Dr. Joanne R. Lupton

(Reading, Writing, Speaking)

National Institutes of Environmental Health Sciences: Center for Environmental and Rural Health, Mar 1, 2002 to Mar 31, 2007.
National Institutes of Health/National Cancer Institute: Diet, apoptosis and colon carcinogenesis, Mar 1, 2001 to 2007.
National Aeronautics and Space Administration: Gene Expression in Radiation-Enhanced Colon Cancer, Jul 30, 2003 to Jun 2004.
National lnstitutes of Health/National Cancer Institute: Generalized linear measurement error models in nutrition and cancer, Jul 1, 2000 to Jun 30, 2004.
National Institutes of Health/National Cancer Institute: Nutrition, Biostatistics and Bioinformatics, Aug 1, 2001 to Jul 31, 2006.
National Institutes of Health/National Cancer Institute: Response to DNA Damage: Colon vs Small Intestine, Aug 1, 1994 to Jun 30, 2004.
National Space Biomedical Research Institute: Nutritional countermeasures to radiation exposure, 2004 to 2008.
National Institutes of Health/National Cancer Institute: Colonic cytokinetics and cell signaling: Dietary effect, 2003 to 2008.

• Ma, DW-L, Davidson LA, Callaway ES, Seo J, Fan Y, Lupton JR, Chapkin RS, n-3 PUFA alter caveolae lipid composition and ras location in mouse colon, 2003
• Bancroft LK, Lupton JR, Davidson LA, Taddeo SS, Murphy ME, Carroll RJ, Chapkin RS, Dietary fish oil reduces oxidative DNA damage in rat colonocytes, Free Radical Biology & Medicine, 2003
• Turner ND, Carney AD, Chapkin RS, Lupton JR, Potential for functional foods, 2003
• Davidson LA, Lupton JR, Miskovsky E, Fields AP, Chapkin RS, Quantitation of human intestinal gene expression profiles using exfoliated colonocytes, Biomarkers, 8, 51-61, 2003
• Hong MY, Chapkin RS, Davidson LA, Turner ND, Morris JS, Carroll RJ, Lupton JR, Fish oil enhances targeted apoptosis during colon tumor initiation in part by down regulating bcl-2, Nutrition and Cancer, 2003
• Apanasovich TV, Lupton JR, Popovic N, Chapkin RS, Turner ND, Sheather S, Carroll RJ, Testing for spatial correlation in binary data with application to aberrant crypt foci in colon carginogenesis, 2003
• Turner ND, Zhang J, Davidson LA, Lupton JR, Chapkin RS, Oncogenic ras alters sensitivity of colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis, Cancer Letters, 186, 29-35, 2002
• Lupton JR, Chapkin RS, Chemopreventive effects of Omega-3 fatty acids, 2002
• Turner, ND, Braby LA, Ford J, Lupton JR, Opportunities for nutritional amelioration of radiation-induced cellular damage, Nutrition, 18, 904-912, 2002
• Lupton JR, Zhang J, Wu G, Chapkin RS, For butyrate to initiate synthetic events in colon cells, the cells must first meet their basal metabolic needs, 2002
• Chapkin RS, Hong MY, Fan YY, Davidson LA, Sanders LM, Henderson CE, Barhoumi R., Burghardt RC, Turner ND, Lupton JR, Dietary n-3 polyunsaturated fatty acids alter colonocyte mitochondrial membrane composition and function, Lipids, 37, 193-199, 2002
• Maier SM, Turner ND, Lupton JR, Serium Lipids in hypercholesterolemic men and women consuming oat bran and amaranth products, Cereal Chemistry, 77, 297 - 302, 2002
• Morris JS, Wang N, Lupton JR, Chapkin RS, Turner ND, Hong MY, Carroll RJ, A bayesian analysis of colonic crypt structure and coordinated response to carcinogen exposure incorporating missing crypts, Biostatistics, 3, 529-546, 2002
• Hong MY, Chapkin RS, Barhoumi R, Burghardt RC, Turner ND, Henderson CE, Sanders LM, Fan YY, Davidson LA, Murphy ME, Spinka CM, Carroll RJ, Lupton J.R., Fish oil feeding increases the unsaturation index in mitochondrial phospholipids, enhancing reactive oxygen species generation and initiating apoptosis in rat colonocytes, Carcinogenesis, 23, 1919-1925, 2002
