Dr. William J. Landis

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Northeastern Ohio Universities College of Medicine
Basic Medical Sciences
Microbiology, Immunology, and Biochemistry
ProfessorAppointed: 1998
Case Western Reserve University
Case School of Engineering
Biomedical Engineering
Adjunct ProfessorAppointed: 2000
University of Akron
Biomedical Engineering
Adjunct ProfessorAppointed: 1999
Kent State University
School of Biomedical Sciences
Graduate Faculty
MemberAppointed: 1999
University of Pennsylvania
School of Dental Medicine
Biochemistry
Adjunct ProfessorAppointed: 1999
Northeastern Ohio Universities College of Medicine
Clinical Sciences
Orthopaedic Surgery
ProfessorAppointed: 1999
Professional Headshot of William J. Landis

Mailing Address

Northeastern Ohio Universities College of Medicine
4209 State Route 44
P.O. Box 95
Rootstown, Ohio 44272
United States

Contact Information

Phone: (330) 325-6685
Fax: (330) 325-5925
wjl@neoucom.edu

Qualifications

Ph.D., Massachusetts Institute of Technology, Biophysics, 1972.
M.S., Massachusetts Institute of Technology, Biology, 1967.
B.S., University of Massachusetts Amherst, Physics, 1965.

Expertise and Research Interests

My principal research interests lie in the broad area of skeletal biology. More specifically, I investigate through active funding sources a number of aspects of skeletal biology, including:
- Mineral-matrix structure and interaction in normal (bone, calcifying cartilage and tendon, enamel, dentin, and cementum) and abnormal (osteogenesis imperfecta, osteoporosis, osteopetrosis) vertebrate tissues
- Calcium transport in calcification
- Tissue engineering of calcified tissues
- Effects of forces on calcified tissues (gravitational, mechanical, and electromagnetic)

Keywords

COS Keywords:

Biochemical Markers, Biochemistry, Bioengineering, Biomedical Engineering, Bone, Bone Diseases, Cell Biology, Collagen, Connective Tissue, Extracellular Matrix, Gene Products, Genes, Immunohistochemistry, Immunology, Microbiology, Molecular Pathology, Musculoskeletal System, Orthopedics, Osteology Or Osteopathy, Proteins and Macromolecules, Skeletal Disease, Surgery, Tissue Culture, Tissue Engineering.

Additional Terms:

Extracellular Matrix, Genes, Skeletal Disease.

Memberships

American Association for Gravitational and Space Biology
American Society for Bone and Mineral Research
American Society for Cell Biology
American Society for Matrix Biology
Electron Microscopy Society of America
Fulbright Association
International Association for Dental Research
Microbeam Analysis Society
Microscopy Society of Northeastern Ohio
New England Society for Electron Microscopy
Orthopaedic Research Society

Honors and Awards

2003, Faculty inductee, Alpha Omega Alpha, medical honor society,
2001, Technology Forum Award for the most outstanding abstract presented at Microscopy and Microanalysis 2001,
2000, Visiting professor pro tempore, Department of Orthopaedics, Case Western Reserve University, Cleveland OH,
2000, Keynote speaker, First Annual Orthopaedic Research Day, Department of Orthopaedics, Case Western Reserve University, Cleveland OH,
2000, Guest speaker, Ohio Orthopaedic Society,
1999, Visiting professor pro tempore, Cleveland Clinic Educational Foundation, Cleveland OH,
1997, Harold C. Copp Prize from the German Osteological Society for outstanding and ground-breaking contribution to the literature,
1997, Joseph E. Murray Award for outstanding work presented at the annual meeting of the New England Society of Plastic and Reconstructive Surgeons, Woodstock VT,
1994, American Men and Women of Science,
1991, Cecil E. Hall Award for the most outstanding work presented at the annual meeting of the Electron Microscope Society of America, San Jose CA,
1989, Chairman, Gordon Research Conference on Calcium Phosphates,
1988, Chairman-elect, 1989 Gordon Research Conference on Calcium Phosphates,
1988-1989, Fulbright Senior Research Scholar,
1987, Co-Chairman, Gordon Conference on Calcium Phosphates,
1985, Stauffer Award for the most outstanding basic laboratory manuscript appearing in Investigative Radiology in 1984,
1985, Co-Chairman-elect, 1987 Gordon Conference on Calcium Phosphates,
1984, William F. Milton Fund awardee, 'Elemental Analysis in Vertebrate Calcified Tissues by Imaging Ion Microscopy',
1983, Kappa Delta Award, American Academy of Orthopaedic Surgeons, awarded for scientific contributions to the field of musculoskeletal research,
1981-1983, Whitaker Health Sciences Fund awardee, 'Use of Scanning Auger Microscopy and X-ray Photoelectron Spectroscopy for Studies of Mineralized Biological Tissues',
1972, Sigma Xi,
1965, President, Student Government, University of Massachusetts,
1965, Phi Kappa Phi,
1965, Phi Beta Kappa,
1965, B.S. (Physics), magna cum laude,
1965, Adelphia, senior men's honor society, University of Massachusetts,
1965, Who's Who in American Colleges and Universities,
1965-1972, Predoctoral Traineeship, National Institutes of Health,
1964, Vice-President, Student Government, University of Massachusetts,
1964, Captain, University of Massachusetts nationally undefeated team, General Electric College Bowl - NBC Television competition,
1963, Senator-at-Large, Student Government, University of Massachusetts,
1962, Phi Eta Sigma,
William J. Landis, Japan Society of Plastic and Reconstructive Surgery
William J. Landis, Japan Society of Teratology

