Dr. Hazel Lum

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Rush University Medical Center
Rush Medical College
Pharmacology
Professor

Mailing Address

Rush University Medical Center
Department of Pharmacology
Cohn Research Building; rm 416
1735 W. Harrison St.
Chicago, Illinois 60612
United States

Contact Information

Phone: (312) 563-2560
Fax: (312) 563-3552
hlum@rush.edu

Qualifications

Ph.D., University of California, Davis, Anatomy/Cell Biology, 1981.

Expertise and Research Interests

Inflammation injury is being recognized as a key factor in many diseases, including atherosclerosis, neurological disorders, diabetes, and arthritis. My laboratory is focused on two aspects of endothelial dysfunction that occurs during inflammation: a) increased vascular endothelial permeability and b) increased endothelial adhesion for leukocytes, both factors critical in the development of tissue edema and leukocyte extravasation. The specific research projects are:

Regulation of the assembly and disassembly of the the adherens junction complex (i.e., cadherins, catenins).

Role of key signaling molecules, such as Protein kinase C and Rho GTPases in regulation of the barrier function.

Mechanisms by protection against inflammation-induced increases in endothelial permeabiliyt, including cAMP-dependent Protein Kinase.

Molecular events regulating the active leukocyte-endothelial interactions during migration through endothelial cell junctions (tight and adherens junctions).

Other Expertise

Member of the Editorial Board for the American Journal of Physiology: Lung Cellular and Molecular Physiology.

Peer review of grants for NIH and AHA

Keywords

COS Keywords:

Cell Biology, Diabetes, Inflammation, Oxidative Stress, Pharmacology, Proteins and Macromolecules, Vascular Biology, Vascular Diseases or Injury.

Additional Terms:

Endothelial Junctions, Inflammatory Injury, Leukocyte Extravasation, Oxidative Stress, Protein Kinase C, Vascular Biology, Vascular Endothelial Permeability, cAMP Signaling.

Memberships

American Heart Association
American Physiological Society
American Society for Cell Biology
American Thoracic Society
North American Vascular Biology Organization
Sigma Xi, The Scientific Research Society

Funding Received

  • American Heart Association (AHA): Mechanisms of Enhanced Endothelial Barrier Function, Jan 1, 2000 to Dec 31, 2002.
  • National Institutes of Health (NIH): Neutrophil Transendothelial Migration in Oxidative Stress, Aug 10, 1998 to Jul 31, 2003.
  • National Institutes of Health (NIH): PKA in Reduction of Endothelial Permeability, 8/1/03 to 7/30/07.

