Dr. Laura Beretta

(Reading, Writing, Speaking)

NCI: Markers for HCV-related HCC: plasma profiling, targeted strategies and validation, 2009 to 2014.
Johns Hopkins University: Proteomic Approach for Liver Cancer Biomarker Discovery, 2004 to 2004.
NIDDK: Novel Markers for HCV-related HCC, 2004 to 2010.
NIAID: Functional Analysis of the Role of 4E-BP1 and 4E-BP2 in Translational Control, 2002 to 2008.
U.S. HHS National Institutes of Health: The University of Michigan Rheumatic Diseases Core Center, 2001 to 2006.

• Beretta L (Dec 2009) Comparative analysis of the liver and plasma proteomes as a novel and powerful strategy for hepatocellular carcinoma biomarker discovery, Cancer Letters, 286 (1), 134-9
• Beretta L (Nov 2009) The Human Liver Proteome Project (HLPP) Workshop, August 2008, Amsterdam, The Netherlands, Proteomics, 9 (21), 4830-3
• Beretta, Laura (Nov 2009) The Liver Proteome, The Liver: Biology and Pathobiology, 5th edition, Chichester, UK, Wiley-Blackwell, 961-963 pages, ISBN=978-047072313 (bookchapter)
• Olson KE, Booth GC, Poulin F, Sonenberg N, Beretta L (Sep 2009) Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2, Immunology, 128 (1 Suppl), 376-84
• Parent R, Qu X, Petit MA, Beretta L (Jun 2009) The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity., Hepatology (Baltimore, Md.), 49 (6), 1798-809
• Lee NP, Chen L, Lin MC, Tsang FH, Yeung C, Poon RT, Peng J, Leng X, Beretta L, Sun S, Day PJ, Luk JM (Mar 2009) Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma, J Proteome Res, 8 (3), 1293-1303
• Zheng J, Gao X, Mato J, Beretta L, He F (Aug 2008) Report of the 9th HLPP Workshop October 2007, Seoul, Korea, Proteomics, 8 (17), 3420-3
• Lai KK, Kolippakkam D, Beretta L (Mar 2008) Comprehensive and quantitative proteome profiling of the mouse liver and plasma., Hepatology, 47 (3), 1043-51
• Yi X, Luk JM, Lee NP, Peng JR, Leng XS, Guan XY, Lau GK, Beretta L, Fan ST (Feb 2008) Association of mortalin (HSPA9) with liver cancer metastasis and prediction of early tumor recurrence, Mol Cell Proteomics, 7 (2), 315-325
• Parent R, Beretta L (Jan 2008) Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells, Genome Biology, 9 (1), R19
• Beretta L (Nov 2007) The Human Liver Proteome Project, Mol Cell Proteomics, 6 (11), 2043
• Beretta L (Oct 2007) Proteomics from the clinical perspective: many hopes and much debate, Nat Methods, 4 (10), 785-6
• Ioannou GN, Splan MF, Weiss NS, McDonald GB, Beretta L, Lee SP (Aug 2007) Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis, Clin Gastroenterol Hepatol, 5 (8), 938-45
• Bergeron J, Beretta L (Jul 2007) Barbados Conference 2007, Mol Cell Proteomics, 6 (7), 1287-8
• Mato JM, He F, Beretta L (May 2007) The 2006 Human Liver Proteome Project (HLPP) Workshops, Proteomics Clin Appl, 1 (5), 442-5
• Parent R, Kolippakkam D, Booth GC, Beretta L (May 2007) Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth, Cancer Res, 67 (9), 4337-45
• Mannova P, Fang R, Wang H, Deng B, McIntosh MW, Hanash SM, Beretta L (Dec 2006) Modification of host lipid raft proteome upon hepatitis C virus replication, Mol Cell Proteomics, 5 (12), 2319-25
• Feng JT, Shang S, Beretta L (Jun 2006) Proteomics for the early detection and treatment of hepatocellular carcinoma, Oncogene, 25 (27), 3810-17
• Chignard N, Shang S, Wang H, Marrero J, Bréchot C, Hanash S, Beretta L (Jun 2006) Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: detection of generated fragments in patient sera, Gastroenterology, 130 (7), 2010-22
