Dr. Andrew J. Mackin

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Mississippi State University
CVM College of Veterinary Medicine
Clinical Science
Small Animal Medicine
Professor and Dr. Hugh Ward ChairAppointed: 2002
Professional Headshot of Andrew J. Mackin

Mailing Address

Department of Clinical Sciences
College of Veterinary Medicine
Mail Stop 9825
Mississippi State University
Mississippi State, Mississippi 39762-6100
United States

Contact Information

Phone: (662) 325-6631
Fax: (662) 325-4011
Mobile: (662) 418-3277
mackin@cvm.msstate.edu

Qualifications

D.V.Sc., University of Guelph, Veterinary Clinical Studies, 1994.
M.V.S., University of Melbourne, Veterinary Clinical Science, 1989.
B.V.M.S., Murdoch University, Veterinary Medicine, 1983.
B.Sc., Murdoch University, Veterinary Biology, 1981.

Expertise and Research Interests

* Research - Specific research interest in small animal hematology and hemostasis. Particular areas of research in these fields include evaluation of platelet numbers and function in both dogs and cats, methods of bone marrow collection, feline blood types, transfusion medicine, the genotypic and phenotypic characterization of red blood cell thiopurine methyltransferase enzyme activity in dogs receiving azathioprine and evaluation of the effects of cyclosporine on hemostasis and platelet function using iscoelastometry, point-of-care platelet function analysis and flow cytometric markers of platelet activation, and on the immune system using flow cytometric and PCR analysis of markers of T-cell function.
* Teaching - Strong interest in providing effective clinical training of veterinary students, interns, residents, and practicing veterinarians. Continuing education emphasis on the use of the problem-orientated approach to patients with diagnostically challenging conditions.
* Clinical - General clinical interest in the entire spectrum of presentations and diseases relevant to the specialty of internal medicine.
Clinical focus on small animal hematology, hemostasis and immunohematology. Particular areas of clinical publication and continuing education presentations in these fields include immune-mediated thrombocytopenia and hemolytic anemia in both dogs and cats, immunosuppressive therapy, diagnosis and treatment of hemostatic disorders, bone marrow evaluation, and transfusion therapy.

Other Expertise

Diplomate, American College of Veterinary Internal Medicine (Small Animal Internal Medicine)
Fellow, Australian College of Veterinary Scientists (Canine Medicine)
Diplomate, Small Animal Medicine, Royal College of Veterinary Surgeons

Future Research

Flow cytometric evaluation of the immunosuppressive effects of cyclosporine and other immunosuppressive agents, and of markers of platelet function.

Industrial Relevance

Canine and feline hematologic diseases and diagnostic/therapeutic applications serve as an animal model for research into human hematologic diseases.

Keywords

COS Keywords:

Anemia, Animal Science, Blood Coagulation, Bone Marrow, Bone Marrow Transplantation, Clinical Research Or Studies, Hematology, Veterinary Medicine.

Additional Terms:

Azathioprine, Babesia, Cyclosporine, Enoxaparin, MION, MRI, Platelet, Transfusion, Vincristine.

Memberships

American College of Veterinary Internal Medicine
American Veterinary Medical Association
Australian College of Veterinary Scientists
Mississippi Veterinary Medical Association

Honors and Awards

2006, Carl Norden Distinguished Teacher Award, Pfizer
2000, Petsavers Award, British Small Animal Veterinary Association, Best original research article published in 1999 in the Journal of Small Animal Practice
2000, Dean's Pegasus Award for Research/Creative Achievement College of Veterinary Medicine, Mississippi State University
1992, Distinguished Research Award, American College of Veterinary Internal Medicine, Hematology/hemostasis

Previous Positions

2000-2002, Associate Professor, Mississippi State University, CVM College of Veterinary Medicine, Clinical Sciences, Small Animal Internal Medicine
1998-2000, Assistant Professor, Mississippi State University, CVM College of Veterinary Medicine, Animal Health Center, Small Animal Internal Medicine
1994-1998, Waltham Lecturer, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Veterinary Clinical Studies, Small Animal Medicine and Clinical Nutrition
1990-1994, Resident, University of Guelph, Ontario Veterinary College, Veterinary Clinical Studies, Small Animal Medicine
1985-1989, Intern/Resident, University of Melbourne, Veterinary Clinical Centre, Small Animal Medicine

