Dr. Burra V. Madhukar

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Michigan State University
Pediatrics and Human Development
Associate ProfessorAppointed: 1986

Mailing Address

Department of Pediatrics and Human Development
B-240 Life Sciences
Michigan State University
East Lansing, Michigan 48824-1206
United States

Contact Information

Phone: (517) 432-3934
Fax: (517) 432-4466
madhukar@msu.edu

Qualifications

Ph.D., University of Delhi, Zoology, 1972.

Expertise and Research Interests

Expertise is in the area of molecular and biochemical mechansims of action of environmental toxicants such as pesticides, polychlorinated biphenyls (PCBs) and dioxins. The major focus is to understand how these pollutant chemicals perturb cell signaling pathways, alter gene expression profiles in target cells and exert epigentic carciongenic effects.

Another are of expertise is in the isolation and characterization of stem cells from adult tissue and develop in vitro methods for their contnuous culture and differentiation into specific cell types. The main focus is on the isolation of pancreatic stem cells and their differentiation to insulin producing beta cells for potential use as diabetes therapy. More recently we have isolated stem/progenitor cells from neural tissue of new born rats and are developing methods for their differentiation to cerebellar granule cell neurons. We believe these progenitor cells may have therapeutic use in reversing Parkinsons's symptoms.

Industrial Relevance

The research we are doing could help develop cell based therapies for the treatment of chronic diseases such as diabetes and Parkinson's disease.

Keywords

COS Keywords:

Chemical Carcinogenesis, Environment (Health Or Safety Or Medical), Environmental Health, Environmental Medicine, Environmental Toxicology, Molecular Cloning.

Additional Terms:

Biological Signal Transduction, Cell Signaling Cascades, Chemical Carcinogenesis, Clone Cell, Diacylglycerol, Dioxin, Embryo Fetus Cell Culture, Environmental Toxicology, Enzyme Activity, Epidermal Growth Factor, Epigenetic Toxicity, Gene Expression Profiling, Growth Factor Receptor, Halobiphenyl Halotriphenyl Compound, Microarrays, Molecular Cloning, Neoplastic Transformation, Neural Progenitor Cells, Protein Kinase C, Receptor Expression, Toxicant Screening, Transcrption Factors.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Hindi: (Functional, Functional, Fluent)

Memberships

American Association for the Advancement of Science
Society of Toxicology

Honors and Awards

Member - Study section, National Institutes of Health (NIH)
Member - Cell Biology Study section, United States Department of Defense (DOD)

Patents

Oct-4 and GJIC expression as markers for adult human stem cells and metastatic cells, Patent Number: 200502260623, 2005, Institution, United States of America.
Human pancreatic pluripotent stem cell line, Patent Number: pending, 2005, Institution, United States of America.

Funding Received

  • MIchigan Economic Development Corporation: Human pancreatic stem cells for diabetes treatment, $448,609, 2001 to 2003.
  • Philip Morris External REsearch Program: Signal transduction pathways in peigenetic carcinogenesis, $619,641, 2001 to 2005.
  • Program Director - L.J. Fischer: Health hazards from groundwater contamination, $1,404,000, 2000 to 2006.
  • National Institutes of Health (NIH): Pluripotent human pancreatic ductal cells, $180,000, 1999 to 2001.
  • National Institutes of Health (NIH): Phase I chemopreventive trial of oltipraz in persons at risk for lung cancer - dose finding, safety and biomarker based eficacy, 349,329, 1997 to 1999.
  • PI - V. Natarajan: Mechansims of oxidant-mediated endothelial barrier dysfunction, $925,185, 1997 to 2000.
  • National Institutes of Health (NIH): Health hazards from groundwater contamination. Sub-project - Molecular signals of epigenetic toxicity, $500,000, 1995 to 2000.

Publications

  • B.V. Madhukar, K.D. Linning, (2004) Redox-mediated enrichment of self renewing adult human derived pancreatic cells which possess pluripotent differentiation capability, Pancreas, 29, e64-e76
  • B.V. Madhukar, M.H. Tai (2002) Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells, Pancreas, 26, e18-e26
  • B.V. Madhukar et al. (2001) Inhibtion of MAP kinase activity of human mymphocytes after oral administration of oltipraz, Cancer epidemiology, biomarkers and prevention, 1, 1125-1128
  • R.J. Ruch, J.E. Trosko, B.V. Madhukar (2001) Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation, Journal of Cellular Biochemistry, 83, 163-169
  • Fischer LJ, Wagner MA, Madhukar BV, Potential involvement of calcium, CaM kinase II, and MAP kinases in PCB-stimulated insulin release from RINm5F cells., Toxicology and Applied Pharmacology, 159(3), 194-203, 15 Sep 1999 Abstract
  • L.J. Fischer, M.A. Wagner, B.V. Madhukar (1999) Potential involvement of calcium, CaM kinase II and MAP kinases in PCB-stimulated insulin release from RINm5F cells, Toxicologyy and Applied Pharmacology, 159, 194-203
  • Mousa MA, Ganey PE, Quensen JF 3rd, Madhukar BV, Chou K, Giesy JP, Fischer LJ, Boyd SA, Altered biologic activities of commercial polychlorinated biphenyl mixtures after microbial reductive dechlorination., Environmental Health Perspectives, 106 Suppl 6, 1409-18, December 1998 Abstract
  • Mousa, M.A. et al., B.V. Madhukar (1998) Altered biological activities of commercial PCB mixtures after microbial dechlorination, Environmental Health Perspectives, 106 (suppl.1), 1409-1418
  • B.V. Madhukar (1998) Modulation of protein kinases by xenobiotics, Toxicant-receptor interaction and modulation of gene expression, Washington, D.C., Taylor & Francis, 161-184 pages (bookchapter)
  • B.V. Madhukar, H.L. de Feijter-Rupp, J.E. Trosko (1996) Transient exposure to TPA sustains the inhibitory effect of the tumor promoter on gap junctional intercellular communication in rat liver peithelial cells WB F-344, Cancer Letters, 106, 117-123
  • Trosko JE, Chang CC, Madhukar BV, The role of modulated gap junctional intercellular communication in epigenetic toxicology., Risk Analysis, 14(3), 303-12, 1994 Abstract

Profile Details

Last Updated: 11/2/2006

COS Expertise ID #539378
Reference this profile directly: http://myprofile.cos.com/madhukar