Dr. Wendy M. Leisenring

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Fred Hutchinson Cancer Research Center
Clinical Research Division
Clinical Statistics
Associate MemberAppointed: 2001
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Associate ProfessorAppointed: 2002
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics
Associate Member (Joint Appointment)Appointed: 2001
Professional Headshot of Wendy M. Leisenring

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D5-360
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-4374
Fax: (206) 667-6358
wleisenr@fhcrc.org

Qualifications

Sc.D., Harvard University, Biostatistics, 1992.
M.S., Harvard University, Biostatistics, 1990.
A.B., Bryn Mawr College, Mathematics, 1986.

Expertise and Research Interests

Within the framework of a variety of collaborative and methodological projects, my overall research goals are to ensure that scientific research is carried out that utilizes appropriate statistical methodology. Sometimes this is achieved through application of existing statistical methods and in other instances it involves development of new methodology. My research encompasses several collaborative and methodological subject areas: clinical research related to stem cell transplantation, reproductive epidemiology and developing new statistical methods for the analysis of medical diagnostic test data.

A major focus of my research is collaborative work with clinical investigators who are based in the Center's Clinical Research Division (CRD). CRD is world renown for its pioneering work in stem cell transplantation where the procedure was first used approximately 30 years ago. In collaboration with principal investigators from several large program project grants in the CRD, I carry out the design and analysis of Phase I, II and III clinical trials which aim to further expand and improve our ability to treat patients with a wide range of diseases and prognoses. Over the long history of transplantation at the Center, our group has also developed a large database of patient data that allows us to carry out retrospective analyses to generate hypotheses for future prospective studies.

For patients undergoing stem cell transplantation, infection is a very serious development and more accurate and earlierdetection of disease is an important research topic amongst infectious disease researchers. More globally, diagnostic and screening programs are becoming a large and costly component of our health care system. It is therefore important that research leading to the implementation of new tests be rigorous in determining the accuracy of the tests. A primary goal of my methodological research is to develop statistical methods that allow researchers to answer relevant clinical questions about diagnostic tests. We have described marginal regression methods for the comparison of multiple diagnostic tests and evaluation of covariate impacts on sensitivity and specificity parameters when one or more test outcomes are obtained on each subject studied. Additionally, we developed a new regression methodology for diagnostic likelihood ratios, quantities that describe the degree to which the outcome of a diagnostic test revises the pre-test odds of disease. Most recently, we have developed a statistical test for the comparison of predictive values of diagnostic tests when the data was obtained under paired study designs.

Keywords

COS Keywords:

Biostatistics, Public Health.

Additional Terms:

Biostatistics, Clinical Trials, Hematopoetic Stem Cell Transplant, Medical Diagnostic Tests.

Memberships

American Statistical Association
Biometric Society
Society for Clinical Trials

Honors and Awards

1990-1991, Training Grant Recipient, National Institute of Environmental Health
1989-1991, Harvard University Teaching Fellow,
1988-1990, Training Grant Recipient, National Cancer Institute
1992, Student Prize for Best Paper, ENAR Biometrics Society
1992, Travel Award Recipient, ENAR Biometrics Society
1993, Teratology Society Young Investigators Travel Award,
1994, Best Presentation Award, Society of Toxicology, Risk Assessment Specialty Section

Previous Positions

1998-2002, Affiliate Assistant Professor, University of Washington, Biostatsitics
1997-2001, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1994-1997, Associate in Clinical Research, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1993-1994, Visiting Investigator, Fred Hutchinson Cancer Research Center

