Prof. Lan Ma

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Fudan University
Institutes of Brain Science
DirectorAppointed: 2008
Fudan University
Pharmacology Research Center
DirectorAppointed: 2003
Fudan University
Shanghai Medical College
Neurobiology/Pharmacology
ProfessorAppointed: 1995
Professional Headshot of Lan Ma

Mailing Address

Pharmacology Research Center
Fudan University
138 Yixueyuan Road
Shanghai, 200032
China

Contact Information

Phone: 86-21-54237522
Fax: 86-21-54237621
lanma@shmu.edu.cn

Qualifications

Ph.D., University of North Carolina at Chapel Hill, Biological Chemistry, 1990.
M.S., China Medical University, Immunology, 1984.
B.S., Shenyang College of Pharmacy, Pharmacy, 1982.

Previous Positions

2007-2008, Depeuty Director, Fudan University, Institutes of Brain Science
2004-2008, Professor and Vice Chair, Department of Pharmacology, Shanghai Medical School, Fudan University
2002-2007, Changjiang Professor, Specially appointed by the Ministry of Education
1999-2004, Vice Director, Shanghai Medical University/Fudan University, National Laboratory of Medical Neurobiology
1995-2004, Professor & Principal Investigator, Shanghai Medical University/Fudan University, National Laboratory of Medical Neurobiology, Neurobiology
1993-1995, Postdoctoral Research Scientist, Bayer Corp. (US), Bayer Research Center, Pharmaceutical
1991-1993, Research Associate, University of North Carolina at Chapel Hill, College of Arts and Sciences, Chemistry
1987-1990, Research Assistant, University of North Carolina at Chapel Hill, College of Arts and Sciences, Chemistry
1986-1986, Visiting Research Associate, University of North Carolina at Chapel Hill, School of Medicine, Lineberger Cancer Center
1985-1987, Instructor, Shenyang College of Pharmacy, Pharmaceutics

Honors and Awards

2007, National Natural Science Award, Second Prize, State Council
2006, Natural Science Award, First Prize, Shanghai Municipal Government
2005, National Higher Education Teaching Award, Second Prize, Ministry of Education
2005, Shanghai Higher Education Teaching Award, First Prize, Shanghai Municipal Commission for Education
2003, Science and Technology Achievement Award, Ho Leung Ho Lee Foundation
2002, National Natural Science Award, Second Prize, State Council
2001, National Medical Science and Technology Award, First Prize, Chinese Medical Association
2001, Science & Technology Progress Award, First Prize, Shanghai Municipal Government
1999, Outstanding Young Scholar Prize, Hong Kong Qiushi Foundation of Science and Technology
1998, Science and Technology Progress Award, First Prize, Ministry of Education
1998, National Outstanding Young Scientist Grant, National Natural Science Foundation of China

Expertise and Research Interests

Molecular neuropharmacology
Mechanisms of drug tolerance and addiction
Receptor-mediated signal transduction

Memberships

Editorial Board of Neuroscience Bulletin
Editorial Board of the Journal of Biological Chemistry
Executive Editorial Board of Neuropharmacology

