Hans-Joachim Lehmler |
|
University of Iowa Interdisciplinary Graduate Program in Human Toxicology Faculty Member University of Iowa Graduate College Associate Member of the Graduate FacultyAppointed: 2005 University of Iowa College of Public Health Occupational & Environmental Health Adjunct Assistant ProfessorAppointed: 2005 |
Mailing Address222 IREH Occupational and Environmental Health University of Iowa Iowa City, Iowa 52242United States | Contact Information |
Qualifications
Ph.D., University of Bonn, Organic Chemistry, 1995.
M.S., University of Bonn, Organic Chemistry, 1993.
B.S., University of Bonn, Chemistry, 1990.
Expertise and Research Interests
Dr. Lehmler's primary area of interest is the synthesis of halogenated organic compounds and their utilization for the preparation of novel, nanoscale materials, their use for biomedical applications, and their impact in the environment and for human health. He is particularly interested in the two- and three-dimensional self-assembly of fluorinated surfactants. The unique mesophases formed by fluorinated surfactants make them useful and unique templates for the synthesis of ordered nanoscale ceramics. From a biomedical point of view he is interested in the physicochemical interaction of halogenated compounds with hydrocarbon compounds such as biological lipids and proteins. An understanding of these factors is important to understand the biological effects of a large number of halogenated, persistent organic pollutants (POPs). For example, enantioselective distribution of PCB atropisomers in vivo may be determined by protein binding and/or solubility in cellular fat and lipid storage compartments. Interactions of fluorinated materials with lipid mono- and bilayers may alter their function and cause (adverse) biological effects. Other areas of research are focused on the synthesis of partly fluorinated prodrugs and surfactants for the pulmonary administration of drugs during liquid ventilation.
Other Expertise
Book Chapters:
H.-J. Lehmler, Production of fluorinated surfactants via electrochemical fluorination. In: Handbook of Detergents-Part F Production (Editor: U. Zoller), Taylor & Francis Group LLC, Boca Raton, 2008, in press.
H.-J. Lehmler, L.W. Robertson, Atropisomers of PCBs. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 62-65.
J.M. Arif, H.-J. Lehmler, L.W. Robertson, R.C. Gupta, Covalent interaction of synthetic benzoquinones and hydroquinones of polychlorinated biphenyls (PCBs) with DNA. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 403-404.
R. Slim, M. Toborek, L.W. Robertson, H.-J. Lehmler, B. Hennig, Cellular glutathione status modulates PCB-induced stress response and apoptosis in vascular endothelial cells. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 313-315.
H.-J. Lehmler, C.P. Brock, B. Patrick, L.W. Robertson, Synthesis of polychlorinated biphenyls (PCBs) and their metabolites using the Suzuki coupling. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 57-60.
H.-J. Lehmler, Production of fluorinated surfactants via electrochemical fluorination. In: Handbook of Detergents-Part F Production (Editor: U. Zoller), Taylor & Francis Group LLC, Boca Raton, 2008, in press.
H.-J. Lehmler, L.W. Robertson, Atropisomers of PCBs. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 62-65.
J.M. Arif, H.-J. Lehmler, L.W. Robertson, R.C. Gupta, Covalent interaction of synthetic benzoquinones and hydroquinones of polychlorinated biphenyls (PCBs) with DNA. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 403-404.
R. Slim, M. Toborek, L.W. Robertson, H.-J. Lehmler, B. Hennig, Cellular glutathione status modulates PCB-induced stress response and apoptosis in vascular endothelial cells. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 313-315.
H.-J. Lehmler, C.P. Brock, B. Patrick, L.W. Robertson, Synthesis of polychlorinated biphenyls (PCBs) and their metabolites using the Suzuki coupling. In: PCBs: Recent Advances in the Environmental Toxicology and Health Effects (Editors: L.W. Robertson, L. G. Hansen), University Press of Kentucky, Lexington, 2001, p. 57-60.
