Dr. James Bruce Leverenz

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University of Washington
College of Arts and Sciences
Neurology and Psychiatry and Behavioral Sciences
Associate ProfessorAppointed: 2003
VA Puget Sound Health Care System
Staff NeurologistAppointed: 1999
University of Washington
School of Medicine
Pediatrics
Center on Human Development and Disability
Research AffiliateAppointed: 1992
Professional Headshot of James Bruce Leverenz

Mailing Address

VA-PSHCS
1660 S. Columbian Way
S-116
6 East
Seattle, Washington 98108
United States

Contact Information

Phone: (206) 277-1047
Fax: (206) 768-5456
leverenz@u.washington.edu

Qualifications

M.D., University of Washington, 1985.

Expertise and Research Interests

Clinical and neuropathologic aspects of aging-associated disorders including Alzheiemer's disease, Parkinson's disease, Dementia with Lewy bodies, frontotemporal dementia, Down syndrome.

Keywords

COS Keywords:

Alzheimer's Disease, Dementia, Down Syndrome, Mental Disorders, Neurobiology, Neurodegenerative Diseases, Neurology, Neuropathology, Parkinson's Disease, Pediatrics, Psychiatry, Psychosis, Stress.

Additional Terms:

Alzheimer's Disease, Dementia, Down Syndrome, Lewy Body Dementia, Mental Illness, Neurodegenerative Disease, Parkinson's Disease, Psychosis, Stress.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Academy of Neurology
American Neurological Association
Movement Disorder Society

Honors and Awards

2002, Research Award in Geriatric Neurology, American Academy of Neurology

Previous Positions

1998-2003, Assistant Professor, University of Washington, School of Medicine, Neurology
1996-1998, Acting Assistant Professor, University of Washington, School of Medicine, Neurology (Primary) and Psychiatry
1992-1996, Acting Instructor, University of Washington, School of Medicine, Medicine (Neurology) and Psychiatry

Funding Received

  • Department of Veterans Affairs: Parkinson's Related Neurodegenerative Dementia in a Community Sample, Oct 1, 2001 to Oct 30, 2004.
  • NIH/NIA: A Clinico-pathologic Study of Frontotemporal Dementia, Alzheimer's Disease Coordinating Center- Collabotative Project, Nov 1, 2000 to Nov 31, 2001.
  • NIH/NIA: Alzheimer's Disease Research Center, Jun 1, 2000 to Jun 30, 2005.
  • National Alzheimer's Coordinating Center: Clinical, Pathologic, and Genetic Characteristics of Dementia with Lewy Bodies: A Multicenter Collaborative Study, Jul 1, 2003 to Jul 30, 2004.
  • NIH/NIA: Psychopathology of Alzheimer's: APOE and the HPA Axis, Jul 1, 2001 to Jul 30, 2006.
  • Veterans Administration Hospital: Mental Illness Research, Education and Clinical Center (MIRECC), Jan 1998 to Dec 1999.
  • NIH: Alzheimer's Disease Research Center (co-investigator), Jan 1995 to Nov 1999.
  • National Institutes of Health (NIH): Characterization of DLB: a Collaborative Study, Dec 1, 2003 to Dec 30, 2008.
  • Department of Veterans Affairs: Psychopathology of Alzheimer's: Psychoneuroendocrinology, Apr 1, 2001 to Apr 31, 2006.
  • Washington APDA/Northwest Collaborative Care/Northwest Parkinson's Foundation, State of Washington: Washington Parkinson Disease Registry, Co-Director, State of Washington, 2008 to 2011.
  • National Institutes of Health: Biomarkers for Preclinical Parkinson's Disease, Co-Investigator, 2008 to 2013.
  • National Institutes of Health: Genetic and Environmental Risk Factors for PSP, Site PI, 2006 to 2011.
  • National Institutes of Health: University of Washington Alzheimer's Disease Research Center, Director Education and Information Core, 2005 to 2010.
  • VA REAP: Adrenergic Mechanisms and Treatment for PTSD and Secondary Drug Abuse, Co-Director Molecular Neurobiology Core, 2005 to 2010.
  • National Institutes of Health (NIH): Biomarkers for Parkinson's Disease (PD) and PD Dementia, 2004 to 2009.
  • Veterans Affairs: VA Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Investigator/Clinician (Movement and Memory Clinic), 2001 to .
  • National Institute of Neurological Disorders and Stroke (NINDS): Pacific Northwest Udall Center, Clinical Core Director, 671,248 /yr, 1999 to 2014.
  • Veteran's Affairs: Mental Illness Research, Education, and Clinical Center (MIRECC), Investigator, 1997 to .

