David N. McMurray

powered by
COS Expertise®
Texas A&M University
TAMUSHSC College of Medicine
Medical Microbiology & Immunology
System Health Science Center
ProfessorAppointed: 1991
Professional Headshot of David N. McMurray

Mailing Address

Department of Medical Microbiology & Immunology
Texas A&M University
1114 TAMU
College Station, Texas 77843-1114
United States

Contact Information

Phone: (979) 845-1367
Fax: (979) 845-3479
dmcmurray@tamu.edu

Qualifications

Postdoctoral, Tulane University-International Center of Medical Research, Immunology, 1974.
Ph.D., University of Wisconsin-Madison, Medical Microbiology, 1972.
M.S., University of Wisconsin-Madison, Medical Microbiology, 1971.
B.S., University of Wisconsin-Madison, Chemical Engineering, 1965.

Expertise and Research Interests

Immunology of infectious diseases; pathogenesis of intracellular microbes;
Mechanisms of resistance to pulmonary tuberculosis;
response to vaccination in animal models of tuberculosis;
T cell-macrophage interactions in tuberculosis;
Role of chemokines and cytokines in the pathogenesis of pulmonary tuberculosis;
Impact of dietary protein deficiency on resistance to tuberculosis and other infectious diseases;
Influence of n-3 polyunsaturated fatty acids on T cell activation and inflammatory responses in animal models and cultured cells.

Other Expertise

We have developed considerable expertise and more than 30 years of experience with the delivery of infectious aerosols to small experimental animals (e.g., guinea pigs, mice, rabbits). I assisted in the design of the best aerosol infection chamber currently available at the University of Wisconsin. I have personally consulted in the acquisition, set-up, and initial application of that aerosol infection chamber in several commercial and university laboratories in India, New Zealand, and the United States.

Future Research

The usefulness of the highly relevant guinea pig model of low-dose, pulmonary tuberculosis will be enhanced dramatically by the development of modern immunological tools with which to study the guinea pig's immune response to vaccination and infection with virulent Mycobacterium tuberculosis. We have acquired cDNA clones of several guinea pig cytokines and chemokines, including IFNg, TNFa, TGFb, IL-1b, MCP-1, IL-8 and RANTES. Using these clones we have developed Northern blot techniques for assessment ofmRNA production in guinea pig cells. We are subcloning these genes into expression vectors to produce recombinant proteins with biological activity. Eventually, neutralizing antibodies will be developed and ELISA assays will be designed. We can isolate macrophages and lymphocytes from inflammatory exudates in the airways by bronchoalveolar lavage, and from experimentally-induced pleural effusions. These techniques will allow us to elucidate the precise contribution of these chemokines and cytokines to theaccumulation and activation of protective immune cell infiltrates at isolated anatomical sites of disease in this excellent model of pulmonary tuberculosis.

Industrial Relevance

We are currently collaborating extensively with both large pharma and small biotech companies in the testing of candidate tuberculosis vaccines, new anti-mycobacterial drugs, and novel skin test reagents. The guinea pig model of low-dose, pulmonary tuberculosis is an ideal system in which to test these promising new biologicals.

Keywords

COS Keywords:

Immune System, Immune System Disorders, Immunology, Immunosuppression, Infectious Diseases Or Agents, Nutrition Or Dietetics, Vaccine.

Languages

(Reading, Writing, Speaking)

Spanish: (Functional, Functional, Fluent)
Swahili: (Basic, Basic, Functional)

Memberships

American Academy of Microbiology
American Association of Immunologists
American Society for Nutritional Sciences
International Union Against Tuberculosis and Lung Disease
Society for International Nutrition Research

