Dr. William Maixner

powered by
COS Expertise®
University of North Carolina at Chapel Hill
School of Dentistry
DirectorAppointed: 1985
University of North Carolina at Chapel Hill
School of Medicine
Curriculum in Neurobiology
ProfessorAppointed: 1985
University of North Carolina at Chapel Hill
School of Medicine
Pharmacology
ProfessorAppointed: 1985
Professional Headshot of William Maixner

Mailing Address

Center for Neurosensory Disorders
Rm. 2110 Old Dental Building
School of Dentistry
University of North Carolina
Chapel Hill, North Carolina 27599-7455
United States

Contact Information

Phone: (919) 966-0684
Fax: (919) 966-3683
Bill_Maixner@dentistry.unc.edu

Qualifications

Associate, National Institutes of Health (NIH), Pharmacology, Pain Mechanisms, Pain Management, Neurobiology, 1985.
D.D.S., University of Iowa, Dentistry, 1983.
Ph.D., University of Iowa, Pharmacology, 1982.

Expertise and Research Interests

Dr. Maixner’s research program focuses on identifying the pathophysiological processes that underlie pain perception, persistent pain conditions, and related disorders. His current research focuses on genetic, environmental, biological, and psychological risk factors that contribute to the onset and maintenance of chronic pain conditions. A long term goal of his program is to translate new discoveries into clinical practices that improve the ability to diagnose and treat patients experiencing chronic pain.

Other Expertise

Cardiovascular and CNS Pharmacology

Industrial Relevance

Dr. Maixner's multidisciplinary research program places high emphasis on translational research. Recent focus on human genetics has led to the identification of genetic variants that significantly contribute to human pain perception and the risk of developing common musculoskeletal pain conditions. A short-term goal of his research program is to identify methods that permit the genetic subclassification of chronic pain conditions which will permit tailored therapies. A long-term goal is to elucidate new biological targets for future drug development.

Keywords

COS Keywords:

Anesthesiology, Chronic Pain, Dentistry, Musculoskeletal System, Neurobiology, Neurology, Neuroscience, Pain, Pain Management, Palliative Care, Pathophysiology, Pharmacology.

Additional Terms:

Analgesia, Fibromyalgia, Musculoskeletal Pain, Pain, Pain Genetics, Tempromandibular Disorders.

Memberships

American Pain Society
International Association for Dental Research
International Association for the Study of Pain
Society for Neuroscience

Funding Received

  • NIH/NIDCR DE016558; William Maixner Co-Investigator: COMT and BAR Polymorphism and Development of Painful TMD, 2005 to 2010.
  • NIH/NIDCR DE17018 U01; William Maixner Program Director: Risk Factors for the Onset and Persistence of TMD, 2005 to 2012.
  • NIH/NINDS, NS045685 P01; William Maixner Program Director: CNS Processes Underlying Pain Regulation and Persistence, 2004 to 2009.
  • NIH/NINDS, NS39240 P01; William Maixner Co-Investigator: Persistent Pain: Peripheral and CNS Mechanisms, 2000 to 2005.
  • NIH/NIDA, DA13705 R01; William Maixner Co-Investigator: Gender, Nicotine and Stress Induced Analgesia, 2000 to 2005.