Funding Received

  • Mississippi State University College of Veterinary Medicine: Phenotypic and Genotypic Characterization of Thiopurine Methyltransferase Enzyme Activity in Dogs Receiving Azathioprine, $10,000, Oct 1, 2001 to Oct 1, 2002.
  • American Animal Hospital Association Foundation: Bone Marrow Aspiration from the Canine Rib, $1,208, May 2000 to May 2001.
  • Winn Feline Foundation: Serologic Investigation of Cuterebra Larval Migration as a Cause of Neurologic Disease in Cats, $12,197, Feb 2000 to Sep 2001.
  • Mississippi State University College of Veterinary Medicine Intern Grant Program: Investigation of the Effects of the Addition of Kanamycin to EDTA Blood Collection Tubes on the Incidence of Artifactual Thrombocytopenia in Cats, $646, Dec 2000 to Jun 2001.
  • American Animal Hospital Association Foundation: Giardia Strain Variations and Relationship to Clinical Signs in Cats, $13,602, Apr 2002 to Apr 2004.
  • American Animal Hospital Association Foundation: BAER Potentials in Labrador Retrievers Used for Hunting, $1,041, Apr 2002 to Aug 2002.
  • American Animal Hospital Association Foundation: Acid-Base Status in Hypovolemic Dogs on Intravenous Fluids, $4,200, Apr 2001 to Jul 2001.
  • American Animal Hospital Association Foundation: Kanamycin/EDTA Mix to Prevent Pseudothrombocytopenia in Cats., $950, Apr 2001 to Jul 2001.
  • American Animal Hospital Association Foundation: Damage to Canine Red Cells Associated with Infusion Pumps, $3,427, Apr 1999 to Apr 2000.
  • Mississippi State University Research Initiation Program: Monocrystalline Iron Oxide Nanocompound Labeling of RBCs for Magnetic Resonance Imaging in Dogs, $10,000, 2007 to 2009.
  • MSU Institute for Neurocognitive Science and Technology: Monocrystalline Iron Oxide Nanocompound (MION) Labeling of Red Blood Cells for Magnetic Resonance Imaging in Dogs, $4,033, 2005 to 2006.
  • National Blood Foundation Scientific Research Grant Program: Evaluation of the Efficacy of Phototreatment of Packed Red Blood Cells at Preventing Transfusion-Associated Transmission of Babesiosis in Dogs, $22,733, 2005 to 2006.
  • American Animal Hospital Association Foundation: Pharmacokinetics of Biological Effects of Subcutaneously Administered Enoxaparin, a Low Molecular Weight Heparin, in Dogs, $2,645, 2004 to 2004.
  • Mississippi State University College of Veterinary Medicine: Comparison of Canine Buccal Mucosa Bleeding Times using a Scalpel Blade and Lancet Techniques, $243, 2003 to 2004.
  • American Red Cross: Photoinactivation of Canine Blood Products, $26,432, 2003 to 2004.
  • American Animal Hospital Association Foundation: Comparison of Two Techniques for Regional Anesthesia in the Eye of Dogs, $700, 2002 to 2003.
  • Mississippi State University College of Veterinary Medicine: Comparison of the Modified Seldinger Technique & Through-The-Needle Jugular Catheter Placement Techniques in Dogs, $1,000, 2002 to 2003.
  • International Sled Dog Veterinary Medical Association: Effects of the Level of Vitamin E Supplementation on Hemostasis in Sled Dogs, $4,480, 2000 to 2001.
  • Mississippi State University College of Veterinary Medicine Intern Grant Program: Effects of Rapid Infusion of Normal Saline or Lactated Ringer's Solution on Acid-Base Status of Anesthetized, Hypovolemic Dogs, $1,433, 2000 to 2001.
  • Iams Company: Placement of Esophagostomy Tubes in Dogs, $35,905, 1999 to 2000.
  • Mississippi State University College of Veterinary Medicine Salsbury Grant: Investigation of EDTA-Dependent Pseudothrombocytopenia in the Dog, $1,760, 1999 to 2000.
  • Mississippi State University Research Initiation Program: Characterization of Von Willebrand Factor in Dogs with Hemangiosarcoma, $7,780, 1999 to 2000.
  • Morris Animal Foundation: Characterization of von Willebrand Factor in Dogs with Hemangiosarcoma: A Pilot Study, $4,200, 1999 to 2000.
  • Mississippi State University College of Veterinary Medicine: Collection of Bone Marrow from the Canine Rib, $500, 1999 to 2000.
  • Mississippi State University Intra-College (College of Veterinary Medicine) Multi-Investigator Grant Program: Pharmacokinetics/Toxicology of Oral Methenamine in Dogs, $4,846, 1998 to 2000.
  • Mississippi State University In-House Clinical Grant Program: Von Willebrand Factor in Dogs with Hemangiosarcoma (Pilot), $2,220, 1998 to 2000.
  • British Small Animal Veterinary Association Clinical Studies Trust Fund (Petsavers): Methods of Determination of Platelet Numbers in the Cat, £659, 1997 to 1998.
  • WALTHAM Centre for Pet Nutrition: Immunologic Study of Dogs with Food Allergic Diseases, £53,447, 1996 to Present.
  • British Small Animal Veterinary Association Clinical Studies Trust Fund (Petsavers): Evaluation of the Local Distribution of Feline Blood Types, £750, 1996 to 1998.
  • British Small Animal Veterinary Association Clinical Studies Trust Fund (Petsavers): New CSTF (Petsavers) Small Animal Medicine Residency, £32,500, 1995 to 1998.
  • Ontario Veterinary College Pet Trust: Platelet Responses to Vincristine and Prednisone, $4,000 Can, 1992 to 1993.
  • Ontario Veterinary College Pet Trust: Canine Platelet Responses to Vincristine Sulphate, $6,000 Can, 1990 to 1993.

