Laura R. McCabe

(Reading, Writing, Speaking)

Crohn's and Colitis Foundation: Mechanisms of IBD suppression of skeletal growth and mineral density, 2007 to 2010.
American Diabetes Association: Mechanisms of Type I diabetes induced osteoporosis - the role of marrow adiposity, 2007 to 2010.
National Science Foundation: FRG on microcracking in hydroxyapatite and the implications for bone tissue engineering, 2007 to 2011.
Laura Rackham Award: Nutraceutical regulation of chondrocytes and osteoblasts, 2004 to 2007.
National Institutes of Health (NIH): Mechanisms of Diabetes associated bone loss, 2003 to 2008.
Department of Defense: Molecular mechanisms of loss of estrogen responsiveness in estrogen receptor positive breast cancer cells on laminin, 2003 to 2006.
Pfizer: Enhancement of bone formation, 2002 to 2003.
National Science Foundation (NSF): Bioactive hydroxyapatite Whisker Composite Bone Substitutes, 2000 to 2004.
American Diabetes Association: Mechanisms of diabetes associated osteoporosis, 1999 to 2001.
NASA: Microgravity regulation of gene expression and osteoblast differentiation, 1998 to 2002.
Arthritis Foundation: Oncogenic control of osteoblast differentiation, 1997 to 2000.
National Osteoporosis Foundation: Regulation of osteoblast differentiation by insulin and glucose, 1997 to 1999.