Publications

  • Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W (Dec 2007) Genetic architecture of human pain perception., Trends in genetics : TIG, 23 (12), 605-13 Abstract
  • Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, Max MB, Goldman D, Maixner W (Nov 2007) Influence of psychological factors on risk of temporomandibular disorders., Journal of dental research, 86 (11), 1120-5 Abstract
  • Mechlin B, Morrow AL, Maixner W, Girdler SS (Sep 2007) The relationship of allopregnanolone immunoreactivity and HPA-axis measures to experimental pain sensitivity: Evidence for ethnic differences., Pain, 131 (1-2), 142-52 Abstract
  • Diatchenko L, Slade GD, Nackley AG, Maixner W (Jun 2007) Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-24., 129 (3), 366-370 Abstract
  • Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W (Apr 2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors., Pain, 128 (3), 199-208 Abstract
  • Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, Flood PM (Feb 2007) Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms., Cellular signalling, 19 (2), 251-60 Abstract
  • Fecho K, Manning EL, Maixner W, Schmitt CP (Jan 2007) Effects of carrageenan and morphine on acute inflammation and pain in Lewis and Fischer rats., Brain, behavior, and immunity, 21 (1), 68-78 Abstract
  • Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, Goldman D, Maixner W (Dec 2006) Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli., Pain, 125 (3), 216-24 Abstract
  • Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O, Makarov SS, Maixner W, Diatchenko L (Dec 2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure., Science (New York, N.Y.), 314 (5807), 1930-3 Abstract
  • Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ (Nov 2006) GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence., Nature medicine, 12 (11), 1269-77 Abstract
  • Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W (Aug 2006) Idiopathic pain disorders--pathways of vulnerability., Pain, 123 (3), 226-30 Abstract
  • Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, Belfer I, Goldman D, Max MB, Weir BS, Maixner W (Jul 2006) Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 141 (5), 449-62 Abstract
  • Suarez-Roca H, Quintero L, Arcaya JL, Maixner W, Rao SG (Jun 2006) Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran., Physiology & behavior, 88 (1-2), 82-7 Abstract
  • Zolnoun D, Hartmann K, Lamvu G, As-Sanie S, Maixner W, Steege J (Jun 2006) A conceptual model for the pathophysiology of vulvar vestibulitis syndrome., Obstetrical & gynecological survey, 61 (6), 395-401; quiz 423 Abstract
  • Nackley A, Diatchenko L, Maixner W (May 2006) Perspectives on the genetic basis of opioid-induced hyperalgesia., Anesthesiology, 104 (5), 909-10 Abstract
  • Suarez-Roca H, Silva JA, Arcaya JL, Quintero L, Maixner W, Pinerua-Shuhaibar L (Feb 2006) Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia., Behavioural brain research, 167 (2), 205-11 Abstract
  • Bhalang K, Sigurdsson A, Slade GD, Maixner W (Sep 2005) Associations among four modalities of experimental pain in women., The Journal of Pain : Official Journal of the American Pain Society, 6 (9), 604-11 Abstract
  • Chattipakorn S, Chattipakorn N, Light AR, Narhi M, Maixner W (Sep 2005) Comparison of Fos expression within the ferret's spinal trigeminal nuclear complex evoked by electrical or noxious-thermal pulpal stimulation., The Journal of Pain : Official Journal of the American Pain Society, 6 (9), 569-80 Abstract
  • Fecho K, Nackley AG, Wu Y, Maixner W, Basal and Carrageenan-induced Pain Behavior in Sprague-Dawley, Lewis And Fischer Rats., Physiology & Behavior, 85(2), 177-86, Jun 2005 Abstract
  • Girdler SS, Maixner W, Naftel HA, Stewart PW, Moretz RL, Light KC, Cigarette Smoking, Stress-induced Analgesia and Pain Perception in Men And Women., Pain, 114(3), 372-85, Apr 2005 Abstract
  • Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W, Genetic Basis for Individual Variations in Pain Perception and The Development of a Chronic Pain Condition., Human Molecular Genetics, 14(1), 135-43, Jan 2005 Abstract
  • Edwards RR, Fillingim RB, Maixner W, Sigurdsson A, Haythornthwaite J, Catastrophizing predicts changes in thermal pain responses after resolution of acute dental pain, J Pain, 5(3), 164-70, April 2004 Abstract
  • Campbell TS, Hughes JW, Girdler SS, Maixner W, Sherwood A, Relationship of ethnicity, gender, and ambulatory blood pressure to pain sensitivity: effects of individualized pain rating scales, J Pain, 5(3), 183-91, April 2004 Abstract
  • Wu Y, Willcockson HH, Maixner W, Light AR, Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection, J Pain, 5(1), 48-55, 2004 Abstract
  • Suarez-Roca H, Pinerua-Shuhaibar L, Morales ME, Maixner W, Increased perception of post-ischemic paresthesias in depressed subjects, Journal of Psychosomatic Research, 55(3), 253-7, 2003 Abstract
  • Quintero L, Cuesta MC, Silva JA, Arcaya JL, Pinerua-Suhaibar L, Maixner W, Suarez-Roca H, Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord, Brain Research, 965(1-2), 259-68, 2003 Abstract
  • Roy EA, Hollins M, Maixner W, Reduction of TMD pain by high-frequency vibration: A spatial and temporal analysis, Pain, 101(3), 267-74, February 2003
  • Costello NL, Bragdon EE, Light KC, Sigurdsson A, Bunting S, Grewen K, Maixner W, Temporomandibular disorder and optimism: Relationships to ischemic pain sensitivity and interleukin-6, Pain, 100(1-2), 99-110, November 2002
  • Chattipakorn SC, Sigurdsson A, Light AR, Narhi M, Maixner W, Trigeminal c-Fos expression and behavioral responses to pulpal inflammation in ferrets, Pain, 99(1-2), 61-9, 2002 Abstract
  • Straneva PA, Maixner W, Light KC, Pedersen CA, Costello NL, Girdler SS, Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder, 21(4), 358-67, July 2002
  • Bragdon EE, Light KC, Costello NL, Sigurdsson A, Bunting S, Bhalang K, Maixner W, Group differences in pain modulation: Pain-free women compared to pain-free men and to women with TMD, Pain, 96(3), 227-37, April 2002
  • Nattestad A, Attstrom R, Mattheos N, Ramseier C, Canegallo L, Eaton K, Feeney L, Goffin G, Markovska N, Maixner W, Persson R, Reynolds P, Ruotoistenmaki J, Schittek M, Spohn E, Sudzina M, 4.1 Web-based interactive learning programmes, 6 Suppl 3, 127-37, 2002
  • Sheps DS, Kaufmann PG, Sheffield D, Light KC, McMahon RP, Bonsall R, Maixner W, Carney RM, Freedland KE, Cohen JD, Goldberg AD, Ketterer MW, Raczynski JM, Pepine CJ, Sex differences in chest pain in patients with documented coronary artery disease and exercise-induced ischemia: Results from the PIMI study, American Heart Journal, 142(5), 864-71, 2001 Abstract
  • Vincler M, Maixner W, Vierck CJ, Light AR, Estrous cycle modulation of nociceptive behaviors elicited by electrical stimulation and formalin, Pharmacology, Biochemistry, and Behavior, 69(3-4), 315-24, 2001 Abstract
  • Crews KR, Murthy BP, Hussey EK, Passannante AN, Palmer JL, Maixner W, Brouwer KL, Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers, British Journal of Clinical Pharmacology, 51(4), 309-16, 2001 Abstract
  • Quintero L, Moreno M, Avila C, Arcaya J, Maixner W, Suarez-Roca H, Long-lasting delayed hyperalgesia after subchronic swim stress, Pharmacology, Biochemistry, and Behavior, 67(3), 449-58, 2000 Abstract
  • Sheffield D, Biles PL, Orom H, Maixner W, Sheps DS, Race and sex differences in cutaneous pain perception, Psychosomatic Medicine, 62(4), 517-23, 2000 Abstract
  • Fu KY, Light AR, Maixner W, Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin, Neuroscience, 101(4), 1127-35, 2000 Abstract
  • Cuesta MC, Arcaya JL, Cano G, Sanchez L, Maixner W, Suarez-Roca H, Opposite modulation of capsaicin-evoked substance P release by glutamate receptors, Neurochemistry International, 35(6), 471-8, 1999 Abstract