Publications

  • Wang ZM, Qi YJ, Wu PY, Zhu Y, Dong YL, Cheng ZX, Zhu YH, Dong Y, Ma L, Zheng P (Aug 2008) Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of alpha2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex., The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 11 (5), 611-24 Abstract
  • Sun J, Wang L, Jiang B, Hui B, Lv Z, Ma L (Aug 2008) The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats., Neuroscience letters, 441 (1), 72-6 Abstract
  • Wang F, Chen X, Zhang X, Ma L (Aug 2008) Phosphorylation state of micro-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway., Molecular endocrinology (Baltimore, Md.), 22 (8), 1881-92 Abstract
  • Ji XH, Cao XH, Zhang CL, Feng ZJ, Zhang XH, Ma L, Li BM (Jul 2008) Pre- and postsynaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats., Cerebral cortex (New York, N.Y. : 1991), 18 (7), 1506-20 Abstract
  • Chen Y, Long H, Wu Z, Jiang X, Ma L (Jul 2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation., Molecular biology of the cell, 19 (7), 2973-83 Abstract
  • Zhang X, Wang F, Chen X, Chen Y, Ma L (Jul 2008) Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms., Journal of neurochemistry, 106 (2), 781-92 Abstract
  • Chen Y, Jiang Y, Yue W, Zhou Y, Lu L, Ma L (Apr 2008) Chronic, but Not Acute Morphine Treatment, Up-regulates alpha-Ca(2+)/calmodulin Dependent Protein Kinase II Gene Expression in Rat Brain., Neurochemical research Abstract
  • Cheng ZX, Lan DM, Wu PY, Zhu YH, Dong Y, Ma L, Zheng P (Mar 2008) Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors., Experimental neurology, 210 (1), 128-36 Abstract
  • Wang ZM, Qi YJ, Wu PY, Zhu Y, Dong YL, Cheng ZX, Zhu YH, Dong Y, Ma L, Zheng P (Jan 2008) Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of alpha2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex., The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 1-14 Abstract
  • Bao G, Kang L, Li H, Li Y, Pu L, Xia P, Ma L, Pei G (Aug 2007) Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 (8), 1738-49 Abstract
  • Jin XC, Lu YF, Yang XF, Ma L, Li BM (Jun 2007) Glucocorticoid receptors in the basolateral nucleus of amygdala are required for postreactivation reconsolidation of auditory fear memory., The European journal of neuroscience, 25 (12), 3702-12 Abstract
  • Ma L, Pei G. (2007) Beta-Arrestin signaling and regulation of transcription. (Invited Review), Journal of Cell Science, 120, 213-218
  • Wang W, Zhou Y, Sun J, Pan L, Kang L, Dai Z, Yu R, Jin G, Ma L. (2007) The effect of l-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats, Neuropharmacology, 52, 355-361
  • Dai Z, Kang L, Wang L, Ma L. (2006) Different roles of dopamine receptor subtypes in footshock-stress induced enhancement of morphine conditioned place preference, Neuroscience Letters, 409, 52-56
  • Kang L, Dai Z, Li H, Ma L (2006) Enviromental cues associated with morphine modulate release of glutamate and gamma-aminobutyric in ventral subiculum, Neuroscience Bulletin, 22 (5), 255-60
  • Li H, Zhou Y, Kang L, Ma L (2006) Single and repeated morphine administrations diffently regulate expression of N-ethylmaleimide-sensitive factor gene in the rat brain, Neuroreport, 17, 71-74
  • Jiang B, Shi Y, Li H, Kang L, Ma L. (2006) Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray, Neuroscience Letters, 400, 150-153
  • Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L (2005) Novel nuclear function of beta-arrestin 1: regulation of histone acetylation and gene transcription, Cell, 123 (5), 833-847
  • Zhang X, Wang F, Chen X, Li J, Xiang B, Zhang Y, Li B, Ma L (Oct 2005) Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors, Journal of Neurochemisty, 95 (1), 169-78
  • Lu L, Chen H, Su W, Ge X, Yue W, Su F, Ma L (Aug 2005) Role of withdrawal in reinstatement of morphine-conditioned place preference, Psychopharmacology, 181 (1), 90-100
  • Gao J, Li J, Ma L (Aug 2005) Regulation of EGF-induced ERK/MAPK activation and EGFR internalization by G protein-coupled receptor kinase 2, Acta Biochim Biophys Sin (Shanghai), 37 (8), 525-31
  • Gao J, Li J, Chen Y, Ma L, Activation of Tyrosine Kinase of EGFR Induces Gbetagamma-dependent GRK-EGFR Complex Formation, FEBS Letters, 579(1), 122-6, Jan 2005
  • Ma L, Gao J, Chen X, G-protein Coupled Receptor Kinases, The G Protein Coupled Receptors Handbook. (Devi LA Ed.), Totowa, New Jersey, Humana Press, 149-158, 2005
