Dr. David M. Koelle

powered by
COS Expertise®
University of Washington
School of Medicine
Medicine
Allergy and Infectious Diseases
ProfessorAppointed: 2007
University of Washington
School of Medicine
Laboratory Medicine
Graduate Faculty
Adjunct Associate ProfessorAppointed: 2002
University of Washington
School of Public Health and Community Medicine
Pathobiology
Graduate Faculty
Adjunct Associate ProfessorAppointed: 2002
Fred Hutchinson Cancer Research Center
Clinical Research Division
Program in Infectious Diseases
Affiliate Researcher and Member, Cancer ConsortiumAppointed: 2000
Benaroya Research Institute
Immunology
Affilate ResearcherAppointed: 1999
Professional Headshot of David M. Koelle

Mailing Address

University of Washington
Mail Stop 358117
1616 Eastlake Ave East
Suite 500
Seattle, Washington 98102
United States

Contact Information

Phone: (206) 667-6491
Fax: (206) 667-7711
viralimm@u.washington.edu

Qualifications

Re-certified, American Board of Internal Medicine, Internal Medicine, 2003.
Re-certified, American Board of Internal Medicine, Infectious Diseases, 2003.
American Board of Internal Medicine, Infectious Diseases, 1992.
American Board of Internal Medicine, Internal Medicine, 1989.
M.D., University of Washington, 1985.
B.S., University of Washington, 1980.

Expertise and Research Interests

Our laboratory focuses on cellular immune responses to Herpes viridae and poxivurses that are infectious for humans, and mechanisms of T-cell homing to skin. HSV- and vaccinia-encoded antigens and epitopes have been identified using expression cloning. The spatial localization of antigen-specific T-cells has been studied using biopsies of genital herpes lesions. In collaboration, detailed structure-function studies of HSV epitopes have been performed for epitopes recognized by HLA alleles of interest in the pathogenesis of autoimmune diseases. The diversity and persistence of HSV-specific responses at the clonal level have been studied with clone-specific nucleic acid probes recognizing unique rearranged TCR cDNA sequences. Inhibition of antigen presentation and apoptosis by HSV infection has also been studied as a modulatory influence on the immune response to HSV. Other studies have addressed the mode of transmission and immune response to HHV-8. Antiviral drug sensitivity testing for HSV has been performed and published in support of several drug trials.

Other Expertise

Collaboration with biotech firms evaluating candidate HSV vaccines
Inventor of patented candidate HSV vaccines, antiviral resistance, antigen discovery by expression cloning, T-cell homing

Future Research

Immunodominance of T cell antigens
Lymphocyte homing for skin viral infections

Industrial Relevance

Immunogenicity monitoring of candidate vaccines
Clinical trials of candidate vaccines
Antigen and epitope discovery

Keywords

COS Keywords:

AIDS, Antigens, Antivirals, Autoimmunity, Bacteria, Bacterial Infections, Blood Or Blood Products Or Transfusions, Drug Resistance, Herpes, HIV, Immune System, Immune System Disorders, Immunobiology, Immunology, Infectious Diseases Or Agents, Inflammation, Internal Medicine, Lymphocytes, Microbiology, Pathobiology, Vaccine, Viral Infections, Virology.

Additional Terms:

AIDS: HIV/SIV Infection, Antigen, Antiviral Resistance Testing, Autoimmunity, Bacteria/Bacterial Disease, Epitope, Expression Cloning, Herpes, Homing, Immunology/Immunobiology: Blood/Blood Cells: Lymphocytes, Immunology/Immunobiology: Blood/Blood Cells: White Cells, Immunology/Immunobiology: Inflammation, Infectious Diseases, Kaposi's Sarcoma, Lab Medicine, Microbiology, Poxvirus, Selectin, Tetramer, Vaccines, Vaccinia, Viruses/Viral Disease.

Languages

(Reading, Writing, Speaking)

Hindi (standard textbook): (Basic, Basic, Basic)

Memberships

American College of Physicians
American Society for Clinical Investigation
American Society for Microbiology
Infectious Diseases Society of America

Honors and Awards

2004, Member, American Society for Clinical Investigation

Patents

Immunologically significant herpes simplex virus antigens and methods for using same, Patent Number: 7037509, 2006, Institution, United States of America.
Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same, Patent Number: 7078041, 2006, Institution, United States of America.
Immunological herpes simplex virus antigens and methods for use thereof, Patent Number: 6855317, 2005, Institution, United States of America.
Immunologically significant herpes simplex virus antigens and methods for identifying and using same, Patent Number: 6962709, 2005, Institution, United States of America.
Immunologically significant herpes simplex virus antigens and methods for using same, Patent Number: 6814969, 2004, Institution, United States of America.
Immunological herpes simplex virus antigens and methods for use thereof, Patent Number: 6375952, 2002, Institution-owned, United States.
Immunologically significant herpes simplex virus antigens and methods for identifying and using same, Patent Number: 6413518, 2002, Institution-owned, United States.