  • Pinerua-Shuhaibar L, Prieto-Rincon D, Ferrer A, Bonilla E, Maixner W, Suarez-Roca H, Reduced tolerance and cardiovascular response to ischemic pain in minor depression, Journal of Affective Disorders, 56(2-3), 119-26, 1999 Abstract
  • Cano G, Arcaya JL, Gomez G, Maixner W, Suarez-Roca H, Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers, Neurochemical Research, 24(10), 1203-7, 1999 Abstract
  • Edwards RR, Fillingim RB, Yamauchi S, Sigurdsson A, Bunting S, Mohorn SG, Maixner W, Effects of gender and acute dental pain on thermal pain responses, The Clinical Journal of Pain, 15(3), 233-7, 1999 Abstract
  • Chattipakorn SC, Light AR, Willcockson HH, Narhi M, Maixner W, The effect of fentanyl on c-fos expression in the trigeminal brainstem complex produced by pulpal heat stimulation in the ferret, Pain, 82(2), 207-15, 1999 Abstract
  • Sheps DS, McMahon RP, Light KC, Maixner W, Pepine CJ, Cohen JD, Goldberg AD, Bonsall R, Carney R, Stone PH, Sheffield D, Kaufmann PG, Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study, Journal of the American College of Cardiology, 33(7), 1855-62, 1999 Abstract
  • Fu KY, Light AR, Matsushima GK, Maixner W, Microglial reactions after subcutaneous formalin injection into the rat hind paw, Brain Research, 825(1-2), 59-67, 1999 Abstract
  • Arcaya JL, Cano G, Gomez G, Maixner W, Suarez-Roca H, Dynorphin A increases substance P release from trigeminal primary afferent C-fibers, European Journal of Pharmacology, 366(1), 27-34, 1999 Abstract
  • Fillingim RB, Maixner W, Bunting S, Silva S, Resting blood pressure and thermal pain responses among females: effects on pain unpleasantness but not pain intensity, 30(3), 313-8, November 1998
  • Girdler SS, Koo-Loeb J, Pedersen CA, Brown HJ, Maixner W, Blood pressure-related hypoalgesia in bulimia nervosa, Psychosomatic Medicine, 60(6), 736-43, 1998 Abstract
  • Fillingim RB, Fillingim LA, Hollins M, Sigurdsson A, Maixner W, Generalized vibrotactile allodynia in a patient with temporomandibular disorder, Pain, 78(1), 75-8, 1998 Abstract
  • Maixner W, Fillingim R, Sigurdsson A, Kincaid S, Silva S, Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain, Pain, 76(1-2), 71-81, 1998 Abstract
  • Fillingim RB, Maixner W, Kincaid S, Silva S, Sex differences in temporal summation but not sensory-discriminative processing of thermal pain, Pain, 75(1), 121-7, 1998 Abstract
  • Fillingim RB, Maixner W, Sigurdsson A, Kincaid S, Sexual and physical abuse history in subjects with temporomandibular disorders: relationship to clinical variables, pain sensitivity, and psychologic factors, Journal of Orofacial Pain, 11(1), 48-57, 1997 Abstract
  • Maixner W, Fillingim R, Kincaid S, Sigurdsson A, Harris MB, Relationship between pain sensitivity and resting arterial blood pressure in patients with painful temporomandibular disorders, Psychosomatic Medicine, 59(5), 503-11, 1997 Abstract
  • Pfleeger M, Straneva PA, Fillingim RB, Maixner W, Girdler SS, Menstrual cycle, blood pressure and ischemic pain sensitivity in women: a preliminary investigation, 27(2), 161-6, September 1997
  • Fillingim RB, Maixner W, Girdler SS, Light KC, Harris MB, Sheps DS, Mason GA, Ischemic but not thermal pain sensitivity varies across the menstrual cycle, Psychosomatic Medicine, 59(5), 512-20, 1997 Abstract
  • Vierck CJ Jr, Cannon RL, Fry G, Maixner W, Whitsel BL, Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode, Journal of Neurophysiology, 78(2), 992-1002, 1997 Abstract
  • Keefe FJ, Lefebvre JC, Maixner W, Salley AN Jr, Caldwell DS, Self-efficacy for arthritis pain: relationship to perception of thermal laboratory pain stimuli, 10(3), 177-84, June 1997
  • Mesaros S, Trope M, Maixner W, Burkes EJ, Comparison of two laser Doppler systems on the measurement of blood flow of premolar teeth under different pulpal conditions, International Endodontic Journal, 30(3), 167-74, 1997 Abstract
