Dr. Ajit P. Limaye

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University of Washington
School of Medicine
Laboratory Medicine and Medicine
Associate ProfessorAppointed: 2005
Fred Hutchinson Cancer Research Center
Seattle Cancer Care Alliance
Associate MemberAppointed: 2001
University of Washington
Medical Center
Organ Transplant Infectious Diseases Program
DirectorAppointed: 2000
Professional Headshot of Ajit P. Limaye

Mailing Address

University of Washington
Department of Laboratory Medicine
Box 357110
Seattle, Washington 98195-7110
United States

Contact Information

Phone: (206) 598-6131
Fax: (206) 598-6189
limaye@u.washington.edu

Qualifications

Certified, American Board of Internal Medicine, Infectious Diseases, 2007.
Certified, American Board of Internal Medicine, Internal Medicine, 1996.
M.D., University of Washington, 1992.
B.S., University of Washington, Biology, 1986.

Keywords

COS Keywords:

Cancer or Carcinogenesis, Infectious Diseases or Agents, Internal Medicine, Laboratory Practice or Procedure, Microbiology, Organ Transplantation, Virology.

Additional Terms:

Aspergillus, BK Virus, Cytomegalovirus, Organ Transplantation.

Memberships

Academy of Clinical and Laboratory Physicians and Scientists
American Society for Microbiology
American Society for Transplantation
Fellow, American College of Physicians
Infectious Diseases Society of America

Honors and Awards

2005, Philip and Helen Fialkow Scholar, Dept. of Medicine, Division of Infectious Diseases, University of Washington, for outstanding research, teaching, clinical work, and academic citizenship
2001, Distinguished Staff Award, Seattle Cancer Care Alliance, University of Washington
1993, NIH Research Award for Clinical Trainees NIH
1992, Medical Alumni Research Prize University of Washington
1992, Harold Lamport Research Prize University of Washington
1990, Henry M. Christian Memorial Award, American Federation for Clinical Research
1990, Young Investigator of the Year, American Society of Tropical Medicine and Hygiene
1990, Research Award, Howard Hughes Medical Institute/NIH
1988, Research Fellowship, Howard Hughes Medical Institute & NIH

Previous Positions

2001-2005, Assistant Professor, University of Washington, School of Medicine, Laboratory Medicine
1998-2001, Acting Assistant Professor, University of Washington, School of Medicine, Laboratory Medicine

Funding Received

  • Duke University Lung Central Lab: Phase III Randomized Double-Blind Comparison of Oral Valganciclovir and Placebo for Prevention of CMV Infection After Lung Transplant, $455,322, May 2003 to May 2005.
  • Roche Pharmaceuticals: Reactivation of Cytomegalovirus in Critically-Ill Patients, $323,084, Jun 2003 to Jun 2005.
  • Roche Pharmaceuticals: Short vs. Long-term Valganciclovir Prophylaxis for Prevention of CMV Disease in Lung Transplant Recipients, $513,869, Jul 2003 to Jul 2006.
  • National Institutes of Health/Collaborative Antiviral Study Group: Phase I/II Study of Cidofovir for Treatment of BK Virus Nephropathy in Kidney Transplant Recipients, Jan 2004 to Jan 2007.
  • City of Hope Transplant Institute: Immunologic Correlates of Late CMV Disease in D+R- Liver Transplant Recipients, $25,000, Feb 2004 to Feb 2007.