Previous Positions

1998-2004, Chairperson, Northeastern Ohio Universities College of Medicine, Basic Medical Sciences, Biochemistry & Molecular Pathology

Funding Received

  • National Institutes of Health (NIH): Mineral-Matrix Relations in Vertebrate Calcifying Tissues, $1,173,063, May 1, 2002 to Apr 30, 2007.
  • National Aeronautics and Space Administration (NASA): Effect of Hypergravity on Bone Matrix Production and Mineralization, $352,057, Apr 15, 1997 to Jul 31, 2003.
  • National Aeronautics and Space Administration (NASA): Effect of Hypergravity on Bone Matrix Production and Mineralization, $67,490, 2005 to 2007.
  • National Institutes of Health (NIH): Eighth International Conference on the Chemistry and Biology of Mineralized Tissues, $35,000, 2004 to 2006.
  • Northeastern Ohio Universities College of Medicine Foundation: Slipped Capital Femoral Epiphysis, $43,755, 2004 to 2007.

Publications

  • Jacquet R, Hillyer J, Landis WJ, Analysis of Connective Tissues By Laser Capture Microdissection and Reverse Transcriptase-polymerase Chain Reaction, Analytical Biochemistry, 337, 22-34, 2005
  • Landis WJ, Jacquet R, Hillyer J, Zhang J, Siperko L, Chubinskaya S, Asamura S, Isopgai N, The Potential of Tissue Engineering in Orthopedics, Orthop. Clin. N. Am., 36, 97-104, 2005
  • Kacena MA, Todd P, Gerstenfeld LC, Landis WJ, Experiments With Osteoblasts Cultured Under Hypergravity Conditions, Microgravity Science and Technology, 15, 28-34, 2004
  • Isogai N, Asamura S, Ikada Y, Morita S, Hillyer J, Jacquet R, Landis WJ, Tissue Engineering of An Auricular Cartilage Model Utilizing Cultured Chondrocyte-poly (L-lactide-e-caprolactone) Scaffolds, Tissue Engineering, 10, 673-687, 2004
  • Chubinskaya S, Jacquet R, Isogai N, Asamura S, Landis WJ, Characterization of the Cellular Origin of a Tissue-engineered Human Phalanx Model By in Situ Hybridization, Tissue Engineering, 10, 1204-1213, 2004
  • Su X, Sun K, Cui FZ, Landis WJ, Organization of apatite crystals in human woven bone, Bone, 32(2), 150-62, February 2003
  • Landis WJ, Jacquet R, Hillyer J, Zhang J, Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR, In: Chemistry and Biology of Mineralized Tissues, Proceedings of the Seventh International Conference 2002, Ponte Vedra Beach FL, Connective Tissue Research, 44, 28-32, 2003
  • Kacena MA, Todd P, Landis WJ, Osteoblasts Subjected to Spaceflight and Simulated Space Shuttle Launch Conditions, In Vitro Cellular and Developmental Biology - Animal, 39, 454-459, 2003
  • Landis WJ, Silver FH, The structure and function of normally mineralizing avian tendons, Comparative Biochemistry and Physiology, Part A, Molecular & Integrative Physiology, 133(4), 1135-57, December 2002
  • Potter K, Leapman RD, Basser PJ, Landis WJ, Cartilage calcification studied by proton nuclear magnetic resonance, Journal of Bone and Mineral Research, 17(4), 652-60, April 2002
  • Landis WJ, Kraus BL, Kirker-Head CA, Vascular-mineral spatial correlation in the calcifying turkey leg tendon, Connective Tissue Research, 43(4), 595-605, 2002 Abstract