Publications

  • Upton A, Leisenring W, Marr KA (2006) 1→3) ß-D-glucan assay in the diagnosis of invasive fungal infections, Clinical Infectious Diseases, 42, 1054-1056
  • Bowers DC, Liu Y, Leisenring W, Stovall M, Gurney JG, Packer RJ, Robison LL, Oeffinger KS (2006) Late occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the childhood cancer survivor study (CCSS), Journal of Clinical Oncology, In Press
  • Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS, Schwartz CL, Leisenring W, Robison LL (2006) Chronic health conditions in adult survivors of childhood cancer, New England Journal of Medicine, 355 (15), 1572-1582
  • Rudra CB, Sorensen TK, Leisenring WM, Dashow E, Williams MA (2006) Weight characteristics and height in relation to risk of gestational diabetes mellitus, American Journal of Epidemiology, In Press
  • Leisenring WM, Martin PJ, Petersdorf EW, Regan AE, Aboulhosn N, Stern JM, Aker SN, Salazar RC, McDonald GB (2006) An acute graft-versus-host disease activity index to preduct survival after hematopoietic cell transplantation with myeloablative conditioning regimens, Blood, 108, 749-755
  • Burroughs L, Mielcarek M, Leisenring W, Sandmaier BM, Maloney DG, Baron F, Martin PJ, Flowers MED, Forman SJ, Chauncey TR, Bruno B, Storb R (2006) Extending postgrafting cyclosporine decreases the risk of severe graft-verusu-host disease after nonmyeloablative hematopoietic cell transplantation, Transplantation, 81 (6), 818-825
  • Leisenring W, Friedman DL, Flowers MED, Schwartz JL, Deeg HJ (2006) Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation, Journal of Clinical Oncology, 24 (7), 1119-1126
  • Upton A, Gugel A, Leisenring W, Limaye A, Alexander B, Hayden R, Marr KA (Sep 2005) Reproducibility of low galactomannan enzyme immunoassay index values tested in multiple laboratories., Journal of Clinical Microbiology, 43 (9), 4796-800 Abstract
  • Kahl C, Leisenring W, Deeg HJ, Chauncey TR, Flowers ME, Martin PJ, Sanders JE, Storb R (Sep 2005) Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long-term follow-up., British Journal of Haematology, 130 (5), 747-51 Abstract
  • Mielcarek M, Burroughs L, Leisenring W, Diaconescu R, Martin PJ, Sandmaier BM, Maloney DG, Maris MB, Chauncey TR, Shizuru JA, Blume KG, Hegenbart U, Niederwieser D, Forman S, Bruno B, Woolfrey A, Storb R (May 2005) Prognostic relevance of 'early-onset' graft-versus-host disease following non-myeloablative haematopoietic cell transplantation., British Journal of Haematology, 129 (3), 381-91 Abstract
  • Diaconescu R, Little MT, Leisenring W, Yunusov M, Hogan WJ, Sorror ML, Baron F, Storb R (May 2005) What role is there for antithymocyte globulin in allogeneic nonmyeloablative canine hematopoietic cell transplantation?, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (5), 335-44 Abstract
  • Frederick IO, Williams MA, Dashow E, Kestin M, Zhang C, Leisenring WM (May 2005) Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsia., The Journal of Reproductive Medicine, 50 (5), 332-44 Abstract
  • Sorror ML, Leisenring WM, Deeg HJ, Martin PJ, Storb R (2005) Twenty-year follow-up in patients with aplastic anemia given marrow grafts from HLA-identical siblings and randomized to receive methotrexate/cyclosporine or methotrexate alone for prevention of graft-versus-host disease (letter), Biology of Blood and Marrow Transplantation, 11, 567-568
  • Sorror ML, Leisenring W, Deeg HJ, Martin PJ, Storb R (2005) Twenty-year follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with clclosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-identical marrow grafts for leukemia (letter), Biology of Blood and Marrow Transplantation, 10 (11), 814-815