  • Go BM, Sheffield D, Krittayaphong R, Maixner W, Sheps DS, Association of systolic blood pressure at time of myocardial ischemia with angina pectoris during exercise testing, The American Journal of Cardiology, 79(7), 954-6, 1997 Abstract
  • Fillingim RB, Maixner W, Kincaid S, Sigurdsson A, Harris MB, Pain sensitivity in patients with temporomandibular disorders: relationship to clinical and psychosocial factors, The Clinical Journal of Pain, 12(4), 260-9, 1996 Abstract
  • Fillingim RB, Maixner W, The influence of resting blood pressure and gender on pain responses, Psychosomatic Medicine, 58(4), 326-32, 1996 Abstract
  • Bossut DF, Maixner W, Effects of cardiac vagal afferent electrostimulation on the responses of trigeminal and trigeminothalamic neurons to noxious orofacial stimulation, Pain, 65(1), 101-9, 1996 Abstract
  • Maixner W, Fillingim R, Booker D, Sigurdsson A, Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain, Pain, 63(3), 341-51, 1995 Abstract
  • Suarez-Roca H, Maixner W, Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons, Neuroscience Letters, 194(1-2), 41-4, 1995 Abstract
  • Sheps DS, Ballenger MN, De Gent GE, Krittayaphong R, Dittman E, Maixner W, McCartney W, Golden RN, Koch G, Light KC, Psychophysical responses to a speech stressor: correlation of plasma beta-endorphin levels at rest and after psychological stress with thermally measured pain threshold in patients with co, Journal of the American College of Cardiology, 25(7), 1499-503, 1995 Abstract
  • Sigurdsson A, Maixner W, Effects of experimental and clinical noxious counterirritants on pain perception, Pain, 57(3), 265-75, 1994 Abstract
  • Watkins L, Sherwood A, Goldstein DS, Maixner W, Mechanisms underlying cardiovascular defense reaction evoked by dorsal periaqueductal gray stimulation, The American Journal of Physiology, 265(5 Pt 2), R1155-61, 1993 Abstract
  • Miller PF, Light KC, Bragdon EE, Ballenger MN, Herbst MC, Maixner W, Hinderliter AL, Atkinson SS, Koch GG, Sheps DS, Beta-endorphin response to exercise and mental stress in patients with ischemic heart disease, Journal of Psychosomatic Research, 37(5), 455-65, 1993 Abstract
  • Maixner W, Humphrey C, Gender differences in pain and cardiovascular responses to forearm ischemia, The Clinical Journal of Pain, 9(1), 16-25, 1993 Abstract
  • Suarez-Roca H, Maixner W, Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices, The Journal of Pharmacology and Experimental Therapeutics, 264(2), 648-53, 1993 Abstract
  • Watkins L, Maixner W, Hypotensive effect of clonidine is not mediated by enhanced baroreflex gain in rats, Journal of Cardiovascular Pharmacology, 21(2), 264-71, 1993 Abstract
  • Suarez-Roca H, Maixner W, Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices, European Journal of Pharmacology, 229(1), 1-7, 1992 Abstract
  • Sena AC, Maixner W, Ballenger MN, Herbst MC, Koch G, Sheps DS, The relationship between plasma beta-endorphin, opioid receptor activity, and silent myocardial ischemia, The Clinical Journal of Pain, 8(4), 307-16, 1992 Abstract
  • Sheps DS, Bragdon EE, Gray TF 3rd, Ballenger M, Usedom JE, Maixner W, Relation between systemic hypertension and pain perception, The American Journal of Cardiology, 70(16), 3F-5F, 1992 Abstract
  • Suarez-Roca H, Maixner W, Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes, Brain Research, 579(2), 195-203, 1992 Abstract
  • Bossut DF, Whitsel EA, Maixner W, A parametric analysis of the effects of cardiopulmonary vagal electrostimulation on the digastric reflex in cats, Brain Research, 579(2), 253-60, 1992 Abstract
  • Suarez-Roca H, Abdullah L, Zuniga J, Madison S, Maixner W, Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices, Brain Research, 579(2), 187-94, 1992 Abstract
  • Madison S, Whitsel EA, Suarez-Roca H, Maixner W, Sensitizing effects of leukotriene B4 on intradental primary afferents, Pain, 49(1), 99-104, 1992 Abstract
  • Thomas DA, Oliveras JL, Maixner W, Dubner R, Systemic morphine administration attenuates the perceived intensity of noxious heat in the monkey, Pain, 49(1), 129-35, 1992 Abstract
