Dr. Bruce G. Lindsey

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University of South Florida
College of Medicine
Molecular Pharmacology & Physiology
Chair
University of South Florida
College of Medicine
Molecular Pharmacology & Physiology
Professor

Mailing Address

Dept. of Molecular Pharmacology and Physiology
Room #MDC 3040\Mail Box: MDC 08
University of South Florida COM
12901 Bruce B. Downs Blvd.
Tampa, Florida 33612-4799
United States

Contact Information

Phone: (813) 974-2590
Fax: (813) 974-3079
blindsey@health.usf.edu

Qualifications

Post Doc, University of Pennsylvania, Neurophysiology & Computational Neuroscience, 1977.
Ph.D., University of Pennsylvania, Neurological Sciences and Anatomy, 1974.
B.A., Williams College, Biology, 1971.

Expertise and Research Interests

Summary of Research:
My research interests are (a) neural coding and parallel information processing and computation in the brain, and (b) the neural control of breathing. Problems currently under study include: (1) Methods of detecting recurring spatiotemporal patterns of activity in neuronal assemblies. (2) Neural network mechanisms for the generation of the respiratory rhythm. (3) Induction and expression of memory in long-term potentiation of breathing. (4) Mechanisms by which cardiovascular reflexes modulate the breathing pattern. (5) Neural mechanisms of airway defensive reflexes.

Techniques/Methods: Computational neuroscience, Many-neuron recordings, Spike train analysis of neuronal assemblies, Neural network simulations

Other Expertise

Served as Interim Vice-President for Research, University of South Florida, 2001-2003
4/1/04-3/31/08
5R37 NS19814-19A Lindsey (PI)
NIH/NINDS
Brainstem Respiratory Neuron Interactions
The major goal of this project is to define mechanisms through which carotid baroreceptors and chemoreceptors regulate breathing. These receptors monitor blood pressure and blood gases, respectively.

9/30/02
1R01 NS46062-01 Lindsey (PI)
NIH/NINDS
Computational Studies of the Respiratory Brainstem
This collaborative project brings together researchers in five states to stimulate populations of respiratory neurons with realistic biophysical properties and computationally efficient large-scale simulations.Simulations are being used integrate current knowledge, provide a framework to test and predict the consequences of defined perturbations, and generate testable hypotheses. Associated in vivo and in vitro neurophysiological and pharmacological experiments will test model-based hypotheses on a sub-cellular, cellular, network and systems level mechanisms that transform the respiratory network during the transitions from eupnea to gasping and during sleep and waking.

2 RO1 HL 49813-8 Shannon (PI) 12/01/97 to 11/30/03
NIH/NHLBI
Brainstream Neural Networks and Airway Defensive
The major goal of this project was to define mechanisms of airway defensive reflexes, including cough and the expiratory reflex.
Role:co-investigator

1988-Present
Grant reviewer: National Science Foundation, Veterans Administration, American Heart Association, Wellcome Trust, NIH(service on various study sections, 1988 - present), United States Civilian Research and Development Foundation.

1982-Present
Referee editor for journals: Journal of Neuroscience, Journal of Neurophysiology, Journal of Physiology (London), Journal of Computational Neuroscience, Brain Research, Journal of Applied Physiology, Neuroscience, American Journal of Physiology, Experimental Brain Research, Experimental Neurolog, Journal of Neuroscience Methods, Pediatric Research, Respiration Physiology, Neuroscience Letters

Future Research

Brain stem mechanisms for integration of chemoreceptor, baroreceptor and other afferent systems.

Keywords

COS Keywords:

Computer Simulation Or Modeling, Human Physiology, Neurophysiology, Neuroscience, Pharmacology.

Additional Terms:

Breathing, Computer Simulations, Neural Coding, Neural Networks, Neurophysiology.