Keywords
COS Keywords:
Chemical Sciences, Environmental Health, Medicinal Chemistry, Occupational Health and Safety, Organic Chemistry, Toxicology.Memberships
American Chemical Society
Geographical Society of Cologne
German Chemical Society
Honors and Awards
1995, Post-exam Scholarship,
Fonds der Chemischen Industrie
1994-1995,
Fellowship,
Land Nordrhein Westfalen
1993, Fellowship,
Theodor-Laymann Foundation
1987, Award 'energy technology' in the regional competition,
Jugend forscht
Previous Positions
2003-2005, Associate Research Scientist,
University of Iowa,
College of Public Health,
Occupational & Environmental Health
2000-2003, Associate Member of the Graduate Faculty,
University of Kentucky,
Graduate Center for Toxicology
1999-2003, Research Assistant Professor,
University of Kentucky,
Graduate Center for Toxicology
1998-1998, Postdoctoral Scholar,
University of Kentucky,
Graduate Center for Toxicology
1998-1998, Postdoctoral Scholar,
University of Kentucky,
College of Arts & Sciences,
Chemistry
1997-1997, Postdoctoral Scholar,
University of Kentucky,
College of Pharmacy,
Medicinal Chemistry and Pharmaceutics
1996-1997, Postdoctoral Scholar,
University of Kentucky,
College of Arts & Sciences,
Chemistry
1995-1996, Assistant,
University of Bonn
Funding Received
- National Science Foundation: NIRT (Nanoscale Interdisciplinary Research Teams): Tailored fluorinated surfactant templates for the design of ordered nanoporous ceramics (PI: Rankin), $1,100,000, 8/02 to 7/06.
- American Lung Association of Kentucky and American Lung Association National Office: Pulmonary delivery of drugs with perfluorocarbon vehicle (PI: Lehmler), $49,594, 7/01 to 6/03.
- University of Kentucky Medical Center Research Fund: Prodrugs for Pulmonary Administration by Liquid Ventilation (PI: Lehmler), $14,977, 7/00 to 6/01.
- NIEHS: Core project #B in: Superfund Chemicals: Transport, Metabolism and Toxicity (PI: Robertson, Co-Project Leader: Lehmler), $50,775 (1st year), 4/00 to 3/05.
- NIEHS: Superfund Chemicals: Transport, Metabolism and Toxicity (PI: Robertson), $10,502,197, 4/00 to 3/05.
- Environmental Health Sciences Research Center (EHSRC) pilot grant: Are individual PCB congeners Substrates for the Multidrug Resistance Transporter mdr1a/b in Mice? (PI: I. Kania-Korwel), $30,000, 2007 to 2008.
- Office of the Vice President for Research, University of Iowa: Delivery of anticancer drugs using perfluorocarbon vehicle (PI: Lehmler), $30,000, 2006 to 2007.
- NIEHS: Iowa Superfund Basic Research Program: Semi-volatile PCBs: Sources, Exposures, Toxicities (PI: L.W. Robertson), $2,998,990 (1st yr), 2006 to 2010.
- NIEHS: Distribution of PCB atropisomers (PI: Lehmler), $645,756, 2004 to 2009.
- NSF ($243,391)/University of Iowa cost share ($104,310): Acquisition of Automated and High Sensitivity Instrumentation for the Analysis of Organic Compounds in Complex Matrices (PI: Hornbuckle), $347,700, 2004 to 2006.
- Center for Health Effects of Environmental Contamination (CHEEC): Development of a Passive Air Sampler for Measuring PCBs in Air (PI: Hornbuckle), $23,700, 2004 to 2005.
- Center for Health Effects of Environmental Contaimination: Disposition and Metabolism of N-Methyl Perfluorooctane Sulfonamidoethanol (NMEFOSE) in Rats (PI: Lehmler), $19,950, 1/03 to 12/03.