  • Ness KK, Mertens AC, Hudson MM, Wall MM, Leisenring WM, Oeffinger KC, Sklar CA, Robison LL, Gurney JG (2005) Limitations on physical performance and daily activities among long-term survivors of childhood cancer, Annals of Internal Medicine, 143 (9), 639-647
  • Marr K, Laverdiere M, Gugel A, Leisenring W (2005) Antifungal therapy decreases sensitivity of the aspergillus galactomannan enzyme innunoassay, Clinical Infectious Diseases, 40, 1762-1769
  • Zanis-Neto J, Flowers MED, Medeiros CF, Bitencourt MA, Bonfim CM, Setubal DC, Funke V, Sanders J, Deeg HJ, Kiem HP, Martin P, Leisenring W, Storb R (2005) Low-dose cyclophosphamide conditioning for hematopoietic cell transplantation from HLA-matched related donors in patients with Fanconi anaemia., British Journal of Haematology, 130, 99-106
  • Stevens AM, McDonnell WM, Mullarkey ME, Pang JM, Leisenring W, Nelson JL (Dec 2004) Liver biopsies from human females contain male hepatocytes in the absence of transplantation., Laboratory Investigation; a Journal of Technical Methods and Pathology, 84 (12), 1603-9 Abstract
  • Musher B, Fredricks D, Leisenring W, Balajee SA, Smith C, Marr KA (Dec 2004) Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid., Journal of Clinical Microbiology, 42 (12), 5517-22 Abstract
  • Adams KM, Holmberg LA, Leisenring W, Fefer A, Guthrie KA, Tylee TS, McDonald GB, Bensinger WI, Nelson JL (Sep 2004) Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation., Blood, 104 (6), 1894-7 Abstract
  • Zhang C, Williams MA, Sorensen TK, King IB, Kestin MM, Thompson ML, Leisenring WM, Dashow EE, Luthy DA (Sep 2004) Maternal plasma ascorbic Acid (vitamin C) and risk of gestational diabetes mellitus., Epidemiology (cambridge, Mass.), 15 (5), 597-604 Abstract
  • Butler CL, Williams MA, Sorensen TK, Frederick IO, Leisenring WM (Aug 2004) Relation between maternal recreational physical activity and plasma lipids in early pregnancy., American Journal of Epidemiology, 160 (4), 350-9 Abstract
  • Dempsey JC, Williams MA, Leisenring WM, Shy K, Luthy DA (May 2004) Maternal birth weight in relation to plasma lipid concentrations in early pregnancy., American Journal of Obstetrics and Gynecology, 190 (5), 1359-68 Abstract
  • Pepe MS, Janes H, Longton G, Leisenring W, Newcomb P (May 2004) Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker., American Journal of Epidemiology, 159 (9), 882-90 Abstract
  • Friedman DL, Leisenring W, Schwartz JL, Deeg HJ (Apr 2004) Second malignant neoplasms following hematopoietic stem cell transplantation., International Journal of Hematology, 79 (3), 229-34 Abstract
  • Novicki TJ, Schapiro JM, Ulness BK, Sebeste A, Busse-Johnston L, Swanson KM, Swanzy SR, Leisenring W, Limaye AP (Apr 2004) Convenient selective differential broth for isolation of vancomycin-resistant enterococcus from fecal material., Journal of Clinical Microbiology, 42 (4), 1637-40 Abstract
  • Ning Y, Williams MA, Muy-Rivera M, Leisenring WM, Luthy DA (Mar 2004) Relationship of maternal plasma leptin and risk of pre-eclampsia: a prospective study., The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians., 15 (3), 186-92 Abstract
  • Qiu C, Luthy DA, Zhang C, Walsh SW, Leisenring WM, Williams MA (Feb 2004) A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia., American Journal of Hypertension : Journal of the American Society of Hypertension., 17 (2), 154-60 Abstract