Memberships

American Association for the Advancement of Science
American Physiological Society
Association of Chairs of Departments of Physiology
International Brain Research Organization
Phi Beta Kappa
Sigma Xi
Society for Neuroscience

Honors and Awards

2007, Distinguished University Health Professor - University of South Florida, USF
2005, Outstanding Faculty Research Achievement Award - University of South Florida, USF
2004-2011, Javits Neuroscience Investigator Award, NINDS, NIH, NINDS
1996-1999, Elected Chair, Central Nervous System Section, American Physiological Society, APS

Previous Positions

2001-2003, Interim Vice-President for Research, University of South Florida
1998-2000, Chair, University of South Florida, Ph.D Medical Sciences Program, Neuroscience Concentration Committee
1992-1996, Interim Chair, University of South Florida, Department of Physiology & Biophysics, USF Health Services Center
1983-1988, Associate Professor of Physiology, University of South Florida, Health Sciences Center
1977-1983, Assistant Professor of Physiology, University of South Florida, Health Sciences Center
1974-1977, Postdoctoral Fellowship, National Institute of Health, University of Pennslyvania

Funding Received

  • National Institutes of Health (NIH): Computational Studies of the Respiratory Brainstem, $2,120,326, Sep 30, 2002 to Aug 31, 2007.
  • National Institutes of Health (NIH): Brainstem Respiratory Neuron Interactions, $1,934,640, 2004 to 2011.