Publications
- Lehmler HJ, Xu L, Vyas SM, Ojogun VA, Knutson BL, Ludewig G (Apr 2008) Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle., International journal of pharmaceutics, 353 (1-2), 35-44
- Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H-J (2008) Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice, Food Chem Toxicol, 46 (2), 637-44
- Shaikh NS, Parkin S, Luthe G, Lehmler H-J (2008) The three-dimensional structure of 3,3',4,4'-tetrachlorobiphenyl, a dioxin-like polychlorinated biphenyl (PCB), Chemosphere, 70 (9), 1964-8
- Kania-Korwel I, Hornbuckle K, Robertson L, Lehmler H-J (2008) Dose-dependent enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl in female mice, Environ Toxicol Chem, 27 (2), 299-305
- Xie W, Kania-Korwel I, Bummer PM, Lehmler HJ (2007) Effect of potassium perfluorooctanesulfonate, perfluorooctanoate and octanesulfonate on the phase transition of dipalmitoylphosphatidylcholine (DPPC) bilayers, Biochim Biphys Acta, 1768 (5), 1299-308
- Lehmler HJ (2007) Perfluorocarbon compounds as vehicles for pulmonary drug delivery, Expert Opin Drug Deliv, 4 (3), 247-62
- Vyas SM, Kania-Korwel I, Lehmler HJ (2007) Differences in the isomer composition of perfluoroctanesulfonyl (PFOS) derivatives, J Environ Sci Health A Tox Hazard Subst Environ Eng, 42 (3), 249-55
- Ghosh K, Vyas SM, Lehmler HJ, Rankin SE, Knutson BL (2007) Tailoring porous silica films through supercritical carbon dioxide processing of fluorinated surfactant templates, J Phys Chem B Condens Matter Mater Surf Interfaces Biophys, 111 (2), 363-70
- Glauert HP, Tharappel JC, Lu Z, Stemm D, Banerjee S, Chan LS, Lee EY, Lehmler H-J, Robertson LW, Spear BT (2007) Role of oxidative stress in the promoting activities of PCBs, Environ Toxicol Pharmacol, In Press
- Osei-Prempeh G, Lehmler H-J, Rankin SE, Knutson BL (2007) Application of fluoro-functionalized mesoporous silica to fluorous separations. ASPA article (doi: 10.1021/ie070538e), Ind Eng Chem Res
- Sadeghi-aliabadi H, Chan K, Lehmler H-J, Robertson LW, O'Brien PJ (2007) Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes, Chemico-Biological Interactions, 167, 184-92
- Kania-Korwell, Shaikh NS, Hornbuckle KC, Robertson LW, Lehmler HJ (2007) Enantioselective disposition of PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration, Chirality, 19 (1), 56-66
- Shaikh NS, Parkin S, Lehmler H-J (2007) Tetrakis(2,4,5-trichlorophenyl)stannane, Acta Cryst. E, 63, m1584-6
- Lehmler H-J, Rama Rao VVVNS, Nauduri D, Vargo JD, Parkin S (2007) Synthesis and structure of environmentally relevant perfluorinated sulfonamides, J Fluorine Chem, 128, 595-607
- Song Y, Parkin S, Lehmler H-J (2007) 4-Bromo-2-chloro-1-methoxybenzene, Acta Cryst. E, 63, o2091-2
- Shaikh NS, Parkin S, Lehmler H-J (2007) N.S. Shaikh, S. Parkin, H.-J. Lehmler, Tetrakis(4-fluorophenyl)stannane, Acta Cryst. E, 63, m927-8
- Bunaciu RP, Tharappel JC, Lehmler H-J, Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP (2007) The effect of eietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats, Toxicology, 239, 147-55
- Liu Y, Apak TI, Lehmler HJ, Robertson LW, Duffel MW (2006) Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1, Chem Res Toxicol, 19 (11), 1420-5
- Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N (2006) Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: Altering enzyme function by blocking the N-Terminal Protein Gate, Biochemistry, 45 (33), 10140-52
- Lehmler HJ, Xie W, Bothun GD, Bummer PM, Knutson BL (2006) Mixing of perfluorooctanesulfonic acid (PFOS) potassium salt with dipalmitoyl phosphatidylcholine (DPPC), Colloids Surf B Biointerfaces, 51 (1), 25-9
