Dr. Michael L. Linenberger

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Fred Hutchinson Cancer Research Center
Clinical Research
Associate MemberAppointed: 2001
Seattle Cancer Care Alliance
Blood and Blood Component Services
DirectorAppointed: 2001
University of Washington
School of Medicine
Medicine
Hematology
Associate ProfessorAppointed: 2000
Professional Headshot of Michael L. Linenberger

Mailing Address

Seattle Cancer Care Alliance
825 Eastlake Ave. E. (G6-800)
P. O. Box 19023
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 288-2038
Fax: (206) 288-1130
linen@u.washington.edu

Qualifications

M.D., University of Kansas, 1982.
B.S., University of Kansas, 1978.

Expertise and Research Interests

Current research interests include studies of mechanisms of drug resistance in acute myeloid leukemia (AML), including drug transporter mechanisms active against antibody-directed therapy. Other interests include optimization of methods for stem cell procurement, therapeutic apheresis approaches for post-transplant graft-versus-host disease, and cellular therapy applications relevant to hematopoietic stem cell transplantation.

Other Expertise

Clinical Interests:
Therapeutic Apheresis;
Marrow and peripheral blood tem cell procurement;
AML treatment with antibody-based agents;
Hypercoagulable disorders;
Iron overload disorders;
Porphyrias;
Benign and malignant hematologic disorders.

Prior Research Activity:
Mechanisms of retroviral-mediated hematopoietic suppression and leukemogenesis.

Future Research

We are working to apply our knowledge of drug resistance mechanisms against antibody-based therapies for AML toward conducting clinical trials using drug resistance modulating agents.

We are working to develop clinical protocols to study the mechanisms and therapeutic efficacy of extracorporeal photochemotherapy for graft-versus-host disease.

Keywords

COS Keywords:

Animal Diseases Or Pathology, Bone Marrow, Cell Biology, Immune System Disorders, Leukemia, Virology.

Additional Terms:

Acute Myeloid Leukemia, Apheresis, Bone Marrow, Hematopoiesis, Hematopoietic Stem Cell Transplantation, Hypercoagulable State, Multidrug Resistance, Photopheresis, Stem Cell, Stem Cell Collection.

Memberships

Alpha Chi Sigma
Alpha Omega Alpha
American Association of Blood Banks
American College of Physicians
American Society for Apheresis
American Society of Hematology
International Society for Cellular Therapy

Previous Positions

1993-2000, Assistant Professor, University of Washington, School of Medicine, Medicine, Hematology
1989-1993 University of Washington, Hematology, Acting Instructor

