Dr. Lakshmi Rajagopal

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University of Washington
School of Medicine
Pediatrics
Infectious Diseases
Assistant ProfessorAppointed: 2008
University of Washington
School of Medicine
Microbiology
Adjunct Assistant ProfessorAppointed: 2008
Professional Headshot of Lakshmi Rajagopal

Mailing Address

Division of Infectious Diseases
Department of Pediatrics
University of Washington
1900 9th AVe
Seattle, Washington 98101
United States

Contact Information

Phone: (206) 884-7336
Fax: (206) 884-7311
lakshmi.rajagopal@seattlechildrens.org

Qualifications

Ph.D., Jawaharlal Nehru University, Life Sciences, Microbiology, 1999.
M.Sc., Madurai-Kamaraj University, Biotechnology, 1993.
B.Sc., Bangalore University, Chemistry, Botany and Zoology, 1991.

Expertise and Research Interests

Our current research centers on the role of signaling events that are important for bacterial disease pathogenesis. Current studies in my laboratory are focused on elucidating the role of a serine/threonine kinase in regulation of adaptive responses and consequently virulence of the human neonatal pathogen, Streptococcus agalactiae or Group B Streptococcus.

Other research interests in our laboratory include understanding signaling events mediated by eukaryotic-type enzymes in human pathogens such as Staphylococcus aureus and Listeria monocytogenes.

Keywords

COS Keywords:

Infectious Diseases Or Agents, Microbiology, Pediatrics.

Additional Terms:

Bacterial Infections, Infectious Disease.

Memberships

American Heart Association
American Society of Microbiology

Previous Positions

2004, Research Assistant Professor, University of Washington, School of Medicine, Pediatrics, Infectious Diseases

Patents

Bacterial mutant BXO65 and a method there of (Shikimate dehydrogenase as a target for developing bactericides against plant pahtogens), Patent Number: 6869601, 2005, Institution, United States of America.

Funding Received

  • National Institutes of Health (NIH): Eukaryotic-type signaling mediates two component regulation of GBS virulence, 225,000, 2007 to 2012.

Publications

  • Lin WJ, Walthers D, Connelly JE, Burnside K, Jewell KA, Kenney LJ, Rajagopal L (Mar 2009) Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR., Molecular microbiology, 71 (6), 1477-95 Abstract
  • Rajagopal L (Mar 2009) Understanding the regulation of Group B Streptococcal virulence factors., Future microbiology, 4, 201-21 Abstract
  • Silvestroni A, Jewell K, Lin WJ, Connelly J, Ivancic M, Tao W, Rajagopal L (Mar 2009) Identification of serine/threonine kinase substrates in the human pathogen Group B Streptococcus., Journal of proteome research Abstract
  • Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A (Jun 2007) Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion., The FEBS journal, 274 (12), 3128-37 Abstract
  • Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A (Jun 2007) Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution., Acta crystallographica. Section D, Biological crystallography, 63 (Pt 6), 738-43 Abstract
  • Rajagopal L, Vo A, Silvestroni A, Rubens CE (Nov 2006) Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae., Molecular microbiology, 62 (4), 941-57 Abstract
  • Rantanen MK, Lehtiö L, Rajagopal L, Rubens CE, Goldman A (Sep 2006) Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase., Acta crystallographica. Section F, Structural biology and crystallization communications, 62 (Pt 9), 891-4 Abstract
  • Rajagopal L, Vo A, Silvestroni A, Rubens CE (Jun 2005) Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae., Molecular microbiology, 56 (5), 1329-46 Abstract
  • Shelver D, Rajagopal L, Harris TO, Rubens CE, MtaR, a regulator of methionine transport, is critical for survival of group B streptococcus in vivo, Journal of Bacteriology, 185(22), 6592-9, Nov 2003 Abstract
  • Rajagopal L, Clancy A, Rubens CE (Apr 2003) A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence., The Journal of biological chemistry, 278 (16), 14429-41 Abstract
  • Goel AK, Rajagopal L, Nagesh N, Sonti RV (Jul 2002) Genetic locus encoding functions involved in biosynthesis and outer membrane localization of xanthomonadin in Xanthomonas oryzae pv. oryzae., Journal of bacteriology, 184 (13), 3539-48 Abstract
  • Goel AK, Rajagopal L, Sonti RV (Jan 2001) Pigment and virulence deficiencies associated with mutations in the aroE gene of Xanthomonas oryzae pv. oryzae., Applied and environmental microbiology, 67 (1), 245-50 Abstract
  • Rajagopal L, Sundari CS, Balasubramanian D, Sonti RV (Sep 1997) The bacterial pigment xanthomonadin offers protection against photodamage., FEBS letters, 415 (2), 125-8 Abstract

Profile Details

Last Updated: 3/26/2009

COS Expertise ID #761479
Reference this profile directly: http://myprofile.cos.com/laxmi