Previous Positions

1993-1996, Chair, Texas A&M University, Interdisciplinary Faculty of Nutrition
1992-1998, Vice-Head, Texas A&M University, College of Medicine, Medical Microbiology & Immunology
1990-1992, Interim Head, Texas A&M University, College of Medicine, Medical Microbiology & Immunology
1982-1991, Associate Professor, Texas A&M University, College of Medicine, Medical Microbiology & Immunology
1976-1982, Assistant Professor, Texas A&M University, College of Medicine, Medical Microbiology & Immunology
1974-1976, Research Associate, Tulane University, International Center of Medical Research
1972-1974, IRAP Post-Doctoral Fellow, Tulane University, International Center of Medical Research
1965-1967, United States Peace Corps, Kenya

Funding Received

  • National Institutes of Health (NIH): Suppression of T-cell activation by dietary fatty acids, $566,320, Mar 1, 1999 to Feb 28, 2003.
  • National Institutes of Health (NIH): A resource for tuberculosis vaccine testing, $220,000, Mar 1, 1994 to Feb 28, 1997.
  • National Institutes of Health (NIH): Dietary deficiencies and tuberculosis vaccine efficacy, $399,556, Mar 1, 1991 to Feb 28, 1994.
  • National Institutes of Health (NIH): Protein and zinc deficiency and vaccine efficacy, $312,373, Mar 1, 1987 to Feb 28, 1991.
  • National Institutes of Health (NIH): Rabbit model for testing candidate tuberculosis vaccines, $188,000, Jun 1, 1994 to May 31, 1997.
  • National Institutes of Health (NIH): TB research materials and vaccine testing contract, $772,198, Jul 1, 1997 to Jun 30, 2004.
  • National Institutes of Health (NIH): Dietary deficiencies and tuberculosis vaccine efficacy, $1,030,732, Feb 1, 2000 to Jan 31, 2005.
  • National Institutes of Health (NIH): Immunoregulatory T cells in pulmonary tuberculosis, $254,588, Feb 1, 1990 to Jan 31, 1994.
  • National Institutes of Health (NIH): Dietary deficiencies and tuberculosis vaccine efficacy, $705,073, Dec 1, 1994 to Nov 30, 1999.
  • Delayed Responses to Infant Diets, USDA, September 1979-December 1982, $175, 000
  • Protein and Zinc Deficiency and Vaccine, NIH/NIAID, September 1979-November 1985, $402, 224
  • Influence of Protein and Zinc Deficiency on Respiratory Tuberculosis, American Lung Association, July 1978-June 1980, $28, 618