  • Watkins L, Maixner W, The effect of pentobarbital anesthesia on the autonomic nervous system control of heart rate during baroreceptor activation, Journal of the Autonomic Nervous System, 36(2), 107-14, 1991 Abstract
  • Maixner W, Bossut DF, Whitsel EA, Evaluation of vagal afferent modulation of the digastric reflex in cats, Brain Research, 560(1-2), 55-62, 1991 Abstract
  • Maixner W, Gracely RH, Zuniga JR, Humphrey CB, Bloodworth GR, Cardiovascular and sensory responses to forearm ischemia and dynamic hand exercise, The American Journal of Physiology, 259(6 Pt 2), R1156-63, 1990 Abstract
  • Miller PF, Sheps DS, Bragdon EE, Herbst MC, Dalton JL, Hinderliter AL, Koch GG, Maixner W, Ekelund LG, Aging and pain perception in ischemic heart disease, American Heart Journal, 120(1), 22-30, 1990 Abstract
  • Sheps DS, Maixner W, Hinderliter AL, Mechanisms of pain perception in patients with silent myocardial ischemia, American Heart Journal, 119(4), 983-7, 1990 Abstract
  • Maixner W, Clark G, Issues bridging basic science and clinical science, Anesthesia Progress, 37(2-3), 144-6, 1990 Abstract
  • Sheps DS, Maixner W, Hinderliter AL, Herbst MC, Bragdon EE, Herdt J, Kropp S, Adams KF, Koch G, Ekelund LG, Relationship between systolic blood pressure, ventricular volume and ischemic pain perception in patients with angina pectoris: a potential role for baroreceptors, Israel Journal of Medical Sciences, 25(9), 482-7, 1989 Abstract
  • Maixner W, Dubner R, Kenshalo DR Jr, Bushnell MC, Oliveras JL, Responses of monkey medullary dorsal horn neurons during the detection of noxious heat stimuli, Journal of Neurophysiology, 62(2), 437-49, 1989 Abstract
  • Dubner R, Kenshalo DR Jr, Maixner W, Bushnell MC, Oliveras JL, The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli, Journal of Neurophysiology, 62(2), 450-7, 1989 Abstract
  • Maixner W, Autonomic and somatosensory interactions: physiological and pathophysiological implications, 85(4-5), 395-407, 1989
  • Maixner W, Dubner R, Bushnell MC, Kenshalo DR Jr, Oliveras JL, Wide-dynamic-range dorsal horn neurons participate in the encoding process by which monkeys perceive the intensity of noxious heat stimuli, Brain Research, 374(2), 385-8, 1986 Abstract
  • Oliveras JL, Maixner W, Dubner R, Bushnell MC, Duncan G, Thomas DA, Bates R, Dorsal horn opiate administration attenuates the perceived intensity of noxious heat stimulation in behaving monkey, Brain Research, 371(2), 368-71, 1986 Abstract
  • Zamir N, Maixner W, The relationship between cardiovascular and pain regulatory systems, Annals of the New York Academy of Sciences, 467, 371-84, 1986 Abstract
  • Randich A, Maixner W, The role of sinoaortic and cardiopulmonary baroreceptor reflex arcs in nociception and stress-induced analgesia, Annals of the New York Academy of Sciences, 467, 385-401, 1986 Abstract
  • Bushnell MC, Duncan GH, Dubner R, Jones RL, Maixner W, Attentional influences on noxious and innocuous cutaneous heat detection in humans and monkeys, 5(5), 1103-10, May 1985
  • Sasaki T, Kassell NF, Torner JC, Maixner W, Turner DM, Pharmacological comparison of isolated monkey and dog cerebral arteries, Stroke; a Journal of Cerebral Circulation, 16(3), 482-9, 1985 Abstract
  • Randich A, Maixner W, Interactions between cardiovascular and pain regulatory systems, Neuroscience and Biobehavioral Reviews, 8(3), 343-67, 1984 Abstract
  • Randich A, Maixner W, [D-Ala2]-methionine enkephalinamide reflexively induces antinociception by activating vagal afferents, Pharmacology, Biochemistry, and Behavior, 21(3), 441-8, 1984 Abstract
  • Sasaki T, Kassell NF, Turner DM, Maixner W, Torner JC, Coester HC, Effects of naloxone on canine cerebral vascular smooth muscle, 4(2), 166-72, June 1984
  • Maixner W, Randich A, Role of the right vagal nerve trunk in antinociception, Brain Research, 298(2), 374-7, 1984 Abstract
