Dr. Wayne T. McCormack

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University of Florida
College of Medicine
Pathology, Immunology and Laboratory Medicine
Associate Professor
University of Florida
College of Medicine
Dean's Office
Graduate Education
Associate Dean for Graduate Education
Professional Headshot of Wayne T. McCormack

Mailing Address

Dept. of Pathology, Immunology & Laboratory Medicine
Box 100275 Health Science Center
1600 SW Archer Road
Gainesville, Florida 32610-0275
United States

Contact Information

Phone: (352) 392-7413
Fax: (352) 846-3466
mccormac@pathology.ufl.edu
http://www.pathology.ufl.edu/~mccormac/

Qualifications

Postdoctoral, University of Michigan, Immunogenetics, 1991.
Ph.D., Florida State University, Genetics and Cell Biology, 1987.
M.S., Florida State University, Genetics and Cell Biology, 1982.
B.S., Creighton University, Biology, 1979.

Expertise and Research Interests

Dr. McCormack's laboratory research is on the genetics of susceptibility to human autoimmune disease, focusing on vitiligo. Susceptibility to autoimmune diseases has both genetic and environmental components. The genes involved in vitiligo susceptibility may be important for normal functioning of the skin pigment-producing melanocytes and/or in cells of the immune system (lymphocytes). Case/control and family-based association methods are being used to provide evidence of genetic association of such genes with vitiligo. Confirmation of a role for these genes is being sought by studies of gene expression and mutation analysis.  The long-term goal of this research is to contribute to an understanding of autoimmune disease pathogenesis, which will hopefully allow identification of 'at risk' individuals and influence strategies for treatment or prevention of vitiligo. 

Dr. McCormack's medical education research focuses on student peer evaluation in medical education. Although a major determinant of later professional success, peer evaluation is under-utilized in medical education. Ongoing studies focus on simplifying the form and analysis of medical student summative peer evaluation, including dimensions of professional competence, interpersonal skills, and humanism. Collaborations are being sought for the UF-GHHS Peer Assessment Project (http://humanism.med.ufl.edu/UF-GHHS-Project.html).

Other Expertise

Academic Experience:
Honors and Awards
Academic Scholarships, Creighton University, 1976-1979
Sigma Xi Grant-in-Aid of Research, 1985
AAI Travel Award, 7th Int'l Congress of Immunology, 1989
New Faculty Award, Division of Sponsored Research, University of Florida, 1992
Research Development Award, Division of Sponsored Research, University of Florida, 1992
"Golden Apple" Medical Student Teaching Award, Co-Director, General Pathology & Immunology course, 2001
Innovation & Research in Medical Education Award, UF College of Medicine Medical Education Week, 2002
Society of Teaching Scholars, UF College of Medicine, 2003

Committees and Reviewerships:
Manuscript Reviewerships:
J. Immunology (primary reviewer pool)
Nucleic Acids Research (ad hoc)
International Immunology (ad hoc)
Journal of Immunology (ad hoc)
Immunogenetics (ad hoc)
J. Invest. Dermatology (ad hoc)

Grant Reviewerships:
NIH Allergy and Immunology Study Section (ad hoc)
USDA Natl Research Initiative Competitive Grants Program (ad hoc)
NSF Integrative Animal Biology Program (ad hoc)
NIH Centers of Biomedical Research Excellence (COBRE) Special Emphasis Panel

National Committees:
Program Committee, AAMC GREAT Group Annual Conference, "GREAT Visions of the Future of Biomedical Research Education and Training", April 2003, Montreal, Quebec, Canada
Program Committee, AAMC GREAT Group Annual Conference, "Implementing a GREAT Vision for Biomedical Education", April 2004, Austin, TX

College and University Committees:
Member, UF Graduate School Curriculum Committee, August 2003 - present
Member, Provost Task Force on Tuition Remission, Dec. 2002 - March 2003
Member, University Faculty Senate, August 2002 - present
Member, Council of Graduate Deans, Univ. Florida, Sept. 2001 - present
Member, Curriculum Review Committee, Interdisciplinary Program in Biomedical Sciences, College of Medicine, April 1999 - present
Chair, Recruiting & Admissions Committee, Interdisciplinary Program in Biomedical Sciences, College of Medicine, September 1997 - August 2002
Chair, Graduate Program Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1997 - present
Member, Graduate Program Committee and Advisory Board, Interdisciplinary Program in Biomedical Sciences, Office of the Dean, College of Medicine, August 1996 - present
Center for Immunology and Transplantation Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1996 - present
Computer Operations Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1996 - present
Graduate Coordinators Committee, College of Medicine, January 1993 - August 1994, August 1997 - present
Graduate Program Committee Member, Graduate Program in Immunology & Molecular Pathology, Dept. of Pathology, Immunology & Laboratory Medicine, August 1992 - present
Interdisciplinary Graduate Program in Biomedical Science Advisory Board and Core Curriculum Focus Group, Office of the Dean, College of Medicine, August 1995 - August 1996
Center for Study of Host Inflammatory Disease and Tissue Injury Committee, Dept. of Pathology, Immunology & Laboratory Medicine, July 1994 - August 1996
Judge, 1993 Graduate Student Forum poster session, U.F. Graduate Student Council
Graduate Coordinator, Graduate Program in Mammalian Genetics, Center for Mammalian Genetics, January 1993 - August 1994
Graduate Studies Committee and Curriculum Committee, Center for Mammalian Genetics, January 1993 - April 1996