Publications

  • Singh N, Lortholary O, Dromer F, Alexander BD, Gupta KL, John GT, del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Et Al (2008) Central nervous system cryptococcosis in solid organ transplant recipients: Clinical relevance of abnormal neuroimaging findings, Transplantation, 86 (5), 647-51
  • Hoffman NG, Cook L, Atienza EE, Limaye AP, Jerome KR (2008) Marked variability of BK virus load measurement using quantitative real-time PCR among commonly used assays, J Clin Microbiol, 46 (8), 2671-80
  • Limaye AP, Kirby KA, Rubenfeld GD, Leisenring WM, Bulger EM, Neff MJ, Gibran NS, Huang ML, Santo Hayes TK, Corey L, Boeckh M (Jul 2008) Cytomegalovirus reactivation in critically ill immunocompetent patients., JAMA : the journal of the American Medical Association, 300 (4), 413-22 Abstract
  • Hansen G, Swanzy S, Gupta R, Cookson B, Limaye AP (Feb 2008) In vitro activity of fluoroquinolones against clinical isolates of Nocardia identified by partial 16S rRNA sequencing., European journal of clinical microbiology & infectious diseases, 27 (2), 115-20 Abstract
  • Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, Del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Albert ND, Wagener MM, Singh N (Feb 2008) Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis., Antimicrobial agents and chemotherapy, 52 (2), 735-8 Abstract
  • La Rosa C, Krishnan A, Longmate J, Martinez J, Manchanda P, Lacey SF, Limaye AP, Diamond DJ (Jan 2008) Programmed death-1 expression in liver transplant recipients as a prognostic indicator of cytomegalovirus disease., The Journal of infectious diseases, 197 (1), 25-33 Abstract
  • Singh N, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Muñoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Wagener MM, Husain S (Jan 2008) Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen., Clinical infectious diseases, 46 (2), e12-18 Abstract
  • Saha DC, Goldman DL, Shao X, Casadevall A, Husain S, Limaye AP, Lyon M, Somani J, Pursell K, Pruett TL, Singh N (Dec 2007) Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients., Clinical and vaccine immunology : CVI, 14 (12), 1550-4 Abstract
  • Li F, Kenyon KW, Kirby KA, Fishbein DP, Boeckh M, Limaye AP (Aug 2007) Incidence and clinical features of ganciclovir-resistant cytomegalovirus disease in heart transplant recipients., Clinical infectious diseases, 45 (4), 439-47 Abstract
  • Hakki M, Limaye AP, Kim HW, Kirby KA, Corey L, Boeckh M (Jun 2007) Invasive Pseudomonas aeruginosa infections: high rate of recurrence and mortality after hematopoietic cell transplantation., Bone marrow transplantation, 39 (11), 687-93 Abstract
  • Harrington A, McCourtney K, Nowowiejski D, Limaye A (May 2007) Differentiation of Candida albicans from non-albicans yeast directly from blood cultures by Gram stain morphology., European journal of clinical microbiology & infectious diseases, 26 (5), 325-9 Abstract
  • La Rosa C, Limaye AP, Krishnan A, Longmate J, Diamond DJ (Mar 2007) Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease., The Journal of infectious diseases, 195 (5), 633-44 Abstract
  • Singh N, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Wagener MM, Husain S (Mar 2007) Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality., The Journal of infectious diseases, 195 (5), 756-64 Abstract
  • Erard V, Limaye AP, Boeckh M (2007) Polyomaviruses In Long SS, Pickering LK, Prober CG (eds), Principles and Practice of Pediatric Infectious Diseases, 3rd Edition, Elsevier (bookchapter)
  • Bollyky PL, Czartoski TJ, Limaye A (Dec 2006) Histoplasmosis presenting as an isolated spinal cord lesion., Archives of neurology, 63 (12), 1802-3 Abstract
  • Alexander J, Limaye AP, Ko CW, Bronner MP, Kowdley KV (Dec 2006) Association of hepatic iron overload with invasive fungal infection in liver transplant recipients., Liver transplantation, 12 (12), 1799-804 Abstract