  • Marr KA, Crippa F, Leisenring W, Hoyle M, Boeckh M, Balajee SA, Nichols WG, Musher B, Corey L (Feb 2004) Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants., Blood, 103 (4), 1527-33 Abstract
  • Marr KA, Leisenring W, Crippa F, Slattery JT, Corey L, Boeckh M, McDonald GB (Feb 2004) Cyclophosphamide metabolism is affected by azole antifungals., Blood, 103 (4), 1557-9 Abstract
  • Benesch M, Platzbecker U, Ward J, Deeg HJ, Leisenring W (Dec 2003) Expression of FLIP(Long) and FLIP(Short) in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis., Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.k., 17 (12), 2460-6 Abstract
  • Meshinchi S, Leisenring WM, Carpenter PA, Woolfrey AE, Sievers EL, Radich JP, Sanders JE (Nov 2003) Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9 (11), 706-13 Abstract
  • Doney K, Hagglund H, Leisenring W, Chauncey T, Appelbaum FR, Storb R (Jul 2003) Predictive factors for outcome of allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9 (7), 472-81 Abstract
  • Mielcarek M, Martin PJ, Leisenring W, Flowers ME, Maloney DG, Sandmaier BM, Maris MB, Storb R (Jul 2003) Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation., Blood, 102 (2), 756-62 Abstract
  • Wells DA, Benesch M, Loken MR, Vallejo C, Myerson D, Leisenring WM, Deeg HJ (Jul 2003) Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation., Blood, 102 (1), 394-403 Abstract
  • Qiu C, Williams MA, Leisenring WM, Sorensen TK, Frederick IO, Dempsey JC, Luthy DA (Mar 2003) Family history of hypertension and type 2 diabetes in relation to preeclampsia risk., Hypertension, 41 (3), 408-13 Abstract
  • Cooper KL, Leisenring WM, Moens CB (Jan 2003) Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron development., Developmental Biology, 253 (2), 200-13 Abstract
  • Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers ME, Cunningham T, Corey L (Jan 2003) Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity., Blood, 101 (2), 407-14 Abstract
  • Xiao R, Sorensen TK, Frederick IO, El-Bastawissi A, King IB, Leisenring WM, Williams MA (Oct 2002) Maternal second-trimester serum ferritin concentrations and subsequent risk of preterm delivery., Paediatric and Perinatal Epidemiology, 16 (4), 297-304 Abstract
  • Koc S, Leisenring W, Flowers ME, Anasetti C, Deeg HJ, Nash RA, Sanders JE, Witherspoon RP, Storb R, Appelbaum FR, Martin PJ (Jul 2002) Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone., Blood, 100 (1), 48-51 Abstract
  • Furlong T, Leisenring W, Storb R, Anasetti C, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Kiem HP, Nash RA, Sanders JE, Witherspoon R, Thompson D, Martin PJ (2002) Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 8 (4), 206-12 Abstract
  • Meshinchi S, Thomson B, Finn LS, Leisenring W, Green C, Radich JP, Loken M, Hawkins D (Dec 2001) Comparison of multidimensional flow cytometry with standard morphology for evaluation of early marrow response in pediatric acute lymphoblastic leukemia., Journal of Pediatric Hematology/oncology : Official Journal of the American Society of Pediatric Hematology/oncology., 23 (9), 585-90 Abstract
  • Benito AI, Milner LA, Leisenring W, Deeg HJ, Woolfrey AE (Sep 2001) Absence of major histocompatibility class II expression does not impair hematopoiesis in mice., Experimental Hematology, 29 (9), 1070-5 Abstract
  • Al-Ghamdi H, Leisenring W, Bensinger WI, Nash RA, Storb R, Appelbaum FR, Martin PJ (May 2001) A proposed objective way to assess results of randomized prospective clinical trials with acute graft-versus-host disease as an outcome of interest., British Journal of Haematology, 113 (2), 461-9 Abstract