Publications

  • Ballweber LR, Panuska C, Huston CL, Vasilopulos R, Pharr GT, Mackin A (Mar 2009) Prevalence of and risk factors associated with shedding of Cryptosporidium felis in domestic cats of Mississippi and Alabama., Veterinary parasitology, 160 (3-4), 306-10 Abstract
  • Lunsford KV, Mackin AJ (May 2007) Thromboembolic therapies in dogs and cats: an evidence-based approach., The Veterinary clinics of North America. Small animal practice, 37 (3), 579-609 Abstract
  • Balch A, Mackin A (Apr 2007) Canine immune-mediated hemolytic anemia: pathophysiology, clinical signs, and diagnosis., Compendium (Yardley, PA), 29 (4), 217-25 Abstract
  • Balch A, Mackin A (Apr 2007) Canine immune-mediated hemolytic anemia: treatment and prognosis., Compendium (Yardley, PA), 29 (4), 230-8; quiz 239 Abstract
  • Skripchenko A, Balch A, Mackin A, Wagner SJ (Feb 2007) In vivo recovery and survival of red cells after photodynamic treatment with thiopyrylium and red light using a canine model., Vox sanguinis, 92 (2), 157-9 Abstract
  • Vasilopulos RJ, Rickard LG, Mackin AJ, Pharr GT, Huston CL (2007) Genotypic analysis of Giardia duodenalis in domestic cats., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 21 (2), 352-5 Abstract
  • Vasilopulos RJ, Mackin AJ, Rickard LG, Pharr GT, Huston CL (2006) Prevalence and factors associated with fecal shedding of Giardia spp. in domestic cats., Journal of the American Animal Hospital Association, 42 (6), 424-9 Abstract
  • Vasilopulos RJ, Mackin A, Lavergne SN, Trepanier LA, Nephrotic Syndrome Associated With Administration Of Sulfadimethoxine/ormetoprim in a Dobermann., The Journal of Small Animal Practice, 46(5), 232-6, May 2005 Abstract
  • Mackin, A (2005) Platelet Disorders In August, JR (eds), Consultations in Feline Internal Medicine, St. Louis, Elsevier Saunders, 575-584 pages (bookchapter)
  • Rodriguez DB, Mackin A, Easley R, Boyle CR, Hou W, Langston C, Walsh AM, Province MA, McLeod HL, Relationship between red blood cell thiopurine methyltransferase activity and myelotoxicity in dogs receiving azathioprine, Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine., 18(3), 339-45, 2004 Abstract
  • Portillo EM, Mackin AJ, Cantwell HD, Trostel CT, Pool RR, What is your diagnosis? A soft tissue opacity in the area of the pyloric antrum, Journal of the American Veterinary Medical Association, 224(5), 665-6, 2004 Abstract
  • Mackin AJ, Lymphoplasmacytic rhinitis, In King L (ed), Textbook of Respiratory Disease in Dogs and Cats, 305, 2004
  • Mackin, A (2004) Lymphoplasmacytic Rhinitis In King, L (eds), Textbook of Respiratory Disease in Dogs and Cats, St. Louis, Saunders, 305-310 pages (bookchapter)
  • Nawrocki MA, Mackin AJ, McLaughlin R, Cantwell HD, Fluoroscopic and endoscopic localization of an esophagobronchial fistula in a dog, Journal of the American Animal Hospital Association, 39(3), 257-61, 2003 Abstract
  • Vasilopulos RJ, Mackin AJ, Humoral hypercalcemia of malignancy: Pathophysiology and clinical signs, Compendium of Continuing Education for the Practicing Veterinarian, 25, 122-128, 2003
  • Vasilopulos RJ, Mackin AJ, Humoral hypercalcemia of malignancy: Diagnosis and treatment, Compendium of Continuing Education for the Practicing Veterinarian, 25, 129-136, 2003
