Dr. Mark A. Bothwell

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University of Washington
School of Medicine
Physiology and Biophysics
ProfessorAppointed: 1989
Professional Headshot of Mark A. Bothwell

Mailing Address

Box 357290
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-7924
Fax: (206) 543-0934
mab@u.washington.edu
http://www.physiol.washington.edu/bothwell

Qualifications

Ph.D., University of California, Berkeley, Biochemistry, 1975.
B.S., University of Michigan, Chemistry, 1970.

Expertise and Research Interests

My main interest is the regulatory functions of growth factors in embryonic development, and particularly, the role of growth factors in mediating trophic interactions in the developing nervous system. Recognizing the relationship of embryonic processes to the processes of functional and anatomic plasticity of the adult nervous system, we are interested also in the functions of growth factors in the adult nervous system, in the processes of memory and learning, in the repair of nervous system injury, and in neurodegenerative conditions. We also are interested in the roles of these factors in tumor biology. Our studies are focused primarily on a family of growth factors - neurotrophins and their receptors. A major focus concerns the function and signal transduction mechanisms of the 75 kDa neurotrophin receptor, p75NTR and a homolog we have recently identified.

Our studies encompass species ranging from invertebrates such as sea urchins to zebrafish to mammals (mice).

Another major interest of our lab is the function of the beta-amyloid precursor protein in normal cellular physiology and in Alzheimer's Disease. We are investigating the hypothesis that APP functions as a cell surface receptor that signals to the nucleus in a manner resembling that of Notch.

Other Expertise

Editorial Responsibilities:
Faculty of 1000; 2003-
Editorial Board Journal of Biological Chemistry, 1991-1996; 2004-
Associated Editor Neuron, 1992 -1994
Editorial Board J. Neurobiology, 1995-
Editorial Board International Journal of Developmental Neuroscience, 1995-2002

Grant Review Committees:
Ad hoc reviewer, NIH Neurology Study Section, 1981, 1984, 1985-86
Member NIH Biomedical Sciences B1-6 Study Section 1987-1991
Chairman, NIH Study Section BI-6, 1989-1991
Member, NIH Reviewer Reserve, 1991-1996
Merit review panelist, Veterans Administration, 1994-1996
Member, NIH Study Section MCDN2, 1998-2001
Member, March of Dimes Review Committee C, 1997-2002
Reviewer, NIH Molecular Genetics Intramural Program, 1999

Business Experience:
Consultant to Johnson and Johnson Corporation, Office of Science & Technology, 1980-1992
Consultant to Chiron Corporation, 1989-92
Member, Scientific Board of Directors, Allelix Pharmaceuticals., 1994-1995

Industrial Relevance

We have developed a high through-put screening method to identify drugs that inhibit cleavage of beta-amyloid precursor protein by beta and gamma-secretase activity.

Keywords

COS Keywords:

Alzheimer's Disease, Animal Development, Apoptosis, Biochemistry, Brain, Brain Development, Cancer Biology, Cardiovascular Biology, Cardiovascular System, Cell Biology, Cell Differentiation, Central Nervous System, Cerebellum, Developmental Biology, Embryogenesis, Embryology, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Hearing, Nervous System, Neurobiology, Neurons.

Additional Terms:

Alzheimer's Disease, Animal Development, Apoptosis, Biochemistry, Biology Cellular, Biology Molecular, Brain, Brain Development, Cancer Biology, Cardiovascular Biology, Cell Biology, Cell Differentiation, Cell-cell Interactions, Central Nervous System, Cerebellum, Developmental Biology, Embryogenesis, Embryology, Gene, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Hearing, Inner Ear, Learning and Memory, Muscle, Nervous System, Neurobiology, Neuroglia, Neurons, Specific Cell Types, Synapses, Transmitters.

