Gabriele Ludewig

(Reading, Writing, Speaking)

• Xie W, Wang K, Robertson LW, Ludewig G (Feb 2010) Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites., Environment international
• Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW (Dec 2009) Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: Effects on hepatic oxidative stress, glutathione and metals status., Environment international
• Xie W, Ludewig G, Wang K, Lehmler HJ (Oct 2009) Model and cell membrane partitioning of perfluorooctanesulfonate is independent of the lipid chain length., Colloids and surfaces. B, Biointerfaces
• Suh YW, Buettner GR, Venkataraman S, Treimer SE, Robertson LW, Ludewig G (Apr 2009) UVA/B-induced formation of free radicals from decabromodiphenyl ether., Environmental science & technology, 43 (7), 2581-8
• Luthe G, Garcia Boy R, Jacobus J, Smith BJ, Rahaman A, Robertson LW, Ludewig G (2008) Xenobiotic Geometry and Media pH Determine Cytotoxicity through Solubility., Chemical research in toxicology, 21 (5), 1017-27
• Lehmler HJ, Xu L, Vyas SM, Ojogun VA, Knutson BL, Ludewig G (Apr 2008) Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle., International journal of pharmaceutics, 353 (1-2), 35-44
• Ludewig G, Lehmann L, Esch H, Robertson LW (2008) Metabolic activation of PCBs to carcinogens in vivo--A review, Environmental Toxicology and Pharmacology Special Issue "Focus on PCBs: Recent Advances in Environmental Distribution and Health Effects", 25 (2), 241-6
• Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G (2008) 2-(4-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres, Environmental Toxicology and Pharmacology Special Issue "Focus on PCBs: Recent Advances in Environmental Distribution and Health Effects", 25 (2), 267-72
• Gregoraszczuk EL, Rak A, Ludewig G, Gasin´ska A (2008) Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells., Environmental Toxicology and Pharmacology, Special Issue "Focus on PCBs: Recent Advances in Environmental Distribution and Health Effects", 25 (2), 227-33
• Maddox C, Wang B, Kirby PA, Wang K, Ludewig G (2008) Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue rats, Environmental Toxicology and Pharmacology, Special Issue "Focus on PCBs: Recent Advances in Environmental Distribution and Health Effects", 25 (2), 260-6
• Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L (2007) Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 cells, Toxicological Sciences, 100, 88-98
• Lehmann L, Esch HL, Kirby PA, Robertson LW, Ludewig G (2007) 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats, Carcinogenesis, 28, 471-8
• Ludewig G, Esch H, Robertson LW (2007) Polyhalogenierte Bi- und Terphenyle,, In: Dunkelberg H, Gebel T, Hartwig A (Editors) Handbuch der Lebensmitteltoxikologie, Chapter 20 Edition, Wiley-VCH Weinheim, 1031-1094 pages (bookchapter)
• Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N (2006) Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: Altering enzyme function by blocking the N-Terminal Protein Gate, Biochemistry, 45 (33), 10140-52
• Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler H-J, Robertson LW, Gregoraszczuk EL (2006) Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary, Toxicol Lett, 166, 200-11
• Ptak A, Ludewig G, Robertson LW, Lehmler H-J, Gregoraszczuk EL (2006) In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity, Toxicology Letters, 164, 113-22
• Kania-Korwel I, Hornbuckle KC, Peck A, Ludewig G, Robertson LW, Sulkowski WW, Espandiari, P, Gairola CG, Lehmler HJ, Congener-specific Tissue Distribution of Aroclor 1254 and a Highly Chlorinated Environmental PCB Mixture in Rats, Environmental Science & Technology, 39(10), 3513-20, 15 May 2005