Publications

  • Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, Danek A, Galasko DR, Arnold SE, Chen-Plotkin A, Karydas A, Miller BL, Trojanowski JQ, Lee VM, Schellenberg GD, Van Deerlin VM (Feb 2010) The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration., Archives of neurology, 67 (2), 161-70 Abstract
  • Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM, Hardy J, Leverenz JB, Del Tredici K, Wszolek ZK, Litvan I (Dec 2009) Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria., Lancet neurology, 8 (12), 1150-7 Abstract
  • Wang LY, Leverenz JB, Larson EB, Vavrek DA, Kukull WA, McCormick W, Bowen JD, Teri L, Montine T, Tsuang DW (Dec 2009) Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample., Journal of geriatric psychiatry and neurology, 22 (4), 256-65 Abstract
  • Cimino PJ, Sokal I, Leverenz J, Fukui Y, Montine TJ (Oct 2009) DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain., The American journal of pathology, 175 (4), 1622-30 Abstract
  • Tsuang D, Larson EB, Li G, Shofer JB, Montine KS, Thompson ML, Sonnen JA, Crane PK, Leverenz JB, Montine TJ (Jun 2009) Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation., Brain pathology (Zurich, Switzerland) Abstract
  • Duerson K, Woltjer RL, Mookherjee P, Leverenz JB, Montine TJ, Bird TD, Pow DV, Rauen T, Cook DG (Apr 2009) Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients., Brain pathology (Zurich, Switzerland), 19 (2), 267-78 Abstract
  • Leverenz JB, Quinn JF, Zabetian C, Zhang J, Montine KS, Montine TJ (2009) Cognitive impairment and dementia in patients with Parkinson disease., Current topics in medicinal chemistry, 9 (10), 903-12 Abstract
  • Leverenz JB, Lopez OL, DeKosky ST (2009) The expanding role of genetics in the Lewy body disease: the glucocerebrosidase gene, Archives of neurology (Editorial), 66, 555-6
  • Keene CD, Change RC, Leverenz JB, Kopyov O, Perlman S, Hevner RF, Born DE, Bird TD, Montine TJ (2009) A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions, Acta neuropathologica, 117, 329-38
  • Lane R, He Y, Morris C, Leverenz JB, Emre M, Ballard C (2009) BuChE-K and APOE ε4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline, Movement disorders, 24, 392-400
  • Tsuang DW, Larson EB, Bolen E, Thompson ML, Peskind E, Bowen J, McCormick W, Teri L, Kukull W, Vavrek D, Montine T, Leverenz JB (2009) Visual hallucination in dementia: a prospective community-based study with autopsy., American journal of geriatric psychiatry, 17, 317-23
  • McMillan P, Korvatska E, Poorkaj P, Evstafjeva Z, Robinson L, Greenup L, Leverenz J, Schellenberg GD, D'Souza I (Dec 2008) Tau isoform regulation is region- and cell-specific in mouse brain., The Journal of comparative neurology, 511 (6), 788-803 Abstract
  • Vuletic S, Li G, Peskind ER, Kennedy H, Marcovina SM, Leverenz JB, Petrie EC, Lee VM, Galasko D, Schellenberg GD, Albers JJ (Nov 2008) Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid., Journal of Alzheimer's disease : JAD, 15 (3), 409-17 Abstract
  • Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH (Sep 2008) Evaluation of alpha-synuclein immunohistochemical methods used by invited experts., Acta neuropathologica, 116 (3), 277-88 Abstract
  • Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, Elman LB, Clay D, Wood EM, Chen-Plotkin AS, Martinez-Lage M, Steinbart E, McCluskey L, Grossman M, Neumann M, Wu IL, Yang WS, Kalb R, Galasko DR, Montine TJ, Trojanowski JQ, Lee VM, Schellenberg GD, Yu CE (May 2008) TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis., Lancet neurology, 7 (5), 409-16 Abstract
  • Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ (Apr 2008) Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient., Brain pathology (Zurich, Switzerland), 18 (2), 220-4 Abstract
  • Mata IF, Samii A, Schneer SH, Roberts JW, Griffith A, Leis BC, Schellenberg GD, Sidransky E, Bird TD, Leverenz JB, Tsuang D, Zabetian CP (Mar 2008) Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders., Archives of neurology, 65 (3), 379-82 Abstract