Languages

(Reading, Writing, Speaking)

French: (Functional, Basic, Basic)

Memberships

American Society for Biochemistry and Molecular Biology
Society for Neuroscience

Previous Positions

1985-03/31/2000, Associate Professor, University of Washington, School of Medicine, Physiology & Biophysics
1978-03/31/2000, Assistant Professor, Princeton University, Biochemistry

Funding Received

  • Alzheimer's Association: Signaling pathways fostering superoxide formation and jun kinase activation in Alzlheimer's Disease, Sep 1, 2000 to Aug 31, 2003.
  • National Science Foundation (NSF): Regulated Secretion of BDNF, Sep 1, 2000 to Aug 31, 2003.
  • National Institutes of Health (NIH): Vascular functions of neurotrophins, Mar 1, 1993 to Nov 1, 1998.
  • National Institutes of Health (NIH): Amyloid Precursor Protein Signaling, Jul 1, 2002 to Jun 30, 2007.
  • March of Dimes: EphA4 function in cerebellar development, Jul 1, 1999 to Jun 30, 2002.
  • National Institutes of Health (NIH): Neurotrophin Receptor Interactions, Jan 1, 1992 to Dec 31, 2005.
  • National Institutes of Health (NIH): Regulation of inner ear developoment and regeneration, Feb 1, 1996 to Jan 31, 1999.
  • March of Dimes: Signaling by Autoactivated Receptor Tyrosine Kinases, 2006 to 2009.
  • National Institutes of Health (NIH): Nogo Receptor Signaling, 2004 to 2008.