• Ptak A, Ludewig G, Lehmler H-J, Wójtowicz AK, Robertson LW, Gregoraszczuk EL, Comparison of the Actions of 4-chlorobiphenyl and Its Hydroxylated Metabolites on Estradiol Secretion By Ovarian Follicles in Primary Cells in Culture, Reproductive Toxicology, 20(57-64), 2005
• Hennig B, Toborek M, Ramadass P, Ludewig G, Robertson LW, Polychlorinated Biphenyls, Oxidative Stress and Diet, Reviews in Food and Nutrition Toxicity, 3, 93-128, 2005
• Kania-Korwel I, Hornbuckle KC, Peck A, Ludewig G, Robertson LW, Sulkowski W, Espandiari P, Gairola CG, Lehmler H-J (2005) Congener specific tissue distribution of Aroclor 1254 and a highly chlorinated environmental PCB mixture in rats, Environmental Science & Technology, 39, 3513-20
• Kodavanti PRS, Ward TR, Ludewig G, Robertson LW, Birnbaum LS (2005) Polybrominated Diphenyl Ether (PBDE) Effects in Rat Neuronal Cultures: 14C-PBDE Accumulation, Biological Effects, and Structure-Activity Relationships, Toxicological Sciences, 88, 181-92
• Xu Y, Fang F, Ludewig G, Jones G, Jones, A Mutation Found in the Promoter Region of the Human Survivin Gene Is Correlated to Overexpression of Survivin in Cancer Cells, Dna and Cell Biology, 23(9), 419-29, September 2004
• Kania-Korwel I, Ludewig G, Robertson LW, Hornbuckle KC, Peck A, Espandiari P, Gairola CG, Sulkowski WW, Lehmler H-J, Biochemical effects of an environmental Chlorofen mixture in comparison with Aroclor 1254 in rats, Organohalogen Compounds, 66, 2985-92, 2004
• Kania-Korwel I, Hornbuckle KC, Peck A, Sulkowski WW, Ludewig G, Robertson LW, Lehmler H-J, Comparison of PCB congener profiles in tissues of PCB-treated rats, Organohalogen Compounds, 66, 2915-22, 2004
• Ptak A, Ludewig G, Lehmler H-J, Robertson LW, Gregoraszczuk EL, Effect of PCB3 and its hydroxylated metabolites on estradiol secretion, cell viability, and caspase-3 activity in porcine small follicles, Organohalogen Compounds, 66, 2973-8, 2004
• Kodavanti PR, Ward T, Burka T, Ludewig G, Robertson L, Birnbaum L, Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effect, and structure-activity relationships, Organohalogen Compounds, 66, 3133-8, 2004
• Tampal NM, Robertson LW, Srinivasan C, Ludewig G, Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1, Toxicology and Applied Pharmacology, 187(3), 168-77, March 2003
• Srinivasan A, Robertson LW, Ludewig G, Sulfhydryl binding and topoisomerase inhibition by PCB metabolites, Chemical Research in Toxicology, 15(4), 497-505, April 2002
• Srinivasan A, Lehmler HJ, Robertson LW, Ludewig G, Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites, Toxicological Sciences : an Official Journal of the Society of Toxicology., 60(1), 92-102, March 2001
• Ludewig G, Srinivasan A, Robertson LW, Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion, Central European Journal of Public Health, 8 Suppl, 15-7, July 2000
• Robertson LW, Espandiari P, Lehmler HJ, Pereg D, Srinivasan A, Tampal N, Twaroski T, Ludewig G, Glauert HP, Arif J, Gupta R, Metabolism and activation of polychlorinated biphenyls (PCBs), Central European Journal of Public Health, 8 Suppl., 14-5, July 2000
• Xu Y, Krishnan A, Wan XS, Majima H, Yeh CC, Ludewig G, Kasarskis EJ, St Clair DK, Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells, Oncogene, 18(1), 93-102, Jan 1999
• Espandiari P, Ludewig G, Glauert HP, Robertson LW, Activation of hepatic NF-kappaB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats, Journal of Biochemical and Molecular Toxicology, 12(6), 339-44, 1998