  • Pan S, Rush J, Peskind ER, Galasko D, Chung K, Quinn J, Jankovic J, Leverenz JB, Zabetian C, Pan C, Wang Y, Oh JH, Gao J, Zhang J, Montine T (Feb 2008) Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform., Journal of proteome research, 7 (2), 720-30 Abstract
  • Poewe W, Gauthier S, Aarsland D, Leverenz JB, Barone P, Weintraub D, Tolosa E, Dubois B (2008) Diagnosis and management of Parkinson's disease dementia, Internation journal of clinical practice, 62, 1581-7
  • Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ (Oct 2007) Pathological correlates of dementia in a longitudinal, population-based sample of aging., Annals of neurology, 62 (4), 406-13 Abstract
  • Brickell KL, Leverenz JB, Steinbart EJ, Rumbaugh M, Schellenberg GD, Nochlin D, Lampe TH, Holm IE, Van Deerlin V, Yuan W, Bird TD (Oct 2007) Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease., Journal of neurology, neurosurgery, and psychiatry, 78 (10), 1050-5 Abstract
  • Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J, Perl DP, Galasko DR, Montine TJ (Sep 2007) Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy., The American journal of pathology, 171 (3), 993-1002 Abstract
  • Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, Masliah E, Kaye J, Clark CM, Montine TJ, Lee VM, Trojanowski JQ (Sep 2007) Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases., Acta neuropathologica, 114 (3), 221-9 Abstract
  • Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J, Peskind ER, Montine TJ (Aug 2007) CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study., Neurology, 69 (7), 631-9 Abstract
  • Keene CD, Sonnen JA, Swanson PD, Kopyov O, Leverenz JB, Bird TD, Montine TJ (Jun 2007) Neural transplantation in Huntington disease: long-term grafts in two patients., Neurology, 68 (24), 2093-8 Abstract
  • Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD (May 2007) A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology., Brain : a journal of neurology, 130 (Pt 5), 1360-74 Abstract
  • Szot P, White SS, Greenup JL, Leverenz JB, Peskind ER, Raskind MA (Apr 2007) Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes., Neuroscience, 146 (1), 471-80 Abstract
  • Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, Tsuang DW, Jin J, Pan C, Shin J, Zhu D, Zhang J (Apr 2007) Proteomic identification of novel proteins in cortical lewy bodies., Brain pathology (Zurich, Switzerland), 17 (2), 139-45 Abstract
  • Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK (Mar 2007) DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers., Neurology, 68 (11), 812-9 Abstract
  • Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz JB, Doran E, Lott IT, Hill M, Head E (2007) Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal aging brain, Neurobiology of Aging, 28, 1493-506
  • Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER (Dec 2006) Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid., Journal of Alzheimer's disease : JAD, 10 (4), 399-406 Abstract
  • Tsuang D, Simpson K, Larson EB, Peskind E, Kukull W, Bowen JB, McCormick W, Teri L, Montine T, Thompson ML, Leverenz JB (Dec 2006) Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease., Journal of geriatric psychiatry and neurology, 19 (4), 195-201 Abstract
  • Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nixon R, Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li GJ, Liu Y, Waichunas D, Montine TJ, Zhang J (Aug 2006) Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders., Journal of Alzheimer's disease : JAD, 9 (3), 293-348 Abstract
  • Tsuang DW, Riekse RG, Purganan KM, David AC, Montine TJ, Schellenberg GD, Steinbart EJ, Petrie EC, Bird TD, Leverenz JB (Aug 2006) Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series., Journal of Alzheimer's disease : JAD, 9 (3), 235-42 Abstract