Publications

  • Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M (Sep 2005) Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment., Journal of Neurochemistry, 94 (5), 1189-201 Abstract
  • Bothwell M (Aug 2005) Human papilloma virus papilloma masquerading as adenoid hypertrophy., Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-head and Neck Surgery., 133 (2), 308-9 Abstract
  • Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, Schecterson LC (Jul 2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 23 (13), 5425-36 Abstract
  • Burke MA, Bothwell M (May 2003) p75 neurotrophin receptor mediates neurotrophin activation of NF-kappa B and induction of iNOS expression in P19 neurons., Journal of Neurobiology, 55 (2), 191-203 Abstract
  • Iwamoto S, Burrows RC, Grossniklaus HE, Orcutt J, Kalina RE, Boehm M, Bothwell MA, Schmidt R (Dec 2002) Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas., Archives of Ophthalmology, 120 (12), 1625-9 Abstract
  • Wong ST, Henley JR, Kanning KC, Huang KH, Bothwell M, Poo MM (Dec 2002) A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein., Nature Neuroscience, 5 (12), 1302-8 Abstract
  • Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB, Rubel EW (Oct 2002) Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem., The Journal of Comparative Neurology, 452 (1), 51-64 Abstract
  • Karam SD, Dottori M, Ogawa K, Henderson JT, Boyd AW, Pasquale EB, Bothwell M (Apr 2002) EphA4 is not required for Purkinje cell compartmentation., Brain Research. Developmental Brain Research, 135 (1-2), 29-38 Abstract
  • Iwamoto S, Burrows RC, Kalina RE, George D, Boehm M, Bothwell MA, Schmidt R (Apr 2002) Immunophenotypic differences between uveal and cutaneous melanomas., Archives of Ophthalmology, 120 (4), 466-70 Abstract
  • Chao MV, Bothwell M (Jan 2002) Neurotrophins: to cleave or not to cleave., Neuron, 33 (1), 9-12 Abstract
  • Karam SD, Kim YS, Bothwell M (Nov 2001) Granule Cells Migrate Within Raphes in the Developing Cerebellum: An Evolutionarily Conserved Morphogenic Event., The Journal of Comparative Neurology, 440 (2), 127-35
  • Hutson LD, Bothwell M (Nov 2001) Expression and Function of Xenopus Laevis P75(NTR) Suggest Evolution Of Developmental Regulatory Mechanisms., Journal of Neurobiology, 49 (2), 79-98
  • Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK, Jaenisch R (September 2001) Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal, Molecular Psychiatry, 6 (5), 593-604 Abstract
  • Chalazonitis A, Pham TD, Rothman TP, DiStefano PS, Bothwell M, Blair-Flynn J, Tessarollo L, Gershon MD (2001) Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons, Journal of Neuroscience, 21 (15), 5620-36 Abstract
  • Iwamoto S, Burrows RC, Agoff SN, Piepkorn M, Bothwell M, Schmidt R (August 2001) The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas, American Journal of Dermatopathology, 23 (4), 288-94 Abstract
  • Yuen EC, Gunther EC, Bothwell M (Nov 2000) Nitric oxide activation of TrkB through peroxynitrite., Neuroreport, 11 (16), 3593-7 Abstract
  • Iwamoto S, Burrows RC, Born DE, Piepkorn M, Bothwell M (Oct 2000) The application of direct immunofluorescence to intraoperative neurosurgical diagnosis., Biomolecular Engineering, 17 (1), 17-22 Abstract
  • Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB, Bothwell M (Sep 2000) Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 20 (17), 6488-500 Abstract
  • Bothwell M, Giniger E (Aug 2000) Alzheimer's disease: neurodevelopment converges with neurodegeneration., Cell, 102 (3), 271-3 Abstract
  • Koblar SA, Krull CE, Pasquale EB, McLennan R, Peale FD, Cerretti DP, Bothwell M (Mar 2000) Spinal motor axons and neural crest cells use different molecular guides for segmental migration through the rostral half-somite., Journal of Neurobiology, 42 (4), 437-47 Abstract
  • Woodnutt DA, Wager-Miller J, O'Neill PC, Bothwell M, Byers MR (Feb 2000) Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp., Cell and Tissue Research, 299 (2), 225-36 Abstract
  • Gunther EC, von Bartheld CS, Goodman LJ, Johnson JE, Bothwell M (2000) The G-protein inhibitor, pertussis toxin, inhibits the secretion of brain-derived neurotrophic factor., Neuroscience, 100 (3), 569-79 Abstract
  • Mason K, Peale FV Jr, Stone JS, Rubel EW, Bothwell M (Nov 1998) Expression of novel potassium channels in the chick basilar papilla., Hearing Research, 125 (1-2), 120-30 Abstract
  • Peale FV Jr, Sugden L, Bothwell M (Jul 1998) Characterization of CMIX, a chicken homeobox gene related to the Xenopus gene mix.1., Mechanisms of Development, 75 (1-2), 167-70 Abstract