- Vyas SM, Parkin S, Robertson LW, Lehmler H-J (2006) 4 -Chloro-2',3'-dimethoxybiphenyl, Acta Crystallographica, E (E62), o3639-o3640
- Kania-Korwel I, Garrison AW, Avants JK, Hornbuckle KC, Robertson LW, Sulkowski WW, Lehmler H-J (2006) Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat, Environmental Science & Technology, 40, 3704-10
- Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler H-J, Robertson LW, Gregoraszczuk (2006) Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary, Toxicol Lett, 166, 200-11
- Shaikh NS, Swenson DC, Lehmler H-J (2006) 2,3,6-Trichloroiodobenzene, Acta Cryst. E, 62, o4672-73
- Vyas SM, Parkin S, Robertson LW, Lehmler H-J (2006) 2,5-Dichloro-4'-methoxybiphenyl, Acta Cryst E, 62, o4162-63
- Shaikh NS, Parkin S, Lehmler H-J (2006) The Ullmann coupling Reaction: A new approach to tetraarylstannanes, Organometallics, 25, 4207-14
- Feliciano J, Xu S, Guan X, Lehmler H-J, Bashas LG, Daunert S (2006) ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls, Anal Bioanal Chem, 385, 807-13
- Vyas SM, Parkin S, Lehmler H-J (2006) 2,2',3,4,4',5,5'-Heptachlorobiphenyl (PCB 180), Acta Cryst E, 62, 2905-6
- Vyas SM, Turánek J, Knötigová P, Kaná A, Kvardová V, Koganti V, Rankin SE, Knutson BL, Lehmler H-J (2006) Synthesis and biocompatibility evaluation of partially fluorinated pyridinium bromides, New J Chem, 30, 944-51
- Shaikh NS, Parkin S, Lehmler H-J (2006) 2,2',3,3',6,6'-Hexachloro-5-nitro-1,1'-biphenyl (5-Nitro PCB 136), Acta Cryst E, 62, o662-3
- Kunz S, Schmitz H-J, Buchmann A, Schwarz M, Schilling B, Päpke O, Lehmler H-J, Robertson LW, Schrenk D (2006) Tumor promoting potency of PCBs 28 and 101 in rat liver, Toxicology Letters, 164, 133-43
- Ptak A, Ludewig G, Robertson LW, Lehmler H-J, Gregoraszczuk EL (2006) In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity, Toxicology Letters, 164, 113-22
- Wang L-Q, Lehmler H-J, Robertson LW, James MO (2006) Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate, Chem-Biol Interactions, 159, 235-46
- Tan B, Vyas SM, Lehmler HJ, Knutson BL, Rankin SE (2005) Unusual dependence of particle architecture on surfactant concentration in partially fluorinated decylpyridinium templated silica, Journal of Physical Chemistry B, 109 (49), 23225-32
- Lehmler HJ, Bummer PM (2005) Lehmler HJ. Bummer PM. Interaction of a partially fluorinated long-chain nicotinate with dipalmitoylphosphatidylcholine, Journal of Lipid Research, 46 (11), 2415-22
- Osei-Prempeh G, Lehmler HJ, Knutson BL, Rankin SE (2005) Fluorinated surfactant templating of vinyl-functionalized nanoporous silica, Microporous & Mesoporous Materials, 85 (1-2), 16-24
- Ghosh K, Lehmler HJ, Rankin SE, Knutson BL, Supercritical Carbon Dioxide Processing of Fluorinated Surfactant Templated Mesoporous Silica Thin Films, Langmuir, 21(14), 6145-9, 5 Jul 2005
- Wang LQ, Lehmler HJ, Robertson LW, Falany CN, James MO, In Vitro Inhibition of Human Hepatic and CDNA-expressed Sulfotransferase
Activity With 3-hydroxybenzo[a]pyrene By Polychlorobiphenylols., Environmental Health Perspectives, 113(6), 680-7, Jun 2005
- Kania-Korwel I, Hornbuckle KC, Peck A, Ludewig G, Robertson LW, Sulkowski WW, Espandiari P, Gairola CG, Lehmler HJ, Congener-specific Tissue Distribution of Aroclor 1254 and a Highly Chlorinated Environmental PCB Mixture in Rats, Environmental Science & Technology, 39(10), 3513-20, 15 May 2005
- Tan B, Lehmler HJ, Vyas SM, Knutson BL, Rankin SE, Controlling Nanopore Size and Shape By Fluorosurfactant Templating of Silica, Chemistry of Materials, 17(4), 916-25, 22 Feb 2005