Funding Received

  • Antigenics, Inc.: Phase I trial of AG-702 for HSV, Jul 1, 2001 to 2004.
  • National Institutes of Health (NIH): Control of Lymphocyte Trafficking in HSV infection, Apr 1, 2003 to 2008.
  • National Institutes of Health (NIH): Immune Correlates of HSV-2 Disease Severity, Apr 1, 2003 to Mar 31, 2008.
  • National Institutes of Health (NIH): HSV Immunotherapeutic Vaccine, 2005 to 2005.
  • NIH, Koelle is significant Co-Inv.: Immunogenetic Correlates of Severity of Genital HSV-2, 2004 to 2009.
  • National Institutes of Health (NIH): Intradermal vaccinia: T-cell specificity and skin homing, 2002 to 2004.

Publications

  • Jing L, McCaughey SM, Davies DH, Chong TM, Felgner PL, De Rosa SP, Wilson CB, Koelle DM (Jun 2009) ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans., Journal of immunological methods Abstract
  • Muller WJ, Dong L, Vilalta A, Byrd B, Wilhelm KM, McClurkan CL, Margalith M, Liu C, Kaslow D, Sidney J, Sette A, Koelle DM (May 2009) Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection., The Journal of general virology, 90 (Pt 5), 1153-63 Abstract
  • Cattamanchi A, Posavad CM, Wald A, Baine Y, Moses J, Higgins TJ, Ginsberg R, Ciccarelli R, Corey L, Koelle DM (Nov 2008) Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system., Clinical and vaccine immunology : CVI, 15 (11), 1638-43 Abstract
  • Jing L, Davies DH, Chong TM, Chun S, McClurkan CL, Huang J, Story BT, Molina DM, Hirst S, Felgner PL, Koelle DM (Jul 2008) An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling., Journal of virology, 82 (14), 7120-34 Abstract
  • Koelle DM, Magaret A, McClurkan CL, Remington ML, Warren T, Teofilovici F, Wald A (May 2008) Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects., Clinical and vaccine immunology : CVI, 15 (5), 773-82 Abstract
  • Bavaro JB, Drolette L, Koelle DM, Almekinder J, Warren T, Tyring S, Wald A (Apr 2008) One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection., Sexually transmitted diseases, 35 (4), 383-6 Abstract
  • Koelle DM, Bergemann TL (Feb 2008) Doctor, why is my herpes so bad? The search continues., The Journal of infectious diseases, 197 (3), 331-4 Abstract
  • Koelle DM, Corey L (2008) Herpes simplex: insights on pathogenesis and possible vaccines., Annual review of medicine, 59, 381-95 Abstract
  • Muller WJ, Orgun NN, Dong L, Koelle DM, Huang ML, Way SS (2008) Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2., Archives of virology, 153 (6), 1165-9 Abstract
  • Bochud PY, Magaret AS, Koelle DM, Aderem A, Wald A (Aug 2007) Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection., The Journal of infectious diseases, 196 (4), 505-9 Abstract
  • Jing L, Chong TM, Byrd B, McClurkan CL, Huang J, Story BT, Dunkley KM, Aldaz-Carroll L, Eisenberg RJ, Cohen GH, Kwok WW, Sette A, Koelle DM (May 2007) Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus., Journal of immunology (Baltimore, Md. : 1950), 178 (10), 6374-86 Abstract
  • Zhu J, Koelle DM, Cao J, Vazquez J, Huang ML, Hladik F, Wald A, Corey L (Mar 2007) Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation., The Journal of experimental medicine, 204 (3), 595-603 Abstract
  • Czartoski T, Liu C, Koelle DM, Schmechel S, Kalus A, Wald A (2006) Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman, Journal of Clinical Microbiology, 44, 1584-1486
  • Martin ET, Koelle DM, Byrd B, Huang ML, Vieira J, Corey L, Wald A (2006) Sequence-based methods for identifying epidemiologically linked herpes simplex virus type 2 strains, Journal of Clinical Microbiology, 44, 2541-2546
  • Hosken N, McGowan P, Meier A, Koelle DM, Sleath P, Wagener F, Elliott M, Grabstein K, Posavad C, Corey L (2006) Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes, Journal of Virology, 80, 5509-5515
  • Koelle DM, Huang H, Hensel MT, McClurkan CL (2006) Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes, Journal of Virology, 80, 2863-2872
  • Koelle DM (2006) Vaccines for herpes simplex virus infections, Current Opinion in Invesigational Drugs, 7, 136-141
  • Jing L, Chong TM, McClurkan CL, Huang J, Story BT (2005) Diversity in the acute CD8 T cell response to vaccinia virus in humans, Journal of Immunology, 175, 7550-7559