  • Pedersen WA, McMillan PJ, Kulstad JJ, Leverenz JB, Craft S, Haynatzki GR (Jun 2006) Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice., Experimental neurology, 199 (2), 265-73 Abstract
  • Zaja-Milatovic S, Keene CD, Montine KS, Leverenz JB, Tsuang D, Montine TJ (May 2006) Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies., Neurology, 66 (10), 1591-3 Abstract
  • Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D (Mar 2006) Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype., Archives of neurology, 63 (3), 370-6 Abstract
  • Szot P, White SS, Greenup JL, Leverenz JB, Peskind ER, Raskind MA (Jan 2006) Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies., The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 (2), 467-78 Abstract
  • Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, Payami H (Jan 2006) Analysis of the LRRK2 G2019S mutation in Alzheimer Disease., Archives of neurology, 63 (1), 156-7 Abstract
  • Bowen JD, Kamin R, Leverenz JB, Fishel MA, McCormick WC, Kukull WA, Larson EB (Oct 2005) Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementia., Journal of the American Geriatrics Society, 53 (10), 1743-7 Abstract
  • Szot P, White SS, Greenup JL, Leverenz JB, Peskind ER, Raskind MA (Oct 2005) Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression., Brain Research. Molecular Brain Research, 139 (2), 367-71 Abstract
  • Rascovsky K, Salmon DP, Lipton AM, Leverenz JB, DeCarli C, Jagust WJ, Clark CM, Mendez MF, Tang-Wai DF, Graff-Radford NR, Galasko D (Aug 2005) Rate of progression differs in frontotemporal dementia and Alzheimer disease., Neurology, 65 (3), 397-403 Abstract
  • Kulstad JJ, McMillan PJ, Leverenz JB, Cook DG, Green PS, Peskind ER, Wilkinson CW, Farris W, Mehta PD, Craft S (Feb 2005) Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque., Journal of Neuropathology and Experimental Neurology, 64 (2), 139-46 Abstract
  • Tsuang DW, Wilson RK, Lopez OL, Luedecking-Zimmer EK, Leverenz JB, DeKosky ST, Kamboh MI, Hamilton RL (Feb 2005) Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease., Neurology, 64 (3), 509-13 Abstract
  • Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB (Apr-Jun 2005) Evaluation of selection bias in an incident-based dementia autopsy case series., Alzheimer Disease and Associated Disorders, 19 (2), 67-73 Abstract
  • McMillan PJ, Wilkinson CW, Greenup L, Raskind MA, Peskind ER, Leverenz JB (Nov 2004) Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus., Journal of Neurochemistry, 91 (4), 843-51 Abstract
  • Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, Bird TD, Leverenz JB, Tsuji S, La Spada AR (Sep 2004) Beta-synuclein gene alterations in dementia with Lewy bodies., Neurology, 63 (5), 805-11 Abstract
  • Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D (Sep 2004) Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study., Journal of the American Geriatrics Society, 52 (9), 1442-8 Abstract
  • Doherty MJ, Bird TD, Leverenz JB, Alpha-synuclein in motor neuron disease: an immunohistologic study, Acta Neuropathol, 107, 169-75, 2004
  • Szot P, Wilkinson CW, White SS, Leverenz JB, Greenup JL, Colasurdo EA, Peskind ER, Raskind MA (2004) Chronic cortisol suppresses pituitary and hypothalamic peptide message expression in pigtailed macaques., Neuroscience, 126 (1), 241-6 Abstract
  • McMillan PJ, Peskind E, Raskind MA, Leverenz JB (Nov-Dec 2004) Increased galanin receptor occupancy in Alzheimer's disease., Neurobiology of Aging, 25 (10), 1309-14 Abstract
  • Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD, Neurodegeneration and defective neurotransmission in a Caenorhabditis, Proceedings of the National Academy of Sciences of the United States of America., 100(17), 9980-5, August 2003
  • Bonner LT, Tsuang DW, Cherrier MM, Eugenio CJ, Du Jennifer Q, Steinbart EJ, Limprasert P, La Spada AR, Seltzer B, Bird TD, Leverenz JB, Familial dementia with Lewy bodies with an atypical clinical presentation, Journal of Geriatric Psychiatry and Neurology, 16(1), 59-64, March 2003 Abstract