  • Peale FV Jr, Mason K, Hunter AW, Bothwell M (Feb 1998) Multiplex display polymerase chain reaction amplifies and resolves related sequences sharing a single moderately conserved domain., Analytical Biochemistry, 256 (2), 158-68 Abstract
  • Bothwell M (Aug 1997) Neurotrophin function in skin., The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research., 2 (1), 27-30 Abstract
  • Iwamoto S, Odland PB, Piepkorn M, Bothwell M (Nov 1996) Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma., Journal of the American Academy of Dermatology, 35 (5 Pt 1), 725-31 Abstract
  • von Bartheld CS, Williams R, Lefcort F, Clary DO, Reichardt LF, Bothwell M (May 1996) Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 16 (9), 2995-3008 Abstract
  • Bothwell M (Apr 1996) p75NTR: a receptor after all., Science, 272 (5261), 506-7 Abstract
  • von Bartheld CS, Byers MR, Williams R, Bothwell M (Feb 1996) Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system., Nature, 379 (6568), 830-3 Abstract
  • Garden GA, Hartlage-Rubsamen M, Rubel EW, Bothwell MA (Jun 1995) Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death., Molecular and Cellular Neurosciences, 6 (3), 293-310 Abstract
  • von Bartheld CS, Schober A, Kinoshita Y, Williams R, Ebendal T, Bothwell M (Mar 1995) Noradrenergic neurons in the locus coeruleus of birds express TrkA, transport NGF, and respond to NGF., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 15 (3 Pt 2), 2225-39 Abstract
  • Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors., Annual Review of Neuroscience, 18, 223-53 Abstract
  • Fukuchi K, Hearn MG, Deeb SS, Smith AC, Dang N, Miyazaki J, Bothwell M, Martin GM (May 1994) Activity assays of nine heterogeneous promoters in neural and other cultured cells., In Vitro Cellular & Developmental Biology. Animal, 30A (5), 300-5 Abstract
  • Borson S, Schatteman G, Claude P, Bothwell M (May 1994) Neurotrophins in the developing and adult primate adenohypophysis: a new pituitary hormone system?, Neuroendocrinology, 59 (5), 466-76 Abstract
  • Garden GA, Canady KS, Lurie DI, Bothwell M, Rubel EW (Apr 1994) A biphasic change in ribosomal conformation during transneuronal degeneration is altered by inhibition of mitochondrial, but not cytoplasmic protein synthesis., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 14 (4), 1994-2008 Abstract
  • Henry MA, Westrum LE, Bothwell M, Press S (Apr 1994) Electron microscopic localization of nerve growth factor receptor (p75)-immunoreactivity in pars caudalis/medullary dorsal horn of the cat., Brain Research, 642 (1-2), 137-45 Abstract
  • von Bartheld CS, Kinoshita Y, Prevette D, Yin QW, Oppenheim RW, Bothwell M (Mar 1994) Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos., Neuron, 12 (3), 639-54 Abstract
  • Wheeler E F, Bothwell M, Schecterson L C, von Bartheld C S (February 1994) Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats., Hearing Research, 73 (1), 46-56 Abstract
  • Wheeler EF, Bothwell M, Schecterson LC, von Bartheld CS (Feb 1994) Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats., Hearing Research, 73 (1), 46-56 Abstract
  • Schecterson LC, Bothwell M (Feb 1994) Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear., Hearing Research, 73 (1), 92-100 Abstract
  • Alpers CE, Hudkins KL, Ferguson M, Johnson RJ, Schatteman GC, Bothwell M (Dec 1993) Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys., Laboratory Investigation; a Journal of Technical Methods and Pathology, 69 (6), 703-13 Abstract
  • Kinoshita Y, Kinoshita C, Heuer JG, Bothwell M (Nov 1993) Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture., Development (cambridge, England), 119 (3), 943-56 Abstract
  • Henry MA, Westrum LE, Bothwell M, Johnson LR (Sep 1993) Nerve growth factor receptor (p75)-immunoreactivity in the normal adult feline trigeminal system and following retrogasserian rhizotomy., The Journal of Comparative Neurology, 335 (3), 425-36 Abstract
  • Patterson SL, Grady MS, Bothwell M (Mar 1993) Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in cerebrospinal fluid of brain injured human patients., Brain Research, 605 (1), 43-9 Abstract
  • Keles GE, Berger MS, Schofield D, Bothwell M (Feb 1993) Nerve growth factor receptor expression in medulloblastomas and the potential role of nerve growth factor as a differentiating agent in medulloblastoma cell lines., Neurosurgery, 32 (2), 274-80; discussion 2 Abstract
