University of Florida College of Medicine Pathology, Immunology and Laboratory Medicine Associate Professor University of Florida College of Medicine Dean's Office Graduate Education Associate Dean for Graduate Education |  |
QualificationsPostdoctoral, University of Michigan, Immunogenetics, 1991. Ph.D., Florida State University, Genetics and Cell Biology, 1987. M.S., Florida State University, Genetics and Cell Biology, 1982. B.S., Creighton University, Biology, 1979. Expertise and Research InterestsDr. McCormack's laboratory research is on the genetics of susceptibility to human autoimmune disease, focusing on vitiligo. Susceptibility to autoimmune diseases has both genetic and environmental components. The genes involved in vitiligo susceptibility may be important for normal functioning of the skin pigment-producing melanocytes and/or in cells of the immune system (lymphocytes). Case/control and family-based association methods are being used to provide evidence of genetic association of such genes with vitiligo. Confirmation of a role for these genes is being sought by studies of gene expression and mutation analysis. The long-term goal of this research is to contribute to an understanding of autoimmune disease pathogenesis, which will hopefully allow identification of 'at risk' individuals and influence strategies for treatment or prevention of vitiligo.
Dr. McCormack's medical education research focuses on student peer evaluation in medical education. Although a major determinant of later professional success, peer evaluation is under-utilized in medical education. Ongoing studies focus on simplifying the form and analysis of medical student summative peer evaluation, including dimensions of professional competence, interpersonal skills, and humanism. Collaborations are being sought for the UF-GHHS Peer Assessment Project (http://humanism.med.ufl.edu/UF-GHHS-Project.html).
Other ExpertiseAcademic Experience: Honors and Awards Academic Scholarships, Creighton University, 1976-1979 Sigma Xi Grant-in-Aid of Research, 1985 AAI Travel Award, 7th Int'l Congress of Immunology, 1989 New Faculty Award, Division of Sponsored Research, University of Florida, 1992 Research Development Award, Division of Sponsored Research, University of Florida, 1992 "Golden Apple" Medical Student Teaching Award, Co-Director, General Pathology & Immunology course, 2001 Innovation & Research in Medical Education Award, UF College of Medicine Medical Education Week, 2002 Society of Teaching Scholars, UF College of Medicine, 2003
Committees and Reviewerships: Manuscript Reviewerships: J. Immunology (primary reviewer pool) Nucleic Acids Research (ad hoc) International Immunology (ad hoc) Journal of Immunology (ad hoc) Immunogenetics (ad hoc) J. Invest. Dermatology (ad hoc)
Grant Reviewerships: NIH Allergy and Immunology Study Section (ad hoc) USDA Natl Research Initiative Competitive Grants Program (ad hoc) NSF Integrative Animal Biology Program (ad hoc) NIH Centers of Biomedical Research Excellence (COBRE) Special Emphasis Panel
National Committees: Program Committee, AAMC GREAT Group Annual Conference, "GREAT Visions of the Future of Biomedical Research Education and Training", April 2003, Montreal, Quebec, Canada Program Committee, AAMC GREAT Group Annual Conference, "Implementing a GREAT Vision for Biomedical Education", April 2004, Austin, TX
College and University Committees: Member, UF Graduate School Curriculum Committee, August 2003 - present Member, Provost Task Force on Tuition Remission, Dec. 2002 - March 2003 Member, University Faculty Senate, August 2002 - present Member, Council of Graduate Deans, Univ. Florida, Sept. 2001 - present Member, Curriculum Review Committee, Interdisciplinary Program in Biomedical Sciences, College of Medicine, April 1999 - present Chair, Recruiting & Admissions Committee, Interdisciplinary Program in Biomedical Sciences, College of Medicine, September 1997 - August 2002 Chair, Graduate Program Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1997 - present Member, Graduate Program Committee and Advisory Board, Interdisciplinary Program in Biomedical Sciences, Office of the Dean, College of Medicine, August 1996 - present Center for Immunology and Transplantation Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1996 - present Computer Operations Committee, Dept. of Pathology, Immunology & Laboratory Medicine, August 1996 - present Graduate Coordinators Committee, College of Medicine, January 1993 - August 1994, August 1997 - present Graduate Program Committee Member, Graduate Program in Immunology & Molecular Pathology, Dept. of Pathology, Immunology & Laboratory Medicine, August 1992 - present Interdisciplinary Graduate Program in Biomedical Science Advisory Board and Core Curriculum Focus Group, Office of the Dean, College of Medicine, August 1995 - August 1996 Center for Study of Host Inflammatory Disease and Tissue Injury Committee, Dept. of Pathology, Immunology & Laboratory Medicine, July 1994 - August 1996 Judge, 1993 Graduate Student Forum poster session, U.F. Graduate Student Council Graduate Coordinator, Graduate Program in Mammalian Genetics, Center for Mammalian Genetics, January 1993 - August 1994 Graduate Studies Committee and Curriculum Committee, Center for Mammalian Genetics, January 1993 - April 1996