  • Cook DG, Leverenz JB, McMillan PJ, Kulstad JJ, Ericksen S, Roth RA, Schellenberg GD, Jin LW, Kovacina KS, Craft S, Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's, American Journal of Pathology, 162(1), 313-9, January 2003
  • Tsuang DW, Dalan AM, Eugenio CJ, Poorkaj P, Limprasert P, La Spada AR, Steinbart EJ, Bird TD, Leverenz JB, Familial dementia with lewy bodies: a clinical and neuropathological study, Archives of Neurology, 59(10), 1622-30, October 2002
  • Silverberg GD, Levinthal E, Sullivan EV, Bloch DA, Chang SD, Leverenz J, Flitman S, Winn R, Marciano F, Saul T, Huhn S, Mayo M, McGuire D, Assessment of low-flow CSF drainage as a treatment for AD: results of a, Neurology, 59(8), 1139-45, October 2002
  • Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB, Clinical and neuropathological characteristics of hippocampal sclerosis: a, Archives of Neurology, 59(7), 1099-106, July 2002
  • Leverenz JB, McKeith IG, Dementia with Lewy bodies, The Medical Clinics of North America, 86(3), 519-35, May 2002 Abstract
  • Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC, Diet-induced hypercholesterolemia enhances brain A beta accumulation in, Neuroreport, 13(4), 455-9, March 2002
  • Husseman JW, Hallows JL, Bregman DB, Leverenz JB, Nochlin D, Jin LW, Vincent I, Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels, Journal of Neuropathology and Experimental Neurology, 60(12), 1219-32, December 2001
  • Leverenz JB, Miller MA, Dobie DJ, Peskind ER, Raskind MA, Increased alpha 2-adrenergic receptor binding in locus coeruleus, Neurobiology of Aging, 22(4), 555-61, 2001
  • Clark AF, Steely HT, Dickerson JE Jr, English-Wright S, Stropki K, McCartney MD, Jacobson N, Shepard AR, Clark JI, Matsushima H, Peskind ER, Leverenz JB, Wilkinson CW, Swiderski RE, Fingert JH, Sheffield VC, Stone EM, Glucocorticoid induction of the glaucoma gene MYOC in human and monkey, Investigative Ophthalmology & Visual Science, 42(8), 1769-80, July 2001
  • Szot P, Leverenz JB, Peskind ER, Kiyasu E, Rohde K, Miller MA, Raskind MA, Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the, Brain Research. Molecular Brain Research, 84(1-2), 135-40, December 2000
  • McMillan PJ, Leverenz JB, Dorsa DM, Specific downregulation of presenilin 2 gene expression is prominent, Brain Research. Molecular Brain Research, 78(1-2), 138-45, May 2000
  • Tsuang D, Larson EB, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz JB, Peskind ER, Lim A, Raskind MA, Thompson ML, Mirra SS, Gearing M, Schellenberg GD, Kukull W, The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer, Archives of Neurology, 56(12), 1489-95, December 1999
  • Miller MA, Kolb PE, Leverenz JB, Peskind ER, Raskind MA, Preservation of noradrenergic neurons in the locus ceruleus that coexpress, Journal of Neurochemistry, 73(5), 2028-36, November 1999
  • Lieberman AP, Trojanowski JQ, Leonard DG, Chen KL, Barnett JL, Leverenz JB, Bird TD, Robitaille Y, Malandrini A, Fischbeck KH, Ataxin 1 and ataxin 3 in neuronal intranuclear inclusion disease, Annals of Neurology, 46(2), 271-3, August 1999 Abstract
  • Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind ER, Raskind M, Larson EB, Clinico-neuropathological correlation of Alzheimer's disease in a, Journal of the American Geriatrics Society, 47(5), 564-9, May 1999
  • Leverenz JB, Wilkinson CW, Wamble M, Corbin S, Grabber JE, Raskind MA, Peskind ER, Effect of chronic high-dose exogenous cortisol on hippocampal neuronal, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 19(6), 2356-61, March 1999
  • Leverenz JB, Yu CE, Schellenberg GD, Aging-associated neuropathology in Werner syndrome, Acta Neuropathologica, 96(4), 421-4, October 1998 Abstract
  • Leverenz JB, Raskind MA, Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis., Experimental Neurology, 150(2), 296-304, April 1998 Abstract
  • Leverenz JB, Yu CE, Schellenberg GD, Aging-associated neuropathology in Werner syndrome, Acta Neuropathol., 96, 421-424, 1998