• Zheng J, Gao X, Beretta L, He F (Mar 2006) The Human Liver Proteome Project (HLPP) Workshop during the 4th HUPO World Congress, Proteomics, 6 (6), 1716-8
• Mannova P, Beretta L (Jul 2005) Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication, J Virol, 79 (14), 8742-9
• Parent R, Beretta L (Jul 2005) Proteomics in the study of liver pathology, J Hepatology, 43 (1), 177-83
• Chignard N, Beretta L (Nov 2004) Proteomics for hepatocellular carcinoma marker discovery, Gastroenterology, 127 (5 Suppl 1), S120-5
• Barnes BJ, Richards J, Mancl M, Hanash S, Beretta L, Pitha PM (Oct 2004) Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection, J Biol Chem, 279 (43), 45194-207
• Girard S, Vossman E, Misek DE, Podevin P, Hanash S, Brechot C, Beretta L (Sep 2004) Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses, Hepatology, 40 (3), 708-18
• Beretta L (May-Aug 2004) Translational control in T lymphocytes, Int Rev Immunol, 23 (3-4), 347-63
• Rolli-Derkinderen M, Machavoine F, Baraban JM, Grolleau A, Beretta L, Dy M (May 2003) ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1, J Biol Chem, 278 (21), 18859-67
• Richards J, Le Naour F, Hanash S, Beretta L (Dec 2002) Integrated genomic and proteomic analysis of signaling pathways in dendritic cell differentiation and maturation, Ann N Y Acad Sci, 975, 91-100
• Le Naour F, Brichory F, Beretta L, Hanash SM (Aug 2002) Identification of tumor-associated antigens using proteomics, Technol Cancer Res Treat, 1 (4), 257-62
• Grolleau A, Bowman J, Pradet-Balade B, Puravs E, Hanash S, Garcia-Sanz JA, Beretta L (Jun 2002) Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics, J Biol Chem, 277 (25), 22175-84
• Girard S, Shalhoub P, Lescure P, Sabile A, Misek DE, Hanash S, Brechot C, Beretta L (Apr 2002) An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis, Virology, 295 (2), 272-83
• Le Naour F, Brichory F, Misek DE, Brechot C, Hanash SM, Beretta L (Mar 2002) A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis, Mol Cell Proteomics, 1 (3), 197-203
• Dua K, Williams TM, Beretta L (Oct 2001) Translational control of the proteome: relevance to cancer, Proteomics, 1 (10), 1191-9
• Delhem N, Sabile A, Gajardo R, Podevin P, Abadie A, Blaton MA, Kremsdorf D, Beretta L, Brechot C (Sep 2001) Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein, Oncogene, 20 (41), 5836-45
• Podevin P, Sabile A, Gajardo R, Delhem N, Abadie A, Lozach PY, Beretta L, Brechot C (Jun 2001) Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner, Hepatology, 33 (6), 1503-11
• Le Naour F, Hohenkirk L, Grolleau A, Misek DE, Lescure P, Geiger JD, Hanash S, Beretta L (May 2001) Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics, J Biol Chem, 276 (21), 17920-31
• Shalhoub P, Kern S, Girard S, Beretta L (2001) Proteomic-based approach for the identification of tumor markers associated with hepatocellular carcinoma, Disease Markers, 17 (4), 217-23
• Grolleau A, Kaplan MJ, Hanash SM, Beretta L, Richardson B (Dec 2000) Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients, J Clin Invest, 106 (12), 1561-8
• Baron-Delage S, Abadie A, Echaniz-Laguna A, Melki J, Beretta L (Nov 2000) Interferons and IRF-1 induce expression of the survival motor neuron (SMN) genes, Mol Med, 6 (11), 957-68
• Grolleau A, Wietzerbin J, Beretta L (Nov 2000) Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2, Leukemia, 14 (11), 1909-14
• Grolleau A, Sonenberg N, Wietzerbin J, Beretta L (Mar 1999) Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation, J Immunol, 162 (6), 3491-7