  • Koelle DM, Ghiasi H (2005) Prospects for developing an effective vaccine against ocular herpes simplex virus infection, Current Eye Research, 30, 929-942
  • Danke, NA, Koelle, DM, Kwok, WW, Persistence of Herpes Simplex Virus Type 2 VP16-specific CD4+ T Cells, Human Immunology, 66, 777-787, Jul 2005
  • Barcy S, Huang ML, Corey L, Koelle DM (Jun 2005) Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood., The Journal of Infectious Diseases, 191 (12), 2012-21 Abstract
  • Diaz GA, Rakita RM, Koelle DM, A Case of Ramsay Hunt-like Syndrome Caused By Herpes Simplex Virus Type 2., Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America., 40(10), 1545-7, May 2005 Abstract
  • Diaz GA, Rakita RM, Koelle DM (May 2005) A case of Ramsay Hunt-like syndrome caused by herpes simplex virus type 2., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 40 (10), 1545-7 Abstract
  • Koelle DM, Gonzalez JC, Johnson AS (Apr 2005) Homing in on the cellular immune response to HSV-2 in humans., American Journal of Reproductive Immunology (new York, N.y. : 1989), 53 (4), 172-81 Abstract
  • Bosnjak L, Miranda-Saksena M, Koelle DM, Boadle RA, Jones CA, Cunningham AL, Herpes Simplex Virus Infection of Human Dendritic Cells Induces Apoptosis and Allows Cross-presentation Via Uninfected Dendritic Cells., Journal of Immunology (baltimore, Md. : 1950), 174(4), 2220-7, Feb 2005 Abstract
  • Gonzalez JC, Kwok WW, Wald A, McClurkan CL, Huang J, Koelle DM, Expression of Cutaneous Lymphocyte-associated Antigen and E-selectin Ligand By Circulating Human Memory CD4+ T Lymphocytes Specific for Herpes Simplex Virus Type 2., The Journal of Infectious Diseases, 191(2), 243-54, Jan 2005 Abstract
  • Gandhi M, Koelle DM, Ameli N, Bacchetti P, Greenspan JS, Navazesh M, Anastos K, Greenblatt RM, Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count, Journal of Dental Research, 83(8), 639-43, August 2004 Abstract
  • Kimball LE, Casper C, Koelle DM, Morrow R, Corey L, Vieira J, Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma, The Journal of Infectious Diseases, 189(11), 2016-22, June 2004 Abstract
  • Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW, Autoreactive T cells in healthy individuals, Journal of Immunology (baltimore, Md. : 1950), 172(10), 5967-72, May 2004 Abstract
  • Koelle DM, Liu Z, McClurkan CL, Cevallos RC, Vieira J, Hosken NA, Meseda CA, Snow DC, Wald A, Corey L, Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor, Proceedings of the National Academy of Sciences of the United States of America., 100(22), 12899-904, October 2003 Abstract
  • Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J, A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition, Journal of Experimental Medicine, 198(5), 679-91, September 2003 Abstract
  • Posavad CM, Wald A, Hosken N, Huang ML, Koelle DM, Ashley RL, Corey L, T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?, Journal of Immunology (baltimore, Md. : 1950), 170(8), 4380-8, April 2003 Abstract
  • Koelle DM, Expression cloning for the discovery of viral antigens and epitopes recognized by T cells, Methods (san Diego, Calif.), 29(3), 213-26, March 2003 Abstract
  • Koelle DM, Corey L, Recent progress in herpes simplex virus immunobiology and vaccine research, Clinical Microbiology Reviews, 16(1), 96-113, January 2003 Abstract
  • Koelle DM, Barcy S, Huang ML, Ashley RL, Corey L, Zeh J, Ashton S, Buchwald D, Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 35(5), 518-25, September 2002 Abstract
  • Koelle DM, Liu Z, McClurkan CM, Topp MS, Riddell SR, Pamer EG, Johnson AS, Wald A, Corey L, Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus, Journal of Clinical Investigation, 110(4), 537-48, Aug 2002 Abstract
  • Koelle DM, Chen HB, McClurkan CM, Petersdorf EW, Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles, Blood, 99(10), 3844-7, May 2002 Abstract
  • Sabath DE, Barcy S, Koelle DM, Zeh J, Ashton S, Buchwald D, Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome, Journal of Infectious Diseases, 185(6), 828-32, March 2002 Abstract
