Dr. Leroy E. Hood

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Institute for Systems Biology
DirectorAppointed: 1999
Institute for Systems Biology
PresidentAppointed: 1999
Professional Headshot of Leroy E. Hood

Mailing Address

Institute for Systems Biology
1441 North 34th Street
Seattle, Washington 98103
United States

Contact Information

Phone: (206) 732-1201
Fax: (206) 732-1254
lhood@systemsbiology.org

Qualifications

Ph.D., California Institute of Technology, 1968.
M.D., Johns Hopkins University, 1964.

Expertise and Research Interests

The challenge in modern biology resides in our ability to decipher complex biological systems and networks, for they encode some of the most interesting aspects of the biology of higher organisms. In this regard, our laboratory is exploring several complex biological systems and developing tools to decipher these systems.

The vertebrate immune system has the ability to recognize foreign macromolecular components, avoid reacting with self components, and initiate autoimmune diseases. We are studying the development of the immune system through the analysis of hematopoietic stem cells; we are using large-scale DNA sequencing to analyze the T-cell receptor and major histocompatibility gene families, and we are using genetic mapping and transgenic animals to analyze genes contributing to autoimmune diseases;

The developmental stages hematopoietic stem cells move through toward the differentiation of the blood white and red cells is of interest. We are using the tools of genomics and proteomics to study these events.

Cancer biology is yet another fascinating systems problem. We are using genome-wide genetic mapping and the DNA array technologies to stratify prostate and ovarian cancers; that is, divide them into their various types. We are also using the tools of expressed sequence tag (EST) sequencing and high speed cell sorting to analyze cancer cells. These studies are moving us toward an exciting systems view of cancer with striking new experimental opportunities. We are also pioneering new blood diagnostics techniques.

The development of high-throughput, highly sensitive analytic tools, very large-scale DNA sequencing, and oligonucleotide arrays, is also one of the major interests of our laboratory. We are also developing new informatics tools to acquire, store, model, analyze and distributebiological information.

Keywords

COS Keywords:

Bioengineering, Bioinformatics, Biotechnology, Cancer Biology, Genomics, Human Services, Immunobiology, Immunology.

Additional Terms:

Developmental Networks, Early Diagnostics, Halobacteria Systems, Hematopoietic Stem Cells, Systems Approach to Cancer, Systems Biology.

Memberships

American Academy of Arts and Sciences
American Philosophical Society
Institute of Medicine
National Academy of Sciences

Honors and Awards

Kyoto Prize in Advanced Technology, Inamori Foundation

Previous Positions

1992-1999, Professor, University of Washington, School of Medicine, Immunology
1992-1999, Chair, University of Washington, School of Medicine, Molecular Biotechnology

Patents

Multiparameter Integration Methods for the Analysis of Biological Networks, Patent Number: 2003/0130798 A1, 2003, United States of America.
Thermostable Polymerase Having Altereed Fidelity and Method of Identifying and Using Same, Patent Number: 6395524 B2, 2002, United States of America.
Tagged Extendable Primers and Extension Products, Patent Number: 6200748 B1, 2001, United States.
PrP-Like Gene, Patent Number: 6277970 B1, 2001, United States.
Human Jagged Polypeptide, Encoding Nucleic Acids and Methods of Use, Patent Number: 6136952, 2000, United States.
Automated DNA Sequencing Technique, Patent Number: 5821058, 1998, United States.
Diagnostic and Therapeutic Aspects of Receptor-Mediated Leukemogenesis, Patent Number: 4786590, 1988, United States.
Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease, U.S. Patent No. 5,494,810, 02-27-1996, Barany; Francis, Zebala; John, Nickerson; Deborah, Kaiser, Jr.; Robert J., Hood; Leroy, Cornell Research Foundation, Inc.,
Method of detecting a nucleotide change in nucleic acids, U.S. Patent No,. 4,988,617, 01-29-1991, Landegren; Ulf, Hood; Leroy, California Institute of Technology, Pasadena CA
Automated DNA sequencing technique, U.S. Patent No. 5,171,534, 12-15-1992, Smith; Lloyd M., Hood; Leroy E., Hunkapiller; Michael W., Hunkapiller; Tim J., California Institute of Technology, Pasadena CA
Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof, U.S. Patent No. 4,886,743, 12-12-1989, Hood; Leroy E., Weissman; Irving L., McGrath; Michael S., California Institute of Technology, Pasadena
Method for the sequential performance of chemical processes, U.S. Patent No. 4,603,114, 07-29-1986, Hood; Leroy E., Hunkapiller; Michael W., Dreyer; William J., Hewick; Rodney M., Stark; Anton W., California Institute of Technology, Pasadena CA
Conversion flask for sequential performance apparatus, U.S. Patent No. 4,610,847, 09-09-1986, Hood; Leroy E., Hunkapiller; Michael W., Dreyer; William J., Hewick; Rodney M., Stark; Anton W., California Institute of Technology, Pasadena CA
Apparatus for the sequential performance of chemical processes, U.S. Patent No. 4,704,256, 11-03-1987, Hood; Leroy E., Hunkapiller; Michael W., Dreyer; William J., Hewick; Rodney M., Stark; Anton W., California Institute of Technology, Pasadena CA
Apparatus for the performance of chemical processes, U.S. Patent No. 4,252,769, 02-24-1981, Hood; Leroy E., Hunkapiller; Michael W., California Institute of Technology, Pasadena CA