Publications

  • Linenberger, M, 'Myeloproliferative Disorders', in American Society of Hematology Self-Assessment Program, edited by James N. George and Michael E. Williams. Blackwell Publishing, 129-164, 2003
  • Reiner AP, Frank MB, Schwartz SM, Linenberger ML, Longstreth WT, Teramura G, Rosendaal FR, Psaty BM, Siscovick DS, Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women, British Journal of Haematology, 116(2), 376-82, February 2002 Abstract
  • Linenberger ML, Maloney DG, Bernstein ID, Antibody-directed therapies for hematological malignancies, Trends in Molecular Medicine, 8(2), 69-76, February 2002 Abstract
  • Sievers EL, Linenberger M, Mylotarg: antibody-targeted chemotherapy comes of age, Current Opinion in Oncology, 13(6), 522-7, November 2001 Abstract
  • Linenberger ML, Hong T, Flowers D, Sievers EL, Gooley TA, Bennett JM, Berger MS, Leopold LH, Appelbaum FR, Bernstein ID, Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin, Blood, 98(4), 988-94, August 2001 Abstract
  • Linenberger ML, Kindelan J, Bennett RL, Reiner AP, Cote HC, Fibrinogen bellingham: a gamma-chain R275C substitution and a beta-promoter polymorphism in a thrombotic member of an asymptomatic family, American Journal of Hematology, 64(4), 242-50, August 2000 Abstract
  • Linenberger ML, Deng T, The effects of feline retroviruses on cytokine expression., Veterinary Immunology and Immunopathology, 72(3-4), 343-68, 30 Dec 1999 Abstract
  • Linenberger ML, Rohn JL, Deng T, Ellis-Smith S, Ingber R, Overbaugh J, Lymphokines modulate the growth and survival of thymic tumor cells containing a novel feline leukemia virus/Notch2 variant, Veterinary Immunology and Immunopathology, 70(3-4), 223-43, 1999 Abstract
  • Schuetze SM, Linenberger M, Acquired protein S deficiency with multiple thrombotic complications after orthotopic liver transplant, Transplantation, 67(10), 1366-9, 1999 Abstract
  • Rohn J L, Gwynn S R, Lauring A S, Linenberger M L, Overbaugh J, Viral genetic variation, AIDS, and the multistep nature of carcinogenesis: the feline leukemia virus model., Leukemia, 10(12), 1867-9, December 1996 Abstract
  • Rohn J L, Lauring A S, Linenberger M L, Overbaugh J, Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma., Journal of Virology, 70(11), 8071-80, November 1996 Abstract
  • Shelton G H, Linenberger M L, Hematologic abnormalities associated with retroviral infections in the cat., Seminars In Veterinary Medicine and Surgery (small Animal), 10(4), 220-33, November 1995 Abstract
  • Linenberger M L, Dow S W, Abkowitz J L, Feline leukemia virus infection downmodulates the production of growth-inhibitory activity by marrow stromal cells., Experimental Hematology, 23(10), 1069-79, September 1995 Abstract
  • Linenberger M L, Jacobson F W, Bennett L G, Broudy V C, Martin F H, Abkowitz J L, Stem cell factor production by human marrow stromal fibroblasts., Experimental Hematology, 23(10), 1104-14, September 1995 Abstract
  • Shelton G H, Linenberger M L, Persik M T, Abkowitz J L, Prospective hematologic and clinicopathologic study of asymptomatic cats with naturally acquired feline immunodeficiency virus infection., Journal of Veterinary Internal Medicine, 9(3), 133-40, Spring 1995 Abstract
  • Linenberger M L, Abkowitz J L, Haematological disorders associated with feline retrovirus infections., Baillieres Clinical Haematology, 8(1), 73-112, March 1995 Abstract
  • Linenberger M L, Beebe A M, Pedersen N C, Abkowitz J L, Dandekar S, Marrow accessory cell infection and alterations in hematopoiesis accompany severe neutropenia during experimental acute infection with feline immunodeficiency virus., Blood, 85(4), 941-51, 15 Feb 1995 Abstract
  • Linenberger, ML and Abkowitz, JL, 'Haematological Disorders Associated with Feline Retrovirus Infections', in Viruses as Agents of Haematological Diseases, edited by NS Young, Balliere's Clinical Haematology Vol. 8, London, Balliere Tindall, 73-112, 1995
  • Rohn J L, Linenberger M L, Hoover E A, Overbaugh J, Evolution of feline leukemia virus variant genomes with insertions, deletions, and defective envelope genes in infected cats with tumors., Journal of Virology, 68(4), 2458-67, April 1994 Abstract
  • Abkowitz J L, Linenberger M L, Persik M, Newton M A, Guttorp P, Behavior of feline hematopoietic stem cells years after busulfan exposure., Blood, 82(7), 2096-103, 1 Oct 1993 Abstract
  • Linenberger, ML and Abkowitz, JL, 'Hematologic Consequences of Feline Leukemia Virus (FeLV) Infection', in Viruses and Bone Marrow: Basic Research and Clinical Practice, edited by NS Young, New York, Marcel Dekker, 315-349, 1993
  • Linenberger M L, Abkowitz J L, In vivo infection of marrow stromal fibroblasts by feline leukemia virus., Experimental Hematology, 20(8), 1022-7, September 1992 Abstract
  • Linenberger M L, Abkowitz J L, Studies in feline long-term marrow culture: hematopoiesis on normal and feline leukemia virus infected stromal cells., Blood, 80(3), 651-62, 1 Aug 1992 Abstract
  • Shelton G H, Linenberger M L, Abkowitz J L, Hematologic abnormalities in cats seropositive for feline immunodeficiency virus., Journal of The American Veterinary Medical Association, 199(10), 1353-7, 15 Nov 1991 Abstract
  • Linenberger M L, Shelton G H, Persik M T, Abkowitz J L, Hematopoiesis in asymptomatic cats infected with feline immunodeficiency virus., Blood, 78(8), 1963-8, 15 Oct 1991 Abstract
  • Abkowitz J L, Linenberger M L, Newton M A, Shelton G H, Ott R L, Guttorp P, Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones., Proceedings of the National Academy of Sciences (USA), 87(22), 9062-6, November 1990 Abstract
  • Shelton G H, Grant C K, Linenberger M L, Abkowitz J L, Severe neutropenia associated with griseofulvin therapy in cats with feline immunodeficiency virus infection., Journal of Veterinary Internal Medicine, 4(6), 317-9, Autumn 1990 Abstract
  • Shelton G H, Linenberger M L, Grant C K, Abkowitz J L, Hematologic manifestations of feline immunodeficiency virus infection., Blood, 76(6), 1104-9, 15 Sep 1990 Abstract
  • Shelton G H, Abkowitz J L, Linenberger M L, Russell R G, Grant C K, Chronic leukopenia associated with feline immunodeficiency virus infection in a cat., Journal of The American Veterinary Medical Association, 194(2), 253-5, 15 Jan 1989 Abstract
  • Linenberger ML, Knisley RE, IgD myeloma with plasma cell leukemia, RI Medical Journal, 68(11), 507-11, November 1985
  • Linenberger, M.L., Dow, S.W., and Abkowitz, J.L.: "Feline leukemia virus infection down-modulates the production of growth-inhibitory activity by marrow stromal cells". Exp. Hematol. 23:1069-1079, 1995
  • Linenberger ML, Jacobsen FW, Bennett LG, Broudy VC, Martin FH, Abkowitz JL,"Stem Cell Factor Production by Human Marrow Stromal Fibroblasts," Exp. Hematol. 23:1104-1114, 1995
  • Linenberger ML, Beebe AM, Pedersen NC, Abkowitz JL, Dandekar S,"Marrow Accessory Cell Infection and Alterations in Hematopoiesis Accompany Severe Neutropenia During Experimental Acute Infection with Feline Immunodeficiency Virus," Blood, 85:941-951, 1995
  • Linenberger ML, Abkowitz JL,"In Vivo Infection of Marrow Stromal Fibroblasts by Feline Leukemia Virus," Exp. Hematol., 20:1022-1027, 1992
  • Linenberger ML, Abkowitz JL,"Studies in Feline Long-term Marrow Culture: Hematopoiesis on Normal and Feline Leukemia Virus Infected Stromal Cells," Blood, 80:651-662, 1992

Profile Details

Last Updated: 1/29/2003

COS Expertise ID #308530
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