Advisory Boards:
National Neurofibromatosis Foundation, Inc., Florida Chapter, Board of Directors, July 1994 - present; Treasurer, October 1994 - July 1998; Vice-President, October 1997 - October 1999; Newsletter Editor, October 2001 - present
American Vitiligo Research Foundation, Medical Advisory Board, May 2003 - present

Community Service:
University Park Neighborhood Association, Gainesville, FL, Member, October 1992 - October 1997; Board of Directors, October 1992 - January 1995
Raintree Neighborhood Association, Gainesville, FL, Member, April 1998 - present
Boy Scouts of America, North Florida Council, Alachua District: Cub Scout Pack 127, September 2003 - December 2006; Boy Scout Troop 125, Assistant Scoutmaster, February 2006 - present; Scout Leader Trainer, August 2004 - present; District Training Chair, January 2006 - present

Keywords

COS Keywords:

Autoimmunity, Immunology, Skin Diseases.

Additional Terms:

Autoimmunity, Immunology, Peer Evaluation, Vitiligo.

Memberships

American Association for the Advancement of Science
American Association of Immunologists
American Vitiligo Research Foundation
Association of American Medical Colleges
Childrens Tumor Foundation
National Vitiligo Foundation
PanAmerican Society for Pigment Cell Research

Publications

  • Casp CB, She JX, McCormack WT, Genes of the LMP/TAP Cluster Are Associated With the Human Autoimmune Disease Vitiligo., Genes and Immunity, 4(7), 492-9, Oct 2003 Abstract
  • Casp CB, She JX, McCormack WT, Genetic association of the catalase gene (CAT) with vitiligo susceptibility, Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society., 15(1), 62-6, February 2002 Abstract
  • Moore JB, Blanchard RK, McCormack WT, Cousins RJ, cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes, Journal of Nutrition, 131(12), 3189-96, December 2001 Abstract
  • Kou ZC, Puhr JS, Rojas M, McCormack WT, Goodenow MM, Sleasman JW, T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children, Clinical and Diagnostic Laboratory Immunology, 7(6), 953-9, November 2000 Abstract
  • Khan SR, Byer KJ, Thamilselvan S, Hackett RL, McCormack WT, Benson NA, Vaughn KL, Erdos GW, Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells, Journal of the American Society of Nephrology : Jasn, 10 Suppl 14, S457-63, November 1999 Abstract
  • Sheng B, McCormack WT, Smith RT, Purified donor T cells alone activate transplantation immunity to the male antigen but induce tolerance in combination with Mac-1+ donor cells, Transplantation, 68(7), 1024-9, October 1999 Abstract
  • Rossi D, Sanchez-Garcia J, McCormack WT, Bazan JF, Zlotnik A, Identification of a chicken 'C' chemokine related to lymphotactin, Journal of Leukocyte Biology, 65(1), 87-93, Jan 1999 Abstract
  • Davis JA, Peen E, Williams RC, Perkins S, Malone CC, McCormack WT, Csernok E, Gross WL, Kolaskar AS, Kulkarni-Kale U, Determination of primary amino acid sequence and unique three-dimensional structure of WGH1, a monoclonal human IgM antibody with anti-PR3 specificity, Clinical Immunology and Immunopathology, 89(1), 35-43, October 1998 Abstract
  • Sanchez-Garcia F J, Aller W W, Mccormack W T, Impaired calcium mobilization and differential tyrosine phosphorylation in intestinal intraepithelial lymphocytes., Immunology, 91(1), 81-7, May 1997 Abstract
  • Six A, Rast J P, McCormack W T, Dunon D, Courtois D, Li Y, Chen C H, Cooper M D, Characterization of avian T-cell receptor gamma genes., Proceedings of the National Academy of Sciences (USA), 93(26), 15329-34, 24 Dec 1996 Abstract
  • Sanchez-Garcia F J, McCormack W T, Chicken gamma delta T cells., Current Topics In Microbiology and Immunology, 212, 55-69, 1996 Abstract
  • Pickel J M, McCormack W T, Chen C H, Cooper M D, Thompson C B, Differential regulation of V(D)J recombination during development of avian B and T cells., International Immunology, 5(8), 919-27, August 1993 Abstract
  • Fuschiotti P, Harindranath N, Mage RG, McCormack WT, Dhanarajan P, Roux KH, Recombination activating genes-1 and -2 of the rabbit: cloning and characterization of germline and expressed genes, Molecular Immunology, 30(11), 1021-32, August 1993 Abstract
  • McCormack W T, Thompson C B, Special features of the development of the chicken humoral immune system., Research In Immunology, 144(6-7), 467-75; discussion 4, July 1993 Abstract