  • von Bartheld CS, Bothwell M (Feb 1993) Development of the mesencephalic nucleus of the trigeminal nerve in chick embryos: target innervation, neurotrophin receptors, and cell death., The Journal of Comparative Neurology, 328 (2), 185-202 Abstract
  • Schatteman GC, Langer T, Lanahan AA, Bothwell MA (1993) Distribution of the 75-kD low-affinity nerve growth factor receptor in the primate peripheral nervous system., Somatosensory & Motor Research, 10 (4), 415-32 Abstract
  • Byers M R, Kvinnsland I, Bothwell M (15 Dec 1992) Analysis of low affinity nerve growth factor receptor during pulpal healing and regeneration of myelinated and unmyelinated axons in replanted teeth., Journal of Comparative Neurology, 326 (3), 470-84 Abstract
  • Patterson S L, Grover L M, Schwartzkroin P A, Bothwell M (December 1992) Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs., Neuron, 9 (6), 1081-8 Abstract
  • Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M (Dec 1992) Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs., Neuron, 9 (6), 1081-8 Abstract
  • Byers MR, Kvinnsland I, Bothwell M (Dec 1992) Analysis of low affinity nerve growth factor receptor during pulpal healing and regeneration of myelinated and unmyelinated axons in replanted teeth., The Journal of Comparative Neurology, 326 (3), 470-84 Abstract
  • Deyerle K L, Sims J E, Dower S K, Bothwell M A (1 Sep 1992) Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes., Journal of Immunology, 149 (5), 1657-65 Abstract
  • Mesulam MM, Mash D, Hersh L, Bothwell M, Geula C (Sep 1992) Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus., The Journal of Comparative Neurology, 323 (2), 252-68 Abstract
  • Deyerle KL, Sims JE, Dower SK, Bothwell MA (Sep 1992) Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes., Journal of Immunology (baltimore, Md. : 1950), 149 (5), 1657-65 Abstract
  • Schecterson LC, Bothwell M (Sep 1992) Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons., Neuron, 9 (3), 449-63 Abstract
  • von Bartheld CS, Bothwell M (Jun 1992) Development and distribution of noradrenergic and cholinergic neurons and their trophic phenotypes in the avian ceruleus complex and midbrain tegmentum., The Journal of Comparative Neurology, 320 (4), 479-500 Abstract
  • Taiji M, Taiji K, Deyerle KL, Bothwell M (May 1992) Basic fibroblast growth factor enhances nerve growth factor receptor gene promoter activity in human neuroblastoma cell line CHP100., Molecular and Cellular Biology, 12 (5), 2193-202 Abstract
  • Wheeler EF, Bothwell M (Mar 1992) Spatiotemporal patterns of expression of NGF and the low-affinity NGF receptor in rat embryos suggest functional roles in tissue morphogenesis and myogenesis., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 12 (3), 930-45 Abstract
  • Vickland H, Kott J N, Bothwell M A, Westrum L E (January 1992) Nerve growth factor receptor and the transplanted rat olfactory bulb., Experimental Neurology, 115 (1), 137-41 Abstract
  • Vickland H, Kott JN, Bothwell MA, Westrum LE (Jan 1992) Nerve growth factor receptor and the transplanted rat olfactory bulb., Experimental Neurology, 115 (1), 137-41 Abstract
  • Byers MR, Wheeler EF, Bothwell M (1992) Altered expression of NGF and P75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting., Growth Factors (chur, Switzerland), 6 (1), 41-52 Abstract
  • Vickland H, Westrum LE, Kott JN, Patterson SL, Bothwell MA (Nov 1991) Nerve growth factor receptor expression in the young and adult rat olfactory system., Brain Research, 565 (2), 269-79 Abstract
  • von Bartheld CS, Patterson SL, Heuer JG, Wheeler EF, Bothwell M, Rubel EW (Oct 1991) Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat., Development (cambridge, England), 113 (2), 455-70 Abstract
  • Garden GA, Bothwell M, Rubel EW (Sep 1991) Lack of correspondence between mRNA expression for a putative cell death molecule (SGP-2) and neuronal cell death in the central nervous system., Journal of Neurobiology, 22 (6), 590-604 Abstract
  • von Bartheld CS, Heuer JG, Bothwell M (Aug 1991) Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: comparison with cholinergic development., The Journal of Comparative Neurology, 310 (1), 103-29 Abstract
  • Santos PM, Winterowd JG, Allen GG, Bothwell MA, Rubel EW (Jul 1991) Nerve growth factor: increased angiogenesis without improved nerve regeneration., Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-head and Neck Surgery., 105 (1), 12-25 Abstract
  • Henry MA, Drangsholt RJ, Westrum LE, Bothwell M (Jul 1991) Localization of nerve growth factor receptor immunoreactivity in the trigeminal nucleus of kittens., Experimental Neurology, 113 (1), 38-46 Abstract
