Kenneth J. Kopecky

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Fred Hutchinson Cancer Research Center
Public Health Sciences
Member
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Professor

Mailing Address

Southwest Oncology Group
1100 Fairview Avenue N., M3-C102
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-4623
kkopecky@fhcrc.org

Qualifications

Ph.D., Oregon State University, 1977.
M.S., Oregon State University, 1975.

Expertise and Research Interests

Southwest Oncology Group Statistical Center (Leukemia And Leukemia Biology) And Radiation Epidemiology.

The Leukemia Committee and Leukemia Biology Program of the Southwest Oncology Group conduct a variety of studies concerning adult leukemias. These include clinical trials of new and promising treatments for the various kinds of leukemia, as well as laboratory studies to elucidate the biological mechanisms underlying the pathogenesis and prognosis of these diseases. The investigators at the Southwest Oncology Group Statistical Center collaborate in the design, conduct, analysis and reporting of these studies.

A continuing major focus of the Southwest Oncology Group's leukemia research is the problem of multidrug resistance. Patients whose leukemia is resistant to remission induction therapy have a very poor prognosis. Recent and ongoing studies have shown that such resistance is a complex phenomenon, possibly involving multiple mechanisms, some of which protect leukemic cells from cytotoxic agents,and others of which may interfere with that protection. The Group's studies are intended to elucidate these mechanisms, with the ultimate goal of finding ways to overcome multidrug resistance.

Radiation epidemiology is the study of how risks of diseases such as certain types of cancer are affected when people are exposed to radiation. The Hanford Thyroid Disease Study investigated whether thyroid disease, including thyroid cancer, has been increased among persons exposed to radioactive iodine released from the Hanford Nuclear Site in south-central Washington State during the 1940s and 1950s. Scientists from the Fred Hutchinson Cancer Research Center are also engaged with Russian colleagues in a multinational project (the International Consortium for Research on the Health Effects of Radiation) to investigate the radiation doses and health consequences in areas of Russia contaminated by fallout from the Chernobyl accident in April 1986. This project includes a case-control studies of thyroid cancer and leukemia among persons who were exposed to radiation from the accident.

Keywords

COS Keywords:

Clinical Trial, Data Analysis, Epidemiology.

Additional Terms:

Clinical Trials Design, Epidemiologic Methodology, Goodness of Fit, Survival Data Analysis.