Publications

  • Qiao, J., Huang, F., Naikawadi, R., Kim, K. S., Said , T., Lum, H. (2006) Lysophosphatidylcholine impairs endothelial barrier function through the G-protein-coupled receptor, GPR4, American Journal of Physiology, 291, L91-L101
  • Carvey PM, Zhao CH, Hendey B, Lum H, Trachtenberg J, Desai BS, Snyder J, Zhu YG, Ling ZD (Sep 2005) 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability., The European Journal of Neuroscience, 22 (5), 1158-68 Abstract
  • Huang F, Subbaiah PV, Holian O, Zhang J, Johnson A, Gertzberg N, Lum H (Aug 2005) Lysophosphatidylcholine increases endothelial permeability: role of PKCalpha and RhoA cross talk., American Journal of Physiology. Lung Cellular and Molecular Physiology, 289 (2), L176-85 Abstract
  • Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL, Lum H, Anand-Apte B, Xu Y (May 2005) GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine., The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 19 (7), 819-21 Abstract
  • Lum, H. (2005) The Activated Endothelial Cell Phenotypes In Patterson, C.E. (eds), Perspectives on Lung Endothelial Barrier Function, Vol. 35, Advances in Edition, Amsterdam, Elsevier, ch. 3 pages, ISBN=0-444-51834-7 (bookchapter)
  • Patterson, C.E., Lum, H. (2005) Advances in Protection of Endothelial Barrier Function, Perspectives on Lung Endothelial Barrier Function, Volume 35, Advances Edition, Amsterdam, Elsevier, ch. 15 pages, ISBN=0-444-51834-7 (bookchapter)
  • Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R (Dec 2004) Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels., The Journal of Biological Chemistry, 279 (50), 52095-105 Abstract
  • Mutlu GM, Ahkmedov AT, Lum H, Factor P (Dec 2004) Potential genetic therapies for acute lung injury., Current Gene Therapy, 4 (4), 487-95 Abstract
  • Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, Giembycz MA (May 2004) Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89., The Journal of Pharmacology and Experimental Therapeutics, 309 (2), 833-44 Abstract
  • Qiao J, Huang F, Lum H, PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction, American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(6), L972-80, June 2003 Abstract
  • Lum, Hazel, Jing Qiao, Robert J. Walter, Fei Huang, P.V. Subbaiah, Kwang S. Kim, and Oksana Holian, Inflammatory Stress Increases Receptor for Lysophosphatidylcholine in Human Microvascular Endothelial Cells, American Journal of Physiology, in press, 2003
  • Boo YC, Hwang J, Sykes M, Michell BJ, Kemp BE, Lum H, Jo H, Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism, American Journal of Physiology. Heart and Circulatory Physiology, 283(5), H1819-28, November 2002 Abstract
  • Lum H, Hao Z, Gayle D, Kumar P, Patterson CE, Uhler MD, Vascular endothelial cells express isoforms of protein kinase A inhibitor, American Journal of Physiology, 282(1), C59-66, January 2002
  • Lum H, Lysophospholipids in the regulation of endothelial barrier function - Editorial, American Journal of Physiology, 281(6), L1335-6, December 2001
  • Lum H, Podolski JL, Gurnack ME, Schulz IT, Huang F, Holian O, Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction, American Journal of Physiology. Lung Cellular and Molecular Physiology, 281(3), L546-55, September 2001 Abstract
  • Lum H, Roebuck KA, Oxidant stress and endothelial cell dysfunction, American Journal of Physiology. Cell Physiology, 280(4), C719-41, April 2001 Abstract
  • Patterson CE, Lum H, Update on pulmonary edema: the role and regulation of endothelial barrier function, Endothelium, 8(2), 75-105, 2001
  • Lum H and P Factor, Gene Therapy for Preservation of Alveolar Endothelial and Epithelial Function, in: Gene Therapy for Acute and Acquired Diseases, Kluwer academic Publ, 2001
  • Patterson CE, Lum H, Schaphorst KL, Verin AD, Garcia JG, Regulation of endothelial barrier function by the cAMP-dependent protein kinase, Endothelium, 7(4), 287-308, 2000 Abstract