Publications

  • McMurray DN, Recent advances in improved tuberculosis vaccines, Indian Journal of Pediatrics, 67, S58-S62, 2000
  • Turner OC, Roberts AD, Frank AA, Phalen SW, McMurray DN, Content J, Denis O, D'Souza S, Tanghe A, Huygen K, Orme IM, Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed agains the hsp60 molecule of Mycobacterium tuberculosis, Infection and Immunity, 68, 3674-3679, 2000
  • Yamamoto T, Phalen S, Uchida K, Umemori K, Nojima Y, Horiuchi Y, Goto Y, McMurray DN, Yamamoto S, Protective efficacy of BCG Tokyo 172 in the guinea pig model of pulmonary tuberculosis, Kekkaku, 75, 379-388, 2000
  • Stover CK, Warrener P, VanDevanter DR, Sherman DR, Arain TM, Langhorne MH, Andersen SW, Towell JA, Yuan Y, McMurray DN, Kreiswirth BN, Barry CE, Baker WR, A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis, Nature, 405, 962-966, 2000
  • McMurray DN, A non-human primate model for preclinical testing of new tuberculosis vaccines, Clinical Infectious Diseases, 30, S210-S212, 2000
  • McMurray DN, Jolly CA, Chapkin RS, Effects of dietary n-3 fatty acids on T cell activation and T cell receptor(TcR)-mediated signal transduction, Journal of Infectious Diseases, 182, S103-S107, 2000
  • Jackson M, Phalen S, Legranderie M, Ensergueix D, Chavarot P, Marchal G, McMurray DN, Gicquel B, Guilhot C, Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine, Infection and Immunity, 67, 2867-2873, 1999
  • Teitelbaum R, Schubert W, Gunther L, Kress Y, Macaluso F, Pollard JW, McMurray DN, Bloom BR, The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis, Immunity, 10, 641-650, 1999
  • Dai G, McMurray DN, The effect of modulating TGF-beta1 on immune responses to mycbacterial infection in protein-deficient guinea pigs, Tubercle Lung Dis, 79, 207-214, 1999
  • McMurray DN, Dai G, Phalen SW, Mechanisms of vaccine-induced resistance in a guinea pig model of pulmonary tuberculosis, Tubercle Lung Dis, 79, 261-266, 1999
  • Cooke MM, Buddle BM, Aldwell FE, McMurray DN, Alley MR, The pathogenesis of experimental endo-brachial Mycobacterium bovis infection in brushtail possums (Trichosurus vulpecula), N Z Vet J, 47, 187-192, 1999
  • Cook MM, Buddle BM, Aldwell FE, McMurray DN, Alley MR, Pathogenesis of experimental endobronchial Mycobacterium bovis infection in brushtail possums (trichosurus vulpecula), New Zealand Vet Journal, 47, 187-192, 1999
  • McMurray DN, Dai G, Phalen S, Mechanisms of vaccine-induced resistance in a guinea pig model of pulmonary tuberculosis., Tubercle and Lung Disease, 79(4), 261-6, 1999 Abstract
  • Jolly CA, McMurray DN, Chapkin RS, Effect of dietary n-3 fatty acids on interleukin-2, interleukin-2 receptor alpha, and protein kinase isozyme expression in activated murine lymphocytes, Prostaglandins Leukotrienes and Essential Fatty Acids, 58, 289-293, 1998
  • Mainali ES, McMurray DN, Protein deficiency induces alterations in the distribution of T cell subsets in experimental pulmonary tuberculosis, Infection and Immunity, 66, 927-931, 1998
  • Mainali ES, McMurray DN, Adoptive transfer of resistance to pulmonary tuberculosis in guinea pigs is altered by protein deficiency, Nutrition Research, 18, 309-317, 1998
  • McMurray DN, Impact of nutritional deficiencies on resistance to experimental pulmonary tuberculosis, Nutrition Reviews, 56, S147-S152, 1998
  • Bartow RA, McMurray DN, Cellular and humoral immune responses to mycobacterial stress proteins in experimental pulmonary tuberculosis, Tubercle Lung Dis, 78, 185-193, 1998
  • Baldwin SL, D'Souza C, Roberts AD, Kelly BP, Frank AA, Lui MA, UlmerJB, Huygen K, McMurray DN, Orme IM, Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis, Infection and Immunity, 66, 2951-2959, 1998
  • Bartow RA, McMurray DN, Lymphocytes expressing Fcgamma receptors suppress antigen-induced proliferation in cells from guinea pigs infected with virulent Mycobacterium tuberculosis, Cell Immunology, 184, 51-57, 1998
  • Dai G, Phalen SW, McMurray DN, Nutritional modulation of host responses to mycobacteria, Frontiers in Bioscience, July, 110-122, 1998
  • Dai G, McMurray DN, Altered cytokine production and impaired antimycobacterial immunity in protein malnourished guinea pigs, Infection and Immunity, 66, 3562-3568, 1998
