1065-78, Mar 2004
- Kliman HJ, Segel L, The Placenta May Predict the Baby., Journal of Theoretical Biology, 225(1), 143-5, Nov 2003
- Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ, Improved Endometrial Assessment Using Cyclin E and P27, Fertility and Sterility, 80(1), 146-56, July 2003
- Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ, Sexual Activity, Orgasm and Tampon Use Are Associated With a Decreased
Risk for Endometriosis, Gynecologic and Obstetric Investigation, 53(3), 163-9, 2002
- Bagot CN, Kliman HJ, Taylor HS, Maternal Hoxa10 Is Required for Pinopod Formation in the Development Of
Mouse Uterine Receptivity to Embryo Implantation, Developmental Dynamics : An Official Publication of the American Association of Anatomists., 222(3), 538-44, November 2001
- Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ, Mouse Ascites Golgi (MAG) Mucin Expression and Regulation By Progesterone
in the Rat Uterus, Journal of the Society for Gynecologic Investigation, 8(4), 216-23, 2001
- Kliman HJ, Uteroplacental Blood Flow. the Story of Decidualization, Menstruation, and Trophoblast Invasion, American Journal of Pathology, 157(6), 1759-68, December 2000
- Acosta AA, Elberger L, Borghi M, Calamera JC, Chemes H, Doncel GF, Kliman H, Lema B, Lustig L, Papie, Endometrial Dating and Determination of the Window of Implantation in Healthy Fertile Women, Fertility and Sterility, 73(4), 788-98, April 2000
- Keltz M D, Attar E, Buradagunta S, Olive D L, Kliman H J, Arici A, Modulation of Leukemia Inhibitory Factor Gene Expression and Protein Biosynthesis in the Human Fallopian Tube., American Journal of Obstetrics and Gynecology, 175(6), 1611-9, December 1996
- Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A, The Effect of Leukemia Inhibitory Factor (LIF) on Trophoblast Differentiation: a Potential Role in Human Implantation, Journal of Clinical Endocrinology and Metabolism, 81(2), 801-6, February 1996
- Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL, Interleukin-8 Concentration in Peritoneal Fluid of Patients With Endometriosis and Modulation of Interleukin-8 Expression in Human Mesothelial Cells, Molecular Human Reproduction, 2(1), 40-5, January 1996
- Kliman H J, Perrotta P L, Jones D C, The Efficacy of the Placental Biopsy, American Journal of Obstetrics and Gynecology, 173(4), 1084-8, October 1995
- Keltz MD, Kliman HJ, Arici AM, Olive DL, Endosalpingiosis Found At Laparoscopy for Chronic Pelvic Pain, Fertility and Sterility, 64(3), 482-5, September 1995
- Feinberg RF, Kliman HJ, Bedian V, Monzon-Bordonaba F, Menzin AW, Wang CL, Monoclonal Antibody X18A4 Identifies An Oncofetal Fibronectin Epitope Distinct From the FDC-6 Binding Site, American Journal of Obstetrics and Gynecology, 172(5), 1526-36, May 1995
- Bahado-Singh R O, Kliman H, Feng T Y, Hobbins J, Copel J A, Mahoney M J, First-trimester Endocervical Irrigation: Feasibility of Obtaining Trophoblast Cells for Prenatal Diagnosis., Obstetrics and Gynecology, 85(3), 461-4, March 1995
- Kliman H J, Feinberg R F, Schwartz L B, Feinman M A, Lavi E, Meaddough E L, A Mucin-like Glycoprotein Identified By MAG (mouse Ascites Golgi) Antibodies. Menstrual Cycle-dependent Localization in Human Endometrium, American Journal of Pathology, 146(1), 166-81, January 1995
- Rotmensch S, Liberati M, Luo J S, Kliman H J, Gollin Y, Bellati U, Hobbins J C, Copel J A, Color Doppler Flow Patterns and Flow Velocity Waveforms of the Intraplacental Fetal Circulation in Growth-retarded Fetuses, American Journal of Obstetrics and Gynecology, 171(5), 1257-64, November 1994
- Feinberg RF, Kliman HJ, Wang CL, Transforming Growth Factor-beta Stimulates Trophoblast Oncofetal Fibronectin Synthesis in Vitro: Implications for Trophoblast Implantation in Vivo, Journal of Clinical Endocrinology and Metabolism, 78(5), 1241-8, May 1994
- Kliman H J, The Placenta Revealed, American Journal of Pathology, 143(2), 332-6, August 1993
- Feinberg RF, Kliman HJ, Fetal Fibronectin and Preterm Labor, New England Journal of Medicine, 326(10), 708; discussion 709, March 1992