  • Lum, H., H. Ari Jaffe, I.T. Schulz, A. Masood, A. RayChaudhury, and R.D. Green, Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction, (Cell Physiology), 277, C580-C588, 1999
  • Vuong PT, Malik AB, Nagpala PG, Lum H, Protein kinase C beta modulates thrombin-induced Ca2 signaling and endothelial permeability increase, Journal of Cellular Physiology, 175(3), 379-87, June 1998 Abstract
  • Yan W, Tiruppathi C, Lum H, Qiao R, Malik AB, Protein kinase C beta regulates heterologous desensitization of thrombin receptor (PAR-1) in endothelial cells, American Journal of Physiology, 274(2 Pt 1), C387-95, February 1998 Abstract
  • Lo SK, Bovis L, Matura R, Zhu B, He S, Lum H, Turco SJ, Ho JL, Leishmania lipophosphoglycan reduces monocyte transendothelial migration: modulation of cell adhesion molecules, intercellular junctional proteins, and chemoattractants, Journal of Immunology, 160(4), 1857-65, February 1998 Abstract
  • Lum, H (1998) Endothelial cell activation and barrier dysfunction In Weir, E.K., Archer, S.I., Reeves, J.T. (eds), in Pulmonary Edema, Armonk, NY, Futura Publishing Company, 247-260 pages (bookchapter)
  • Aschner JL, Lum H, Fletcher PW, Malik AB, Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activation, Journal of Cellular Physiology, 173(3), 387-96, December 1997 Abstract
  • Nguyen LT, Lum H, Tiruppathi C, Malik AB, Site-specific thrombin receptor antibodies inhibit Ca2 signaling and increased endothelial permeability, American Journal of Physiology, 273(5 Pt 1), C1756-63, November 1997 Abstract
  • Lum H, Malik AB, Mechanisms of increased endothelial permeability, Canadian Journal of Physiology and Pharmacology, 74(7), 787-800, July 1996 Abstract
  • Siflinger-Birnboim A, Lum H, Del Vecchio PJ, Malik AE, Involvement of Ca2 in the H2O2-induced increase in endothelial permeability, American Journal of Physiology, 270(6 Pt 1), L973-8, June 1996 Abstract
  • Yan W, Tiruppathi C, Qiao R, Lum H, Malik AB, Tumor necrosis factor decreases thrombin receptor expression in endothelial cells, Journal of Cellular Physiology, 166(3), 561-7, March 1996 Abstract
  • Nagpala PG, Malik AB, Vuong PT, Lum H, Protein kinase C beta 1 overexpression augments phorbol ester-induced increase in endothelial permeability, Journal of Cellular Physiology, 166(2), 249-55, February 1996 Abstract
  • Qiao RL, Yan W, Lum H, Malik AB, Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response, American Journal of Physiology, 269(1 Pt 1), C110-7, July 1995 Abstract
  • Lum H, Malik AB, Regulation of vascular endothelial barrier function, American Journal of Physiology, 267(3 Pt 1), L223-41, September 1994 Abstract
  • Lum H, Andersen TT, Fenton JW 2nd, Malik AB, Thrombin receptor activation peptide induces pulmonary vasoconstriction, American Journal of Physiology, 266(2 Pt 1), C448-54, February 1994 Abstract
  • Lum H, Gibbs L, Lai L, Malik AB, CD18 integrin-dependent endothelial injury: effects of opsonized zymosan and phorbol ester activation, Journal of Leukocyte Biology, 55(1), 58-63, January 1994 Abstract
  • Qiao R, Siflinger-Birnboim A, Lum H, Tiruppathi C, Malik AB, Albumin and Ricinus communis agglutinin decrease endothelial permeability via interactions with matrix, American Journal of Physiology, 265(2 Pt 1), C439-46, August 1993 Abstract
  • Smith TJ, Kottke RJ, Lum H, Andersen TT, Human orbital fibroblasts in culture bind and respond to endothelin, American Journal of Physiology, 265(1 Pt 1), C138-42, July 1993 Abstract
  • Lum H, Andersen TT, Siflinger-Birnboim A, Tiruppathi C, Goligorsky MS, Fenton JW 2d, Malik AB, Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization, Journal of Cell Biology, 120(6), 1491-9, March 1993 Abstract
  • Tiruppathi C, Lum H, Andersen TT, Fenton JW 2d, Malik AB, Thrombin receptor 14-amino acid peptide binds to endothelial cells and stimulates calcium transients, American Journal of Physiology, 263(5 Pt 1), L595-601, November 1992 Abstract