Publications

  • Nuding SC, Segers LS, Shannon R, O'Connor R, Morris KF, Lindsey BG (Sep 2009) Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphé-pontomedullary respiratory network., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364 (1529), 2501-16 Abstract
  • Dick TE, Baekey DM, Paton JF, Lindsey BG, Morris KF (Aug 2009) Cardio-respiratory coupling depends on the pons., Respiratory physiology & neurobiology, 168 (1-2), 76-85 Abstract
  • Nuding SC, Segers LS, Baekey DM, Dick TE, Solomon IC, Shannon R, Morris KF, Lindsey BG (Jun 2009) Pontine-ventral respiratory column interactions through raphe circuits detected using multi-array spike train recordings., Journal of neurophysiology, 101 (6), 2943-60 Abstract
  • Segers LS, Nuding SC, Dick TE, Shannon R, Baekey DM, Solomon IC, Morris KF, Lindsey BG (Oct 2008) Functional connectivity in the pontomedullary respiratory network., Journal of neurophysiology, 100 (4), 1749-69 Abstract
  • Rybak IA, O'Connor R, Ross A, Shevtsova NA, Nuding SC, Segers LS, Shannon R, Dick TE, Dunin-Barkowski WL, Orem JM, Solomon IC, Morris KF, Lindsey BG (Oct 2008) Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments., Journal of neurophysiology, 100 (4), 1770-99 Abstract
  • Dick TE, Shannon R, Lindsey BG, Nuding SC, Segers LS, Baekey DM, Morris KF (Sep 2008) Pontine respiratory-modulated activity before and after vagotomy in decerebrate cats., The Journal of physiology, 586 (Pt 17), 4265-82 Abstract
  • Lindsey BG, Gerstein GL (Jan 2006) Two enhancements of the gravity algorithm for multiple spike train analysis., Journal of neuroscience methods, 150 (1), 116-27 Abstract
  • Dick TE, Shannon R, Lindsey BG, Nuding SC, Segers LS, Baekey DM, Morris KF (Aug 2005) Arterial pulse modulated activity is expressed in respiratory neural output., Journal of applied physiology (Bethesda, Md. : 1985), 99 (2), 691-8 Abstract
  • Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG (Aug 2004) Pontine respiratory group neuron discharge is altered during fictive cough in the decerebrate cat., Respiratory physiology & neurobiology, 142 (1), 43-54 Abstract
  • Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG, Shannon R (Jun 2004) Ventrolateral medullary respiratory network participation in the expiration reflex in the cat., Journal of applied physiology (Bethesda, Md. : 1985), 96 (6), 2057-72 Abstract
  • Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG (2004) Production of reflex cough by brainstem respiratory networks., Pulmonary pharmacology & therapeutics, 17 (6), 369-76 Abstract
  • Morris KF, Baekey DM, Nuding SC, Dick TE, Shannon R, Lindsey BG, Plasticity in Respiratory Motor Control: Invited review: Neural network plasticity in respiratory control, Journal of Applied Physiology, 94(3), 1242-52, March 2003
  • Morris KF, Baekey DM, Nuding SC, Dick TE, Shannon R, Lindsey BG (Mar 2003) Invited review: Neural network plasticity in respiratory control., Journal of applied physiology (Bethesda, Md. : 1985), 94 (3), 1242-52 Abstract
  • Morris KF, Baekey DM, Nuding SC, Dick TE, Shannon R, Lindsey BG (Mar 2003) Invited review: Neural network plasticity in respiratory control., Journal of applied physiology (Bethesda, Md. : 1985), 94 (3), 1242-52 Abstract
  • Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG, Shannon R, Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat, Journal of Applied Physiology, 94(1), 93-100, January 2003
  • Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG, Shannon R (Jan 2003) Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat., Journal of applied physiology (Bethesda, Md. : 1985), 94 (1), 93-100 Abstract
  • Morris KF, Shannon R, Lindsey BG, Changes in cat medullary neurone firing rates and synchrony following induction of respiratory long-term facilitation, Journal of Physiology, 532(Pt 2), 483-97, April 2001 Abstract
  • Morris KF, Shannon R, Lindsey BG (Apr 2001) Changes in cat medullary neurone firing rates and synchrony following induction of respiratory long-term facilitation., The Journal of physiology, 532 (Pt 2), 483-97 Abstract
  • Lindsey, B.G (2001) How is the respiratory central pattern generator configured and reconfigured? A workshop summary, Adv. Exp. Biol, 499, 179-184
  • Lindsey, B.G, Baekey, D.M., Morris, K.F., Gestreau, C., Li, Z., Shannon, R. (2001) Medullary respiratory neurones controlling laryngeal motoneurone discharge during eupnoea and fictive cough in the cat, Journal of Physiology, 534, 565-581
  • Lindsey BG, Morris KF, Segers LS, Shannon R, Respiratory neuronal assemblies, Respiration Physiology, 122(2-3), 183-96, September 2000 Abstract
  • Chang EY, Morris KF, Shannon R, Lindsey BG, Repeated sequences of interspike intervals in baroresponsive respiratory related neuronal assemblies of the cat brain stem, Journal of Neurophysiology, 84(3), 1136-48, September 2000 Abstract
  • Lindsey BG, Morris KF, Segers LS, Shannon R (Sep 2000) Respiratory neuronal assemblies., Respiration physiology, 122 (2-3), 183-96 Abstract
  • Chang EY, Morris KF, Shannon R, Lindsey BG (Sep 2000) Repeated sequences of interspike intervals in baroresponsive respiratory related neuronal assemblies of the cat brain stem., Journal of neurophysiology, 84 (3), 1136-48 Abstract
  • Morris KF, Baekey DM, Shannon R, Lindsey BG, Respiratory neural activity during long-term facilitation, Respiration Physiology, 121(2-3), 119-33, July 2000 Abstract