Publications

  • Aebersold R, Hood LE, Watts JD, Equipping scientists for the new biology, Nature Biotechnology, 18(4), 359, April 2000 Abstract
  • Osman GE, Hannibal MC, Anderson JP, Lasky SR, Ladiges WC, Hood L, FVB/N \(H2\(q\)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments., Immunogenetics, 49(10), 851-9, September 1999 Abstract
  • Lin B, Ferguson C, White JT, Wang S, Vessella R, True LD, Hood L, Nelson PS, Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2., Cancer Research, 59(17), 4180-4, 1 Sep 1999 Abstract
  • Liu AY, True LD, LaTray L, Ellis WJ, Vessella RL, Lange PH, Higano CS, Hood L, van den Engh G, Analysis and sorting of prostate cancer cell types by flow cytometry., Prostate, 40(3), 192-9, 1 Aug 1999 Abstract
  • Osman GE, Hannibal MC, Anderson JP, Cheunsuk S, Lasky SR, Liggitt HD, Ladiges WC, Hood LE, T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction., Immunogenetics, 49(9), 764-72, August 1999 Abstract
  • Huang GM, Ng WL, Farkas J, He L, Liang HA, Gordon D, Yu J, Hood L, Prostate cancer expression profiling by cDNA sequencing analysis., Genomics, 59(2), 178-86, 15 Jul 1999 Abstract
  • Cheunsuk S, Gerken E, Osman G, Hood L, Ladiges W, Predictive parameters of joint disease in DBA/1 transgenic mice., Journal of Gerontol A Biol Sci Med Sci, 54(7), B271-5, July 1999 Abstract
  • Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K, Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression., Proceedings of the National Academy of Sciences (USA), 96(6), 3114-9, 16 Mar 1999 Abstract
  • Hawkins V, Doll D, Bumgarner R, Smith T, Abajian C, Hood L, Nelson PS, PEDB: the Prostate Expression Database., Nucleic Acids Research, 27(1), 204-8, 1 Jan 1999 Abstract
  • Osman GE, Cheunsuk S, Allen SE, Chi E, Liggitt HD, Hood LE, Ladiges WC, Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice., Int Immunol, 10(11), 1613-22, November 1998 Abstract
  • Ng WV, Ciufo SA, Smith TM, Bumgarner RE, Baskin D, Faust J, Hall B, Loretz C, Seto J, Slagel J, Hood L, DasSarma S, Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid or minichromosome?, Genome Research, 8(11), 1131-41, November 1998 Abstract
  • Choi K B, Wong F, Harlan J M, Chaudhary P M, Hood L, Karsan A, Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway., Journal of Biological Chemistry, 273(32), 20185-8, 7 Aug 1998 Abstract
  • Li L, Huang G M, Banta A B, Deng Y, Smith T, Dong P, Friedman C, Chen L, Trask B J, Spies T, Rowen L, Hood L, Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene., Genomics, 51(1), 45-58, 1 Jul 1998 Abstract
  • Chaudhary P M, Ferguson C, Nguyen V, Nguyen O, Massa H F, Eby M, Jasmin A, Trask B J, Hood L, Nelson P S, Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans., Blood, 91(11), 4020-7, 1 Jun 1998 Abstract
  • Frenkel L M, Mullins J I, Learn G H, Manns-Arcuino L, Herring B L, Kalish M L, Steketee R W, Thea D M, Nichols J E, Liu S L, Harmache A, He X, Muthui D, Madan A, Hood L, Haase A T, Zupancic M, Staskus K, Wolinsky S, Krogstad P, Zhao J, Chen I, Koup R, Ho D, Roberts N J Jr, et al, Genetic evaluation of suspected cases of transient HIV-1 infection of infants., Science, 280(5366), 1073-7, 15 May 1998 Abstract
  • Kuo C L, Chen M L, Wang K, Chou C K, Vernooij B, Seto D, Koop B F, Hood L, A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors., Proceedings of the National Academy of Sciences (USA), 95(7), 3839-44, 31 Mar 1998 Abstract
  • Nelson P S, Plymate S R, Wang K, True L D, Ware J L, Gan L, Liu A Y, Hood L, Hevin, an antiadhesive extracellular matrix protein, is down-regulated in metastatic prostate adenocarcinoma., Cancer Research, 58(2), 232-6, 15 Jan 1998 Abstract
  • Nelson P S, Ng W L, Schummer M, True L D, Liu A Y, Bumgarner R E, Ferguson C, Dimak A, Hood L, An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones., Genomics, 47(1), 12-25, 1 Jan 1998 Abstract
  • Li L, Milner L A, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask B J, Hood L, Torok-Storb B, The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1., Immunity, 8(1), 43-55, Jan 1998 Abstract
  • Edmonson P, Murphey-Corb M, Martin L N, Delahunty C, Heeney J, Kornfeld H, Donahue P R, Learn G H, Hood L, Mullins J I, Evolution of a simian immunodeficiency virus pathogen., Journal of Virology, 72(1), 405-14, Jan 1998 Abstract
  • Roach J C, Wang K, Gan L, Hood L, The molecular evolution of the vertebrate trypsinogens., Journal of Molecular Evolution, 45(6), 640-52, December 1997 Abstract
  • Boysen C, Simon M I, Hood L, Fluorescence-based sequencing directly from bacterial and P1-derived artificial chromosomes., Biotechniques, 23(6), 978-82, December 1997 Abstract
  • Wang K, Boysen C, Shizuya H, Simon M I, Hood L, Complete nucleotide sequence of two generations of a bacterial artificial chromosome cloning vector., Biotechniques, 23(6), 992-4, December 1997 Abstract
  • Schummer M, Ng W, Nelson P S, Bumgarner R E, Hood L, Inexpensive handheld device for the construction of high-density nucleic acid arrays., Biotechniques, 23(6), 1087-92, December 1997 Abstract
  • Chaudhary P M, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L, Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway., Immunity, 7(6), 821-30, December 1997 Abstract
  • Cheng K C, Chiang H J, Wang K, Krug M S, Yoo T J, Hood L, TCRV and TCRJ gene usage in MBP responding T cells from (B10.PL x PL/J)F1 mice is biased towards that of B10.PL mice., Journal of Neuroimmunology, 80(1-2), 13-22, December 1997 Abstract
  • Rowen L, Mahairas G, Hood L, Sequencing the human genome., Science, 278(5338), 605-7, 24 Oct 1997 Abstract
  • Han D K, Chaudhary P M, Wright M E, Friedman C, Trask B J, Riedel R T, Baskin D G, Schwartz S M, Hood L, MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death., Proceedings of the National Academy of Sciences (USA), 94(21), 11333-8, 14 Oct 1997 Abstract