  • Zhang C, Williams MA, Sanchez SE, King IB, Ware-Jauregui S, Larrabure G, Bazul V, Leisenring WM (Mar 2001) Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women., American Journal of Epidemiology, 153 (6), 572-80 Abstract
  • Limaye AP, Huang ML, Leisenring W, Stensland L, Corey L, Boeckh M (Feb 2001) Cytomegalovirus (CMV) DNA load in plasma for the diagnosis of CMV disease before engraftment in hematopoietic stem-cell transplant recipients., The Journal of Infectious Diseases, 183 (3), 377-82 Abstract
  • Walters MC, Patience M, Leisenring W, Rogers ZR, Aquino VM, Buchanan GR, Roberts IA, Yeager AM, Hsu L, Adamkiewicz T, Kurtzberg J, Vichinsky E, Storer B, Storb R, Sullivan KM, Multicenter Investigation of Bone Marrow Transplantation for Sickle Cell Disease (2001) Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 7 (12), 665-73 Abstract
  • Storb R, Blume KG, O'Donnell MR, Chauncey T, Forman SJ, Deeg HJ, Hu WW, Appelbaum FR, Doney K, Flowers ME, Sanders J, Leisenring W (2001) Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 7 (1), 39-44 Abstract
  • Gooley TA, Leisenring W, Crowley J, Storer BE (2001) Why Kaplan-Meier fails and cumulative incidence succeeds when estimating failure probabilities in the presence of competing risks, Handbook of Statistics in Clinical Oncology, New York, Marcel Dekker, Inc., 513-523 pages (bookchapter)
  • Koc S, Leisenring W, Flowers ME, Anasetti C, Deeg HJ, Nash RA, Sanders JE, Witherspoon RP, Appelbaum FR, Storb R, Martin PJ (Dec 2000) Thalidomide for treatment of patients with chronic graft-versus-host disease., Blood, 96 (12), 3995-6 Abstract
  • Emanuel I, Leisenring W, Williams M, Kimpo C, Estee S, O'Brien W, Hale CB, Authors' reply to the commentary Maternal birthweight and newborn status., Paediatric and Perinatal Epidemiology, 14(4), 378-80, Oct 2000 Abstract
  • Mielcarek M, Leisenring W, Torok-Storb B, Storb R, Graft-versus-host disease and donor-directed hemagglutinin titers after ABO-mismatched related and unrelated marrow allografts: evidence for a graft-versus-plasma cell effect, Blood, 96(3), 1150-6, August 2000 Abstract
  • Deeg HJ, Flowers ME, Leisenring W, Appelbaum FR, Martin PJ, Storb RF, Cyclosporine (CSP)or CSP plus methylprednisolone for graft-versus-host disease prophylaxis in patients with high-risk lymphohemopoietic malignancies: long-term follow-up of a randomized trial [letter], Blood, 96(3), 1194-5, August 2000 Abstract
  • Shy K, Kimpo C, Emanuel I, Leisenring W, Williams MA, Maternal birth weight and cesarean delivery in four race-ethnic groups, American Journal of Obstetrics and Gynecology, 182(6), 1363-70, June 2000 Abstract
  • Leisenring W, Alonzo T, Pepe MS, Comparisons of predictive values of binary medical diagnostic tests for paired designs, Biometrics, 56(2), 345-51, June 2000 Abstract
  • Yu J, Leisenring W, Fritschle W, Heimfeld S, Shulman H, Bensinger WI, Holmberg LA, Rowley SD (Jun 2000) Enumeration of HPC in mobilized peripheral blood with the Sysmex SE9500 predicts final CD34+ cell yield in the apheresis collection., Bone Marrow Transplantation, 25 (11), 1157-64 Abstract
  • Walters MC, Storb R, Patience M, Leisenring W, Taylor T et al, Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report, Blood, 95(6), 1918-24, 15 Mar 2000
  • Strandjord TP, Emanuel I, Williams MA, Leisenring WM, Kimpo C, Respiratory distress syndrome and maternal birth weight effects, Obstetrics and Gynecology, 95(2), 174-9, February 2000 Abstract