• Motyl KJ, Botolin S, Irwin R, Appledorn DM, Kadakia T, Amalfitano A, Schwartz RC, McCabe LR (Mar 2009) Bone inflammation and altered gene expression with type I diabetes early onset., Journal of cellular physiology, 218 (3), 575-83
• Harris L, Senagore P, Young VB, McCabe LR (Mar 2009) Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice., American journal of physiology. Gastrointestinal and liver physiology
• Motyl KJ, McCabe LR (Feb 2009) Leptin treatment prevents type I diabetic marrow adiposity but not bone loss in mice., Journal of cellular physiology, 218 (2), 376-84
• McCabe LR (Dec 2007) Understanding the pathology and mechanisms of type I diabetic bone loss., Journal of cellular biochemistry, 102 (6), 1343-57
• Martin LM, McCabe LR (Aug 2007) Type I diabetic bone phenotype is location but not gender dependent., Histochemistry and cell biology, 128 (2), 125-33
• Irwin R, LaPres JJ, Kinser S, McCabe LR (Feb 2007) Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype., Journal of cellular biochemistry, 100 (3), 762-72
• Botolin S, McCabe LR (Jan 2007) Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice., Endocrinology, 148 (1), 198-205
• Irwin R, Lin HV, Motyl KJ, McCabe LR (Dec 2006) Normal bone density obtained in the absence of insulin receptor expression in bone., Endocrinology, 147 (12), 5760-7
• Botolin S, McCabe LR (Dec 2006) Inhibition of PPARgamma prevents type I diabetic bone marrow adiposity but not bone loss., Journal of cellular physiology, 209 (3), 967-76
• Botolin S, McCabe LR (Oct 2006) Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways., Journal of cellular biochemistry, 99 (2), 411-24
• Porter K, Hossain M, Wang M, Radano CP, Baker GL, Smith MR, McCabe LR (Mar 2006) Regulation of osteoblast gene expression and phenotype by polylactide-fatty acid surfaces., Molecular biology reports, 33 (1), 1-12
• Smith IO, McCabe LR, Baumann MJ (2006) MC3T3-E1 osteoblast attachment and proliferation on porous hydroxyapatite scaffolds fabricated with nanophase powder., International journal of nanomedicine, 1 (2), 189-94
• Botolin S, Faugere MC, Malluche H, Orth M, Meyer R, McCabe LR, Increased Bone Adiposity and Peroxisomal Proliferator-activated Receptor-gamma2 Expression in Type I Diabetic Mice., Endocrinology, 146(8), 3622-31, Aug 2005
• Hossain M, Irwin R, Baumann MJ, McCabe LR, Hepatocyte Growth Factor (HGF) Adsorption Kinetics and Enhancement Of Osteoblast Differentiation on Hydroxyapatite Surfaces., Biomaterials, 26(15), 2595-602, May 2005
• Xie J, Baumann MJ, McCabe LR, Adsorption of Serum Fetuin to Hydroxylapatite Does Not Contribute to Osteoblast Phenotype Modifications, J Biomed Mater Res a, 73(1), 39-47, 1 Apr 2005
• Dentel JN, Blanchard SG, Ankrapp DP, McCabe LR, Wiseman RW, Inhibition of Cross-bridge Formation Has No Effect On Contraction-associated Phosphorylation of P38 MAPK in Mouse Skeletal Muscle., American Journal of Physiology. Cell Physiology, 288(4), C824-30, Apr 2005
• Meganck JA, Baumann MJ, Case ED, McCabe LR, Allar JN, Biaxial Flexure Testing of Calcium Phosphate Bioceramics for Use in Tissue Engineering., Journal of Biomedical Materials Research. Part a, 72(1), 115-26, Jan 2005
• Xie J, Baumann MJ, McCabe LR, Osteoblasts Respond to Hydroxyapatite Surfaces With Immediate Changes In Gene Expression., Journal of Biomedical Materials Research. Part a, 71A(1), 108-17, Oct 2004
• Iyer V, McCabe LR, and R Schwartz, CCAAT/Enhancer-Binding Protein-beta has a Role in Osteoblast Proliferation and Differentiation, Experimental Cell Research, 2004
• Ontiveros C, R Irwin, RW Wiseman and LR McCabe, Hypoxia suppresses runx2 independent of modeled microgravity, Journal of Cellular Physiology, 2004
• Smith IO, MJ Baumann, LR McCabe, Electrostatic interactions as a predictor for biomaterial-biologic attachment, Journal of Biomedical Materials Research, 2004
• Upham BL, Suzuki J, Chen G, Wang Y, McCabe LR, Chang CC, Krutovskikh VA, Yamasaki H, Trosko JE, Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43, Molecular Carcinogenesis, 37(4), 192-201, Aug 2003
• Ontiveros C and LR McCabe, Simulated microgravity suppresses osteoblast phenotype, runx2 levels and AP-1 transactivation, Journal of Cellular Biochemistry, 88(3), 427-437, 2003
• Shu R, McMullen R, Crimp MJ and LR McCabe, Hydroxyapatite accelerates differentiation and suppresses growth of MC3T3-E1 osteoblasts, Journal of Biomaterials Research, 1196-1204, 2003
• Parameswaran N, CS Hall, LR McCabe, WS Spielman, Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase A and p38 MAPK, Cellular Physiology and Biochemistry, 367-374, 2003
• McGrath J, Liu B, McCabe LR, M Baumann, Responses of murine osteoblasts to cryopreservation: the influence of attachment to hydroxyapatite scaffolds, Bioceramics: Materials and Applications, 121-130, 2003
• Zayzafoon M, Botolin S, McCabe LR, P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose, Journal of Biological Chemistry, 277(40), 37212-8, October 2002
• Liu BL, J McGrath, L McCabe, and M Crimp, Response of murine osteoblasts and porous hydroxyapatite scaffolds to two-step, slow freezing and vitrification processes, Cell Preservation Technology, 1(1), 33-44, 2002
• McCauley LK, Koh-Paige AJ, Chen H, Chen C, Ontiveros C, Irwin R, McCabe LR, Parathyroid hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo, Endocrinology, 142(5), 1975-81, May 2001
• Zayzafoon M, Stell C, Irwin R, McCabe LR, Extracellular glucose influences osteoblast differentiation and c-Jun expression, Journal of Cellular Biochemistry, 79(2), 301-10, August 2000
• F Aslam, LR McCabe, J Stein, J Lian, and G Stein, AP-1 regulation of VD stimulated osteocalcin expression, Endocrinology, 140, 63-70, Jan 1999
• Banerjee C, McCabe L R, Choi J Y, Hiebert S W, Stein J L, Stein G S, Lian J B, Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex, Journal of Cellular Biochemistry, 66(1), 1-8, 1 Jul 1997
• McCabe L R, Banerjee C, Kundu R, Harrison R J, Dobner P R, Stein J L, Lian J B, Stein G S, Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation, Endocrinology, 137(10), 4398-408, October 1996
• Hoffmann H M, Beumer T L, Rahman S, McCabe L R, Banerjee C, Aslam F, Tiro J A, van Wijnen A J, Stein J L, Stein G S, Lian J B, Bone tissue-specific transcription of the osteocalcin gene: role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box, Journal of Cellular Biochemistry, 61(2), 310-24, May 1996
• Lian J B, Stein G S, Stein J L, Van Wijnen A, McCabe L, Banerjee C, Hoffmann H, The osteocalcin gene promoter provides a molecular blueprint for regulatory mechanisms controlling bone tissue formation: role of transcription factors involved in development, Connective Tissue Research, 35(1-4), 15-21, 1996
• McCabe L R, Kockx M, Lian J, Stein J, Stein G, Selective expression of fos- and jun-related genes during osteoblast proliferation and differentiation, Experimental Cell Research, 218(1), 255-62, May 1995
• Hoffmann H M, Catron K M, van Wijnen A J, McCabe L R, Lian J B, Stein G S, Stein J L, Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins, Proceedings of the National Academy of Sciences (USA), 91(26), 12887-91, 20 Dec 1994
• McCabe L R, Last T J, Lynch M, Lian J, Stein J, Stein G, Expression of cell growth and bone phenotypic genes during the cell cycle of normal diploid osteoblasts and osteosarcoma cells, Journal of Cellular Biochemistry, 56(2), 274-82, October 1994
• Breen E C, Ignotz R A, McCabe L, Stein J L, Stein G S, Lian J B, TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype, Journal of Cellular Physiology, 160(2), 323-35, August 1994
• Kockx M, McCabe L, Stein J L, Lian J B, Stein G S, Influence of DNA replication inhibition on expression of cell growth and tissue-specific genes in osteoblasts and osteosarcoma cells, Journal of Cellular Biochemistry, 54(1), 47-55, January 1994