  • Liu A Y, True L D, LaTray L, Nelson P S, Ellis W J, Vessella R L, Lange P H, Hood L, van den Engh G, Cell-cell interaction in prostate gene regulation and cytodifferentiation., Proceedings of the National Academy of Sciences (USA), 94(20), 10705-10, 30 Sep 1997 Abstract
  • McIndoe R A, Stanford J L, Gibbs M, Jarvik G P, Brandzel S, Neal C L, Li S, Gammack J T, Gay A A, Goode E L, Hood L, Ostrander E A, Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25., American Journal of Human Genetics, 61(2), 347-53, August 1997 Abstract
  • Funkhouser W, Koop B F, Charmley P, Martindale D, Slightom J, Hood L, Evolution and selection of primate T cell antigen receptor BV8 gene subfamily., Molecular Phylogenetics and Evolution, 8(1), 51-64, August 1997 Abstract
  • Li L, Krantz I D, Deng Y, Genin A, Banta A B, Collins C C, Qi M, Trask B J, Kuo W L, Cochran J, Costa T, Pierpont M E, Rand E B, Piccoli D A, Hood L, Spinner N B, Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1, Nature Genetics, 16(3), 243-51, July 1997 Abstract
  • Varma C K, Li S W, Hood L E, Ladiges W, Osman G E, Rapid detection of bovine type II collagen-specific T-cell hybridomas., Hybridoma, 16(3), 287-90, June 1997 Abstract
  • Suzuki M, Avicola A K, Hood L, Loeb L A, Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I., Journal of Biological Chemistry, 272(17), 11228-35, 25 Apr 1997 Abstract
  • Osman G E, Jacobson D P, Li S W, Hood L E, Liggitt H D, Ladiges W C, SWR: an inbred strain suitable for generating transgenic mice., Laboratory Animal Science, 47(2), 167-71, April 1997 Abstract
  • Smith T M, Abajian C, Hood L, Hopper: software for automating data tracking and flow in DNA sequencing., Computer Applications In The Biosciences, 13(2), 175-82, April 1997 Abstract
  • Boysen C, Simon M I, Hood L, Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones., Genome Research, 7(4), 330-8, April 1997 Abstract
  • Liu A Y, Corey E, Vessella R L, Lange P H, True L D, Huang G M, Nelson P S, Hood L, Identification of differentially expressed prostate genes: increased expression of transcription factor ETS-2 in prostate cancer., Prostate, 30(3), 145-53, 15 Feb 1997 Abstract
  • Wang K, Gan L, Kuo C L, Hood L, A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region., Immunogenetics, 46(5), 376-82, 1997 Abstract
  • Ng W L, Schummer M, Cirisano F D, Baldwin R L, Karlan B Y, Hood L, High-throughput plasmid mini preparations facilitated by micro-mixing., Nucleic Acids Research, 24(24), 5045-7, 15 Dec 1996 Abstract
  • Huang G M, Farkas J, Hood L, High-throughput cDNA screening utilizing a low order neural network filter., Biotechniques, 21(6), 1110-4, December 1996 Abstract
  • Smith T M, Lee M K, Szabo C I, Jerome N, McEuen M, Taylor M, Hood L, King M C, Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1., Genome Research, 6(11), 1029-49, November 1996 Abstract
  • Suzuki M, Baskin D, Hood L, Loeb L A, Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure., Proceedings of the National Academy of Sciences (USA), 93(18), 9670-5, 3 Sep 1996 Abstract
  • Rowen L, Koop B F, Hood L, The complete 685-kilobase DNA sequence of the human beta T cell receptor locus., Science, 272(5269), 1755-62, 21 Jun 1996 Abstract
  • McElrath M J, Corey L, Greenberg P D, Matthews T J, Montefiori D C, Rowen L, Hood L, Mullins J I, Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen., Proceedings of the National Academy of Sciences (USA), 93(9), 3972-7, 30 Apr 1996 Abstract
  • McIndoe R A, Hood L, Bumgarner R E, An analysis of the dynamic range and linearity of an infrared DNA sequencer., Electrophoresis, 17(4), 652-8, April 1996 Abstract
  • Meyer A, Gienapp I, Cox K, Goverman J, Hood L, Whitacre C, Oral tolerance in myelin basic protein TCR transgenic mice., Annals of The New York Academy of Sciences, 778, 412-3, 13 Feb 1996 Abstract
  • Baldwin R L, Stolowitz M L, Hood L, Wisnieski B J, Structural changes of tumor necrosis factor alpha associated with membrane insertion and channel formation., Proceedings of the National Academy of Sciences (USA), 93(3), 1021-6, 6 Feb 1996 Abstract
  • Dong P, Hood L, Mcindoe R A, Detection of a large RIII-derived chromosomal segment on chromosome 10 in the H-2 congenic strain B10.RIII(71NS)/Sn, Genomics, 31(2), 266-9, 15 Jan 1996 Abstract
  • Dattamajumdar A K, Li S W, Jacobson D P, Ladiges W, Hood L E, Osman G E, Characterization of the mouse Tcra-V22 gene subfamily., Immunogenetics, 44(6), 432-40, 1996 Abstract
  • Blanchard, A.P., Kaiser, R.J., Hood, L.E., High-density oligonucleotide arrays, Biosensors and Bioelectronics, v 11, p 687-690, 1996
  • McIndoe, Richard A., Bumgarner, R.E., Welti, Russ, Hood, Leroy M.D., High-throughput genotyping: practical considerations concerning the day-to-day application, Proceedings of SPIE - The International Society for Optical Engineering, v 2680, p 341-348, 1996
  • Boysen C, Carlson C, Hood E, Hood L, Nickerson D A, Identifying DNA polymorphisms in human TCRA/D variable genes by direct sequencing of PCR products, Immunogenetics, 44(2), 121-7, 1996 Abstract
  • Dattamajumdar A K, Jacobson D P, Hood L E, Osman G E, Rapid cloning of any rearranged mouse immunoglobulin variable genes, Immunogenetics, 43(3), 141-51, 1996 Abstract
  • Charmley P, Concannon P, Hood L, Rowen L, Frequency and polymorphism of simple sequence repeats in a contiguous 685-kb DNA sequence containing the human T-cell receptor beta-chain gene complex., Genomics, 29(3), 760-5, 10 Oct 1995 Abstract
  • Cheng K C, Chiang H J, Wang K, Lee M K, Yoo T J, Hood L, Dominant usage of T-cell receptor alpha gene segments from one parent in experimental autoimmune encephalomyelitis induced in F1 mice., Annals of The New York Academy of Sciences, 756, 329-30, 7 Jul 1995 Abstract
  • McIndoe R A, Linhardt M S, Hood L, Single-tube genomic DNA isolation from whole blood without pre-isolating white blood cells., Biotechniques, 19(1), 30, 32-3, July 1995 Abstract
  • Hood L, Rowen L, Koop B F, Human and mouse T-cell receptor loci: genomics, evolution, diversity, and serendipity., Annals of The New York Academy of Sciences, 758, 390-412, 30 Jun 1995 Abstract