  • Vasilopulos RJ, Mackin AJ, Jennings D, Read R, What is your neurologic diagnosis? Nerve sheath tumor involving the brachial plexus with involvement of the spinal cord, Journal of the American Veterinary Medical Association, 221(10), 1397-9, November 2002 Abstract
  • Nawrocki MA, Mackin AJ, Cantwell HD, Ellis B, What is your diagnosis? Spherical soft tissue opacity in the area of the distal portion of the trachea, Journal of the American Veterinary Medical Association, 221(6), 783-4, September 2002 Abstract
  • Character BJ, Mackin AJ, Cantwell HD, Austin FW, What is your diagnosis? Perihepatic abscess due to Clostridium perfringens, Journal of the American Veterinary Medical Association, 221, 37-38, 2002
  • Carpenter DH Jr, Mackin AJ, Gellasch KL, ECG of the month. Cardiac tamponade secondary to A. niger-induced constrictive pericarditis, Journal of the American Veterinary Medical Association, 218(12), 1890-2, 2001 Abstract
  • Tasker S, Cripps P, Mackin A, Evaluation of methods of platelet counting in the cat, Journal of Small Animal Practice, 42, 362, June 2001
  • Kergosien DH, Couto GC, Mackin A, Challenging cases in internal medicine: What's your diagnosis? Canine lead poisoning, Veterinary Medicine, 206, March 2001
  • Clifford CA, Hughes D, Beal MW, Mackin AJ, Henry CJ, Shofer FS, Sorenmo KU, Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma, Journal of Veterinary Internal Medicine, 15(2), 131-5, 2001 Abstract
  • Stonehewer J, Mackin AJ, Tasker S, Simpson JW, Mayhew IG, Idiopathic phenobarbital-responsive hypersialosis in the dog: an unusual form of limbic epilepsy?, Journal of Small Animal Practice, 41(9), 416-21, September 2000 Abstract
  • Clifford CA, Mackin AJ, Henry CJ, Treatment of canine hemangiosarcoma: 2000 and beyond, Journal of Veterinary Internal Medicine, 14(5), 479-85, 2000 Abstract
  • Mackin AJ, Anticoagulant rodenticides, In Day MJ, Mackin AJ, Littlewood JD (eds), Manual of Canine and Feline Haematology and Transfusion Medicine, 243, 2000
  • Mackin AJ, Immune-mediated haemolytic anaemia, In Day MJ, Mackin AJ, Littlewood JD (eds), Manual of Canine and Feline Haematology and Transfusion Medicine, 67, 2000
  • Day MJ, Mackin AJ, Littlewood JD (eds), Manual of Canine and Feline Haematology and Transfusion Medicine, 2000
  • Allen DG, Mackin A, Cor pulmonale, In Tilley LP, Goodwin JK (eds). Manual of Canine and Feline Cardiology (3rd Ed), 197, 2000
  • Tasker S, Knottenbelt CM, Munro EA, Stonehewer J, Simpson JW, Mackin AJ, Aetiology and diagnosis of persistent nasal disease in the dog: a retrospective study of 42 cases, Journal of Small Animal Practice, 40(10), 473-8, October 1999 Abstract
  • Knottenbelt CM, Day MJ, Cripps PJ, Mackin AJ, Measurement of titres of naturally occurring alloantibodies against feline blood group antigens in the UK, Journal of Small Animal Practice, 40(8), 365-70, August 1999 Abstract
  • Kushner LI, Mackin AJ, Anesthesia case of the month. Cyanosis in a dog during anesthesia, Journal of the American Veterinary Medical Association, 214(7), 1007-9, April 1999 Abstract
  • Tasker S, Mackin AJ, Day MJ, Primary immune-mediated thrombocytopenia in a cat, Journal of Small Animal Practice, 40(3), 127-31, March 1999 Abstract
  • Knottenbelt CM, Addie DD, Day MJ, Mackin AJ, Determination of the prevalence of feline blood types in the UK, Journal of Small Animal Practice, 40(3), 115-8, March 1999 Abstract
  • Tasker S, Cripps PJ, Mackin AJ, Estimation of platelet counts on feline blood smears, Veterinary Clinical Pathology, 28(2), 42, 1999