  • Woolverton CJ, Fulton JA, Lopina ST, Landis WJ, Mimicking the natural tissue environment, In: Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications, Lewandrowski K-U, Wise DL, Trantolo DJ, Gresser JD, Yaszemski MJ, Altobelli DE, eds., New York: Marcel Dekker, 43-75, 2002
  • Grabner B, Landis WJ, Roschger P, Rinnerthaler S, Peterlik H, Klaushofer K, Fratzl P, Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim), Bone, 29(5), 453-7, November 2001 Abstract
  • Silver FH, Freeman JW, Horvath I, Landis WJ, Molecular basis for elastic energy storage in mineralized tendon, Biomacromolecules, 2(3), 750-6, 2001 Abstract
  • Siperko LM, Landis WJ, Aspects of mineral structure in normally calcifying avian tendon, Journal of Structural Biology, 135(3), 313-20, September 2001 Abstract
  • Potter K, Landis WJ, Spencer RG, Histomorphometry of the embryonic avian growth plate by proton nuclear, Journal of Bone and Mineral Research, 16(6), 1092-100, June 2001
  • Isogai N, Landis WJ, Phalanges and small joints, In: Methods of Tissue Engineering, Atala A, Lanza R, eds., San Diego: Academic Press, 1041-1047, 2001
  • Silver FH, Christiansen D, Snowhill PB, Chen Y, Landis WJ, The role of mineral in the storage of elastic energy in turkey tendons, Biomacromolecules, 1(2), 180-5, Summer 2000
  • Landis WJ, Hodgens KJ, Block D, Toma CD, Gerstenfeld LC, Spaceflight effects on cultured embryonic chick bone cells, Journal of Bone and Mineral Research, 15(6), 1099-112, June 2000
  • Isogai N, Landis WJ, Mori R, Gotoh Y, Gerstenfeld LC, Upton J, Vacanti JP, Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells, Plastic and Reconstructive Surgery, 105(3), 953-63, March 2000 Abstract
  • Landis WJ, Owen CH, Hodgens KJ, Block D, Hand AR, Gronowicz G, Buttle K, Marko, Studies of adhesion and signal transduction through localization of bone proteins by 3D immunocytochemistry, In: Chemistry and Biology of Mineralized Tissues, Proceedings of the Sixth International Conference 1998, Vittel France, American Academy of Orthopedic Surgeons, Goldberg M, Boskey A, Robinson C, eds., Rosemont IL, 243-247, 2000
  • Mehta S, Antich PP, Daphtary M, Lewis M, Smith B, Landis WJ, Studies of bone biophysics using ultrasound velocity, In: Acoustical Imaging, Lee H, ed., New York: Plenum Press, 24, 341-348, 2000
  • Landis WJ, An overview of vertebrate mineralization with emphasis on collagen-mineral, Gravitational and Space Biology Bulletin, 12(2), 15-26, May 1999
  • Mehta SS, Antich PP, Landis WJ, Bone material elasticity in a murine model of osteogenesis imperfecta, Connective Tissue Research, 40(3), 189-98, 1999 Abstract
  • Isogai N, Landis WJ, Kim TH, Gerstenfeld LC, Upton J, Vacanti JP, Formation of phalanges and small joints by tissue engineering, Journal of Bone and Joint Surgery, 81A, 306-316, 1999
  • Shum-Tim D, Stock U, Hrkach J, Shinoka T, Lien J, Moses M, Stamp A, Taylor G, Moran A, Landis W, Langer R, Vacanti J, Mayer JE Jr, Tissue engineering of autologous aorta using a new biodegradable polymer, Annals of Thoracic Surgery, 68, 2298-2305, 1999

Profile Details

Last Updated: 7/14/2006

COS Expertise ID #460525
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