  • Wang K, Gan L, Lee I, Hood L, Isolation and characterization of the chicken trypsinogen gene family., Biochemical Journal, 307 ( Pt 2), 471-9, 15 Apr 1995 Abstract
  • Wang K, Gan L, Boysen C, Hood L, A microtiter plate-based high-throughput DNA purification method., Analytical Biochemistry, 226(1), 85-90, 20 Mar 1995 Abstract
  • Roach J C, Boysen C, Wang K, Hood L, Pairwise end sequencing: a unified approach to genomic mapping and sequencing., Genomics, 26(2), 345-53, 20 Mar 1995 Abstract
  • Li H, Hood L, Multiplex genotype determination at a DNA sequence polymorphism cluster in the human immunoglobulin heavy-chain region., Genomics, 26(2), 199-206, 20 Mar 1995 Abstract
  • Seto D, Seto J, Deshpande P, Hood L, DMSO resolves certain compressions and signal dropouts in fluorescent dye labeled primer-based DNA sequencing reactions, Dna Sequence, 5(3), 131-40, 1995 Abstract
  • Orr S L, Hughes T P, Sawyers C L, Kato R M, Quan S G, Williams S P, Witte O N, Hood L, Isolation of unknown genes from human bone marrow by differential screening and single-pass cDNA sequence determination., Proceedings of the National Academy of Sciences (USA), 91(25), 11869-73, 6 Dec 1994 Abstract
  • Huang G M, Wang K, Kuo C, Paeper B, Hood L, A high-throughput plasmid DNA preparation method., Analytical Biochemistry, 223(1), 35-8, 15 Nov 1994 Abstract
  • Slightom J L, Siemieniak D R, Koop B F, Hood L, The complete nucleotide sequence of cosmid vector pTL5: location and origin of its genetic components., Gene, 147(1), 77-9, 15 Sep 1994 Abstract
  • Wang K, Koop B F, Hood L, A simple method using T4 DNA polymerase to clone polymerase chain reaction products., Biotechniques, 17(2), 236-8, August 1994 Abstract
  • Nishimura M I, Kawakami Y, Charmley P, O'Neil B, Shilyansky J, Yannelli J R, Rosenberg S A, Hood L, T-cell receptor repertoire in tumor-infiltrating lymphocytes. Analysis of melanoma-specific long-term lines., Journal of Immunotherapy With Emphasis On Tumor Immunology, 16(2), 85-94, August 1994 Abstract
  • Fujiyoshi T, Hood L, Yoo T J, Restoration of brain stem auditory-evoked potentials by gene transfer in shiverer mice., Annals of Otology, Rhinology, & Laryngology, 103(6), 449-56, June 1994 Abstract
  • Koop B F, Hood L, Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA., Nature Genetics, 7(1), 48-53, May 1994 Abstract
  • Wang K, Klotz J L, Kiser G, Bristol G, Hays E, Lai E, Gese E, Kronenberg M, Hood L, Organization of the V gene segments in mouse T-cell antigen receptor alpha/delta locus., Genomics, 20(3), 419-28, April 1994 Abstract
  • Seto D, Koop B F, Deshpande P, Howard S, Seto J, Wilk E, Wang K, Hood L, Organization, sequence, and function of 34.5 kb of genomic DNA encompassing several murine T-cell receptor alpha/delta variable gene segments., Genomics, 20(2), 258-66, 15 Mar 1994 Abstract
  • Slightom J L, Siemieniak D R, Sieu L C, Koop B F, Hood L, Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs., Genomics, 20(2), 149-68, 15 Mar 1994 Abstract
  • Harrington M G, Lee K H, Bailey J E, Hood L E, Sponge-like electrophoresis media: mechanically strong materials compatible with organic solvents, polymer solutions and two-dimensional electrophoresis., Electrophoresis, 15(2), 187-94, February 1994 Abstract
  • Koop B F, Rowen L, Wang K, Kuo C L, Seto D, Lenstra J A, Howard S, Shan W, Deshpande P, Hood L, The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA., Genomics, 19(3), 478-93, February 1994 Abstract
  • Gobel T W, Chen C L, Lahti J, Kubota T, Kuo C L, Aebersold R, Hood L, Cooper M D, Identification of T-cell receptor alpha-chain genes in the chicken., Proceedings of the National Academy of Sciences (USA), 91(3), 1094-8, 1 Feb 1994 Abstract
  • Hood, Leroy, Human project: a technological challenge of striking dimension, Proceedings of the International Quantum Electronics Conference (IQEC'94), p 25, 1994
  • Wang K, Kuo C L, Cheng K C, Lee M K, Paeper B, Koop B F, Yoo T J, Hood L, Structural analysis of the mouse T-cell receptor Tcra V2 subfamily, Immunogenetics, 40(2), 116-22, 1994 Abstract
  • Wang K, Kuo C L, Koop B F, Hood L, The expression of mouse T-cell receptor TCRDV genes in BALB/c spleen, Immunogenetics, 40(4), 271-9, 1994 Abstract
  • Charmley P, Nickerson D, Hood L, Polymorphism detection and sequence analysis of human T-cell receptor V alpha-chain-encoding gene segments., Immunogenetics, 39(2), 138-45, 1994 Abstract
  • Mathisen P M, Pease S, Garvey J, Hood L, Readhead C, Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo., Proceedings of the National Academy of Sciences (USA), 90(21), 10125-9, 1 Nov 1993 Abstract
  • Wang Y, Kobori J A, Hood L, The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression., Molecular and Cellular Biology, 13(9), 5691-701, September 1993 Abstract
  • Vernooij B T, Lenstra J A, Wang K, Hood L, Organization of the murine T-cell receptor gamma locus., Genomics, 17(3), 566-74, September 1993 Abstract
  • Jensen N A, Smith G M, Garvey J S, Shine H D, Hood L, Cyclic AMP has a differentiative effect on an immortalized oligodendrocyte cell line., Journal of Neuroscience Research, 35(3), 288-96, 15 Jun 1993 Abstract
  • Drmanac R, Drmanac S, Strezoska Z, Paunesku T, Labat I, Zeremski M, Snoddy J, Funkhouser W K, Koop B, Hood L, et al, DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing [published erratum appears in Science 1994 Feb 4;163(5147):596], Science, 260(5114), 1649-52, 11 Jun 1993 Abstract
  • Beall S S, Biddison W E, McFarlin D E, McFarland H F, Hood L E, Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes., Journal of Neuroimmunology, 45(1-2), 53-60, June 1993 Abstract
  • Jensen N A, Rodriguez M L, Garvey J S, Miller C A, Hood L, Transgenic mouse model for neurocristopathy: Schwannomas and facial bone tumors., Proceedings of the National Academy of Sciences (USA), 90(8), 3192-6, 15 Apr 1993 Abstract
  • Stahl N, Baldwin M A, Teplow D B, Hood L, Gibson B W, Burlingame A L, Prusiner S B, Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing., Biochemistry, 32(8), 1991-2002, 2 Mar 1993 Abstract