  • Corey L, Brodie S, Huang ML, Koelle DM, Wald A, HHV-8 infection: a model for reactivation and transmission, Reviews in Medical Virology, 12(1), 47-63, 2002 Abstract
  • Limaye AP, Raghu G, Koelle DM, Ferrenberg J, Huang ML, Boeckh M, High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy, Journal of Infectious Diseases, 185(1), 20-7, January 2002 Abstract
  • Kwok WW, Gebe JA, Liu A, Agar S, Ptacek N, Hammer J, Koelle DM, Nepom GT, Rapid epitope identification from complex class-II-restricted T-cell antigens, Trends in Immunology, 22(11), 583-8, November 2001 Abstract
  • Augenbraun M, Corey L, Reichelderfer P, Wright DJ, Burns D, Koelle DM, Robison E, Cohen M, Women's Health Studies 002 Study Group, Herpes simplex virus shedding and plasma human immunodeficiency virus RNA levels in coinfected women, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 33(6), 885-90, September 2001 Abstract
  • Novak EJ, Liu AW, Gebe JA, Falk BA, Nepom GT, Koelle DM, Kwok WW, Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens, Journal of Immunology (baltimore, Md. : 1950), 166(11), 6665-70, June 2001 Abstract
  • Greenblatt RM, Jacobson LP, Levine AM, Melnick S, Anastos K, Cohen M, DeHovitz J, Young MA, Burns D, Miotti P, Koelle DM, Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women, The Journal of Infectious Diseases, 183(7), 1130-4, April 2001 Abstract
  • Koelle DM, Chen HB, Gavin MA, Wald A, Kwok WW, Corey L, CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells, Journal of Immunology (baltimore, Md. : 1950), 166(6), 4049-58, March 2001 Abstract
  • Malhotra U, Holte S, Dutta S, Berrey MM, Delpit E, Koelle DM, Sette A, Corey L, McElrath MJ, Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment, Journal of Clinical Investigation, 107(4), 505-17, February 2001 Abstract
  • Koelle DM, Schomogyi M, McClurkan C, Reymond SN, Chen HB, CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins, Journal of Virology, 74(23), 11422-5, December 2000 Abstract
  • Koelle DM, Reymond SN, Chen H, Kwok WW, McClurkan C, Gyaltsong T, Petersdorf EW, Rotkis W, Talley AR, Harrison DA, Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans, Journal of Virology, 74(23), 10930-8, December 2000 Abstract
  • Pauk J, Huang ML, Brodie SJ, Wald A, Koelle DM, Schacker T, Celum C, Selke S, Corey L, Mucosal shedding of human herpesvirus 8 in men, New England Journal of Medicine, 343(19), 1369-77, 2000 Abstract
  • Koelle DM, Schomogyi M, Corey L, Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection, Journal of Infectious Diseases, 182(3), 662-70, September 2000 Abstract
  • Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M, Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants, Lancet, 356(9230), 645-9, August 2000 Abstract
  • Posavad CM, Huang ML, Barcy S, Koelle DM, Corey L, Long term persistence of herpes simplex virus-specific CD8 CTL in persons with frequently recurring genital herpes, Journal of Immunology, 165(2), 1146-52, July 2000 Abstract
  • Kwok WW, Liu AW, Novak EJ, Gebe JA, Ettinger RA, Nepom GT, Reymond SN, Koelle DM, HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells, Journal of Immunology, 164(8), 4244-9, April 2000 Abstract
  • Koelle DM, Wald A, Herpes simplex virus: the importance of asymptomatic shedding, Journal of Antimicrobial Chemotherapy, 45 Suppl T3, 1-8, April 2000 Abstract
  • Reichstetter S, Kwok WW, Kochik S, Koelle DM, Beaty JS, Nepom GT, MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition., Human Immunology, 60(7), 608-18, July 1999 Abstract
  • Kwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT, Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition., Human Immunology, 60(7), 619-26, July 1999 Abstract
  • Holterman AX, Rogers K, Edelmann K, Koelle DM, Corey L, Wilson CB, An important role for major histocompatibility complex class I-restricted T cells, and a limited role for gamma interferon, in protection of mice against lethal herpes simplex virus infection., Journal of Virology, 73(3), 2058-63, March 1999 Abstract
  • Doherty D G, Penzotti J E, Koelle D M, Kwok W W, Lybrand T P, Masewicz S, Nepom G T, Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the, Journal of Immunology, 161(7), 3527-35, 1 Oct 1998 Abstract