  • Converse PJ, Dannenberg AM, Shigenaga T, McMurray DN, Phalen SW, et al, Pulmonary bovine-type tuberculosis in rabbits: bacillary virulence, inhaled dose effects, tuberculin hypersensitivity, and Mycobacterium vaccae immunotherapy, Clinical and Diagnostic Laboratory Immunology, 5, 871-881, 1998
  • Zhang X, McMurray DN, Suppression of lymphoproliferation by alveolar macrophages in the guinea pig, Tubercle Lung Dis, 79, 119-126, 1998
  • McMurray DN, Nutritional determinants of resistance to tuberculosis, Journal of Nutritional Immunology, 5, 3-10, 1997
  • Jolly CA, Jiang YH, Chapkin RS, McMurray DN, Dietary n-3 polyunsaturated fatty acid modulation of murine lymphoproliferation and interleukin-2 secretion: correation with alterations in diacylglycerol and ceramide mass, Journal of Nutrition, 127, 37-43, 1997
  • Champney TH, Prado J, Youngblood T, Appel K, McMurray DN, Immune responsiveness of splenocytes after chronic daily melatonin administration in male Syrian hamsters, Immunology Letters, 58(2), 95-100, 1997
  • Jolly C, Laurenz JC, McMurray DN, Chapkin RS, Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes, Immunology Letters, 49, 43-48, 1996
  • Kubena KS, McMurray DN, Nutrition and the immune system: a review of nutrient-nutrient interactions, Journal of the American Dietetics Association, 96, 1156-1164, 1996
  • Johnson BJ, McMurray DN, Cytokine gene expression of cultures of human lymphocytes with autologous Mycobacterium tuberculosis-infected monocytes, Infection and Immunity, 62, 1444-1450, 1994
  • McMurray DN, Mainali ES, Phalen S, Malnutrition, immunoregulatory defects, and the White Plague, Adv. Biosci., 86, 19-28, 1993
  • Phalen SW, McMurray DN, T lymphocyte response in a guinea pig model of tuberculous pleuritis, Infection and Immunity, 61, 142-145, 1993
  • Fowler KH, Chapkin RS, McMurray DN, Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function, Journal of Immunology, 151, 5186-5197, 1993
  • Hernandez-Frontera E, McMurray DN, Dietary vitamin D affects cell-mediated hypersensitivity but not resistance to experimental pulmonary tuberculosis in guinea pigs, Infection and Immunity, 61, 2116-2121, 1993
  • Fowler KH, McMurray DN, Fan YY, Aukema HM, Chapkin RS, Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in Concanavalin A-stimulated murine splenocytes, Biochemica et Biophysica Acta, 1210, 89-96, 1993
  • McMurray DN, Bartow RA, Immunosuppression and alteration of resistance to pulmonary tuberculosis in guinea pigs by protein undernutrition, Journal of Nutrition, 122, 738-743, 1992
  • McMurray DN, Bartow RA, Mintzer CL, Hernandez-Frontera E, Micronutrient status and immune function in tuberculosis, Annals of the New York Academy of Sciences, 587, 59-69, 1990
  • McMurray DN, Bartow RA, Mintzer CL, Protein malnutrition alters the distribution of FcgammaR+ and FcmuR+ T lymphocytes in experimental pulmonary tuberculosis, Infection and Immunity, 58, 563-565, 1990
  • Tetzlaff CL, McMurray DN, Rice-Ficht AC, Isolation and characterization of a gene associated with a virulent strain of Babesia microti, Molecular and Biochemical Parasitology, 40, 183-192, 1990
  • Bartow RA, McMurray DN, Erythrocyte receptor (CD2)-bearing T lymphocytes are affected by diet in experimental pulmonary tuberculosis, Infection and Immunity, 58, 1843-1847, 1990
  • Bartow RA, McMurray DN, Vaccination with Mycobacterium bovis BCG affects the distribution of Fc receptor-bearing T lymphocytes in experimental pulmonary tuberculosis, Infection and Immunity, 57, 1374-1379, 1989
  • McMurray DN, Mintzer CL, Bartow RA, Parr RL, Dietary protein deficiency and Mycobacterium bovis BCG affect interleukin-2 activity in experimental pulmonary tuberculosis, Infection and Immunity, 57, 2606-2611, 1989
  • Cohen MK, Bartow RA, and Mintzer CL, McMurray DN, Effects of diet and genetics on Mycobacterium bovis BCG vaccine efficacy in inbred guinea pigs, Infection and Immunity, 55, 314-319, 1987

Profile Details

Last Updated: 2/26/2001

COS Expertise ID #235750
Reference this profile directly: http://myprofile.cos.com/mcmurrad50