Dr. Martin William McIntosh

(Reading, Writing, Speaking)

• McIntosh M, Anderson G, Drescher C, Hanash S, Urban N, Brown P, Gambhir SS, Coukos G, Laird PW, Nelson B, Palmer C (Nov 2008) Ovarian cancer early detection claims are biased., Clinical cancer research : an official journal of the American Association for Cancer Research, 14 (22), 7574
• Fang Q, Strand A, Law W, Faca VM, Fitzgibon MP, Hamel N, Houle B, Liu X, May DH, Poschmann G, Roy L, Stühler K, Ying W, Zhang J, Zheng Z, Bergeron JJ, Hanash S, He F, Leavitt BR, Meyer HE, Qian X, McIntosh MW (Nov 2008) Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington's disease., Molecular & cellular proteomics : MCP
• Martin DB, Holzman T, May D, Peterson A, Eastham A, Eng J, McIntosh M (Nov 2008) MRMer, an interactive open source and cross-platform system for data extraction and visualization of multiple reaction monitoring experiments., Molecular & cellular proteomics : MCP, 7 (11), 2270-8
• May D, Liu Y, Law W, Fitzgibbon M, Wang H, Hanash S, McIntosh M (Oct 2008) Peptide Sequence Confidence in Accurate Mass and Time Analysis and Its Use in Complex Proteomics Experiments., Journal of proteome research
• Lowe KA, Shah C, Wallace E, Anderson G, Paley P, McIntosh M, Andersen MR, Scholler N, Bergan L, Thorpe J, Urban N, Drescher CW (Sep 2008) Effects of personal characteristics on serum CA125, mesothelin, and HE4 levels in healthy postmenopausal women at high-risk for ovarian cancer., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17 (9), 2480-7
• Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM (Jun 2008) A mouse to human search for plasma proteome changes associated with pancreatic tumor development., PLoS medicine, 5 (6), e123
• Pitteri SJ, Faca VM, Kelly-Spratt KS, Kasarda AE, Wang H, Zhang Q, Newcomb L, Krasnoselsky A, Paczesny S, Choi G, Fitzgibbon M, McIntosh MW, Kemp CJ, Hanash SM (Apr 2008) Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells., Journal of proteome research, 7 (4), 1481-9
• Palmer C, Duan X, Hawley S, Scholler N, Thorpe JD, Sahota RA, Wong MQ, Wray A, Bergan LA, Drescher CW, McIntosh MW, Brown PO, Nelson BH, Urban N (2008) Systematic evaluation of candidate blood markers for detecting ovarian cancer., PLoS ONE, 3 (7), e2633
• Faça VM, Ventura AP, Fitzgibbon MP, Pereira-Faça SR, Pitteri SJ, Green AE, Ireton RC, Zhang Q, Wang H, O'Briant KC, Drescher CW, Schummer M, McIntosh MW, Knudsen BS, Hanash SM (2008) Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains., PLoS ONE, 3 (6), e2425
• Scholler N, Gross JA, Garvik B, Wells L, Liu Y, Loch CM, Ramirez AB, McIntosh MW, Lampe PD, Urban N (2008) Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery., Journal of translational medicine, 6, 41
• Fitzgibbon M, Li Q, McIntosh M (Jan 2008) Modes of inference for evaluating the confidence of peptide identifications., Journal of proteome research, 7 (1), 35-9
• Loch CM (2007) Use of High Density Antibody Arrays to Validate and Discover Cancer Serum Biomarkers, Molecular Oncology, 1 (3), 313-320
• Whiteaker JR, Zhang H, Zhao L, Wang P, Kelly-Spratt KS, Ivey RG, Piening BD, Feng LC, Kasarda E, Gurley KE, Eng JK, Chodosh LA, Kemp CJ, McIntosh MW, Paulovich AG (Oct 2007) Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer., Journal of proteome research, 6 (10), 3962-75
• McIntosh MW, Liu Y, Drescher C, Urban N, Diamandis EP (Aug 2007) Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma., Clinical cancer research : an official journal of the American Association for Cancer Research, 13 (15 Pt 1), 4422-8
• McIntosh M (2007) Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma, Clinical Cancer Research, 13 (15(pt 1)), 4422-4428
• May D, Fitzgibbon M, Liu Y, Holzman T, Eng J, Kemp CJ, Whiteaker J, Paulovich A, McIntosh M (Jul 2007) A platform for accurate mass and time analyses of mass spectrometry data., Journal of proteome research, 6 (7), 2685-94