  • Seto D, Koop B F, Hood L, An experimentally derived data set constructed for testing large-scale DNA sequence assembly algorithms., Genomics, 15(3), 673-6, March 1993 Abstract
  • Koop B F, Rowan L, Chen W Q, Deshpande P, Lee H, Hood L, Sequence length and error analysis of Sequenase and automated Taq cycle sequencing methods., Biotechniques, 14(3), 442-7, March 1993 Abstract
  • Goverman J, Woods A, Larson L, Weiner L P, Hood L, Zaller D M, Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity., Cell, 72(4), 551-60, 26 Feb 1993 Abstract
  • Jensen N A, Smith G M, Shine H D, Garvey J S, Hood L, Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice., Journal of Neuroscience Research, 34(3), 257-64, 15 Feb 1993 Abstract
  • Osman G E, Toda M, Kanagawa O, Hood L E, Characterization of the T cell receptor repertoire causing collagen arthritis in mice, Journal of Experimental Medicine, 177(2), 387-95, 1 Feb 1993 Abstract
  • Fors L, Hood L, Saavedra R A, Sequence similarities of myelin basic protein promoters from mouse and shark: implications for the control of gene expression in myelinating cells [published erratum appears in J Neurochem 1993 Apr;60, Journal of Neurochemistry, 60(2), 513-21, February 1993 Abstract
  • Du Z, Hood L, Wilson R K, Automated fluorescent DNA sequencing of polymerase chain reaction products, Methods In Enzymology, 218, 104-21, 1993 Abstract
  • Hood L, Koop B F, Rowen L, Wang K, Human and mouse T-cell-receptor loci: the importance of comparative large-scale DNA sequence analyses, Cold Spring Harbor Symposia On Quantitative Biology, 58, 339-48, 1993 Abstract
  • Harrington M G, Lee K H, Yun M, Zewert T, Bailey J E, Hood L, Mechanical precision in two-dimensional electrophoresis can improve protein spot positional reproducibility, Applied and Theoretical Electrophoresis, 3(6), 347-53, 1993 Abstract
  • Harrington M G, Aebersold R, Martin B M, Merril C R, Hood L, Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein, Applied and Theoretical Electrophoresis, 3(5), 229-34, 1993 Abstract
  • Kaiser R, Hunkapiller T, Heiner C, Hood L, Specific primer-directed DNA sequence analysis using automated fluorescence detection and labeled primers, Methods In Enzymology, 218, 122-53, 1993 Abstract
  • Charmley P, Wang K, Hood L, Nickerson D A, Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele, Journal of Experimental Medicine, 177(1), 135-43, 1 Jan 1993 Abstract
  • Yun M, Wu W, Hood L, Harrington M, Human cerebrospinal fluid protein database: edition 1992., Electrophoresis, 13(12), 1002-13, December 1992 Abstract
  • Wilson R K, Koop B F, Chen C, Halloran N, Sciammis R, Hood L, Nucleotide sequence analysis of 95 kb near the 3' end of the murine T-cell receptor alpha/delta chain locus: strategy and methodology., Genomics, 13(4), 1198-208, August 1992 Abstract
  • Koop B F, Wilson R K, Wang K, Vernooij B, Zallwer D, Kuo C L, Seto D, Toda M, Hood L, Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor C alpha/C delta region., Genomics, 13(4), 1209-30, August 1992 Abstract
  • Kwok P Y, Gremaud M F, Nickerson D A, Hood L, Olson M V, Automatable screening of yeast artificial-chromosome libraries based on the oligonucleotide-ligation assay., Genomics, 13(4), 935-41, August 1992 Abstract
  • Seto D, Koop B F, Seto J, Hood L, Complete nucleotide sequence of the cosmid vector pWE15A., Nucleic Acids Research, 20(14), 3786, 25 Jul 1992 Abstract
  • Harrington M G, Coffman J A, Calzone F J, Hood L E, Britten R J, Davidson E H, Complexity of sea urchin embryo nuclear proteins that contain basic domains., Proceedings of the National Academy of Sciences (USA), 89(14), 6252-6, 15 Jul 1992 Abstract
  • Orr S L, Gese E, Hood L, A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning., Molecular Biology of The Cell, 3(7), 761-73, July 1992 Abstract
  • Coffman J A, Moore J G, Calzone F J, Britten R J, Hood L E, Davidson E H, Automated sequential affinity chromatography of sea urchin embryo DNA binding proteins., Molecular Marine Biology and Biotechnology, 1(2), 136-46, April 1992 Abstract
  • Kobori J A, Hood L, Shastri N, Structure-function relationship among T-cell receptors specific for lysozyme peptides bound to Ab or Abm-12 molecules., Proceedings of the National Academy of Sciences (USA), 89(7), 2940-4, 1 Apr 1992 Abstract
  • Funkhouser S W, Concannon P, Charmley P, Vredevoe D L, Hood L, Differences in T cell receptor restriction fragment length polymorphisms in patients with rheumatoid arthritis., Arthritis and Rheumatism, 35(4), 465-71, April 1992 Abstract
  • Lessnick S L, Lyczak J B, Bruce C, Lewis D G, Kim P S, Stolowitz M L, Hood L, Wisnieski B J, Localization of diphtheria toxin nuclease activity to fragment A., Journal of Bacteriology, 174(6), 2032-8, March 1992 Abstract
  • Nickerson D A, Whitehurst C, Boysen C, Charmley P, Kaiser R, Hood L, Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping, Genomics, 12(2), 377-87, February 1992 Abstract
  • Eghtesady P, Brorson K A, Cheroutre H, Tigelaar R E, Hood L, Kronenberg M, Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells [published erratum appears in Immunogenetics 1993;38(1):80], Immunogenetics, 36(6), 377-88, 1992 Abstract
  • Hood L, Koop B, Goverman J, Hunkapiller T, Model genomes: the benefits of analysing homologous human and mouse sequences., Trends in Biotechnology, 10(1-2), 19-22, Winter 1992 Abstract
  • Mashimo H, Chorney M J, Pontarotti P, Fisher D A, Hood L, Nathenson S G, Nucleotide sequence of the BALB/c H-2T region gene, T3d., Immunogenetics, 36(5), 326-32, 1992 Abstract
  • Shine H D, Readhead C, Popko B, Hood L, Sidman R L, Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis., Journal of Neurochemistry, 58(1), 342-9, January 1992 Abstract
  • Yager T D, Nickerson D A, Hood L E, The Human Genome Project: creating an infrastructure for biology and medicine., Trends In Biochemical Sciences ), 16(12), 454, 456, 458 passim, December 1991 Abstract