  • McCormack W T, Liu M, Postema C, Thompson C B, Turka L A, Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes., International Immunology, 5(7), 801-4, July 1993 Abstract
  • McCormack W T, Hurley E A, Thompson C B, Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens., Molecular and Cellular Biology, 13(2), 821-30, February 1993 Abstract
  • McCormack W T, Tjoelker L W, Thompson C B, Immunoglobulin gene diversification by gene conversion., Progress In Nucleic Acid Research and Molecular Biology, 45, 27-45, 1993 Abstract
  • McCormack W T, Tjoelker L W, Stella G, Postema C E, Thompson C B, Chicken T-cell receptor beta-chain diversity: an evolutionarily conserved D beta-encoded glycine turn within the hypervariable CDR3 domain., Proceedings of the National Academy of Sciences (USA), 88(17), 7699-703, 1 Sep 1991 Abstract
  • Turka L A, Schatz D G, Oettinger M A, Chun J J, Gorka C, Lee K, McCormack W T, Thompson C B, Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking., Science, 253(5021), 778-81, 16 Aug 1991 Abstract
  • Carlson L M, Oettinger M A, Schatz D G, Masteller E L, Hurley E A, McCormack W T, Baltimore D, Thompson C B, Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion., Cell, 64(1), 201-8, 11 Jan 1991 Abstract
  • McCormack W T, Tjoelker L W, Thompson C B, Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion., Annual Review of Immunology, 9, 219-41, 1991 Abstract
  • Tjoelker L W, Carlson L M, Lee K, Lahti J, McCormack W T, Leiden J M, Chen C L, Cooper M D, Thompson C B, Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain., Proceedings of the National Academy of Sciences (USA), 87(20), 7856-60, October 1990 Abstract
  • McCormack W T, Thompson C B, Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity., Genes and Development, 4(4), 548-58, April 1990 Abstract
  • Carlson L M, McCormack W T, Postema C E, Humphries E H, Thompson C B, Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion., Genes and Development, 4(4), 536-47, April 1990 Abstract
  • Petryniak B, Staudt L M, Postema C E, McCormack W T, Thompson C B, Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution., Proceedings of the National Academy of Sciences (USA), 87(3), 1099-103, February 1990 Abstract
  • McCormack W T, Thompson C B, Somatic diversification of the chicken immunoglobulin light-chain gene., Advances In Immunology, 48, 41-67, 1990 Abstract
  • McCormack WT, Tjoelker LW, Barth CF, Carlson LM, Petryniak B, Humphries EH, Thompson CB, Selection for B cells with productive IgL gene rearrangements occurs in the bursa of Fabricius during chicken embryonic development, Genes and Development, 3(6), 838-47, June 1989 Abstract
  • McCormack WT, Tjoelker LW, Carlson LM, Petryniak B, Barth CF, Humphries EH, Thompson CB, Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments, Cell, 56(5), 785-91, March 1989 Abstract
  • McCormack WT, Dhanarajan P, Roux KH, Comparison of latent and nominal rabbit Ig VHa1 allotype cDNA sequences, Journal of Immunology (baltimore, Md. : 1950), 141(6), 2063-71, September 1988 Abstract
  • McCormack WT, Laster SM, Marzluff WF, Roux KH, Dynamic gene interactions in the evolution of rabbit VH genes: a four codon duplication and block homologies provide evidence for intergenic exchange, Nucleic Acids Research, 13(19), 7041-54, October 1985 Abstract
  • Roux KH, McCormack WT, Dhanarajan P, A reevaluation of rabbit anti-allotype antibody for the presence of cross-reactive idiotypes. I. A species-specific idiotype on rabbit anti-a1 antibody is recognized by guinea pig anti-IdX, Journal of Immunology (baltimore, Md. : 1950), 135(3), 1961-6, September 1985 Abstract
  • Roux KH, McCormack WT, Dhanarajan P, A reevaluation of rabbit anti-allotype antibody for the presence of cross-reactive idiotypes. II. Expression of rabbit a1-like images on goat antibody after immunization with anti-a1 antib, Journal of Immunology (baltimore, Md. : 1950), 135(3), 1967-74, September 1985 Abstract
  • McCormack WT, Roux KH, Monoclonal antibodies specific for the b5 allotype of rabbit kappa light chains, Hybridoma, 2(1), 97-107, 1983 Abstract

Profile Details

Last Updated: 11/6/2006

COS Expertise ID #383135
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