Dr. Kristin R. Swanson

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University of Washington
School of Medicine
Pathology
Neuropathology
Research Assistant ProfessorAppointed: 2002
University of Washington
College of Arts and Sciences
Applied Mathematics
Adjunct Research Assistant ProfessorAppointed: 2002

Mailing Address

Department of Pathology, Box 359791
Harborview Medical Center
325-9th Avenue
Laboratory of Neuropathology
Seattle, Washington 98104
United States

Contact Information

Phone: (206) 221-6577
Fax: (206) 731-8240
swanson@amath.washington.edu
http://www.pathology.washington.edu/research/labs/labpage.php?LAB=swanson

Qualifications

Ph.D., University of Washington, Mathematical Biology, 1999.
M.S., University of Washington, Mathematical Biology, 1998.
B.S., Tulane University, Mathematics / Physics, 1996.

Expertise and Research Interests

Using mathematical modeling to elucidate biomedical problems including: the growth and invasion of brain tumors (gliomas), the dynamics of prostate specific antigen, the kinetics of PET tracers in oncology.

Other Expertise

Brain Cancer. Analysis of a quantitative spatio-temporal model for glioma (brain tumor) growth and invasion. The model helps to quantify the effects of growth and diffusion of malignant gliomas on recurrence following surgical removal or other treatments. The model incorporates polyclonality of tumor cells and the complex heterogeneity of the three-dimensional brain. We are working with clinicians at the Pitié-Salpêtrière Hospital in Paris relating to the study of low-grade gliomas as well as a number of clinical collaborators throughout the UW Medical Center system studying problems related to brain tumors including using PET imaging protocols to better understand treatment response and tumor activity and analyzing radiation treatment planning protocols. In collaboration with Dr. E. C. Alvord, Jr. (Pathology) and Dr. J. D. Murray (Applied Mathematics) at the University of Washington.

Stroke and Wallerian Degeneration. Development of a mathematical model to describe Wallerian degeneration of axons within the adult human pyramidal tract following massive supra-medullory stroke. Model results are compared with autopsy data to determine the effect of the size of the axon on the subsequent degeneration rates.

Prostate Cancer. Development and analysis of a nonlinear dynamical system model for prostate cancer tumor growth and subsequent expression of Prostate Specific Antigen (PSA) as a marker of the cancer. Analysis of animial xenograft data demonstrates a strong fit to the model predictions. Recently, we have begun to incorporate histopathological indices (MIB-1, Ki67, etc) to predict the time course of disease for these patients. In collaboration with Prof. J. D. Murray (Applied Mathematics), Dr. L. True (Pathology), Dr. D. W. Lin (Urology), Dr. R. Vessella (Urology) at the University of Washington and Dr. P. Nelson (Fred Hutchinson Cancer Research Center).

Immunology and the Thymus. Study of a model to estimate the role of the thymus in T-cell reconstitution following immunosuppression associated with HIV or other diseases. In collaboration with Dr. J. M. McCune at the Gladstone Institute of Virology and Immunology (University of California at San Francisco) and Prof. S. M. Blower (Biomathematics) at the University of California at Los Angeles.

Relationship Psychology. Studyand development of nonlinear dynamical models for conflict resolution and relationship interactions to predict marriage breakdown. In collaboration with Prof. J. M. Gottman (Psychology), Prof. J. D. Murray (AppliedMathematics), C. C. Swanson (Psychology) at the University of Washington and the Relationship Research Institute.

Keywords

COS Keywords:

Applied Mathematics, Bioinformatics, Brain Tumors, Cancer or Carcinogenesis, Energy Biological or Biomedical Sciences, Magnetic Resonance, Magnetic Resonance Imaging, Mathematical Modeling, Mathematical Modeling (Medical), Medical or Diagnostic Imaging, Oncology, Pathology, Prostate Cancer.

Additional Terms:

Bioinformatics, Brain Tumor, Cancer, Complex Systems, Glioma, Imaging, Magnetic Resonance, Mathematical Modeling, Positron Emission Tomography, Prostate Cancer, Prostate Specific Antigen, Wallerian Degeneration.

Languages

(Reading, Writing, Speaking)

Spanish: (Basic, Basic, Basic)

Memberships

Society for Industrial and Applied Mathematics
Society for Mathematical Biology
Society for Neuro-Oncology

Honors and Awards

2003-2005, Program in Brain and Immuno-Imaging Grant (Principal Investigator), Dana Foundation, “Integration of MR and PET Imaging Characteristics with Mathematical Modeling to Define the Extent of Invasion of Gliomas”
2002-2005, Grant (Co-Investigator), French Ministry of Science, Université Pierre et Marie Curie & University of Washington, “Interaction Between the Functional Brain and Glioma Growth: Modeling of the Static and Temporal Metabolic, Electrophysiological and Hemodynamic Dynamics”
1999-2002, Mathematical Sciences Postdoctoral Fellowship, National Science Foundation
1996, Kappa Kappa Gamma Prize in Mathematics, Tulane University
1996, Elsie Field Dupre Memorial Prize in Physics, Tulane University
1996, Senior Scholar in Mathematics, Tulane University
1996, Outstanding Senior Mathematics Major, Newcomb College, Tulane University
1995, Mortar Board National Senior Honor Society,
1995, Martha Gilmore Robinson Honorary Scholarship, Tulane University
1994, Viola V. Knapp Honorary Scholarship, Tulane University
1993, Florence Kerwin Honorary Scholarship, Tulane University