- Tharappel JC, Stemm DN, Bunaciu RP, Robertson LW, Lehmler H-J, Spear BT, Glauert HP,, Effects of Selected Dietary Antioxidant Phytochemicals on the Hepatic Tumor Promoting Activity of PCB – 77, Toxicol Sci, 84(1-S), 303, 2005
- Stemm DN, Robertson LW, Tharappel JC, Spear BT, Lehmler H-J, Glauert HP, Effects of Dietary Selenium on the Hepatic Tumor Promoting Activities of PCBs, Toxicol Sci, 84(1-S), 303, 2005
- Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S,Tharappel JC, Stemm DN, Lehmler H-J, Lee EY; Robertson LW, Spear BT, Dietary Vitamin E Does Not Inhibit the Promotion of Liver Carcinogenesis By Polychlorinated Biphenyls in Rats, Journal of Nutrition, 135, 283-6, 2005
- Lehmler H-L, Robertson LW, Garrison AW, Kodavanti PRS, Effects of PCB 84 Enantiomers on [3H] Phorbol Ester Binding in Rat Cerebellar Granule Cells and 45Ca2+-uptake in Rat Cerebellum, Toxicology Lett, 156, 391-400, 2005
- Lehmler H-J,Fortis-Santiago A, Nauduri D, Bummer PM, Interaction of Long-chain Nicotinates With Dipalmitoylphosphatidylcholine (DPPC), J Lipid Res, 46, 535-46, 2005
- Lehmler H-L, Synthesis of Environmentally Relevant Fluorinated Surfactants, Chemosphere, 58, 1471-96, 2005
- Ptak A,Ludewig G,Lehmler H-J,Wójtowicz A, Robertson LW, Gregoraszczuk EL, Comparison of the Actions of 4-chlorobiphenyl and Its Hydroxylated Metabolites on Estradiol Secretion By Ovarian Follicles in Primary Cells in Culture, Reproductive Toxicology, 20, 57-64, 2005
- Lehmler H-J, Robertson LW, Parkin S (2005) 2,2',3,3',6-Pentachlorobiphenyl (PCB 84), Acta Crystallographica Section, E61, o3025-6
- Tan B, Lehmler H-J, Vyas SM, Knutson Bl, Ranking SE (2005) Fluorinated-surfactant-templated synthesis of hollow silica particles with a single layer of mesopores in their shells, Adv Mater, 17, 2368-71
- Lehmler H-J, Parkin S (2005) 3,3',5,5'-tetrabromo-4,4'-dihydroxybiphenyl, Acta Cryst E, 61, o2828-30
- Lehmler H-J, Bummer PM (2005) Mixing behavior of 10-(perfluorohexyl)-decanol and DPPC, Colloids Surf B, 44, 74-81
- Tan B, Lehmler H-J, Vyas SM, Knutson BL, Rankin SE (2005) Large- and small- nanopore silica prepared with a short-chain cationic fluorinated surfactant, Nanotechnology, 16, S502-7
- Rankin SE, Bing T, Lehmler HJ, Hindman KP, Knutson BL, Well-ordered mesoporous silica prepared by cationic fluorinated surfactant templating, Microporous & Mesoporous Materials, 73(3), 197-202, 06 Sep 2004
- Kania-Korwel I, Parkin S, Robertson LW, Lehmler HJ, 2,4,5-Trichlorobiphenyl, Acta Crystallographica, Section e (Structure Reports Online), 60(Part 9), O1652-3, September 2004
- Lehmler HJ, Bummer PM, Mixing of perfluorinated carboxylic acids with dipalmitoylphosphatidylcholine, Biochimica et Biophysica Acta - Biomembranes, 1664(2), 141-9, 30 Aug 2004
- Tan B, Dozier A, Lehmler HJ, Knutson BL, Rankin SE, Elongated silica nanoparticles with a mesh phase mesopore structure by fluorosurfactant templating, Langmuir, 20(17), 6981-4, 17 Aug 2004
- Lehmler HJ, Parkin S, Brock CP, Packing conflicts in the Z' = 5 structure of CF(3)(CF(2))(3)(CH(2))(10)COOH, Acta Crystallographica. Section B, Structural Science, 60(Pt 3), 325-32, 2004
- Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Bansal R, Zoeller RT, Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors, Environmental Health Perspectives, 112(5), 516-23, April 2004
- Espandiari P, Glauert HP, Lehmler H-J, Lee EY, Srinivasan C, Robertson LW, Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model, Toxicological Sciences, 79, 41-6, 2004