  • Ding Y, Kang L, Li B, Ma L (2005) Enhanced cocaine self-administration in adult rats with adolescent isolation experience, Pharmacology Biochemistry and Behavior, 82, 673-677
  • Zhu M, Fan XL, Yang WL, Jiang Y, Ma L, [Regulation of G Protein-coupled Receptor Kinase 5 MRNA and Protein Level in Rat Brain By Addictive Drugs], Sheng Li Xue Bao [Acta Physiologica Sinica], 56(5), 559-65, Oct 2004
  • Jiang Y, Yang W, Zhou Y, Ma L, Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations, Neuroscience Letters, 352(3), 216-20, December 2003
  • Lu L, Bao G, Chen H, Xia P, Fan X, Zhang J, Pei G, Ma L, Modification of hippocampal neurogenesis and neuroplasticity by social environments, Experimental Neurology, 183(2), 600-9, October 2003
  • Li J, Xiang B, Su W, Zhang X, Huang Y, Ma L (August 2003) Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo, Journal of Biological Chemistry, 278 (32), 30219-26
  • Wang P, Wu Y, Ge X, Ma L, Pei G (March 2003) Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus, Journal of Biological Chemistry, 278 (13), 11648-53
  • Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G (February 2003) Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2, Journal of Biological Chemistry, 278 (8), 6363-70
  • Ma L, Analysis of Opioid-induced Kinase Activation, Opioid Research: Methods and Protocols (Pan Z.Z. Ed), Totowa, New Jursey, Humana Press, 84, 39-46, 2003
  • Fan XL, Zhang JS, Zhang XQ, Yue W, Ma L, Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine, Neuroscience, 117(2), 383-9, 2003
  • Fan XL, Zhang JS, Zhang XQ, Ma L, Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain, Neuroscience, 122(4), 997-1002, 2003
  • Sun Y, Cheng Z, Ma L, Pei G (December 2002) Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation, Journal of Biological Chemistry, 277 (51), 49212-9
  • Fan X, Zhang J, Zhang X, Yue W, Ma L, Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain, Neuropharmacology, 43(5), 809-16, October 2002
  • Pu L, Bao GB, Xu NJ, Ma L, Pei G (Mar 2002) Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates, The Journal of Neuroscience., 22 (5), 1914-21
  • Lu L, Xu NJ, Ge X, Yue W, Su WJ, Pei G, Ma L, Reactivation of morphine conditioned place preference by drug priming: role of environmental cues and sensitization, Psychopharmacology, 159(2), 125-32, Jan 2002
  • Lu L, Su WJ, Yue W, Ge X, Su F, Pei G, Ma L, Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor, Life Sciences, 69(1), 37-46, 2001
  • Cen B, Xiong Y, Ma L, Pei G, Direct and differential interaction of beta-arrestins with the intracellular domains of different opioid receptors, Molecular Pharmacology, 59(4), 758-64, April 2001
  • Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G (March 2001) Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor, Journal of Neurochemistry, 76 (6), 1887-94
  • Xiang B, Yu GH, Guo J, Chen L, Hu W, Pei G, Ma L (2001) Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization, Journal of Biological Chemistry, 276 (7), 4709-16
  • Guo J, Wu Y, Zhang W, Zhao J, Devi LA, Pei G, Ma L, Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation, Molecular Pharmacology, 58(5), 1050-6, November 2000
  • Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G (Jan 2000) Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase, Journal of Biological Chemistry, 275 (4), 2513-9
  • Zhang Z, Xin SM, Wu GX, Zhang WB, Ma L, Pei G (October 1999) Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C, Journal of Neurochemistry, 73 (4), 1502-9
  • Pu L, Bao GB, Ma L, Pei G (October 1999) Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons, European Journal of Neuroscience, 11 (10), 3610-6
  • Ling K, Wang P, Zhao J, Wu YL, Cheng ZJ, Wu GX, Hu W, Ma L, Pei G, Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors, Proceedings of the National Academy of Sciences (USA), 96(14), 7922-7, July 1999
  • Fan GH, Wang LZ, Qiu HC, Ma L, Pei G, Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence, Molecular Pharmacology, 56(1), 39-45, July 1999
  • Zhou H, Ge X, Wang LZ, Ma L, Pei G, Attenuation of morphine tolerance and dependence in scopolamine-treated rats, Neuroreport, 10(10), 2007-10, July 1999
  • Liu XL, Li HM, Zhao J, Pei G, Ma L, Expression, purification and characterization of regulatory subunit of type I cAMP-dependent protein kinase in E. coli, Acta Biochimica et Biophysica Sinica, 31(4), 459-462, July 1999