  • Flowers ME, Leisenring W, Beach K, Riddell S, Radich JP, Higano CS, Rowley SD, Chauncey TR, Sanders JE, Anasetti C, Storb R, Wade J, Appelbaum FR, Martin P (2000) Granulocyte colony-stimulating factor given to donors before apheresis does not prevent aplasia in patients treated with donor leukocyte infusion for recurrent chronic myeloid leukemia after bone marrow transplantation., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 6 (3A), 321-6 Abstract
  • Pepe M, Leisenring W, Rutter C (2000) Evaluating diagnostic tests in public health, Handbook of Statistics 18: Bioenvironmental and Public Health Statistics, Amsterdam, Elsevier Science B.V., 397-423 pages (bookchapter)
  • Holmberg LA, Boeckh M, Hooper H, Leisenring W, Rowley S, Heimfeld S, Press O, Maloney DG, McSweeney P, Corey L, Maziarz RT, Appelbaum FR, Bensinger W, Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation, Blood, 94(12), 4029-35, December 1999 Abstract
  • Williams MA, Emanuel I, Kimpo C, Leisenring WM, Hale CB, A population-based cohort study of the relation between maternal birthweight and risk of gestational diabetes mellitus in four racial/ethnic groups, Paediatric and Perinatal Epidemiology, 13(4), 452-65, October 1999 Abstract
  • Emanuel I, Leisenring W, Williams MA, Kimpo C, Estee S, O'Brien W, Hale CB, The Washington State Intergenerational Study of Birth Outcomes: methodology and some comparisons of maternal birthweight and infant birthweight and gestation in four ethnic groups, Paediatric and Perinatal Epidemiology, 13(3), 352-69, July 1999 Abstract
  • Yu J, Leisenring W, Bensinger WI, Holmberg LA, Rowley SD, The predictive value of white cell or CD34 cell count in the peripheral blood for timing apheresis and maximizing yield, Transfusion, 39(5), 442-50, May 1999 Abstract
  • Williams MA, Havel PJ, Schwartz MW, Leisenring WM, King IB, Zingheim RW, Zebelman AM, Luthy DA (Apr 1999) Pre-eclampsia disrupts the normal relationship between serum leptin concentrations and adiposity in pregnant women., Paediatric and Perinatal Epidemiology, 13 (2), 190-204 Abstract
  • Gooley TA, Leisenring W, Crowley J, Storer BE, Estimation of failure probabilities in the presence of competing risks: new representations of old estimators, Statistics in Medicine, 18(6), 695-706, March 1999 Abstract
  • Boeckh M, Gooley T, Leisenring W, Myerson D, Corey L (1999) Does high-dose acyclovir add benefit in allogeneic marrow transplant recipients receiving prophylactic or preemptive ganciclovir (letter), The Journal of Infectious Diseases, 180, 572-574
  • Stucki A, Leisenring W, Sandmaier BM, Sanders J, Anasetti C, Storb R, Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis), Blood, 92(8), 2742-9, October 1998 Abstract
  • van Burik JH, Leisenring W, Myerson D, Hackman RC, Shulman HM, Sale GE, Bowden RA, McDonald GB, The effect of prophylactic fluconazole on the clinical spectrum of fungal diseases in bone marrow transplant recipients with special attention to hepatic candidiasis. An autopsy study of 355 patients, Medicine, 77(4), 246-54, July 1998 Abstract
  • Leisenring W, Pepe MS, Regression modelling of diagnostic likelihood ratios for the evaluation of medical diagnostic tests, Biometrics, 54(2), 444-52, June 1998 Abstract
  • Deeg HJ, Leisenring W, Storb R, Nims J, Flowers ME, Witherspoon RP, Sanders J, Sullivan KM, Long-term outcome after marrow transplantation for severe aplastic anemia, Blood, 91(10), 3637-45, May 1998 Abstract