  • Lacey SF, La Rosa C, Zhou W, Sharma MC, Martinez J, Krishnan A, Gallez-Hawkins G, Thao L, Longmate J, Spielberger R, Forman SJ, Limaye A, Zaia JA, Diamond DJ (Nov 2006) Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients., The Journal of infectious diseases, 194 (10), 1410-21 Abstract
  • Copp DH, Godwin JD, Kirby KA, Limaye AP (Nov 2006) Clinical and radiologic factors associated with pulmonary nodule etiology in organ transplant recipients., American journal of transplantation, 6 (11), 2759-64 Abstract
  • Phan BA, Laflamme MA, Stempien-Otero A, Limaye AP, Buckner FS, Levy WC (Sep 2006) Confirmation of Chagas' cardiomyopathy following heart transplantation., Heart and vessels, 21 (5), 325-7 Abstract
  • Singh N, Limaye AP, Forrest G, Safdar N, Muñoz P, Pursell K, Houston S, Rosso F, Montoya JG, Patton PR, Del Busto R, Aguado JM, Wagener MM, Husain S (Aug 2006) Late-onset invasive aspergillosis in organ transplant recipients in the current era., Medical mycology : official publication of the International Society for Human and Animal Mycology, 44 (5), 445-9 Abstract
  • Singh N, Husain S, Limaye AP, Pursell K, Klintmalm GB, Pruett TL, Somani J, Stosor V, del Busto R, Wagener MM, Steele C (Aug 2006) Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infection., Transplant immunology, 16 (2), 69-72 Abstract
  • Barton TD, Blumberg EA, Doyle A, Ahya VN, Ferrenberg JM, Brozena SC, Limaye AP (Jun 2006) A prospective cross-sectional study of BK virus infection in non-renal solid organ transplant recipients with chronic renal dysfunction., Transplant infectious disease, 8 (2), 102-7 Abstract
  • Limaye AP, Bakthavatsalam R, Kim HW, Randolph SE, Halldorson JB, Healey PJ, Kuhr CS, Levy AE, Perkins JD, Reyes JD, Boeckh M (Jun 2006) Impact of cytomegalovirus in organ transplant recipients in the era of antiviral prophylaxis., Transplantation, 81 (12), 1645-52 Abstract
  • Singh N, Limaye AP, Forrest G, Safdar N, Muñoz P, Pursell K, Houston S, Rosso F, Montoya JG, Patton P, Del Busto R, Aguado JM, Fisher RA, Klintmalm GB, Miller R, Wagener MM, Lewis RE, Kontoyiannis DP, Husain S (Feb 2006) Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter, observational study., Transplantation, 81 (3), 320-6 Abstract
  • Krieger JN, Ross SO, Limaye AP, Riley DE (Oct 2005) Inconsistent localization of gram-positive bacteria to prostate-specific specimens from patients with chronic prostatitis., Urology, 66 (4), 721-5 Abstract
  • Singh N, Lortholary O, Alexander BD, Gupta KL, John GT, Pursell KJ, Muñoz P, Klintmalm GB, Stosor V, Del Busto R, Limaye AP, Somani J, Lyon M, Houston S, House AA, Pruett TL, Orloff S, Humar A, Dowdy LA, Garcia-Diaz J, Kalil AC, Fisher RA, Heitman J, Husain S (Oct 2005) Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection., Transplantation, 80 (8), 1033-9 Abstract
  • Singh N, Lortholary O, Alexander BD, Gupta KL, John GT, Pursell K, Munoz P, Klintmalm GB, Stosor V, delBusto R, Limaye AP, Somani J, Lyon M, Houston S, House AA, Pruett TL, Orloff S, Humar A, Dowdy L, Garcia-Diaz J, Fisher RA, Husain S (Oct 2005) Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome., Transplantation, 80 (8), 1131-3 Abstract
  • Krymskaya L, Sharma MC, Martinez J, Haq W, Huang EC, Limaye AP, Diamond DJ, Lacey SF (Sep 2005) Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides., Journal of virology, 79 (17), 11170-8 Abstract
  • Upton A, Gugel A, Leisenring W, Limaye A, Alexander B, Hayden R, Marr KA (Sep 2005) Reproducibility of low galactomannan enzyme immunoassay index values tested in multiple laboratories., Journal of clinical microbiology, 43 (9), 4796-800 Abstract
  • Erard V, Kim HW, Corey L, Limaye A, Huang ML, Myerson D, Davis C, Boeckh M (Aug 2005) BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients., Blood, 106 (3), 1130-2 Abstract
  • Singh N, Lortholary O, Alexander BD, Gupta KL, John GT, Pursell K, Munoz P, Klintmalm GB, Stosor V, del Busto R, Limaye AP, Somani J, Lyon M, Houston S, House AA, Pruett TL, Orloff S, Humar A, Dowdy L, Garcia-Diaz J, Kalil AC, Fisher RA, Husain S (Jun 2005) An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients., Clinical infectious diseases, 40 (12), 1756-61 Abstract