• May D, Fitzgibbon M, Liu Y, Holzman T, Eng J, Kemp CJ, Whiteaker J, Paulovich A, McIntosh M (Jul 2007) A platform for accurate mass and time analyses of mass spectrometry data., Journal of proteome research, 6 (7), 2685-94
• Wang P, Tang H, Fitzgibbon MP, McIntosh M, Coram M, Zhang H, Yi E, Aebersold R (Apr 2007) A statistical method for chromatographic alignment of LC-MS data., Biostatistics (Oxford, England), 8 (2), 357-67
• Whiteaker JR, Zhang H, Eng JK, Fang R, Piening BD, Feng LC, Lorentzen TD, Schoenherr RM, Keane JF, Holzman T, Fitzgibbon M, Lin C, Cooke K, Liu T, Camp DG, Anderson L, Watts J, Smith RD, McIntosh MW, Paulovich AG (Feb 2007) Head-to-head comparison of serum fractionation techniques., Journal of proteome research, 6 (2), 828-36
• Whiteaker JR, Zhang H, Eng JK, Fang R, Piening BD, Feng LC, Lorentzen TD, Schoenherr RM, Keane JF, Holzman T, Fitzgibbon M, Lin C, Cooke K, Liu T, Camp DG, Anderson L, Watts J, Smith RD, McIntosh MW, Paulovich AG (Feb 2007) Head-to-head comparison of serum fractionation techniques., Journal of proteome research, 6 (2), 828-36
• Thorpe JD, Duan X, Forrest R, Lowe K, Brown L, Segal E, Nelson B, Anderson GL, McIntosh M, Urban N (2007) Effects of blood collection conditions on ovarian cancer serum markers., PLoS ONE, 2 (12), e1281
• MacLean B, Eng JK, Beavis RC, McIntosh M (Nov 2006) General framework for developing and evaluating database scoring algorithms using the TANDEM search engine., Bioinformatics (Oxford, England), 22 (22), 2830-2
• Bellew M, Coram M, Fitzgibbon M, Igra M, Randolph T, Wang P, May D, Eng J, Fang R, Lin C, Chen J, Goodlett D, Whiteaker J, Paulovich A, McIntosh M (Aug 2006) A suite of algorithms for the comprehensive analysis of complex protein mixtures using high-resolution LC-MS., Bioinformatics (Oxford, England), 22 (15), 1902-9
• Faca V, Coram M, Phanstiel D, Glukhova V, Zhang Q, Fitzgibbon M, McIntosh M, Hanash S (Aug 2006) Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS., Journal of proteome research, 5 (8), 2009-18
• Goodell, V, Salazar LG, Urban N, Drescher CW, Gray H, Swensen RE, McIntosh MW, Disis ML (2006) Antibody Immunity to the p53 Oncogenic Protein Is a Prognostic Indicator in Ovarian Cancer, Journal of Clinical Oncology, 24 (5), 762-8
• Rauch A, Bellew M, Eng J, Fitzgibbon M, Holzman T, Hussey P, Igra M, Maclean B, Lin CW, Detter A, Fang R, Faca V, Gafken P, Zhang H, Whiteaker J, Whitaker J, States D, Hanash S, Paulovich A, McIntosh MW (Jan 2006) Computational Proteomics Analysis System (CPAS): an extensible, open-source analytic system for evaluating and publishing proteomic data and high throughput biological experiments., Journal of proteome research, 5 (1), 112-21
• Baker SG, Kramer BS, McIntosh M, Patterson BH, Shyr Y, Skates S (2006) Evaluating markers for the early detection of cancer: overview of study designs and methods., Clinical trials (London, England), 3 (1), 43-56
• Wang P, Tang H, Zhang H, Whiteaker J, Paulovich AG, Mcintosh M (2006) Normalization regarding non-random missing values in high-throughput mass spectrometry data., Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 315-26
• Sato AH, Anderson GL, Urban N, McIntosh MW (2006) Comparing adaptive and non-adaptive algorithms for cancer early detection with novel biomarkers., Cancer biomarkers : section A of Disease markers, 2 (3-4), 151-62
• Wang P, Tang H, Zhang H, Whiteaker J, Paulovich AG, McIntosh M (2006) Normalization regarding non-random missing values in high-throughput mass spectrometry data, Proceedings of the Pacific Symposium on Biocomputing, 11, 315-326
• Adam Rauch, Matthew Bellew, Jimmy Eng, Matthew Fitzgibbon, Ted Holzman, Peter Hussey, Mark Igra, Brendan Maclean, ChenWei Lin, Andrea Detter, Ruihua Fang, Vitor Faca, Phil Gafken, Heidi Zhang, Jeffrey Whitaker, David States, Sam Hanash, Amanda Paulovich, Martin W. McIntosh (2006) Computational Proteomics Analysis System (CPAS): An extensible open source analytic system for evaluating and publishing proteomic data and high throughput biological experiments, Journal of Proteome Research, 5 (1), 112-21