  • Storb R, Raff R, Deeg HJ, Graham T, Appelbaum FR, Schuening FG, Shulman H, Seidel K, Leisenring W, Dose rate-dependent sparing of the gastrointestinal tract by fractionated total body irradiation in dogs given marrow autografts, International Journal of Radiation Oncology, Biology, Physics, 40(4), 961-6, March 1998 Abstract
  • Martin P, Nash R, Sanders J, Leisenring W, Anasetti C, Deeg HJ, Storb R, Appelbaum F, Reproducibility in retrospective grading of acute graft-versus-host disease after allogeneic marrow transplantation, Bone Marrow Transplantation, 21(3), 273-9, February 1998 Abstract
  • Fink JC, Leisenring WM, Sullivan KM, Sherrard DJ, Weiss NS, Avascular necrosis following bone marrow transplantation: a case-control study, Bone, 22(1), 67-71, Jan 1998 Abstract
  • Wald A, Leisenring W, van Burik JA, Bowden RA (1998) Prevention of aspergillosis in bone marrow transplantation (letter), The Journal of Infectious Diseases, 177, 1775-1776
  • Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Yeager A, Kurtzberg J, Bunin N, Scott JP, Wall DA, Wayne AS, Wiley J, Darbyshire PJ, Mentzer WC, Smith FO, Sullivan KM, Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions, Biology of Blood and Marrow Transplantation, 3(6), 310-5, December 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum FR, Deeg HJ, Doney K, Martin P, Sullivan KM, Witherspoon R, Pettinger M, Bensinger W, Buckner CD, Clift R, Flowers ME, Hansen JA, Pepe M, Chauncey T, Sanders J, Thomas ED, Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?, Biology of Blood and Marrow Transplantation, 3(4), 194-201, October 1997 Abstract
  • Torok-Storb B, Boeckh M, Hoy C, Leisenring W, Myerson D, Gooley T, Association of specific cytomegalovirus genotypes with death from myelosuppression after marrow transplantation, Blood, 90(5), 2097-102, September 1997 Abstract
  • Kiem HP, Myerson D, Storb R, McDonald GB, Spurgeon CL, Leisenring W, Prevalence of hepatitis G virus in patients with aplastic anemia [letter], Blood, 90(3), 1335-6, August 1997 Abstract
  • Leisenring W, Pepe MS, Longton G, A marginal regression modelling framework for evaluating medical diagnostic tests, Statistics in Medicine, 16(11), 1263-81, June 1997 Abstract
  • Wald A, Leisenring W, van Burik JA, Bowden RA, Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation, Journal of Infectious Diseases, 175(6), 1459-66, June 1997 Abstract
  • Leisenring W, Pepe MS, Longton G (Jun 1997) A marginal regression modelling framework for evaluating medical diagnostic tests., Statistics in Medicine, 16 (11), 1263-81 Abstract
  • Charuhas PM, Fosberg KL, Bruemmer B, Aker SN, Leisenring W, Seidel K, Sullivan KM, A double-blind randomized trial comparing outpatient parenteral nutrition with intravenous hydration: effect on resumption of oral intake after marrow transplantation, Jpen. Journal of Parenteral and Enteral Nutrition, 21(3), 157-61, 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum FR, Buckner CD, Bensinger WI, Chauncey T, Clift RA, Deeg HJ, Doney KC, Flowers ME, Hansen JA, Martin PJ, Sanders JE, Sullivan KM, Witherspoon RP, Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin [letter], Blood, 89(10), 3890-1, May 1997 Abstract
  • Deeg HJ, Lin D, Leisenring W, Boeckh M, Anasetti C, Appelbaum FR, Chauncey TR, Doney K, Flowers M, Martin P, Nash R, Schoch G, Sullivan KM, Witherspoon RP, Storb R, Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective, randomized trial, Blood, 89(10), 3880-7, May 1997 Abstract
  • Storb R, Yu C, Wagner JL, Deeg HJ, Nash RA, Kiem HP, Leisenring W, Shulman H, Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation, Blood, 89(8), 3048-54, April 1997 Abstract