  • Diamond C, Brodie S J, Krieger J N, Huang M L, Koelle D M, Diem K, Muthui D, Corey L, Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma., Journal of Virology, 72(7), 6223-7, July 1998 Abstract
  • Posavad C M, Koelle D M, Corey L, Tipping the scales of herpes simplex virus reactivation: the important responses are local, Nature Medicine, 4(4), 381-2, April 1998 Abstract
  • Koelle DM, Posavad CM, Barnum GR, Johnson ML, Frank JM, Corey L, Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes., Journal of Clinical Investigation, 101(7), 1500-8, 1 1998 Abstract
  • Chandran B, Smith M S, Koelle D M, Corey L, Horvat R, Goldstein E, Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs, Virology, 243(1), 208-17, 30 Mar 1998 Abstract
  • Swetter S M, Hill E L, Kern E R, Koelle D M, Posavad C M, Lawrence W, Safrin S, Chronic vulvar ulceration in an immunocompetent woman due to acyclovir-resistant, thymidine kinase-deficient herpes simplex virus, Journal of Infectious Diseases, 177(3), 543-50, March 1998 Abstract
  • Jerome K R, Tait J F, Koelle D M, Corey L, Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis, Journal of Virology, 72(1), 436-41, Jan 1998 Abstract
  • Schacker T, Hu H L, Koelle D M, Zeh J, Saltzman R, Boon R, Shaughnessy M, Barnum G, Corey L, Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons. A double-blind, placebo-controlled trial, Annals of Internal Medicine, 128(1), 21-8, 1 Jan 1998 Abstract
  • Jerome KR, Tait JF, Koelle DM, Corey L, Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis., Journal of Virology, 72(1), 436-41, 1998 Abstract
  • Koelle DM, Frank JM, Johnson ML, Kwok WW, Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions, Journal of Virology, 72(9), 7476-83, 1998
  • Posavad C M, Koelle D M, Shaughnessy M F, Corey L, Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses, Proceedings of the National Academy of Sciences (USA), 94(19), 10289-94, 16 Sep 1997 Abstract
  • Vieira J, Huang M L, Koelle D M, Corey L, Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma, Journal of Virology, 71(9), 7083-7, September 1997 Abstract
  • Koelle D M, Huang M L, Chandran B, Vieira J, Piepkorn M, Corey L, Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates, Journal of Infectious Diseases, 176(1), 94-102, July 1997 Abstract
  • Koelle D M, Johnson M L, Ekstrom A N, Byers P, Kwok W W, Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201, Human Immunology, 53(2), 195-205, 1 Apr 1997 Abstract
  • Posavad C M, Koelle D M, Corey L, High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes, Journal of Virology, 70(11), 8165-8, November 1996 Abstract
  • Kwok W W, Domeier M E, Johnson M L, Nepom G T, Koelle D M, HLA-DQB1 codon 57 is critical for peptide binding and recognition, Journal of Experimental Medicine, 183(3), 1253-8, 1 Mar 1996 Abstract
  • Van Voorhis W C, Barrett L K, Koelle D M, Nasio J M, Plummer F A, Lukehart S A, Primary and secondary syphilis lesions contain mRNA for Th1 cytokines, Journal of Infectious Diseases, 173(2), 491-5, February 1996 Abstract
  • Koelle D M, Abbo H, Peck A, Ziegweid K, Corey L, Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions, Journal of Infectious Diseases, 169(5), 956-61, May 1994 Abstract
  • Koelle D M, Corey L, Burke R L, Eisenberg R J, Cohen G H, Pichyangkura R, Triezenberg S J, Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions, Journal of Virology, 68(5), 2803-10, May 1994 Abstract
  • Koelle D M, Tigges M A, Burke R L, Symington F W, Riddell S R, Abbo H, Corey L, Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes, Journal of Clinical Investigation, 91(3), 961-8, March 1993 Abstract
  • Koelle D M, Benedetti J, Langenberg A, Corey L, Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes, Annals of Internal Medicine, 116(6), 433-7, 15 Mar 1992 Abstract
  • Tigges M A, Koelle D, Hartog K, Sekulovich R E, Corey L, Burke R L, Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens, Journal of Virology, 66(3), 1622-34, March 1992 Abstract

Profile Details

Last Updated: 6/25/2009

COS Expertise ID #135098
Reference this profile directly: http://myprofile.cos.com/KOELLE1