Publications

  • Davis S, Day RW, Kopecky KJ, Mahoney MC, McCarthy PL, Michalek AM, Moysich KB, Onstad LE, Stepanenko VF, Voilleque PG, Childhood Leukemia in Belarus, Russia and Ukraine Following the Chernobyl Power Station Accident: Results from an International Collaborative Population-based Case-control Study, International Journal of Epidemiology, 35, 386-396, 2006
  • Cardis E, Howe G, Ron E, Bebeshko V, Bogdanova T, Bouville A, Carr Z, Chumak V, Davis S, Demidchik Y, Drozdovitch V, Gentner N, Gudzenko N, Hatch M, Ivanov V, Jacob P, Kapitonova E, Kenigsberg Y, Kesminiene A, Kopecky KJ, Et Al, Cancer consequences of the Chernobyl accident: 20 years on, J Radiol Prot, 26, 127-140, 2006
  • Stirewalt D, Kopecky KJ, Meshinchi S, Engel JH, Pogosova-Agadjanyan EL, Linsley J, Slovak ML, Willman CL, Radich JP, Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia, Blood, 107(9), 3724-3726, 2006
  • Wilson CS, Davidson GS, Martin SB, Andries E, Potter J, Harvey R, Ar K, Xu Y, Kopecky KJ, Et Al, Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome predic, Blood, 108(2), 685-696, 2006
  • Kopecky KJ, Stepanenko V, Rivkind N, Voillequé P, Onstad L, Shakhtarin V, Parshkov E, Kulikov S, Lushnikov E, Abrosimov A, Troshin V, Romanova G, Doroschenko V, Proshin A, Tsyb A, Davis S, Childhood thyroid cancer, radiation dose from Chernobyl, and dose uncertainties in Bryansk Oblast, Russia: a population-based case-control study, Radiation Research, 166, 367-374, 2006
  • Kimmel RR, Zhao LP, Nguyen D, Lee S, Aronszajn M, Cheng C, Troshin VP, Abrosimov A, Delrow J, Tuttle RM, Tsyb A, Kopecky KJ, Davis S, Nieman PE, Microarray comparative genomic hybridization reveals genome-wide patterns of DNA gains and losses in post-Chernobyl thyroid cancer, Radiation Research, 166(3), 519-531, 2006
  • Appelbaum FR, Kopecky KJ, Tallman MS, Slovak ML, Gundacker KM, Kim HT, Dewald GW, Kantarjian HM, Pierce SR, Estey EH, The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations, British Journal of Haematology, 135, 165-173, 2006
  • Weiss JR, Kopecky KJ, Godwin J, Anderson I, Willman CL, Moysich KB, Slovak ML, Hoque A, Ambrosone CB, Glutathione S-transferase (GSTM1, GSTT1, and GSTA1) polymorphisms and outcomes after treatment for acute myeloid leukemia: pharmacogenetics in Southwest Oncology Group (SWOG) clinical trials, Leukemia, 20, 2169-2171, 2006
  • Kopecky KJ, Green S (2006) Noninferiority Trials In Crowley J, Ankerst DP (eds), Handbook of Statistics in Clinical Oncology, Second Edition, Boca Raton FL, Chapman and Hall/CRC, 191-205 pages, ISBN=0-8247-2339-2 (bookchapter)
  • Kopecky KJ, Onstad LE, Hamilton TE, Davis S, Thyroid Ultrasound Abnormalities in Persons Exposed During Childhood to I-131 From the Hanford Nuclear Site, Thyroid, 16(6), 604-613, Jul 2005
  • Hamilton TE, Davis S, Onstad L, Kopecky KJ, Hyperparathyroidism in Persons Exposed to Iodine-131 from the Hanford Nuclear Site, Journal of Clinical Endocrinology and Metabolism, 90(12), 6545-6548, 2005
  • Davis S, Kopecky KJ, Hamilton TE, Onstad L, Hanford Thyroid Disease Study Team, Thyroid Neoplasia, Autoimmune Thyroiditis, and Hypothyroidism in Persons Exposed to Iodine 131 From the Hanford Nuclear Site., Jama : the Journal of the American Medical Association, 292(21), 2600-13, Dec 2004 Abstract
  • McCarthy PL Jr, Paltiel O, Maslova E, Kulikov S, Hahn T, Kopecky KJ, Drozdova V, Shmatina N, Tichonova L, Van Hoff J, Gavrilova I, Weinstein H, Histopathologic Verification of Acute Leukemia (AL) in a Cohort of 463 Post-Chernobyl Patients From Belarus, Russia and Ukraine., Leukemia Research, 28(12), 1273-80, Dec 2004 Abstract
  • Davis S, Stepanenko V, Rivkind N, Kopecky KJ, Voilleque P, Shakhtarin V, Parshkov E, Kulikov S, Lushnikov E, Abrosimov A, Troshin V, Romanova G, Doroschenko V, Proshin A, Tsyb A, Risk of thyroid cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station accident, Radiation Research, 162(3), 241-8, Sep 2004 Abstract
  • Kopecky KJ, Davis S, Hamilton TE, Saporito MS, Onstad LE, Estimation of Thyroid Radiation Doses for the Hanford Thyroid Disease Study: Results and Implications for Statistical Power of the Epidemiological Analyses, Health Physics, 87(1), 15-32, Jul 2004 Abstract
  • Cheson BD, Bennett JM, Kopecky KJ, Buchner T, Willman CL, Estey EH, Schiffer CA, Doehner H, Tallman MS, Lister TA, LoCocco F, Willemze R, Biondi A, Hiddemann W, Larson RA, Lowenberg B, Sanz MA, Head DR, Ohno R, Bloomfield CD, International Working Group f, Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute, Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology., 21(24), 4642-9, Dec 2003 Abstract
  • Stram DO, Kopecky KJ, Power and uncertainty analysis of epidemiological studies of radiation-related disease risk in which dose estimates are based on a complex dosimetry system: some observations, Radiation Research, 160(4), 408-17, Oct 2003 Abstract
  • Shakhtarin VV, Tsyb AF, Stepanenko VF, Orlov MY, Kopecky KJ, Davis S, Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident, International Journal of Epidemiology, 32(4), 584-91, Aug 2003 Abstract
  • Hsi ED, Kopecky KJ, Appelbaum FR, Boldt D, Frey T, Loftus M, Hussein MA, Prognostic Significance of CD38 and CD20 Expression As Assessed By Quantitative Flow Cytometry in Chronic Lymphocytic Leukaemia., British Journal of Haematology, 120(6), 1017-25, Mar 2003 Abstract