  • Peskind ER, Leverenz J, Farlow MR, Ito RK, Provow SA, Siegel RS, Cleveland M, Morgan CH, Pandian MR, Corbin S, Nochlin D, Schellenberg GD, Raskind MA, Wagner SL, Clinicopathologic correlations of soluble amyloid beta-protein precursor in cerebrospinal fluid in patients with Alzheimer disease and controls., Alzheimer Disease and Associated Disorders, 11(4), 201-6, December 1997 Abstract
  • Edland SD, Wijsman EM, Schoder-Ehri GL, Leverenz JB, Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome., Neuroreport, 8(16), 3463-5, November 1997 Abstract
  • Matsushima H, Peskind ER, Clark JM, Leverenz JB, Wilkinson CW, Clark JI, Protein changes during aging and the effects of long-term cortisol treatment in macaque monkey lens., Optometry and Vision Science, 74(4), 190-7, April 1997 Abstract
  • Tsuang D, Raskind MA, Leverenz J, Peskind ER, Schellenberg G, Bird TD, The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles., Biological Psychiatry, 41(2), 191-5, January 1997 Abstract
  • McMillan PJ, Leverenz JB, Poorkaj P, Schellenberg GD, Dorsa DM, Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease., Journal of Histochemistry and Cytochemistry, 44(11), 1215-22, November 1996 Abstract
  • Borson S, Leverenz JB, Basic mechanisms in neurodegenerative disease: Implications for behavioral pathogenesis and treatment., Seminars in Clinical Neuropsychiatry, 1, 248-60, 1996
  • Frumkin LR, Patterson BK, Leverenz JB, Agy MB, Wolinsky SM, Morton WR, Corey L, Infection of Macaca nemestrina brain with human immunodeficiency virus type 1., Journal of General Virology, 76 ( Pt 10), 2467-76, October 1995 Abstract
  • Leverenz JB, Dementia. Epidemiology, diagnosis and medical management of Alzheimer's disease., Proc. Straub Found., 59, 12-5, 1995
  • Bennett DA, Cochran EJ, Saper CB, Leverenz JB, Gilley DW, Wilson RS, Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease., Neurobiology of Aging, 14(6), 589-96, 1993 Abstract
  • Rye DB, Leverenz J, Greenberg SG, Davies P, Saper CB, The distribution of Alz-50 immunoreactivity in the normal human brain., Neuroscience, 56(1), 109-27, September 1993 Abstract
  • Leverenz J, Sumi SM, Parkinson's disease in patients with Alzheimer's disease., Archives of Neurology, 43(7), 662-4, July 1986 Abstract
  • Cohen D, Eisdorfer C, Leverenz J, Alzheimer's disease and maternal age., Journal of the American Geriatrics Society, 30(10), 656-9, October 1982 Abstract
  • Cohen D, Eisdorfer C, Prinz P, Leverenz J, Davis M, Immunoglobulins, cognitive status and duration of illness in Alzheimer's disease., Neurobiology of Aging, 1 (2), 165-8, 1980
  • Sonnen J, Postupna N, Larson E, Shannon R, Montine K, Leverenz J, Montine T, Pathologic correlates of dementia in individuals with Lewy bidy disease, Brain pathology, In Press
  • Watson GS, Leverenz JB, Profile of Cognitive Impairment in Pakinson's Disease, Brain pathology, In Press
  • Hwang H, Zhang J, Chung KA, Leverenz JB, Zabetian CP, Peskind ER, Jakovic J, Su Z, Hancock AM, Pan C, Montine TJ, Pan S, Nutt J, Albin R, Gearing M, Beyer RP, Shi M, Zhang, Glycoproteomics in neurodegenerative diseases, Mass spectrometry reviews, In Press
  • Poorkaj P, Raskind E, Leverenz J, Matsushita M, Zabetian C, Samii A, Kim S, Gazi N, Nutt J, Wolff J, Yearout D, Greenup J, Steinbart E, Bird T, A novel X-linked 4-repeat taupathy with parkinsonism and spasticity, Movement disorders, In Press
  • Jayadev S, Leverenz JB, Steinbart E, Stahl J, Klunk W, Bird TD, Alzheimer's disease phenotypes and genotypes with mutations in presenilin 2 (PSEN2), Brain, In Press
  • Zhen H, Shi M, Chung K, Quinn J, Peskind E, Galasko D, Jankovic J, Zabetian C, Leverenz J, Baird G, Montine T, Hancock A, Pan Catherine, Zhang J, DJ-1 and alpha-synuclein in human CSF as biomarkers of Parkinson's disease, Brain, In Press

Profile Details

Last Updated: 2/22/2010

COS Expertise ID #424157
Reference this profile directly: http://myprofile.cos.com/leverenzj