• McIntosh MW (2005) Could high plasma bikunin predict a favorable outcome in ovarian cancer?, Nature Clinical Practice Oncology, 2 (10), 502-503
• Qinghua Feng, Akhila Balasubramanian, Stephen Hawes, Papa Toure, Papa Salif Sow, Amadou Dem, Birama Dembele, Cathy Critchlow, Long Fu Xi, Hiep Lu, Martin W McIntosh, Alicia M Young, Nancy Kiviat (2003) Detection of Hypermethylated Genes in Biopsies and Exfoliated Cell Samples in Women with and without Cervical Neoplasia and Cervical Cancer, Journal of the National Cancer Institute, 97 (4), 273-82
• Sow PS, Hawes SE, Critchlow CW, McIntosh MW, Diop A, Diouf MB, Gottlieb GS, Starling AK, Coll-Seck AM, Kiviat NB (2005) Characteristics and presenting complaints of outpatients with undiagnosed HIV infection: potential utility for triage to HIV testing, Characteristics and Presenting Complaints of Outpatients With Undiagnosed HIV Infection: Potential Utility in Selecting S, Journal Acquire Immune Deficiency Syndrome, 37 (4), 1520-1528
• McIntosh MW, Drescher C, Karlan B, Scholler N, Urban N, Hellstrom KE, Hellstrom I (Oct 2004) Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma., Gynecologic oncology, 95 (1), 9-15
• McIntosh MW, Drescher C, Urban N, Hellstrom KE, Hellstrom I (2004) Combining CA125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma, Gynecol Oncology, 95 (1), 9-15
• Urban N, McIntosh MW, Andersen MR, Karlan BY (2003) Ovarian cancer screening, Hematology/Oncology Clinics of North America, 17 (4), 989-1005, ix
• Hellstrom I, Raycraft J, Ledbetter M, Ledbetter J, Schummer M, McIntosh MW, Drescher C, Urban N, Hellstrom KE (2003) The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma, Cancer Research, 63 (13), 3695-3700
• Etzioni R, Urban N, Ramsey S, McIntosh M, Schwartz S, Reid B, Radich J, Anderson G, Hartwell L (2003) The case for early detection, Nature Reviews Cancer, 3 (4), 243-252
• Bogusky M, McIntosh MW (2003) Biomedical informatics for proteomics, Nature, 422 (6928), 233-237
• McIntosh MW, Urban N (Jan 2003) A parametric empirical Bayes method for cancer screening using longitudinal observations of a biomarker., Biostatistics (Oxford, England), 4 (1), 27-40
• McIntosh, MW, Urban, N, A Parametric Empirical Bayes Method for Cancer Screening using Longitudinal Observations of a Biomarker, Biostatistics, 3(3), December 2002
• McIntosh MW, Pepe MS, Combining several screening tests: optimality of the risk score, Biometrics, 58(3), 657-64, September 2002
• McIntosh MW, Pepe MS (Sep 2002) Combining several screening tests: optimality of the risk score., Biometrics, 58 (3), 657-64
• McIntosh MW, Urban N, Karlan B, Generating longitudinal screening algorithms using novel biomarkers for disease, Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 11(2), 159-66, February 2002
• McIntosh MW, Urban N, Karlan B (Feb 2002) Generating longitudinal screening algorithms using novel biomarkers for disease., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 11 (2), 159-66
• Martin W McIntosh, Ramsey S, Berry K, Urban N., Solicitation and Estimation for Cost Effectivness Studies, Health Economics, 10(1), Jan 2001
• McIntosh M.W., Instrumental variables when evaluating screening trials: estimating the benefit of detecting cancer by screening, Statistics in Medicine, 18(20), 2775-94, October 1999
• McIntosh M.W, Rubin D.B., On estimating the causal effects of DNR orders [editorial, Medical Care, 37(8), 722-6, August 1999
• Schmid CH, Lau J, McIntosh MW, Cappelleri JC, An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis of clinical trials, Statistics in Medicine, 17(17), 1923-42, September 1998
• Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J, Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment, Journal of Clinical Epidemiology, 50(4), 401-10, April 1997
• McIntosh M.W., The population risk as an explanatory variable in research synthesis of clinical trials, Statistics in Medicine, 15(16), 1713-28, August 1996