  • Bothwell M (Jun 1991) Keeping track of neurotrophin receptors., Cell, 65 (6), 915-8 Abstract
  • Kullas CD, Henry MA, Westrum LE, Johnson LR, Bothwell M (May 1991) Retrogasserian rhizotomy causes expression of nerve growth factor receptor-immunoreactive protein in motoneurons within the adult feline trigeminal motor nucleus., Neuroscience Letters, 126 (2), 145-8 Abstract
  • Bothwell M (1991) Tissue localization of nerve growth factor and nerve growth factor receptors., Current Topics in Microbiology and Immunology, 165, 55-70 Abstract
  • Heuer JG, von Bartheld CS, Kinoshita Y, Evers PC, Bothwell M (Sep 1990) Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system., Neuron, 5 (3), 283-96 Abstract
  • Byers MR, Schatteman GC, Bothwell M (Jun 1990) Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity., Development (cambridge, England), 109 (2), 461-71 Abstract
  • Heuer JG, Fatemie-Nainie S, Wheeler EF, Bothwell M (Feb 1990) Structure and developmental expression of the chicken NGF receptor., Developmental Biology, 137 (2), 287-304 Abstract
  • Thompson SJ, Schatteman GC, Gown AM, Bothwell M (Oct 1989) A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue., American Journal of Clinical Pathology, 92 (4), 415-23 Abstract
  • Mufson EJ, Bothwell M, Kordower JH (Sep 1989) Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain., Experimental Neurology, 105 (3), 221-32 Abstract
  • Mufson EJ, Bothwell M, Hersh LB, Kordower JH (Jul 1989) Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons., The Journal of Comparative Neurology, 285 (2), 196-217 Abstract
  • Sehgal A, Bothwell M, Chao M (Jul 1989) Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts., Nucleic Acids Research, 17 (14), 5623-32 Abstract
  • Mesulam MM, Geula C, Bothwell MA, Hersh LB (May 1989) Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons., The Journal of Comparative Neurology, 283 (4), 611-33 Abstract
  • Kordower JH, Gash DM, Bothwell M, Hersh L, Mufson EJ (Jan-Feb 1989) Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients., Neurobiology of Aging, 10 (1), 67-74 Abstract
  • Kordower JH, Bartus RT, Bothwell M, Schatteman G, Gash DM (Nov 1988) Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes., The Journal of Comparative Neurology, 277 (4), 465-86 Abstract
  • Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M (Mar 1988) Expression of NGF receptor in the developing and adult primate central nervous system., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 8 (3), 860-73 Abstract
  • Marano N, Dietzschold B, Earley JJ Jr, Schatteman G, Thompson S, Grob P, Ross AH, Bothwell M, Atkinson BF, Koprowski H (Jan 1987) Purification and amino terminal sequencing of human melanoma nerve growth factor receptor., Journal of Neurochemistry, 48 (1), 225-32 Abstract
  • Breakefield XO, Ozelius L, Bothwell MA, Chao MV, Axelrod F, Kramer PL, Kidd KK, Lanahan AA, Johnson DE, Ross AH, Et Al. (Dec 1986) DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia., Molecular Biology & Medicine, 3 (6), 483-94 Abstract
  • Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M (Nov 1986) Expression and structure of the human NGF receptor., Cell, 47 (4), 545-54 Abstract
  • Chao MV, Bothwell MA, Ross AH, Koprowski H, Lanahan AA, Buck CR, Sehgal A (Apr 1986) Gene transfer and molecular cloning of the human NGF receptor., Science, 232 (4749), 518-21 Abstract
  • Huebner K, Isobe M, Chao M, Bothwell M, Ross AH, Finan J, Hoxie JA, Sehgal A, Buck CR, Lanahan A, Et Al. (Mar 1986) The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias., Proceedings of the National Academy of Sciences of the United States of America., 83 (5), 1403-7 Abstract
  • Ross AH, Herlyn M, Maul GG, Koprowski H, Bothwell M, Chao M, Pleasure D, Sonnenfeld KH (1986) The nerve growth factor receptor in normal and transformed neural crest cells., Annals of the New York Academy of Sciences, 486, 115-23 Abstract
  • Bothwell M, Block T (1986) Use of iron- or selenium-coupled monoclonal antibodies to cell surface antigens as a positive selection system for cells., Methods in Enzymology, 121, 771-83 Abstract
  • Grob PM, Ross AH, Koprowski H, Bothwell M (Jul 1985) Characterization of the human melanoma nerve growth factor receptor., The Journal of Biological Chemistry, 260 (13), 8044-9 Abstract
  • Strazdis J, Lanahan A, Johnson DE, Bothwell M, Kucherlapati R (Apr 1985) The epidermal growth factor (EGF) receptor gene studied using gene transfer., The International Journal of Neuroscience, 26 (1-2), 129-40 Abstract