  • Doney K, Leisenring W, Storb R, Appelbaum FR, Primary treatment of acquired aplastic anemia: outcomes with bone marrow transplantation and immunosuppressive therapy. Seattle Bone Marrow Transplant Team, Annals of Internal Medicine, 126(2), 107-15, January 1997 Abstract
  • Huss R, Deeg HJ, Gooley T, Bryant E, Leisenring W, Clift R, Buckner CD, Martin P, Storb R, Appelbaum FR, Effect of mixed chimerism on graft-versus-host disease, disease recurrence and survival after HLA-identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia, Bone Marrow Transplantation, 18(4), 767-76, October 1996 Abstract
  • Kiem HP, Leisenring W, Raff R, Deeg HJ, Schuening FG, Appelbaum FR, Storb R, Failure of recombinant stem cell factor to enhance engraftment of L-leucyl-L-leucine methyl ester treated canine marrow after irradiation., Blood, 88(5), 1896-7, Sep 1996 Abstract
  • Leroux BG, Leisenring WM, Moolgavkar SH, Faustman EM, A biologically-based dose-response model for developmental toxicology, Risk Analysis, 16(4), 449-58, August 1996 Abstract
  • Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM, Bone marrow transplantation for sickle cell disease, New England Journal of Medicine, 335(6), 369-76, August 1996 Abstract
  • Walters MC, Patience M, Leisenring W, Eckman JR, Buchanan GR, Rogers ZR, Olivieri NE, Vichinsky E, Davies SC, Mentzer WC, Powars D, Scott JP, Bernaudin F, Ohene-Frempong K, Darbyshire PJ, Wayne A, Roberts IA, Dinndorf P, Brandalise S, Sanders JE, Matthews DC, Appelbaum FR, Storb R, Sullivan KM (May 1996) Barriers to bone marrow transplantation for sickle cell anemia., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 2 (2), 100-4 Abstract
  • Bean MA, Graham T, Appelbaum FR, Deeg HJ, Schuening F, Sale GE, Leisenring W, Pepe M, Storb R, Gamma radiation of blood products prevents rejection of subsequent DLA-identical marrow grafts. Tolerance versus abrogation of sensitization to non-DLA antigens, Transplantation, 61(2), 334-5, January 1996 Abstract
  • Holmberg LA, Seidel K, Leisenring W, Torok-Storb B, Aplastic anemia: analysis of stromal cell function in long-term marrow cultures, Blood, 84(11), 3685-90, December 1994 Abstract
  • Leisenring WM, Breslow NE, Evans IE, Beckwith JB, Coppes MJ, Grundy P, Increased birth weights of National Wilms' Tumor Study patients suggest a growth factor excess, Cancer Research, 54(17), 4680-3, September 1994 Abstract
  • Storb R, Leisenring W, Deeg HJ, Anasetti C, Appelbaum F, Bensinger W, Buckner CD, Clift R, Doney K, Hansen J, Et Al., Long-term follow-up of a randomized trial of graft-versus-host disease prevention by methotrexate/cyclosporine versus methotrexate alone in patients given marrow grafts for severe aplastic anemia., Blood, 83(9), 2749-50, May 1994 Abstract
  • Donnelly C, Leisenring W, Kanki P, Awerbuch T, Sandberg S, Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal, Bulletin of Mathematical Biology, 55(4), 731-43, 1993 Abstract
  • Kanki P, M'Boup S, Marlink R, Travers K, Hsieh CC, Gueye A, Boye C, Sankale JL, Donnelly C, Leisenring W, Et Al. (Oct 1992) Prevalence and risk determinants of human immunodeficiency virus type 2 (HIV-2) and human immunodeficiency virus type 1 (HIV-1) in west African female prostitutes., American Journal of Epidemiology, 136 (7), 895-907 Abstract
  • Leisenring W, Ryan L, Statistical properties of the NOAEL, Regulatory Toxicology and Pharmacology, 15(2 Pt 1), 161-71, April 1992 Abstract

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Last Verified: 11/14/2006

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