  • Hunkapiller T, Hood L, LIMS and the Human Genome Project., bio/technology, 9(12), 1344-5, December 1991 Abstract
  • Wright J A, Hood L, Concannon P, Human T-cell receptor V alpha gene polymorphism., Human Immunology, 32(4), 277-83, December 1991 Abstract
  • Hunkapiller T, Kaiser R J, Koop B F, Hood L, Large-scale and automated DNA sequence determination., Science, 254(5028), 59-67, 4 Oct 1991 Abstract
  • Puckett C, Gomez C M, Korenberg J R, Tung H, Meier T J, Chen X N, Hood L, Molecular cloning and chromosomal localization of one of the human glutamate receptor genes., Proceedings of the National Academy of Sciences (USA), 88(17), 7557-61, 1 Sep 1991 Abstract
  • Aldrich C J, Hammer R E, Jones-Youngblood S, Koszinowski U, Hood L, Stroynowski I, Forman J, Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules., Nature, 352(6337), 718-21, 22 Aug 1991 Abstract
  • Lai E, Wang K, Avdalovic N, Hood L, Rapid restriction map constructions using a modified pWE15 cosmid vector and a robotic workstation., Biotechniques, 11(2), 212-4, 216-7, August 1991 Abstract
  • Puckett C, Concannon P, Casey C, Hood L, Genomic structure of the human prion protein gene [see comments], American Journal of Human Genetics, 49(2), 320-9, August 1991 Abstract
  • Charmley P, Beall S S, Concannon P, Hood L, Gatti R A, Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism., Journal of Neuroimmunology, 32(3), 231-40, June 1991 Abstract
  • Cheroutre H, Kronenberg M, Brorson K, Hunt S W 3d, Eghtesady P, Hood L, Nickerson D A, Analysis of MHC class I gene expression in adult bone marrow and fetal liver of the BALB/c mouse., Journal of Immunology, 146(10), 3263-72, 15 May 1991 Abstract
  • Aldrich C J, Lowen L C, Mann D, Nishimura M, Hood L, Stroynowski I, Forman J, The Q7 alpha 3 domain alters T cell recognition of class I antigens., Journal of Immunology, 146(9), 3082-90, 1 May 1991 Abstract
  • Mononen I, Heisterkamp N, Kaartinen V, Williams J C, Yates J R 3d, Griffin P R, Hood L E, Groffen J, Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase., Proceedings of the National Academy of Sciences (USA), 88(7), 2941-5, 1 Apr 1991 Abstract
  • Kaartinen V, Williams J C, Tomich J, Yates J R 3d, Hood L E, Mononen I, Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline., Journal of Biological Chemistry, 266(9), 5860-9, 25 Mar 1991 Abstract
  • Hunkapiller T, Kaiser R J, Koop B F, Hood L, Large-scale DNA sequencing., Current Opinion In Biotechnology, 2(1), 92-101, February 1991 Abstract
  • Sanders J Z, Petterson A A, Hughes P J, Connell C R, Raff M, Menchen S, Hood L E, Teplow D B, Imaging as a tool for improving length and accuracy of sequence analysis in automated fluorescence-based DNA sequencing, Electrophoresis, 12(1), 3-11, January 1991 Abstract
  • Ulker N, Lewis K D, Hood L E, Stroynowski I, Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen., Embo Journal, 9(12), 3839-47, December 1990 Abstract
  • Nickerson D A, Kaiser R, Lappin S, Stewart J, Hood L, Landegren U, Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay., Proceedings of the National Academy of Sciences (USA), 87(22), 8923-7, November 1990 Abstract
  • Ulker N, Hood L E, Stroynowski I, Molecular signals for phosphatidylinositol modification of the Qa-2 antigen., Journal of Immunology, 145(7), 2214-9, 1 Oct 1990 Abstract
  • Seto D, Rohrabacher C, Seto J, Hood L, Phosphorescent zinc sulfide is a nonradioactive alternative for marking autoradiograms., Analytical Biochemistry, 189(1), 51-3, 15 Aug 1990 Abstract
  • Koop B F, Wilson R K, Chen C, Halloran N, Sciammis R, Hood L, Lindelien J W, Sequencing reactions in microtiter plates., Biotechniques, 9(1), 32, 34-7, July 1990 Abstract
  • Oesch B, Teplow D B, Stahl N, Serban D, Hood L E, Prusiner S B, Identification of cellular proteins binding to the scrapie prion protein., Biochemistry, 29(24), 5848-55, 19 Jun 1990 Abstract
  • Zaller D M, Osman G, Kanagawa O, Hood L, Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies., Journal of Experimental Medicine, 171(6), 1943-55, 1 Jun 1990 Abstract
  • Gomez C M, Muggleton-Harris A L, Whittingham D G, Hood L E, Readhead C, Rapid preimplantation detection of mutant (shiverer) and normal alleles of the mouse myelin basic protein gene allowing selective implantation and birth of live young., Proceedings of the National Academy of Sciences (USA), 87(12), 4481-4, June 1990 Abstract
  • Charmley P, Chao A, Concannon P, Hood L, Gatti R A, Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms., Proceedings of the National Academy of Sciences (USA), 87(12), 4823-7, June 1990 Abstract
  • Aebersold R, Pipes G D, Wettenhall R E, Nika H, Hood L E, Covalent attachment of peptides for high sensitivity solid-phase sequence analysis., Analytical Biochemistry, 187(1), 56-65, 15 May 1990 Abstract
  • Fors L, Saavedra R A, Hood L, Cloning of the shark Po promoter using a genomic walking technique based on the polymerase chain reaction., Nucleic Acids Research, 18(9), 2793-9, 11 May 1990 Abstract
  • Wilson R K, Chen C, Avdalovic N, Burns J, Hood L, Development of an automated procedure for fluorescent DNA sequencing., Genomics, 6(4), 626-34, April 1990 Abstract
  • Goverman J, Gomez S M, Segesman K D, Hunkapiller T, Laug W E, Hood L, Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation., Cell, 60(6), 929-39, 23 Mar 1990 Abstract
  • Boylan K B, Takahashi N, Paty D W, Sadovnick A D, Diamond M, Hood L E, Prusiner S B, DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis., Annals of Neurology, 27(3), 291-7, March 1990 Abstract
  • Readhead C, Hood L, The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shimld)., Behavior Genetics, 20(2), 213-34, March 1990 Abstract
  • Kumar V, Urban J L, Horvath S J, Hood L, Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental alle, Proceedings of the National Academy of Sciences (USA), 87(4), 1337-41, February 1990 Abstract