- Kania-Korwel I, Parkin S, Robertson LW, Lehmler H-J, Synthesis of polychlorinated biphenyls and their metabolites with a modified Suzuki-coupling, Chemosphere, 56, 735-44, 2004
- Glauert H, Tharappel J, Stemm D, Lehmler H, Robertson L, Spear B, Effect of dietary antioxidants on the promotion of hepatocarcinogenesis by PCBs, Organohalogen Compounds, 66, 3148-52, 2004
- Ptak A, Ludewig G, Lehmler H-J, Robertson LW, Gregoraszczuk EL, Effect of PCB3 and its hydroxylated metabolites on estradiol secretion, cell viability, and caspase-3 activity in porcine small follicles, Organohalogen Compounds, 66, 2973-8, 2004
- Fonnum F, Dreiem A, Lehmler H-J, Mariussen E, Rykken S, L Robertson, The effect of hydroxylated PCBs on DCF-fluorescence and cell death in cultured rat cerebellar granule cells, Organohalogen Compounds, 66, 3120-3, 2004
- Kunz S, Schmitz H-J, Buchmann A, Schwarz M, Schilling B, Päpke O, Robertson LW, Lehmler H-J, Schrenk D, Analysis of the tumor-promoting potency of 2,4,4’-trichlorobiphenyl and 2,2’,4,5,5’-pentachlorobiphenyl in rat liver, Organohalogen Compounds, 66, 3603-9, 2004
- Kania-Korwel I, Ludewig G, Robertson LW, Hornbuckle KC, Peck A, Espandiari P, Gairola CG, Sulkowski WW, Lehmler H-J, Biochemical effects of an environmental Chlorofen mixture in comparison with Aroclor 1254 in rats, Organohalogen Compounds, 66, 2985-92, 2004
- Kania-Korwel I, Hornbuckle KC, Peck A, Sulkowski WW, Ludewig G, Robertson LW, Lehmler H-J, Comparison of PCB congener profiles in tissues of PCB-treated rats, Organohalogen Compounds, 66, 2915-22, 2004
- Lehmler H-J, Kania-Korwel I, Avants JK, Hornbuckle KC, Sulkowski WW, Robertson LW, Garrison WA, Distribution of chiral PCBs in selected tissues in the laboratory rat, Organohalogen Compounds, 66, 452-9, 2004
- Kania-Korwell, Robertson LW, Lehmler H-J, 2,4,6-Trichloro-iodobenzene, Acta Cryst, E59(Part 11), o1770-o1771, November 2003
- Espandiari P, Glauert HP, Lehmler HJ, Lee EY, Srinivasan C, Robertson LW, Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant
hepatocyte model, Toxicology and Applied Pharmacology, 186(1), 55-62, January 2003
- Arif JM, Lehmler HJ, Robertson LW, Gupta RC, Interaction of benzoquinone- and hydroquinone-derivatives of lower
chlorinated biphenyls with DNA and nucleotides in vitro, Chemico-biological Interactions, 142(3), 307-16, January 2003
- Lehmler HJ, Price DJ, Garrison AW, Birge WJ, Robertson LW, Distribution of PCB 84 Enantiomers in C57Bl/6 Mice, Fresenius Environmental Bulletin, 12, 254-60, 2003
- Kania-Korwel I, Lehmler HJ, Robertson LW, 2,4,5-trichloro-1iodobenzene, Acta Crystallographica, Section e Structure(59 Part 7), 01048-9, 2003
- van den Hurk P, Kubiczak GA, Lehmler HJ, James MO, Hydroxylated polychlorinated biphenyls as inhibitors of the sulfation and
glucuronidation of 3-hydroxy-benzo[a]pyrene, Environmental Health Perspectives, 110(4), 343-8, April 2002
- Lehmler HJ, Parkin S, Robertson LW, The three-dimensional structure of 3, 3', 5'-trichloro-4-methoxybiphenyl,
a 'coplanar' polychlorinated biphenyl (PCB) derivative, Chemosphere, 46(3), 485-8, January 2002
- Lehmler HJ, Robertson LW, Parkin S, Brock CP, A Z’=4 structure without obvious pseudosymmetry: Implications for the formation of solid-state compounds, Acta Crystallographica, B58, 140-7, 2002
- Lehmler HJ, Robertson LW, Parkin S, 2-(3,4-Dichlorophenyl)-1,4-benzoquinone, Acta Crystallographica, E58, o366-7, 2002
- Lehmler HJ, Bergosh R, Meier MS, Carlson RMK, A novel three-step synthesis of linear and branched long-chain alkanes, Bioscience, Biotechnology, and Biochemistry, 66, 523-31, 2002