- Lavi E, Montone KT, Rorke LB, Kliman HJ, Fetal Akinesia Deformation Sequence (Pena-Shokeir Phenotype) Associated With Acquired Intrauterine Brain Damage [see Comments], Neurology, 41(9), 1467-8, September 1991
- Feinberg RF, Kliman HJ, Cohen AW, Preeclampsia, Trisomy 13, and the Placental Bed, Obstetrics and Gynecology, 78(3 Pt 2), 505-8, September 1991
- Feinberg R F, Kliman H J, Lockwood C J, Is Oncofetal Fibronectin a Trophoblast Glue for Human Implantation?, American Journal of Pathology, 138(3), 537-43, March 1991
- Coutifaris C, Babalola G O, Abisogun A O, Kao L C, Chin U, Vadillo-Ortega F, Osheroff J, Kliman H J, Strauss J F 3d, In Vitro Systems for the Study of Human Trophoblast Implantation, Annals of the New York Academy of Sciences, 622, 191-201, 1991
- Kliman H J, Feinberg R F, Haimowitz J E, Human Trophoblast-endometrial Interactions in An in Vitro Suspension Culture System, Placenta, 11(4), 349-67, July 1990
- Kliman HJ, Feinberg RF, Human Trophoblast-extracellular Matrix (ECM) Interactions in Vitro: ECM Thickness Modulates Morphology and Proteolytic Activity, Proceedings of the National Academy of Sciences (USA), 87(8), 3057-61, April 1990
- Babalola GO, Coutifaris C, Soto EA, Kliman HJ, Shuman H, Strauss JF 3d, Aggregation of Dispersed Human Cytotrophoblastic Cells: Lessons Relevant to the Morphogenesis of the Placenta, Developmental Biology, 137(1), 100-8, January 1990
- Feinberg RF, Kao LC, Haimowitz JE, Queenan JT Jr, Wun TC, Strauss JF 3d, Kliman HJ, Plasminogen Activator Inhibitor Types 1 and 2 in Human Trophoblasts. PAI-1 Is An Immunocytochemical Marker of Invading Trophoblasts, Laboratory Investigation, 61(1), 20-6, July 1989
- Nulsen JC, Silavin SL, Kao LC, Ringler GE, Kliman HJ, Strauss JF 3d, Control of the Steroidogenic Machinery of the Human Trophoblast By Cyclic AMP, Journal of Reproduction and Fertility, 37(Supplement), 147-53, 1989
- Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT Jr, Feinberg RF, Strauss JF 3d, The Human Trophoblast: Homotypic and Heterotypic Cell-cell Interactions, Progress in Clinical and Biological Research, 294, 425-34, 1989
- Kao LC, Caltabiano S, Wu S, Strauss JF 3d, Kliman HJ, The Human Villous Cytotrophoblast: Interactions With Extracellular Matrix Proteins, Endocrine Function, and Cytoplasmic Differentiation in the Absence of Syncytium Formation, Developmental Biology, 130(2), 693-702, December 1988
- Roy-Choudhury S, Sen-Majumdar A, Murthy U, Mishra VS, Kliman HJ, Nestler JE, Strauss JF 3d, Das M, Biosynthesis and Turnover of a 34-kDa Protein Growth Factor in Human Cytotrophoblasts, European Journal of Biochemistry, 172(3), 777-83, March 1988
- Feinman MA, Kliman HJ, Main EK, HLA Antigen Expression and Induction By Gamma-interferon in Cultured Human Trophoblasts, American Journal of Obstetrics and Gynecology, 157(6), 1429-34, December 1987
- Ulloa-Aguirre A, August AM, Golos TG, Kao LC, Sakuragi N, Kliman HJ, Strauss JF 3d, 8-Bromo-adenosine 3',5'-monophosphate Regulates Expression of Chorionic Gonadotropin and Fibronectin in Human Cytotrophoblasts, Journal of Clinical Endocrinology and Metabolism, 64(5), 1002-9, May 1987
- Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF 3d, Purification, Characterization, and in Vitro Differentiation of Cytotrophoblasts From Human Term Placentae, Endocrinology, 118(4), 1567-82, April 1986
- Soto EA, Kliman HJ, Strauss JF 3d, Paavola LG, Gonadotropins and Cyclic Adenosine 3',5'-monophosphate (cAMP) Alter the Morphology of Cultured Human Granulosa Cells, Biology of Reproduction, 34(3), 559-69, April 1986
- Kliman HJ and Feinberg RF. (1992) Trophoblast Differentiation. In: The First Twelve Weeks of Gestation. Barnea ER, Hustin J, Jauniaux E (eds). Springer-Verlag, New York
Profile Details
Last Updated: 9/27/2005
COS Expertise ID #1206674
Reference this profile directly: http://myprofile.cos.com/klimanh16
Individual Expertise profile of Harvey J. Kliman, Copyright Harvey J. Kliman.
© COS ExpertiseTM, 2009, ProQuest LLC All rights reserved.