  • Anderson JE, Kopecky KJ, Willman CL, Head D, O'Donnell MR, Luthardt FW, Norwood TH, Chen IM, Balcerzak SP, Johnson DB, Appelbaum FR, Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group, Blood, 100(12), 3869-3876, 1 Dec 2002
  • List AF, Kopecky KJ, Willman CL, Head DR, Slovak ML, Douer D, Dakhil SR, Appelbaum FR, Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase, Blood, 100(5), 1910-2, September 2002 Abstract
  • List AF, Kopecky KJ, Willman CL, Head DR, Persons DL, Slovak ML, Dorr R, Karanes C, Hynes HE, Doroshow JH, Shurafa M, Appelbaum FR, Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study, Blood, 98(12), 3212-20, December 2001 Abstract
  • Stirewalt DL, Kopecky KJ, Meshinchi S, Appelbaum FR, Slovak ML, Willman CL, Radich JP, FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia, Blood, 97(11), 3589-95, June 2001 Abstract
  • Toyota M, Kopecky KJ, Toyota MO, Jair KW, Willman CL, Issa JP, Methylation profiling in acute myeloid leukemia, Blood, 97(9), 2823-9, May 2001 Abstract
  • Petersdorf SH, Kopecky KJ, Head DR, Boldt DH, Balcerzak SP, Wun T, Roy V, Veith RW, Appelbaum FR, Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group , Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.k, 15(2), 208-16, February 2001 Abstract
  • Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A, Paietta E, Willman CL, Head DR, Rowe JM, Forman SJ, Appelbaum FR, Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study, Blood, 96(13), 4075-83, December 2000 Abstract
  • Flinn IW, Kopecky KJ, Foucar MK, Head D, Bennett JM, Hutchison R, Corbett W, Cassileth P, Habermann T, Golomb H, Rai K, Eisenhauer E, Appelbaum F, Cheson B, Grever MR, Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin, Blood, 96(9), 2981-6, November 2000 Abstract
  • Zhang FF, Murata-Collins JL, Gaytan P, Forman SJ, Kopecky KJ, Willman CL, Appelbaum FR, Slovak ML, Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia, Genes, Chromosomes and Cancer, 28(3), 318-28, July 2000 Abstract
  • Chauncey TR, Rankin C, Anderson JE, Chen I, Kopecky KJ, Godwin JE, Kalaycio ME, Moore DF, Shurafa MS, Petersdorf SH, Kraut EH, Leith CP, Head DR, Luthardt FW, Willman CL, Appelbaum FR, A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group, Leukemia Research, 24(7), 567-74, July 2000 Abstract
  • Rimsza LM, Kopecky KJ, Ruschulte J, Chen IM, Slovak ML, Karanes C, Godwin J, List A, Willman CL, Microsatellite instability is not a defining genetic feature of acute myeloid leukemogenesis in adults: results of a retrospective study of 132 patients and review of the literature, Leukemia, 14(6), 1044-51, June 2000 Abstract
  • Crump C, Chen C, Appelbaum FR, Kopecky KJ, Schwartz SM, Willman CL, Slovak ML, Weiss NS, Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia, Cancer Epidemiology, Biomarkers and Prevention, 9(5), 457-60, May 2000 Abstract
  • Hopke PK, Borak TB, Doull J, Cleaver JE, Eckerman KF, Gundersen LCS, Harley NH, Hess CT, Kinnear NE, Kopecky KJ, McKone TE, Sextro RG, Simon SL., Health risks due to radon in drinking water, Environmental Science and Technology, 34(6), 921-926, 2000
  • Tallman MS, Hakimian D, Kopecky KJ, Wheaton S, Wollins E, Foucar K, Cassileth PA, Habermann T, Grever M, Rowe JM, Peterson LC, Minimal residual disease in patients with hairy cell leukemia in complete remission treated with 2-chlorodeoxyadenosine or 2-deoxycoformycin and prediction of early relapse, Clinical Cancer Research, 5(7), 1665-70, July 1999 Abstract
  • Leith CP, Kopecky KJ, Chen I-M, Eijdems L, Slovak ML, McConnell TS, Head DR, Weick J, Grever MR, Appelbaum FR, Willman CL., Frequency and clinical signficance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia. A Southwest Oncology Group study, Blood, 94(3), 1086-1099, 1999
  • Li Q, Kopecky KJ, Mohen A, Willman C, Appelbaum FR, Weick JK, Issa J-P., Estrogen receptor methylation is associated with improved survival in adult meyloid leukemia, Clinical Cancer Research, 5, 1077-1084, 1999
  • Karanes C, Kopecky KJ, Head DR, Grever MR, Hynes HE, Kraut EH, Vial RH, Lichtin A, Nand S, Samlowski SE, Appelbaum FR., A phase III comparison of high dose ARA-C (HIDAC) vs HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia. A Southwest Oncology Group study, Leukemia Research, 23(9), 787-794, 1999
  • Hogge DE, Willman CL, Kreitman RJ, Berger M, Hall PD, Kopecky KJ, McLain C, Tagge EP, Eaves CJ, Frankel AE, Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein, Blood, 92(2), 589-95, July 1998 Abstract
  • Godwin J, Kopecky KJ, Head DR, et al., A double blind placebo controlled trial of G-CSF in elderly patients with previously untreated acute myeloid leukemia. A Southwest Oncology Group study (9031), Blood, 91(10), 3607-3615, 1998
  • Leith CP, Kopecky JK, Godwin J, et al., Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biological subgroups with remarkably distinct responses to standard chemotherapy. A Sou, Blood, 89(9), 3323-3329, 1997
  • Appelbaum FR, Kopecky KJ., Long-term survival after chemotherapy for acute myeloid leukemia: the experience of the Southwest Oncology Group, Cancer, 80, 2199-2204, 1997
  • Davis S, Kopecky KJ, Hamilton T, Amundson B., The Handford Thyroid Disease Study, Environmental Dose Reconstruction and Risk Implications: Proceedings of the Thirty-First Annual Meeting of the National Council on Radiation Protection and Measurements, JE Till, editor, 1996

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Last Updated: 12/26/2006

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