- Lehmler HJ, Bummer PM, Mixing of partially fluorinated carboxylic acids with their hydrocarbon analogs at the air-water interface, Journal of Colloid and Interface Science, 249, 381-7, 2002
- Tampal N, Lehmler HJ, Espandiari P, Malmberg T, Robertson LW, Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs), Organohalogen Compounds, 55, 453-6, 2002
- Machala M, Blaha L, Pliskova M, Vondraeek J, Lehmler HJ, Robertson LW, Malmberg T, Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines, Organohalogen Compounds, 56, 25-8, 2002
- Lehmler HJ, Bummer PM, Behavior of 10-(perfluorohexyl)-decanol, a partially fluorinated analog of hexadecanol, at the air-water interface, Journal of Fluorine Chemistry, 117, 17-22, 2002
- Arif JM, Lehmler HJ, Robertson LW, Gupta RC, Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro, Chem-Biol Interactions, 142, 307-16, 2002
- Tampal N, Lehmler HJ, Espandiari P, Malmberg T, Robertson LW, Glucuronidation of hydroxylated polychlorinated biphenyls, Chemical Research in Toxicology, 15, 1259-66, 2002
- Lehmler HJ, Robertson LW, Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling, Chemosphere, 45(8), 1119-27, December 2001
- Lehmler HJ, Robertson LW, Synthesis of polychlorinated biphenyls (PCBs) using the Suzuki-coupling, Chemosphere, 45(2), 137-43, October 2001
- Oakley GG, Roe AL, Blouin RA, Twaroski TP, Ganguly TC, Vore M, Lehmler HJ, Robertson LW, 2,4,4'-trichlorobiphenyl increases STAT5 transcriptional activity, Molecular Carcinogenesis, 30(4), 199-208, April 2001
- Srinivasan A, Lehmler HJ, Robertson LW, Ludewig G, Production of DNA strand breaks in vitro and reactive oxygen species in
vitro and in HL-60 cells by PCB metabolites, Toxicological Sciences : an Official Journal of the Society of Toxicology., 60(1), 92-102, March 2001
- Lehmler HJ, Oyewumi MO, Jay M, Bummer PM, Behavior of partially fluorinated carboxylic acids at the air-water interface, Journal of Fluorine Chemistry, 107, 141-6, 2001
- Lehmler HJ, Parkin S, Robertson LW, 2,3,4’-Trichlorobiphenyl, Acta Crystallographica, E57, o111-2, 2001
- Lehmler HJ, Robertson LW, Parkin S, 4-Chloro-3’,4’-dihydroxybiphenyl, Acta Crystallographica, E57, o590-1, 2001
- Slim R, Toborek M, Robertson LW, Lehmler HJ, Hennig B, Cellular glutathione status modulates polychlorinated biphenyl-induced
stress response and apoptosis in vascular endothelial
cells, Toxicology and Applied Pharmacology, 166(1), 36-42, July 2000
- Lehmler HJ, Jay M, Bummer PM, Mixing of partially fluorinated carboxylic acids and their hydrocarbon analogs with diplamitoylphosphatidylcholine at the air-water interface, Langmuir, 16, 10161-6, 2000
- Lehmler HJ, Parkin S, 1-octanoyl-5-fluorouracil, Acta Crystallographica, C56, e518-9, 2000
- Ludewig G, Lehmler HJ, Bergman A, Robertson LW, Metabolites of biphenyls and halogenated biphenyls: reactivity of dihydroxylated biphenyls in vitro and in vivo, Organohalogen Compounds, 42, 445-58, 1999
- Williams TD, Jay M, Lehmler HJ, Clark ME, Stalker DJ, Bummer PM, Solubility enhancement of phenol and phenol derivatives in perfluorooctyl
bromide, Journal of Pharmaceutical Sciences, 87(12), 1585-9, December 1998
- Lehmler HJ, Nieger M, Breitmaier E, Tricarbonyls: Reactive model dienophiles for asymmetric Diels-Alder reactions, Synthesis, 105-110, 1996
Profile Details
Last Updated: 7/10/2008
COS Expertise ID #1094310
Reference this profile directly: http://myprofile.cos.com/lehmler
Individual Expertise profile of Hans-Joachim Lehmler, Copyright Hans-Joachim Lehmler.
© COS ExpertiseTM, 2008, ProQuest LLC All rights reserved.