  • Maixner W, Flynn JR, Arneric SP, Cannon JG, Long JP, II. Pharmacological studies with derivatives of 2-aminotetralin, benzhydro[f]quinoline, benzhydro[g]quinoline, apomorphine and clonidine suggest a pharmacological dissimilarity between per, The Journal of Pharmacology and Experimental Therapeutics, 224(2), 352-8, 1983 Abstract
  • Maixner W, Verimer T, Zeit-Har MS, Cannon JG, Long JP, I. Pharmacological studies with derivatives of 2-aminotetralin, benzhydro[f]quinoline and clonidine suggest a pharmacological identity between peripheral and central alpha-2 adrenoceptors, The Journal of Pharmacology and Experimental Therapeutics, 224(2), 346-51, 1983 Abstract
  • Cannon JG, Crockatt DM, Long JP, Maixner W, (+/-)-cis-2-acetoxycyclobutyltrimethylammonium iodide: a semirigid analogue of acetylcholine, Journal of Medicinal Chemistry, 25(9), 1091-4, 1982 Abstract
  • Maixner W, Touw KB, Brody MJ, Gebhart GF, Long JP, Factors influencing the altered pain perception in the spontaneously hypertensive rat, Brain Research, 237(1), 137-45, 1982 Abstract
  • Galeno TM, Van Hoesen GW, Maixner W, Johnson AK, Brody MJ, Contribution of the amygdala to the development of spontaneous hypertension, Brain Research, 246(1), 1-6, 1982 Abstract
  • Arneric SP, Maixner W, Long JP, Mott J, Barfknecht CF, Perez JA, Cannon JG, Structure-activity relationships of 2-aminotetralins and 2-aminoindanes: inhibitory neuroeffector mechanisms in isolated guinea-pig ilea, Archives Internationales De Pharmacodynamie Et De Therapie, 258(1), 84-99, 1982 Abstract
  • Randich A, Maixner W, Acquisition of conditioned suppression and responsivity to thermal stimulation in spontaneously hypertensive, renal hypertensive and normotensive rats, Physiology & Behavior, 27(4), 585-90, 1981 Abstract
  • Maixner W, Wright CB, Jaffe BM, Gall WE, Schoepfle WJ, The peripheral hemodynamics of exogenously administered prostaglandin E1 during major venous occlusion in the dog, The Journal of Surgical Research, 30(6), 563-8, 1981 Abstract
  • Maixner W, Arneric SP, Abou Zeit-Har MS, Lecompte J, Verimer T, Cannon JG, Lee T, Long JP, Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum, European Journal of Pharmacology, 71(4), 475-82, 1981 Abstract
  • Maixner W, Long JP, Wright CB, Diana JN, Cannon JG, Hake HL, Peripheral vascular effects of a new dopamine analog: 5-6-dihydroxy-2-methylaminotetralin (M-8), Journal of Cardiovascular Pharmacology, 3(2), 381-9, 1981 Abstract
  • Maixner W, Wright CB, Schoepfle WJ, Barnes RW, Femoral artery flow velocities: a sensitive index of limb hemodynamics associated with venous occlusion, The Journal of Surgical Research, 29(4), 326-30, 1980 Abstract
  • Maixner W, Rittenhouse EA, Barnes RW, Early detection of hypovolemia from directional arterial flow velocity, Circulatory Shock, 5(1), 35-41, 1978 Abstract
  • Hummel BW, Hummel BA, Mowbry A, Maixner W, Barnes RW, Reactive hyperemia vs treadmill exercise testing in arterial disease, Archives of Surgery (chicago, Ill. : 1960), 113(1), 95-8, 1978 Abstract
  • Barnes RW, Baker WH, Shanik G, Maixner W, Hayes AC, Lin R, Clarke W, Value of concomitant sympathectomy in aortoiliac reconstruction. Results of a prospective, randomized study, Archives of Surgery (chicago, Ill. : 1960), 112(11), 1325-30, 1977 Abstract
  • Young JA, Maixner W, Burr JW, Wright CB, Ergotism: experimental assessment of therapy, Surgical Forum, 28, 215-7, 1977 Abstract
  • Rittenhouse EA, Maixner W, Knott HW, Barnes RW, Jaffe BM, The role of prostaglandin E in the hemodynamic response to aortic clamping and declamping, Surgery, 80(1), 137-44, 1976 Abstract
  • Mechlin MB, Maixner W, Light KC, Fisher JM, Girdler SS, African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures., Psychosomatic medicine, 67 (6), 948-56 Abstract

Profile Details

Last Updated: 1/2/2008

COS Expertise ID #334662
Reference this profile directly: http://myprofile.cos.com/maixnerw