  • Wilson R K, Chen C, Hood L, Optimization of asymmetric polymerase chain reaction for rapid fluorescent DNA sequencing., Biotechniques, 8(2), 184-9, February 1990 Abstract
  • Klein J, Benoist C, David C S, Demant P, Lindahl K F, Flaherty L, Flavell R A, Hammerling U, Hood L E, Hunt S W 3d, et al, Revised nomenclature of mouse H-2 genes., Immunogenetics, 32(3), 147-9, 1990 Abstract
  • Readhead C, Takasashi N, Shine H D, Saavedra R, Sidman R, Hood L, Role of myelin basic protein in the formation of central nervous system myelin, Annals of The New York Academy of Sciences, 605, 280-5, 1990 Abstract
  • Wilson R K, Lai E, Kim L D, Hood L, Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily, Immunogenetics, 32(6), 406-12, 1990 Abstract
  • Boylan K B, Ayres T M, Popko B, Takahashi N, Hood L E, Prusiner S B, Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism, Genomics, 6(1), 16-22, January 1990 Abstract
  • Parraga G, Horvath S, Hood L, Young E T, Klevit R E, Spectroscopic studies of wild-type and mutant "zinc finger" peptides: determinants of domain folding and structure., Proceedings of the National Academy of Sciences (USA), 87(1), 137-41, January 1990 Abstract
  • Shine H D, Readhead C, Popko B, Hood L, Sidman R L, Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system., Progress In Clinical and Biological Research, 336, 81-92, 1990 Abstract
  • Kumar V, Urban J L, Hood L, In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005], Journal of Experimental Medicine, 170(6), 2183-8, 1 Dec 1989 Abstract
  • Levedakou E N, Landegren U, Hood L E, A strategy to study gene polymorphism by direct sequence analysis of cosmid clones and amplified genomic DNA., Biotechniques, 7(5), 438-42, May 1989 Abstract
  • Fisher D A, Pecht M, Hood L, DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence., Journal of Molecular Evolution, 28(4), 306-12, April 1989 Abstract
  • Birren B W, Hood L, Lai E, Pulsed field gel electrophoresis: studies of DNA migration made with the programmable, autonomously-controlled electrode electrophoresis system., Electrophoresis, 10(5-6), 302-9, Spring 1989 Abstract
  • Biddison W E, Beall S S, Concannon P, Charmley P, Gatti R A, Hood L E, McFarland H F, McFarlin D E, The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis., Research In Immunology, 140(2), 212-5; discussion 24, February 1989 Abstract
  • Klotz J L, Barth R K, Kiser G L, Hood L E, Kronenberg M, Restriction fragment length polymorphisms of the mouse T-cell receptor gene families [published erratum appears in Immunogenetics 1989;30(3):235], Immunogenetics, 29(3), 191-201, 1989 Abstract
  • Lai E, Davi NA, Hood LE, Effect of electric field switching on the electrophoretic mobility of single-stranded DNA molecules in polyacrylamide gels, Electrophoresis, 10, 65-7, 1989 Abstract
  • Birren BW, Lai E, Hood L, Simon MI, Pulsed field gel electrophoresis techniques for separating 1- to 50-kilobase DNA fragments, Analytical Biochemistry, 177, 282-6, 1989 Abstract
  • Kaiser RJ, MacKellar SL, Vinayak RS, Sanders JZ, Saavedra RA, Hood LE, Specific-primer-directed DNA sequencing using automated fluorescence detection, Nucleic Acids Research, 17, 6087-102, 1989 Abstract
  • Brorson KA, Richards S, Hunt SW 3d, Cheroutre H, Lindahl KF, Hood L, Analysis of a new class I gene mapping to the Hmt region of the mouse, Immunogenetics, 30, 273-83, 1989 Abstract
  • Brorson KA, Hunt SW 3d, Hunkapiller T, Sun YH, Cheroutre H, Nickerson DA, Hood L, Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse, Journal Of Experimental Medicine, 170, 1837-58, 1989 Abstract
  • Lai E, Wilson RK, Hood LE, Physical maps of the mouse and human immunoglobulin-like loci, Advances In Immunology, 46, 1-59, 1989 Abstract
  • Lai E, Birren BW, Clark SM, Simon MI, Hood L, Pulsed field gel electrophoresis, Biotechniques, 7, 34-42, 1989 Abstract
  • Hunkapiller T, Goverman J, Koop BF, Hood L, Implications of the diversity of the immunoglobulin gene superfamily, Cold Spring Harbor Symposia On Quantitative Biology, 54 Pt 1, 15-29, 1989 Abstract
  • Haraguchi T, Fisher S, Olofsson S, Endo T, Groth D, Tarentino A, Borchelt DR, Teplow D, Hood L, Burlingame A, et al, Asparagine-linked glycosylation of the scrapie and cellular prion proteins, Archives Of Biochemistry And Biophysics, 274, 1-13, 1989 Abstract
  • Kumar V, Kono DH, Urban JL, Hood L, The T-cell receptor repertoire and autoimmune diseases, Annual Review Of Immunology, 7, 657-82, 1989 Abstract
  • Clayton JP, Gammon GM, Ando DG, Kono DH, Hood L, Sercarz EE, Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein, Journal Of Experimental Medicine, 169, 1681-91, 1989 Abstract
  • Urban JL, Horvath SJ, Hood L, Autoimmune T cells: immune recognition of normal and variant peptide epitopes and peptide-based therapy [retracted by Hood L, Urban JL, Horvath SJ. In: Cell 1991 Jan 25;64(2):231-2], Cell, 59, 257-71, 1989 Abstract
  • Saavedra RA, Fors L, Aebersold RH, Arden B, Horvath S, Sanders J, Hood L, The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system, Journal Of Molecular Evolution, 29, 149-56, 1989 Abstract
  • Hood L, Kumar V, Osman G, Beall SS, Gomez C, Funkhouser W, Kono DH, Nickerson D, Zaller DM, Urban JL, Autoimmune disease and T-cell immunologic recognition, Cold Spring Harbor Symposia On Quantitative Biology, 54 Pt 2, 859-74, 1989 Abstract
  • Olson M, Hood L, Cantor C, Botstein D, A common language for physical mapping of the human genome, Science, 245, 1434-5, 1989 Abstract
  • Hunkapiller T, Hood L, Diversity of the immunoglobulin gene superfamily, Advances In Immunology, 44, 1-63, 1989 Abstract
  • Beall S S, Concannon P, Charmley P, McFarland H F, Gatti R A, Hood L E, McFarlin D E, Biddison W E, The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis, Journal of Neuroimmunology, 21(1), 59-66, January 1989 Abstract
  • Hood L, Biotechnology and medicine of the future, Jama, 259, 1837-44, 1988 Abstract
  • Parraga G, Horvath SJ, Eisen A, Taylor WE, Hood L, Young ET, Klevit RE, Zinc-dependent structure of a single-finger domain of yeast ADR1, Science, 241, 1489-92, 1988 Abstract