  • Day MJ, Mackin A. Day MJ (ed), Immune-mediated renal and reproductive disease, Clinical Immunology of the Dog and Cat, 171, 1999
  • Day MJ, Mackin AJ. Day MJ (ed), Immune-mediated haematological disease, Clinical Immunology of the Dog and Cat, 69, 1999
  • Knottenbelt C, Mackin A, Blood transfusions in the dog and cat. Part 2. Indications and safe administration, In Practice, 20(4), 191, 1998
  • Knottenbelt C, Mackin A, Blood transfusions in the dog and cat. Part 1. Blood collection techniques, In Practice, 20(3), 110, 1998
  • Hodson S, Mackin AJ, Thrombocytopenia in the cat, Feline Focus: Journal of the European Society of Feline Medicine, 8, 2, 1998
  • Mackin A, La trombocitopenia immunomediata nel cane - Parte II, Veterinaria Cremona, 12(3), 45, 1998
  • Mackin A, La trombocitopenia immunomediata nel cane - Parte I, Veterinaria Cremona, 12(2), 43, 1998
  • Knottenbelt C, Mackin A, Transfusion medicine. Part 3. Indications for blood transfusions and the administration of transfusions to dogs and cats, Veterinary Practice Nurse, 10(1), 4, 1998
  • Mackin AJ, (ed). Gorman NT, Bleeding disorders, Canine Medicine and Therapeutics (4th Ed), 281, 1998
  • Mackin A, Abnormalities of the thoracic bellows: stress fractures of the ribs and hiatal hernia [letter, Journal of Veterinary Internal Medicine, 12(6), 478-80, 1998 Abstract
  • Mackin AJ, Friendship RM, Wilcock BP, Ball RO, Ayles HL, Development and evaluation of an endoscopic technique permitting rapid visualization of the cardiac region of the porcine stomach, Canadian Journal of Veterinary Research, 61(2), 121-7, April 1997 Abstract
  • Knottenbelt C, Mackin, A, Transfusion medicine. Part 2. Practical blood collection in the cat, Veterinary Practice Nurse, 9(4), 4, 1997
  • Knottenbelt C, Mackin A, Transfusion medicine. Part 1. Practical blood collection in the dog, Veterinary Practice Nurse, 9(3), 27, 1997
  • Mackin AJ, Allen DG, Johnston IB, Effects of vincristine and prednisone on platelet numbers and function in clinically normal dogs, American Journal of Veterinary Research, 56(1), 100-8, January 1995 Abstract
  • Mackin A, Canine immune-mediated thrombocytopenia - Part II, Compendium of Continuing Education for the Practicing Veterinarian, 17, 515, 1995
  • Mackin A, Canine immune-mediated thrombocytopenia - Part I, Compendium of Continuing Education for the Practicing Veterinarian, 17, 353, 1995
  • Allen DG, Mackin AJ, (eds). Miller MS, Tilley LP, Cor pulmonale, Manual of Canine and Feline Cardiology (2nd Ed), 211, 1995
  • Langlais-Burgess L, Lumsden JH, Mackin A, Concurrent hypoadrenocorticism and hypoalbuminemia in dogs: a retrospective study, Journal of the American Animal Hospital Association, 31(4), 307-11, 1995 Abstract
  • Mackin A, Serum erythropoietin assays [letter, Journal of Veterinary Internal Medicine, 8(4), 314-5, 1994 Abstract
  • O'Grady MR, Allen DG, Mackin AJ, Van Gorder J, Exercise in electrocardiography, Canadian Veterinary Journal, 32, 47, 1991
  • Parry BW, Holloway SA, Birch DJ, Mackin AJ, Haemophilia A in a cocker spaniel dog, Australian Veterinary Journal, 65(10), 326-7, October 1988 Abstract
  • Mackin A, Dunsmore J, Clark WT, Fleabite allergic dermatitis in dogs: review of 78 cases, Australian Veterinary Practitioner, 13, 5, 1982

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