  • Yuan S, Astion ML, Schapiro J, Limaye AP (May 2005) Clinical impact associated with corrected results in clinical microbiology testing., Journal of Clinical Microbiology, 43 (5), 2188-93 Abstract
  • Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, Mihatsch MJ, Nickeleit V, Ramos E, Randhawa P, Shapiro R, Steiger J, Suthanthiran M, Trofe J (May 2005) Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations., Transplantation, 79 (10), 1277-86 Abstract
  • Limaye AP, Smith KD, Cook L, Groom DA, Hunt NC, Jerome KR, Boeckh M (Mar 2005) Polyomavirus nephropathy in native kidneys of non-renal transplant recipients., American journal of transplantation, 5 (3), 614-20 Abstract
  • Limbago B, Limaye AP (2005) Diagnostic Microbiology In Shah SS, Hu K (eds), Blueprints: Infectious Diseases, Blackwell (bookchapter)
  • Smith JM, McDonald RA, Finn LS, Healey PJ, Davis CL, Limaye AP, Polyomavirus Nephropathy in Pediatric Kidney Transplant Recipients., American Journal of Transplantation, 4(12), 2109-17, Dec 2004 Abstract
  • Erard V, Storer B, Corey L, Nollkamper J, Huang ML, Limaye A, Boeckh M (Dec 2004) BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis., Clinical infectious diseases, 39 (12), 1861-5 Abstract
  • Limaye AP, Bakthavatsalam R, Kim HW, Kuhr CS, Halldorson JB, Healey PJ, Boeckh M, Late-onset Cytomegalovirus Disease in Liver Transplant Recipients Despite Antiviral Prophylaxis., Transplantation, 78(9), 1390-6, Nov 2004 Abstract
  • Schapiro JM, Gupta R, Stefansson E, Fang FC, Limaye AP, Isolation of Metronidazole-resistant Bacteroides Fragilis Carrying The NimA Nitroreductase Gene From a Patient in Washington State., Journal of Clinical Microbiology, 42(9), 4127-9, Sep 2004 Abstract
  • de Bruyn G, Whelan TP, Mulligan MS, Raghu G, Limaye AP, Invasive Pneumococcal Infections in Adult Lung Transplant Recipients., American Journal of Transplantation, 4(8), 1366-71, Aug 2004 Abstract
  • Panackal AA, Houze YB, Prentice J, Leopold SS, Cookson BT, Liles WC, Limaye AP, Prosthetic joint infection due to "Helcococcus pyogenica", Journal of Clinical Microbiology, 42(6), 2872-4, Jun 2004 Abstract
  • de Bruyn G, Limaye AP, BK virus-associated nephropathy in kidney transplant recipients, Reviews in Medical Virology, 14(3), 193-205, May-J 2004 Abstract
  • Wilson JR, Limaye AP, Risk factors for mortality in patients with anaerobic bacteremia, European Journal of Clinical Microbiology & Infectious Diseases, 23(4), 310-6, Apr 2004 Abstract
  • Novicki TJ, Schapiro JM, Ulness BK, Sebeste A, Busse-Johnston L, Swanson KM, Swanzy SR, Leisenring W, Limaye AP, Convenient selective differential broth for isolation of vancomycin-resistant enterococcus from fecal material, Journal of Clinical Microbiology, 42(4), 1637-40, Apr 2004 Abstract
  • Herwaldt BL, de Bruyn G, Pieniazek NJ, Homer M, Lofy KH, Slemenda SB, Fritsche TR, Persing DH, Limaye AP, Babesia divergens-like infection, Washington State, Emerging Infectious Diseases, 10(4), 622-9, Apr 2004 Abstract
  • Selvarangan R, Bui U, Limaye AP, Cookson BT, Rapid identification of commonly encountered Candida species directly from blood culture bottles, Journal of Clinical Microbiology, 41(12), 5660-4, December 2003 Abstract
  • Pottumarthy S, Limaye AP, Prentice JL, Houze YB, Swanzy SR, Cookson BT, Nocardia veterana, a new emerging pathogen, Journal of Clinical Microbiology, 41(4), 1705-9, April 2003 Abstract
  • Turgeon DK, Novicki TJ, Quick J, Carlson L, Miller P, Ulness B, Cent A, Ashley R, Larson A, Coyle M, Limaye AP, Cookson BT, Fritsche TR, Six rapid tests for direct detection of Clostridium difficile and its toxins in fecal samples compared with the fibroblast cytotoxicity assay, Journal of Clinical Microbiology, 41(2), 667-70, February 2003 Abstract