  • Clark-Lewis I, Lopez AF, To LB, Vadas MA, Schrader JW, Hood LE, Kent SB, Structure-function studies of human granulocyte-macrophage colony-stimulating factor. Identification of residues required for activity, Journal Of Immunology, 141, 881-9, 1988 Abstract
  • Woolf T, Lai E, Kronenberg M, Hood L, Mapping genomic organization by field inversion and two-dimensional gel electrophoresis: application to the murine T-cell receptor gamma gene family, Nucleic Acids Research, 16, 3863-75, 1988 Abstract
  • Birren BW, Lai E, Clark SM, Hood L, Simon MI, Optimized conditions for pulsed field gel electrophoretic separations of DNA, Nucleic Acids Research, 16, 7563-82, 1988 Abstract
  • Landegren U, Kaiser R, Sanders J, Hood L, A ligase-mediated gene detection technique, Science, 241, 1077-80, 1988 Abstract
  • Aebersold RH, Pipes GD, Nika H, Hood LE, Kent SB, Covalent immobilization of proteins for high-sensitivity sequence analysis: electroblotting onto chemically activated glass from sodium dodecyl sulfate-polyacrylamide gels, Biochemistry, 27, 6860-7, 1988 Abstract
  • Aebersold RH, Pipes G, Hood LE, Kent SB, N-terminal and internal sequence determination of microgram amounts of proteins separated by isoelectric focusing in immobilized pH gradients, Electrophoresis, 9, 520-30, 1988 Abstract
  • Clark-Lewis I, Hood LE, Kent SB, Role of disulfide bridges in determining the biological activity of interleukin 3, Proceedings of the National Academy of Sciences (USA), 85, 7897-901, 1988 Abstract
  • Wilson RK, Yuen AS, Clark SM, Spence C, Arakelian P, Hood LE, Automation of dideoxynucleotide DNA sequencing reactions using a robotic workstation, Biotechniques, 6, 776-7 781-7, 1988 Abstract
  • Clark SM, Lai E, Birren BW, Hood L, A novel instrument for separating large DNA molecules with pulsed homogeneous electric fields, Science, 241, 1203-5, 1988 Abstract
  • Landegren U, Kaiser R, Caskey CT, Hood L, DNA diagnostics--molecular techniques and automation, Science, 242, 229-37, 1988 Abstract
  • Lai E, Birren BW, Clark SM, Hood L, Relaxation intervals alter the mobility of large DNA molecules in pulsed field gel electrophoresis, Nucleic Acids Research, 16, 10376, 1988 Abstract
  • Barry RA, Vincent MT, Kent SB, Hood LE, Prusiner SB, Characterization of prion proteins with monospecific antisera to synthetic peptides, Journal Of Immunology, 140, 1188-93, 1988 Abstract
  • Korber B, Mermod N, Hood L, Stroynowski I, Regulation of gene expression by interferons: control of H-2 promoter responses, Science, 239, 1302-6, 1988 Abstract
  • Wilson RK, Lai E, Concannon P, Barth RK, Hood LE, Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families, Immunological Reviews, 101, 149-72, 1988 Abstract
  • Lai E, Concannon P, Hood L, Conserved organization of the human and murine T-cell receptor beta-gene families, Nature, 331, 543-6, 1988 Abstract
  • Jameson BA, Rao PE, Kong LI, Hahn BH, Shaw GM, Hood LE, Kent SB, Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein, Science, 240, 1335-9, 1988 Abstract
  • Kono DH, Urban JL, Horvath SJ, Ando DG, Saavedra RA, Hood L, Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice, Journal Of Experimental Medicine, 168, 213-27, 1988 Abstract
  • Urban JL, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercarz EE, Hood L, Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy, Cell, 54, 577-92, 1988 Abstract
  • Popko B, Puckett C, Hood L, A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts, Neuron, 1, 221-5, 1988 Abstract
  • Turk E, Teplow DB, Hood LE, Prusiner SB, Purification and properties of the cellular and scrapie hamster prion proteins, European Journal Of Biochemistry, 176, 21-30, 1988 Abstract
  • Hood LE, Hunkapiller MW, Smith LM, Automated DNA sequencing and analysis of the human genome, Genomics, 1, 201-12, 1987 Abstract
  • Aebersold RH, Leavitt J, Saavedra RA, Hood LE, Kent SB, Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose, Proceedings of the National Academy of Sciences (USA), 84, 6970-4, 1987 Abstract
  • Klein MH, Concannon P, Everett M, Kim LD, Hunkapiller T, Hood L, Diversity and structure of human T-cell receptor alpha-chain variable region genes, Proceedings of the National Academy of Sciences (USA), 84, 6884-8, 1987 Abstract
  • Kuo CL, Hood L, Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes, Proceedings of the National Academy of Sciences (USA), 84, 7614-8, 1987 Abstract
  • Passmore HC, Kobori JA, Zimmerer EJ, Spinella DG, Hood L, Molecular characterization of meiotic recombination within the major histocompatibility complex of the mouse: mapping of crossover sites within the I region, Biochemical Genetics, 25, 513-26, 1987 Abstract
  • Smith, Lloyd M., Sanders, Jane Z., Kaiser, Robert J., Hughes, Peter, Dodd, Chris, Connell, Charles R., Heiner, Cheryl, Kent, Stephen B. H., Hood, Leroy E., FLUORESCENCE DETECTION IN AUTOMATED DNA SEQUENCE ANALYSIS., Nature, v 321, p 674-679, 1986
  • Stroynowski I, Forman J, Goodenow R S, Schiffer S G, McMillan M, Sharrow S O, Sachs D H, Hood L, Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens., Journal of Experimental Medicine, 161(5), 935-52, 1 May 1985 Abstract
  • Goverman J, Minard K, Shastri N, Hunkapiller T, Hansburg D, Sercarz E, Hood L, Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction., Cell, 40(4), 859-67, April 1985 Abstract
  • Kobori JA, Winoto A, McNicholas J, Hood L, Molecular characterization of the recombination region of six murine major histocompatibility complex (MHC) I-region recombinants, Journal Of Molecular And Cellular Immunology, 1, 125-35, 1984 Abstract
  • Hood, Leroy E., BIOTECHNOLOGY AND MEDICINE OF THE FUTURE., Annual Conference on Mass Spectrometry and Allied Topics, p 18, 1983
  • Kim S, Davis M, Sinn E, Patten P, Hood L, Antibody diversity: somatic hypermutation of rearranged VH genes, Cell, 27, 573-81, 1981 Abstract

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