• Hong MY, Chapkin S, Morris JS, Wang N, Carroll RJ, Turner ND, Chang Wc, Davidson LA, Lupton Jr., Anatomical site-specific response to DNA damage is related to later tumor development in the rat AOM colon carcinogenesis model, Carcinogenesis, 22, 1831 - 1835, 2001
• Morris JS, Wang N, Lupton JR, Chapkin RS, Turner ND, Hong MY, Carroll RJ, Parametric and nonparametric methods for understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon, Journal of the American Statistical Association, 96, 816-826, 2001
• Collett ED, Davidson LA, Fan YY, Lupton JR, Chapkin RS, N-6 and N-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes, American Journal of Physiology, 280(C), 1066-1075, 2001
• Lupton JR, Fahey GC, Jenkins DA, Marlett JA, Slavin Jl, Story JA, Williams CL, Dietary reference intakes. Proposed definition of dietary fiber. A report of the panel on the definition of dietary fiber and the standing committee on the scientific evaluation of dietary reference, 2001
• Collett Ed, Davidson LA, Lupton JR, Chapkin RS, Dietary fish oil reduces colon cancer risk, Current Organic Chemistry, 4, 945-957, 2000
• Chapkin RS, Lupton JR, Fan YY, Effect of diet on colonic-programmed cell death: Molecular mechanism of action, Toxicology Letters, 112-113; 411-414, 2000
• Lupton JR, Is fiber protective against colon cancer? Where the research is leading us, Nutrition, 16, 558-561, 2000
• Hong MY, Lupton JR, Morris JS, Wang N, Chapkin RS, Carroll RJ, Davidson LA, Elder RH, Dietary fish oil reduces O6 methylyguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation, Cancer Epidemiology, Biomarkers and Prevention, 9, 819-826, 2000
• Davison LA, Brown RE, Chang W-CL, Morris JS, Wang N, Carroll RJ, Turner ND, Lupton JR, Chapkin RS, Morphodensitometric analysis of protein kinase CBII expression in rat colon: Modulation by diet and relation to in situ cell proliferation and apoptosis, Carcinogenesis, 21, 1513-1519, 2000
• Hong MY, Chapkin RS, Wild CP, Morris JS, Wang N, Carroll RJ, Turner ND, Lupton JR, Relationship between DNA adduct levels, repair enzyme, and apoptosis as a function of DNA methylation by azoxymethane, Cell Growth and Differentiation, 10(11), 749-58, November 1999
• Lupton JR, Turner ND, Potential protective mechanisms of wheat bran fiber, American Journal of Medicine, 106, 245-275, 1999
• Davidson LA, Lupton JR, Jiang YH, Chapkin RS, Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics, Carcinogenesis, 20, 785-791, 1999
• Chapkin RS, Clark AE, Davidson LA, Schroeder F, Zoran DL, Lupton JR, Dietary fiber differentially alters cellular fatty acid binding protein expression in exfoliated colonocytes during tumor development, Nutrition and Cancer, 31, 107-112, 1998
• Zhang J, Wu G, Chapkin RS, Lupton JR, Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen, Journal of Nutrition, 1262-1269, 1998
• Lupton JR, Chang W-CL, Hong MY, Chapkin RS, Diet effects on apoptosis during colon carcinogenesis, Annals of the Academy of Studenica, 1, 37-40, 1998
• Chang W-CL, Chapkin RS, Lupton JR, Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis, Carcinogenesis, 18, 721-730, 1997
• Jiang YH, Lupton JR, Chapkin RS, Dietary fat and fiber modulate the effect of carcinogen on colonic PKC lamda expression in rats, Journal of Nutrition, 127, 1938-1943, 1997
• Jiang YH, Davidson LA, Lupton JR, Chapkin RS, Rapid competitive PCR determination of relative gene expression in limiting tissue samples, Clinical Chemistry, 42(2), 227-31, 1996
• Jiang YH, Davidson LA, Lupton JR, Chapkin RS, A rapid RT-PCR method for detection of intact RNA in formalin-fixed paraffin-embedded tissues, Nucleic Acids Research, 23(15), 3071-2, 11 1995
• Lupton JR, Chen XQ, Frolich W, Calcium phosphate supplementation results in lower rat fecal bile acid concentrations and a more quiescent colonic cell proliferation pattern than does calcium lactate, Nutrition and Cancer, 23(2), 221-31, 1995