  • Zhao J, Ben LH, Wu YL, Hu W, Ling K, Xin SM, Nie HL, Ma L, Pei G (July 1999) Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors, Journal of Experimental Medicine, 190 (1), 101-11
  • Chen L, Xu Q, Liu XL, Zhao J, Ma L, Differential and tissue-specific expression of mitochondrial elongation factor Tu and Ts during development, Acta Biochimica et Biophysica Sinica, 31(1), 37-40, Jan 1999
  • Zhao J, Ma L, Wu YL, Wang P, Hu W, Pei G (October 1998) Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization, Journal of Cellular Biochemistry, 71 (1), 36-45
  • Cheng ZJ, Yu QM, Wu YL, Ma L, Pei G (September 1998) Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling, Journal of Biological Chemistry, 273 (38), 24328-33
  • Fan GH, Zhao J, Wu YL, Lou LG, Zhang Z, Jing Q, Ma L, Pei G, N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C, Molecular Pharmacology, 53(4), 684-90, April 1998
  • Yang R, Lu SD, Zheng ZL, Zhao J, Zhang XN, Chen L, Pei G, Ma L, Expression of opioid-receptor-like receptor (ORL1) gene in rat brain, Sheng Li Hsueh Pao [acta Physiologica Sinica], 50(2), 139-44, April 1998
  • Bazzoni G, Ma L, Blue ML, Hemler ME (March 1998) Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins, Journal of Biological Chemistry, 273 (12), 6670-8
  • Lou LG, Zhang Z, Ma L, Pei G (March 1998) Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor, Journal of Neurochemistry, 70 (3), 1316-22
  • Ling K, Ma L, Pei G, Differential efficacies of kappa agonists to induce homologous desensitization of human kappa opioid receptor, Neuroscience Letters, 240(1), 25-8, Jan 1998
  • Lou LG, Ma L, Pei G, Nociceptin/orphanin FQ activates protein kinase C, and this effect is mediated through phospholipase C/Ca2 pathway, Biochemical and Biophysical Research Communications, 240(2), 304-8, November 1997
  • Zhao J, Pei G, Huang YL, Zhong FM, Ma L, Carboxyl terminus of delta opioid receptor is required for agonist-dependent receptor phosphorylation, Biochemical and Biophysical Research Communications, 238(1), 71-6, September 1997
  • Pei G, Ling K, Pu L, Cunningham MD, Ma L, Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C, FEBS Letters, 412(1), 253-6, July 1997
  • Woriax VL, Bullard JM, Ma L, Yokogawa T, Spremulli LL, Mechanistic studies of the translational elongation cycle in mammalian mitochondria, Biochimica Et Biophysica Acta, 1352(1), 91-101, May 1997
  • Cheng ZJ, Fan GH, Zhao J, Zhang Z, Wu YL, Jiang LZ, Zhu Y, Pei G, Ma L, Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization, Neuroreport, 8(8), 1913-8, May 1997
  • Cai YC, Ma L, Fan GH, Zhao J, Jiang LZ, Pei G, Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors, Molecular Pharmacology, 51(4), 583-7, April 1997
  • Ma L, Cheng ZJ, Fan GH, Cai YC, Jiang LZ, Pei G, Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells, FEBS Letters, 403(1), 91-4, February 1997
  • Webb DL, Conrad PJ, Ma L, Blue ML (April 1996) Induction of mouse beta integrin expression following transfection with human alpha 4 chain, Journal of Cellular Biochemistry, 61 (1), 127-38
  • Ma L, Conrad PJ, Webb DL, Blue ML (August 1995) Aspartate 698 within a novel cation binding motif in alpha 4 integrin is required for cell adhesion, Journal of Biological Chemistry, 270 (31), 18401-7
  • Ma L, Spremulli LL (January 1995) Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA, Journal of Biological Chemistry, 270 (4), 1859-65
  • Lin Q, Ma L, Burkhart W, Spremulli LL (April 1994) Isolation and characterization of cDNA clones for chloroplast translational initiation factor-3 from Euglena gracilis, Journal of Biological Chemistry, 269 (13), 9436-44
  • Ma L, Spremulli LL (September 1992) Immunological characterization of the complex forms of chloroplast translational initiation factor 2 from Euglena gracilis, Journal of Biological Chemistry, 267 (26), 18356-60
  • Roney WB, Ma L, Wang CC, Spremulli LL, Recent progress on understanding the initiation of translation in the chloroplast of Euglena gracilis, in The Translational Apparatus of Photosynthestic Organelles (Mache et al. eds.), 197-205(Springer-Verlag), Berlin, 1991
  • Ma L, Spremulli LL (August 1990) Identification and characterization of large, complex forms of chloroplast translational initiation factor 2 from Euglena gracilis, Journal of Biological Chemistry, 265 (23), 13560-5

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Last Updated: 8/20/2008

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