Dr. Luis Fernando Santana

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University of Washington
School of Medicine
Physiology and Biophysics
Associate ProfessorAppointed: 2001
University of Vermont
College of Medicine
Pharmacology
Visiting FacultyAppointed: 1999
Professional Headshot of Luis Fernando Santana

Mailing Address

University of Washington
Department of Physiology and Biophysics
Box 357290
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-0986
Fax: (206) 685-0619
santana@u.washington.edu
http://depts.washington.edu/pbiopage/faculty/santana.html

Qualifications

Post Doc., University of Vermont, Vascular Biology (M.T. Nelson, mentor), 1999.
Post Doc., University of Maryland, Biophysics (W.J. Lederer, mentor), 1998.
Ph.D., University of Maryland at Baltimore, Physiology, 1996.
B.S., University of Puerto Rico, San Juan, Marine Biology, 1991.

Expertise and Research Interests

Cardiac and smooth muscle excitation contraction coupling
Regulation of ion channel expression in muscle
Calcium signaling

Keywords

COS Keywords:

Neurobiology, Neurophysiology, Pharmacology.

Additional Terms:

EC Coupling, Na+ Currents, Regulation of Intracellular Calcium in Muscle.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Spanish: (Fluent, Fluent, Fluent)

Memberships

American Heart Association
American Physiological Society
Biophysical Society
Society of General Physiologists

Honors and Awards

Science in Medicine Lecture, University of Washington, University of Washington

Previous Positions

1999-2001, Assistant Professor, University of Puerto Rico, San Juan, Medical Sciences Campus, Institute of Neurobiology

Funding Received

  • NHLBI: Molecular Mechanisms of Arrhythmias During Heart Failure, Sep 30, 2001 to Jun 30, 2005.
  • NINDS: Regulation of Cerebrovascular Smooth Muscle Tone by Local Calcium Signals, Sep 1, 2000 to Aug 30, 2005.

Publications

  • Navedo MF, Amberg GC, Votaw VS, Santana LF (Aug 2005) Constitutively active L-type Ca2+ channels., Proceedings of the National Academy of Sciences of the United States of America., 102 (31), 11112-7 Abstract
  • Harris DM, Mills GD, Chen X, Kubo H, Berretta RM, Votaw VS, Santana LF, Houser SR, Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca2+ Release., Circulation Research, 96(5), 543-50, Mar 2005 Abstract
  • Amberg GC, Rossow CF, Navedo MF, Santana LF, NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle., The Journal of Biological Chemistry, 279(45), 47326-34, Nov 2004 Abstract
  • Rossow CF, Minami E, Chase EG, Murry CE, Santana LF, NFATc3-induced Reductions in Voltage-gated K+ Currents After Myocardial Infarction., Circulation Research, 94(10), 1340-50, May 2004 Abstract
  • Amberg GC, Santana LF, Downregulation of the BK Channel Beta1 Subunit in Genetic Hypertension., Circulation Research, 93(10), 965-71, Nov 2003 Abstract
  • Amberg GC, Bonev AD, Rossow CF, Nelson MT, Santana LF, Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension, Journal of Clinical Investigation, 112(5), 717-724, 1 Sep 2003
  • Heppner TJ, Bonev AD, Santana LF, Nelson MT, Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries, American Journal of Physiology. Heart and Circulatory Physiology, 283(6), H2169-76, December 2002 Abstract
  • Santana LF, Chase EG, Votaw VS, Nelson MT, Greven R, Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes, Journal of Physiology, 544(Pt 1), 57-69, October 2002 Abstract
  • Guatimosim S, Dilly K, Santana LF, Saleet Jafri M, Sobie EA, Lederer WJ, Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient, Journal of Molecular and Cellular Cardiology, 34(8), 941-50, Aug 2002 Abstract
  • Wellman GC, Santana LF, Bonev AD, Nelson MT, Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP, American Journal of Physiology. Cell Physiology, 281(3), C1029-37, September 2001 Abstract
  • Ufret-Vincenty CA, Baro DJ, Santana LF, Differential contribution of sialic acid to the function of repolarizing K(+) currents in ventricular myocytes, American Journal of Physiology. Cell Physiology, 281(2), C464-74, August 2001 Abstract
  • Ufret-Vincenty CA, Baro DJ, Lederer WJ, Rockman HA, Quinones LE, Santana LF, Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure, Journal of Biological Chemistry, 276(30), 28197-203, 2001 Abstract
  • Santos Cruz JD, Santana LF, Frederick CA, Isom LA, Malhotra JD, Mattei LN, Kass RS, Xia J, An RH, Lederer WJ, Whether slip-mode occurs, Science, 711a, 1999
  • Santana LF, Gomez AM, Lederer WJ, Ca 2+ flux through cardiac Na+ channels: Splip-mode conductance, Science, 1027-1033, 1998
  • Wessely R, Klingel K, Santana LF, Dalton N, Hongo M, Lederer WJ, Kandolf R, Knowlton KU, Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation contraction coupling and dilated cardiomyopathy, Journal of Clinical Investigation, 1444-1453, 1998
  • Gomez AM, Valdivia HH, Cheng H, Lederer M, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ, Uncoupling of excitation to contraction in heart failure, Science, 800-806, 1997
  • Santana LF, Gomez AM, Kranias EG, Lederer WJ, Ca 2+ sparks and excitation-contraction coupling in phospholamban-deficient mice, Journal of Physiology, 21-29, 1997
  • Santana LF, Gomez AM, Kranias EG, Lederer WJ, The amount of calcium in the sarcoplasmic reticulum, influences excitation-contraction coupling in heart muscle, Heart and Vessels, 44-49, 1997
  • Santana LF, Cheng H, Gomez AM, Cannell MB, Lederer WJ, Relation between the sarcolemmal Ca2+ current and Ca 2+ sparks and local control theories for cardiac excitation-contraction coupling, Circulation Research, 166-171, 1996
  • Two mechanisms of quantized calcium release in skeletal muscle, Nature, 455-458, 1996
  • Nelson, MT, Cheng H., Rubart M., Santana LF, Bonev AD, Knot HJ, Lederer WJ, Relaxation of arterial smooth muscle by calcium sparks, Science, 455-458, 1995

Profile Details

Last Updated: 9/7/2006

COS Expertise ID #302844
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