  • Arata A, Hernandez YM, Lindsey BG, Morris KF, Shannon R, Transient configurations of baroresponsive respiratory-related brainstem neuronal assemblies in the cat, Journal of Physiology, 525 Pt 2, 509-30, June 2000 Abstract
  • Arata A, Hernandez YM, Lindsey BG, Morris KF, Shannon R (Jun 2000) Transient configurations of baroresponsive respiratory-related brainstem neuronal assemblies in the cat., The Journal of physiology, 525 Pt 2, 509-30 Abstract
  • Shannon R, Baekey DM, Morris KF, Li Z, Lindsey BG, Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat, Journal of Physiology, 525 Pt 1, 207-24, May 2000 Abstract
  • Li Z, Morris KF, Baekey DM, Shannon R, Lindsey BG, Responses of simultaneously recorded respiratory-related medullary neurons to stimulation of multiple sensory modalities, Journal of Neurophysiology, 82(1), 176-87, July 1999 Abstract
  • Li Z, Morris KF, Baekey DM, Shannon R, Lindsey BG, Multimodal medullary neurons and correlational linkages of the respiratory network, Journal of Neurophysiology, 82(1), 188-201, July 1999 Abstract
  • Lindsey BG, Arata A, Morris KF, Hernandez YM, Shannon R, Medullary raphe neurones and baroreceptor modulation of the respiratory motor pattern in the cat, Journal of Physiology, 512 ( Pt 3), 863-82, November 1998 Abstract
  • Shannon R, Baekey DM, Morris KF, Lindsey BG, Ventrolateral medullary respiratory network and a model of cough motor pattern generation, Journal of Applied Physiology (bethesda, Md. : 1985), 84(6), 2020-35, June 1998 Abstract
  • Lindsey, B.G, Morris, K.F., Shannon, R., Gerstein, G.L. (1997) Repeated patterns of distributed synchrony in neuronal assemblies, Journal of Neurophysiology, 78, 1714-1719
  • Lindsey, B.G, Shannon, R., Baekey, D.M., Morris, K.F. (1997) Brainstem respiratory networks and cough, Pulmonary Pharmacology, 9, 343-347
  • Morris, K.F., Arata, A., Shannon, R., Lindsey, B.G. (1996) Long-term faciliation of phrenic nerve activity in the cat: responses and short-time scale correlations of medullary neurone., Journal of Physiology, 490, 463-480
  • Morris, K.F., Arata, A., Lindsey, B.G. (1996) Inspiratory drive and phase duration during carotid chemoreceptor stimulation in the cat: medullary neurone correlations, Journal of Physiology, 491, 241-259
  • Lindsey, B.G, Segers, L.S., Morris, K.F., Hernandez, Y.M., Saporta, S., Shannon, R. (1994) Distributed actions and dynamic associations in respiratory-related neuronal assemblies of the ventrolateral medulla and brainstem midline: Evidence from spike train analysis, Journal of Neurophysiology, 72, 1830-1851
  • Lindsey, B.G, Balis, U.J., Morris, K.F., Koleski, J. (1994) Simulations of ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation, Biological Cybernetics, 70, 311-327
  • Lindsey, B.G, Davenport, P.W., Shannon, R., Mercak, A., Reep, R.L. (1993) Cerebral cortical evoked potentials elicited by cat intercoastal muscle mechanoreceptors., Journal of Applied Physiology, 74, 799-804
  • Lindsey, B.G, Hernadez, Y.M., Morris, K.F., Shannon, R., Gerstein, G.L. (1992) Dynamic reconfiguration of brain stem neural assemblies: Respiratory phase-dependent synchrony versus modulation of firing rates, Journal of Neurophysiology, 67, 923-930
  • Lindsey, B.G, Hernadez, Y.M., Morris, K.F., Shannon, R. (1992) Respiratory related neural assemblies in the brain stem midline, Journal of Neurophysiology, 67, 905-922
  • Lindsey, B.G, Hernadez, Y.M., Morris, K.F., Shannon, R. (1992) Functional connectivity between brain stem midline neurons with respiratory modulated firing rates., Journal of Neurophysiology, 67, 890-904
  • Lindsey, B.G, Segers, L.S., Shannon, R. (1989) Discharge patterns of augmenting expiratory neurons in rostral lateral medulla of cat: Regulation by concurrent network processes, Journal of Neurophysiology, 61, 1185-1196
  • Lindsey, B.G., Segers, L.S., Shannon, R. (1987) Functional associations among simultaneously monitored lateral respiratory neurons in the cat. II. Evidence for inhibitory actions of expiratory neurons, Journal of Neurophysiology, 57, 1101-1117
  • Lindsey, B.G., Segers, L.S., Shannon, R., Saporta, S. (1987) Functional associations among simultaneously monitored latereal medullary respiratory neurons in the cat. I. Evidence for excitatory and inhibitory actions of inspiratory neurons, Journal of Neurophysiology, 57, 1078-1100
  • Lindsey, B.G., Shannon, R., Segers, L.S. (1985) Interactions between rostral pontine and ventral medullary respiratory neurons, Journal of Neurophysiology, 54, 318-334
  • Morris KF, Arata A, Shannon R, Lindsey BG. Long-term facilitation of phrenic nerve activity in the cat: responses and short-time scale correlations of medullary neurones. J of Physiol. (London) 1996,490:463-480
  • Lindsey BG, Segers LS, Morris KF, Hernandez YM, Saporta S, Shannon R. Distributed actions and dynamic associations in respiratory-related neuronal assemblies of the ventrolateral medulla and brainstem midline: Evidence from spike train analysis. J of Neurophysiol. 1994: 72:1830-1851
  • Morris KF, Arata A, Shannon R, Lindsey BG. Inspiratory drive and phase duration during carotid chemoreceptor stimulation in the cat: medullary neurone correlations. J of Physiol. (London) 1996,491:241-259

Profile Details

Last Updated: 8/30/2009

COS Expertise ID #367244
Reference this profile directly: http://myprofile.cos.com/lindseyb44