Advisory Boards: National Neurofibromatosis Foundation, Inc., Florida Chapter, Board of Directors, July 1994 - present; Treasurer, October 1994 - July 1998; Vice-President, October 1997 - October 1999; Newsletter Editor, October 2001 - present American Vitiligo Research Foundation, Medical Advisory Board, May 2003 - present
Community Service: University Park Neighborhood Association, Gainesville, FL, Member, October 1992 - October 1997; Board of Directors, October 1992 - January 1995 Raintree Neighborhood Association, Gainesville, FL, Member, April 1998 - present Boy Scouts of America, North Florida Council, Alachua District: Cub Scout Pack 127, September 2003 - December 2006; Boy Scout Troop 125, Assistant Scoutmaster, February 2006 - present; Scout Leader Trainer, August 2004 - present; District Training Chair, January 2006 - present KeywordsCOS Keywords:Autoimmunity, Educational Evaluation Or Assessment, Graduate Education, Immunology, Skin Diseases.Additional Terms:Autoimmunity, Immunology, Peer Evaluation, Vitiligo.MembershipsAmerican Association for the Advancement of Science American Association of Immunologists American Vitiligo Research Foundation Association of American Medical Colleges Childrens Tumor Foundation National Vitiligo Foundation PanAmerican Society for Pigment Cell Research Publications- Casp CB, She JX, McCormack WT, Genes of the LMP/TAP Cluster Are Associated With the Human Autoimmune
Disease Vitiligo., Genes and Immunity, 4(7), 492-9, Oct 2003
 - Casp CB, She JX, McCormack WT, Genetic association of the catalase gene (CAT) with vitiligo
susceptibility, Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society., 15(1), 62-6, February 2002
 - Moore JB, Blanchard RK, McCormack WT, Cousins RJ, cDNA array analysis identifies thymic LCK as upregulated in moderate
murine zinc deficiency before T-lymphocyte population
changes, Journal of Nutrition, 131(12), 3189-96, December 2001
 - Kou ZC, Puhr JS, Rojas M, McCormack WT, Goodenow MM, Sleasman JW, T-Cell receptor Vbeta repertoire CDR3 length diversity differs within
CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency
virus-infected children, Clinical and Diagnostic Laboratory Immunology, 7(6), 953-9, November 2000
 - Khan SR, Byer KJ, Thamilselvan S, Hackett RL, McCormack WT, Benson NA, Vaughn KL, Erdos GW, Crystal-cell interaction and apoptosis in oxalate-associated injury of
renal epithelial cells, Journal of the American Society of Nephrology : Jasn, 10 Suppl 14, S457-63, November 1999
 - Sheng B, McCormack WT, Smith RT, Purified donor T cells alone activate transplantation immunity to the male
antigen but induce tolerance in combination with Mac-1+ donor
cells, Transplantation, 68(7), 1024-9, October 1999
 - Rossi D, Sanchez-Garcia J, McCormack WT, Bazan JF, Zlotnik A, Identification of a chicken 'C' chemokine related to lymphotactin, Journal of Leukocyte Biology, 65(1), 87-93, Jan 1999
 - Davis JA, Peen E, Williams RC, Perkins S, Malone CC, McCormack WT, Csernok E, Gross WL, Kolaskar AS, Kulkarni-Kale U, Determination of primary amino acid sequence and unique three-dimensional
structure of WGH1, a monoclonal human IgM antibody with anti-PR3
specificity, Clinical Immunology and Immunopathology, 89(1), 35-43, October 1998
 - Sanchez-Garcia F J, Aller W W, Mccormack W T, Impaired calcium mobilization and differential tyrosine phosphorylation in intestinal intraepithelial lymphocytes., Immunology, 91(1), 81-7, May 1997
 - Six A, Rast J P, McCormack W T, Dunon D, Courtois D, Li Y, Chen C H, Cooper M D, Characterization of avian T-cell receptor gamma genes., Proceedings of the National Academy of Sciences (USA), 93(26), 15329-34, 24 Dec 1996
 - Sanchez-Garcia F J, McCormack W T, Chicken gamma delta T cells., Current Topics In Microbiology and Immunology, 212, 55-69, 1996
 - Pickel J M, McCormack W T, Chen C H, Cooper M D, Thompson C B, Differential regulation of V(D)J recombination during development of avian B and T cells., International Immunology, 5(8), 919-27, August 1993