  • Del Vecchio PJ, Siflinger-Birnboim A, Belloni PN, Holleran LA, Lum H, Malik AB, Culture and characterization of pulmonary microvascular endothelial cells, In Vitro Cellular and Developmental Biology, 28A(11-12), 711-5, 1992 Abstract
  • Lum H, Aschner JL, Phillips PG, Fletcher PW, Malik AB, Time course of thrombin-induced increase in endothelial permeability: relationship to Ca2 i and inositol polyphosphates [published erratum appears in Am J Physiol 1992 Oct;263(4 Pt 1):section L follow, American Journal of Physiology, 263(2 Pt 1), L219-25, August 1992 Abstract
  • Lum H, Barr DA, Shaffer JR, Gordon RJ, Ezrin AM, Malik AB, Reoxygenation of endothelial cells increases permeability by oxidant-dependent mechanisms, Circulation Research, 70(5), 991-8, May 1992 Abstract
  • Lo SK, Del Vecchio PJ, Lum H, Malik AB, Fibrin contact increases endothelial permeability to albumin, Journal of Cellular Physiology, 151(1), 63-70, April 1992 Abstract
  • Siflinger-Birnboim A, Schnitzer J, Lum H, Blumenstock FA, Shen CP, Del Vecchio PJ, Malik AB, Lectin binding to gp60 decreases specific albumin binding and transport in pulmonary artery endothelial monolayers [published erratum appears in J Cell Physiol 1992 Jun;151(3):642], Journal of Cellular Physiology, 149(3), 575-84, December 1991 Abstract
  • Ge M, Ryan TJ, Lum H, Malik AB, Fibrinogen degradation product fragment D increases endothelial monolayer permeability, American Journal of Physiology, 261(4 Pt 1), L283-9, October 1991 Abstract
  • Lum H, Siflinger-Birnboim A, Blumenstock F, Malik AB, Serum albumin decreases transendothelial permeability to macromolecules, Microvascular Research, 42(1), 91-102, July 1991 Abstract
  • Kaslovsky RA, Horgan MJ, Lum H, McCandless BK, Gilboa N, Wright SD, Malik AB, Pulmonary edema induced by phagocytosing neutrophils. Protective effect of monoclonal antibody against phagocyte CD18 integrin, Circulation Research, 67(4), 795-802, October 1990 Abstract
  • Lum H, Huang I, Mitzner W, Morphological evidence for alveolar recruitment during inflation at high transpulmonary pressure, Journal of Applied Physiology, 68(6), 2280-6, June 1990 Abstract
  • Horgan MJ, Lum H, Malik AB, Pulmonary edema after pulmonary artery occlusion and reperfusion, American Review of Respiratory Disease, 140(5), 1421-8, November 1989 Abstract
  • Goligorsky MS, Menton DN, Laszlo A, Lum H, Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells, Journal of Biological Chemistry, 264(28), 16771-5, October 1989 Abstract
  • Phillips PG, Lum H, Malik AB, Tsan MF, Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin, American Journal of Physiology, 257(3 Pt 1), C562-7, September 1989 Abstract
  • Lum H, Del Vecchio PJ, Schneider AS, Goligorsky MS, Malik AB, Calcium dependence of the thrombin-induced increase in endothelial albumin permeability, Journal of Applied Physiology, 66(3), 1471-6, March 1989 Abstract
  • Siflinger-Birnboim A, Cooper JA, del Vecchio PJ, Lum H, Malik AB, Selectivity of the endothelial monolayer: effects of increased permeability, Microvascular Research, 36(3), 216-27, November 1988 Abstract
  • Malik, A.B., M.R. Powers, H. Lum, J.M. Shepard and A. Siflinger-Birnboim, 'Endothelial Monolayer Permeability' (book chapter), In: ACP - Applied Cardiopulmonary Pathophysiology, Kluwer Academic Publ, 131-140, 1988
  • Lum H, Mitzner W, A species comparison of alveolar size and surface forces, Journal of Applied Physiology, 62(5), 1865-71, May 1987 Abstract
  • Lum H, Mitzner W, Effects of 10% formalin fixation on fixed lung volume and lung tissue shrinkage. A comparison of eleven laboratory species, American Review of Respiratory Disease, 132(5), 1078-83, November 1985 Abstract
  • Lum H, Tyler WS, Hyde DM, Plopper CG, Morphometry of in situ and lavaged pulmonary alveolar macrophages from control and ozone-exposed rats, Experimental Lung Research, 5(1), 61-77, July 1983 Abstract

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Last Updated: 10/21/2006

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