  • Heidemann SR, Joshi HC, Schechter A, Fletcher JR, Bothwell M (Mar 1985) Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells., The Journal of Cell Biology, 100 (3), 916-27 Abstract
  • Ross AH, Grob P, Bothwell M, Elder DE, Ernst CS, Marano N, Ghrist BF, Slemp CC, Herlyn M, Atkinson B, Et Al. (Nov 1984) Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies., Proceedings of the National Academy of Sciences of the United States of America., 81 (21), 6681-5 Abstract
  • Grob PM, Bothwell MA (Dec 1983) Modification of nerve growth factor receptor properties by wheat germ agglutinin., The Journal of Biological Chemistry, 258 (23), 14136-43 Abstract
  • Grob PM, Berlot CH, Bothwell MA (Nov 1983) Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells., Proceedings of the National Academy of Sciences of the United States of America., 80 (22), 6819-23 Abstract
  • Block T, Bothwell M (Jun 1983) The nerve growth factor receptor on PC12 cells: interconversion between two forms with different binding properties., Journal of Neurochemistry, 40 (6), 1654-63 Abstract
  • Block T, Bothwell M (Jan 1983) Use of iron- or selenium-coupled monoclonal antibodies to cell-surface antigens as a positive selection system for cells., Nature, 301 (5898), 342-4 Abstract
  • Bothwell M (1982) Insulin and somatemedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons., Journal of Neuroscience Research, 8 (2-3), 225-31 Abstract
  • Schechter AL, Bothwell MA (Jun 1981) Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association., Cell, 24 (3), 867-74 Abstract
  • Gunning PW, Landreth GE, Bothwell MA, Shooter EM (May 1981) Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells., The Journal of Cell Biology, 89 (2), 240-5 Abstract
  • Harris-Warrick RM, Bothwell MA, Shooter EM (Dec 1980) Subunit interactions inhibit the binding of beta nerve growth factor to receptors on embryonic chick sensory neurons., The Journal of Biological Chemistry, 255 (23), 11284-9 Abstract
  • Bothwell MA, Schechter AL, Vaughn KM (Oct 1980) Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor., Cell, 21 (3), 857-66 Abstract
  • Davies RL, Grosse VA, Kucherlapati R, Bothwell M (Jul 1980) Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7., Proceedings of the National Academy of Sciences of the United States of America., 77 (7), 4188-92 Abstract
  • Bothwell MA, Schachman HK (Mar 1980) Equilibrium and kinetic studies of the association of catalytic and regulatory subunits of aspartate transcarbamoylase., The Journal of Biological Chemistry, 255 (5), 1962-70 Abstract
  • Bothwell MA, Schachman HK (Mar 1980) A model for the assembly of aspartate transcarbamoylase from catalytic and regulatory subunits., The Journal of Biological Chemistry, 255 (5), 1971-7 Abstract
  • Bothwell MA, Wilson WH, Shooter EM (Aug 1979) The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland., The Journal of Biological Chemistry, 254 (15), 7287-94 Abstract
  • Bothwell MA, Shooter EM (Dec 1978) Thermodynamics of interaction of the subunits of 7 S nerve growth factor. The mechanism of activation of the esteropeptidase activity by chelators., The Journal of Biological Chemistry, 253 (23), 8458-64 Abstract
  • Bothwell MA, Howlett GJ, Schachman HK (Apr 1978) A sedimentation equilibrium method for determining molecular weights of proteins with a tabletop high speed air turbine centrifuge., The Journal of Biological Chemistry, 253 (7), 2073-7 Abstract
  • Bothwell MA, Shooter EM (Dec 1977) Dissociation equilibrium constant of beta nerve growth factor., The Journal of Biological Chemistry, 252 (23), 8532-6 Abstract
  • Subramani S, Bothwell MA, Gibbons I, Yang YR, Schachman HK (Sep 1977) Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamolylase., Proceedings of the National Academy of Sciences of the United States of America., 74 (9), 3777-81 Abstract
  • Bothwell M, Schachman HK (Aug 1974) Pathways of assembly of aspartate transcarbamoylase from catalytic and regulatory subunits., Proceedings of the National Academy of Sciences of the United States of America., 71 (8), 3221-5 Abstract
  • Bothwell MA, Datta P (Apr 1971) Effects of K+ on the catalytic and regulatory properties of homoserine dehydrogenase of Pseudomonas fluorescens., Biochimica Et Biophysica Acta, 235 (1), 1-13 Abstract

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Last Updated: 6/20/2006

COS Expertise ID #903276
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