 - Fuschiotti P, Harindranath N, Mage RG, McCormack WT, Dhanarajan P, Roux KH, Recombination activating genes-1 and -2 of the rabbit: cloning and
characterization of germline and expressed genes, Molecular Immunology, 30(11), 1021-32, August 1993
 - McCormack W T, Thompson C B, Special features of the development of the chicken humoral immune system., Research In Immunology, 144(6-7), 467-75; discussion 4, July 1993
 - McCormack W T, Liu M, Postema C, Thompson C B, Turka L A, Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes., International Immunology, 5(7), 801-4, July 1993
 - McCormack W T, Hurley E A, Thompson C B, Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens., Molecular and Cellular Biology, 13(2), 821-30, February 1993
 - McCormack W T, Tjoelker L W, Thompson C B, Immunoglobulin gene diversification by gene conversion., Progress In Nucleic Acid Research and Molecular Biology, 45, 27-45, 1993
 - McCormack W T, Tjoelker L W, Stella G, Postema C E, Thompson C B, Chicken T-cell receptor beta-chain diversity: an evolutionarily conserved D beta-encoded glycine turn within the hypervariable CDR3 domain., Proceedings of the National Academy of Sciences (USA), 88(17), 7699-703, 1 Sep 1991
 - Turka L A, Schatz D G, Oettinger M A, Chun J J, Gorka C, Lee K, McCormack W T, Thompson C B, Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking., Science, 253(5021), 778-81, 16 Aug 1991
 - Carlson L M, Oettinger M A, Schatz D G, Masteller E L, Hurley E A, McCormack W T, Baltimore D, Thompson C B, Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion., Cell, 64(1), 201-8, 11 Jan 1991
 - McCormack W T, Tjoelker L W, Thompson C B, Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion., Annual Review of Immunology, 9, 219-41, 1991
 - Tjoelker L W, Carlson L M, Lee K, Lahti J, McCormack W T, Leiden J M, Chen C L, Cooper M D, Thompson C B, Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain., Proceedings of the National Academy of Sciences (USA), 87(20), 7856-60, October 1990
 - McCormack W T, Thompson C B, Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity., Genes and Development, 4(4), 548-58, April 1990
 - Carlson L M, McCormack W T, Postema C E, Humphries E H, Thompson C B, Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion., Genes and Development, 4(4), 536-47, April 1990
 - Petryniak B, Staudt L M, Postema C E, McCormack W T, Thompson C B, Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution., Proceedings of the National Academy of Sciences (USA), 87(3), 1099-103, February 1990
 - McCormack W T, Thompson C B, Somatic diversification of the chicken immunoglobulin light-chain gene., Advances In Immunology, 48, 41-67, 1990
 - McCormack WT, Tjoelker LW, Barth CF, Carlson LM, Petryniak B, Humphries EH, Thompson CB, Selection for B cells with productive IgL gene rearrangements occurs in
the bursa of Fabricius during chicken embryonic development, Genes and Development, 3(6), 838-47, June 1989
 - McCormack WT, Tjoelker LW, Carlson LM, Petryniak B, Barth CF, Humphries EH, Thompson CB, Chicken IgL gene rearrangement involves deletion of a circular episome and
addition of single nonrandom nucleotides to both coding
segments, Cell, 56(5), 785-91, March 1989
 - McCormack WT, Dhanarajan P, Roux KH, Comparison of latent and nominal rabbit Ig VHa1 allotype cDNA sequences, Journal of Immunology (baltimore, Md. : 1950), 141(6), 2063-71, September 1988
 - McCormack WT, Laster SM, Marzluff WF, Roux KH, Dynamic gene interactions in the evolution of rabbit VH genes: a four
codon duplication and block homologies provide evidence for intergenic
exchange, Nucleic Acids Research, 13(19), 7041-54, October 1985
 - Roux KH, McCormack WT, Dhanarajan P, A reevaluation of rabbit anti-allotype antibody for the presence of
cross-reactive idiotypes. I. A species-specific idiotype on rabbit anti-a1
antibody is recognized by guinea pig anti-IdX, Journal of Immunology (baltimore, Md. : 1950), 135(3), 1961-6, September 1985
 - Roux KH, McCormack WT, Dhanarajan P, A reevaluation of rabbit anti-allotype antibody for the presence of
cross-reactive idiotypes. II. Expression of rabbit a1-like images on goat
antibody after immunization with anti-a1 antib, Journal of Immunology (baltimore, Md. : 1950), 135(3), 1967-74, September 1985
 - McCormack WT, Roux KH, Monoclonal antibodies specific for the b5 allotype of rabbit kappa light
chains, Hybridoma, 2(1), 97-107, 1983

Profile DetailsIndividual Expertise profile of Wayne T. McCormack, Copyright Wayne T. McCormack. © COS Expertise TM, 2009, ProQuest LLC All rights reserved. |