  • Kadambi PV, Josephson MA, Williams J, Corey L, Jerome KR, Meehan SM, Limaye AP, Treatment of refractory BK virus-associated nephropathy with cidofovir, American Journal of Transplantation, 3(2), 186-91, Feb 2003 Abstract
  • Limaye AP, Antiviral Resistance in Cytomegalovirus: An Emerging Problem in Organ Transplant Recipients., Seminars in Respiratory Infections, 17(4), 265-73, Dec 2002 Abstract
  • Selvarangan R, Limaye AP, Cookson BT, Rapid identification and differentiation of Candida albicans and Candida dubliniensis by capillary-based amplification and fluorescent probe hybridization, Journal of Clinical Microbiology, 40(11), 4308-12, November 2002 Abstract
  • Limaye AP, Ganciclovir-resistant cytomegalovirus in organ transplant recipients, Clinical Infectious Diseases, 35(7), 866-72, Oct 2002 Abstract
  • Limaye AP, Raghu G, Koelle DM, Ferrenberg J, Huang ML, Boeckh M, High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy, The Journal of Infectious Diseases, 185(1), 20-7, January 2002 Abstract
  • Gottlieb GS, Limaye AP, Chen YC, Van Voorhis WC, Candida Dubliniensis Fungemia in a Solid Organ Transplant Patient: Case, Medical Mycology, 39(6), 483-5, Dec 2001 Abstract
  • Chen YC, Eisner JD, Kattar MM, Rassoulian-Barrett SL, Lafe K, Bui U, Limaye AP, Cookson BT, Polymorphic internal transcribed spacer region 1 DNA sequences identify medically important yeasts, Journal of Clinical Microbiology, 39(11), 4042-51, November 2001 Abstract
  • Limaye AP, Jerome KR, Kuhr CS, Ferrenberg J, Huang ML, Davis CL, Corey L, Marsh CL, Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients, The Journal of Infectious Diseases, 183(11), 1669-72, June 2001 Abstract
  • Limaye AP, Huang ML, Leisenring W, Stensland L, Corey L, Boeckh M, Cytomegalovirus (CMV) DNA load in plasma for the diagnosis of CMV disease before engraftment in hematopoietic stem-cell transplant recipients, The Journal of Infectious Diseases, 183(3), 377-82, February 2001 Abstract
  • Limaye AP, Connolly PA, Sagar M, Fritsche TR, Cookson BT, Wheat LJ, Stamm WE, Transmission of Histoplasma capsulatum by organ transplantation, The New England Journal of Medicine, 343(16), 1163-6, October 2000 Abstract
  • Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M, Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants, Lancet, 356(9230), 645-9, August 2000 Abstract
  • Chen YC, Eisner JD, Kattar MM, Rassoulian-Barrett SL, LaFe K, Yarfitz SL, Limaye AP, Cookson BT, Identification of medically important yeasts using PCR-based detection of DNA sequence polymorphisms in the internal transcribed spacer 2 region of the rRNA genes, Journal of Clinical Microbiology, 38(6), 2302-10, June 2000 Abstract
  • Limaye AP, Turgeon DK, Cookson BT, Fritsche TR, Pseudomembranous colitis caused by a toxin A(-) B(+) strain of Clostridium difficile, Journal of Clinical Microbiology, 38(4), 1696-7, April 2000 Abstract
  • Kattar MM, Chavez JF, Limaye AP, Rassoulian-Barrett SL, Yarfitz SL, Carlson LC, Houze Y, Swanzy S, Wood BL, Cookson BT, Application of 16S rRNA gene sequencing to identify Bordetella hinzii as the causative agent of fatal septicemia, Journal of Clinical Microbiology, 38(2), 789-94, February 2000 Abstract
  • Limaye AP, Huang ML, Atienza EE, Ferrenberg JM, Corey L, Detection of Epstein-Barr Virus DNA in Sera From Transplant Recipients With Lymphoproliferative Disorders., Journal of Clinical Microbiology, 37(4), 1113-6, Apr 1999 Abstract
  • Hebert MF, Kowdley KV, Davis CL, Limaye AP, Carithers RL Jr. (1999) Liver transplantation: Long-term post-transplant management In Bacon BR, DiBisceglie AM (eds), Liver Disease: Diagnosis and Management, WB Saunders (bookchapter)
  • Limaye AP, Liles WC, Ramsey PG (1997) Infectious Diseases In Larson EB, Ramsey PG (eds), Medical Therapeutics, 3rd Edition, WB Saunders (bookchapter)

Profile Details

Last Updated: 9/16/2008

COS Expertise ID #919421
Reference this profile directly: http://myprofile.cos.com/lima6