Previous Positions

2001-2003, Acting Instructor, University of Washington, School of Medicine, Pathology, Neuropathology
2001-2003, Acting Instructor, University of Washington, College of Arts and Sciences, Applied Mathematics
2000-2001, Senior Fellow / NSF Fellow, University of Washington, School of Medicine, Pathology, Neuropathology
2000-2001, Senior Fellow / NSF Fellow, University of Washington, College of Arts and Sciences, Applied Mathematics
1999-2000, NSF Postdoctoral Fellow, University of California, San Francisco, Medicine

Funding Received

  • James F. McDonnell Foundation 21st Century Pilot Research Award: “Dynamics of Glioma Growth and Invasion”, 2005 to 2006.
  • NIH/NCI Program Project Grant: “Molecular Imaging of Cancer and Its Response to Therapy”, 2004 to 2009.
  • NIH/NCI University of Washington/Fred Hutchison Cancer Research Center Cancer Consortium Pilot Award: “Glioma Growth, Invasion and Angiogenesis: Integrating Mathematical Modeling and Imaging”, 2004 to 2005.
  • Dana Foundation Program in Brain and Immuno-Imaging: 'Integration of MR and PET Imaging Characteristics with Mathematical Modeling to Define the Extent of Invasion of Gliomas”, 2003 to 2005.
  • French Ministry of Science (Co-Investigator): 'Interaction Between the Functional Brain and Glioma Growth: Modeling of the Static and Temporal Metabolic, Electrophysiological and Hemodynamic Dynamics”, 2002 to 2005.
  • National Science Foundation (NSF): Mathematical Sciences Postdoctoral Fellowship, 1999 to 2002.
  • Landau/Busenberg: Travel Grant, 1999 to 1999.
  • National Science Foundation (NSF): Mathematical Biology Training Grant, 1997 to 1999.
  • Boeing: Graduate Research Fellowship, 1997 to 1997.
  • Newcomb College: Fellows Research Grant, 1993 to 1993.

Publications

  • Jbabdi S, Mandonnet E, Duffau H, Capelle L, Swanson KR, Pelegrini-Issac M, Guillevin R, Benali H, Simulation of Anisotropic Growth of Low-grade Gliomas Using Diffusion Tensor Imaging., Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine., 54(3), 616-24, Sep 2005 Abstract
  • Spence AM, Muzi M, Mankoff DA, O'Sullivan SF, Link JM, Lewellen TK, Lewellen B, Pham P, Minoshima S, Swanson K, Krohn KA, 18F-FDG PET of Gliomas At Delayed Intervals: Improved Distinction Between Tumor and Normal Gray Matter., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine., 45(10), 1653-9, Oct 2004 Abstract
  • Palfi S, Swanson KR, De Bouard S, Chretien F, Oliveira R, Gherardi RK, Kros JM, Peschanski M, Christov C, Correlation of in Vitro Infiltration With Glioma Histological Type In Organotypic Brain Slices., British Journal of Cancer, 91(4), 745-52, Aug 2004 Abstract
  • Swanson KR, Bridge C, Murray JD, Alvord EC, Virtual and real brain tumors: using mathematical modeling to quantify glioma growth and invasion, Journal of the Neurological Sciences, 216(1), 1-10, December 2003 Abstract
  • Swanson KR, True LD, Murray JD, On the use of quantitative modeling to help understand prostate-specific antigen dynamics and other medical problems, American Journal of Clinical Pathology, 119(1), 14-7, January 2003 Abstract
  • Mandonnet E, Delattre J-Y, Tanguy M-L, Swanson KR, Carpentier AF, Duffau H, Cornu P,Van Effenterre R, Alvord EC Jr, Capelle L, Continuous growth of mean tumor diameter in a subset of WHO grade II gliomas, Annals of Neurology, 53, 524-528, 2003
  • Swanson KR, Alvord EC Jr, Murray JD, Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy, British Journal of Cancer, 86(1), 14-8, January 2002 Abstract
  • Swanson KR , Alvord EC Jr., Murray JD, Quantifying Efficacy of Chemotherapy of Brain Tumors (Gliomas) with Homogeneous and Heterogeneous Drug Delivery, Acta Biotheoretica, 50(4), 223-237, 2002
  • Swanson KR, True LD, Lin DW, Buhler KR, Vessella R, Murray JD, A quantitative model for the dynamics of serum prostate-specific antigen as a marker for cancerous growth: an explanation for a medical anomaly, American Journal of Pathology, 158(6), 2195-9, June 2001 Abstract
  • Swanson KR , Alvord EC, Murray JD, A quantitative model for differential motility of gliomas in grey and white matter, Cell Proliferation, 33(5), 317-330, 2000

Profile Details

Last Updated: 9/28/2005

COS Expertise ID #1056803
Reference this profile directly: http://myprofile.cos.com/kswanson