Dr. Michael Lawrence Cunningham

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Children's Hospital and Regional Medical Center
Children's Craniofacial Center
Pediatrics
Medical Director
University of Washington
Craniofacial Medicine
Jean Renny Endowed Chair
University of Washington
School of Medicine
Pediatrics
Craniofacial Medicine
Associate Professor
University of Washington
School of Dentistry
Oral Biology
Adjunct Associate Professor
University of Washington
School of Medicine
Biological Structure
Adjunct Associate Professor
University of Washington
School of Dentistry
Pediatric Dentistry
Adjunct Associate Professor
Professional Headshot of Michael Lawrence Cunningham

Mailing Address

University of Washington
HSB RR537A
Box 356320
1959 N.E. Pacific Street
Seattle, Washington 98195-6320
United States

Contact Information

Phone: (206) 987-2528
Fax: (206) 987-3824
mcunning@u.washington.edu

Qualifications

Ph.D., University of Washington, Biological Structure, 1996.
Residency, University of Washington, Pediatrics, 1991.
M.D., University of Vermont, Medicine, 1988.
B.A., University of Vermont, Biology, 1983.

Expertise and Research Interests

Michael L. Cunningham, MD, PhD, is chief of the Division of Craniofacial Medicine at Seattle Children's Hospital and associate professor of pediatrics at the University of Washington School of Medicine. He is medical director of Seattle Children's Craniofacial Center and the Jean Renny Endowed Chair in Craniofacial Medicine. He is also adjunct associate professor at the university School of Medicine and School of Dentistry. Dr. Cunningham balances responsibilities in administration, patient care and research. He does bedside teaching of medical students, dental students and pediatric residents. His clinical interests focus on the diagnosis and long-term interdisciplinary care of children with craniofacial malformations with a particular interest in the craniosynostoses. He is co-investigator on several clinical research projects, ranging from the epidemiology of positional plagiocephaly to the risk factors for obstructive sleep apnea. Dr. Cunningham's basic molecular and developmental biology lab has been open since 1993 and is using mouse and tissue culture models to investigate the molecular causes of craniosynostosis and developmental pathogenesis of midface hypoplasia associated with syndromic craniosynostosis.

Other Expertise

Board Certified, Pediatrics




Keywords

COS Keywords:

Birth or Congenital Defects, Craniofacial Disorders, Developmental Biology, Embryology, Gene Mapping, Gene Products, Genes, Genetic Diseases, Genetics, Growth Factor Receptors, Growth Factors, Human Development, Molecular Biology, Molecular Genetics, Orphan Rare Diseases, Pediatrics, Receptors, Teratology.

Additional Terms:

Birth Defects, Craniofacial Development, Craniofacial Malformations, Craniosynostosis, Developmental Biology, Embryology, Genetics, Osteoblast Biology.

Memberships

American Academy of Pediatrics
American Cleft Palate-Craniofacial Association
American Pediatric Society
Society for Pediatric Research
Teratology Society

Honors and Awards

2001, The Clarke Fraser New Investigator Award, Teratology Society, Human Malformation
1994-1996, Child Heath Research Center Award, Department of Pediatrics, University of Washington, Embryology
1993, The James G. Wilson Award for Excellence in Teratology Research, Teratology Society, Embryology
1993-1998, Physician Scientist Research Award, National Institutes of Health, University of Washington, Embryology
1983, Phi Beta Kappa Honor Society,

Funding Received

  • National Institutes of Health (NIH): Craniofacial Microsomia and Genetic Variation in Hemostasis and Vasculogenesis, 2007 to 2010.
  • National Institutes of Health (NIH): Craniofacial Microsomia: The Vascular Disruption Hypothesis, 2006 to 2008.
  • National Institutes of Health (NIH): Neurodevelopment among Infants with Deformational Plagiocephaly, 2005 to 2010.
  • National Institutes of Health (NIH): Dental and Orthodontic Access in Craniofacial Care, 2002 to 2004.
  • National Institutes of Health (NIH): Quality of Life in Youth with Craniofacial Anomalies: Phase II, 2002 to 2005.
  • National Institutes of Health (NIH): Neurobehavioral Correlates of Craniosynostosis, 2001 to 2008.
  • March of Dimes: Inhibition of Apoptosis: The Biologic Mechanism of Craniosynostosis, 2000 to 2003.
  • National Institutes of Health (NIH): Genetic Mapping of a Syndrome with Hearing Loss, 2000 to 2005.
  • National Institutes of Health (NIH), P60 Subproject-Comprehensive Oral Health Research Center (COHRC): Craniosynostosis and Suture Biology: A Chimeric Approach, 1999 to 2004.
  • National Institutes of Health (NIH): Outcomes Following Prenatal Exposure to Antidepressants, 1998 to 2000.
  • March of Dimes: Positional Cloning of Dac: The Mouse Model of Human SHFM3, 1998 to 2000.
  • National Institutes of Health (NIH), K08: Embryonic Phagocytosis in Mouse Morphogenesis, 1993 to 1998.

Publications

  • Speltz ML, Kapp-Simon K, Collett B, Keich Y, Gaither R, Cradock MM, Buono L, Cunningham ML (May 2007) Neurodevelopment of infants with single-suture craniosynostosis: presurgery comparisons with case-matched controls, Plastic Reconstructive Surgery, 119 (6), 1874-1881
  • Cunningham ML, Seto ML, Ratisoontorn C, Heike CL, Hing AV (May 2007) Syndromic craniosynostosis: from history to hydrogen bonds, Orthodontics and Craniofacial Research, 10, 67-81
  • Seto ML, Hing AV, Chang J, Hu M, Kapp-Simon KA, Patel PK, Burton BK, Kane A, Smyth MD, Hopper R, Ellenbogen RG, Stevenson K, Speltz ML, Cunningham ML (April 2007) Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations, American Journal of Medical Genetics Part A, 143, 678-686
  • Kapp-Simon KA, Speltz ML, Cunningham ML, Patel PK, Tomita T (March 2007) Neurodevelopment of children with single suture craniosynostosis: a review, Child's Nervous System, 23 (3), 269-281
  • Cunningham, ML (December 2006) Three-dimensional ultrasonography is superior to 2-dimensional ultrasonography in the detection of orofacial clefts during the second trimester of pregnancy, Journal of Evidence Based Dental Practice, 6 (4), 278-279
  • Hatch NE, Hudson M, Seto ML, Cunningham ML, Bothwell M (September 2006) Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F, Journal of Biological Chemistry, 281 (37), 27292-27305
  • Ruiz-Correa S, Sze RW, Starr JR, Lin HT, Speltz ML, Cunningham ML, Hing AV (March 2006) New scaphocephaly severity indices of sagittal craniosynostosis: a comparative study with cranial index quantifications, Cleft Palate Craniofacial Journal, 43 (2), 211-221
  • Cunningham ML, Seto ML, Hing AV, Bull MJ, Hopkin RJ, Leppig KA (February 2006) Cleidocranial dysplasia with severe parietal bone dysplasia: C-terminal RUNX2 mutations, Birth Defects Research Part A: Clinical and Molecular Teratology, 76 (2), 78-85
  • Tempero RM, Hannibal M, Finn LS, Manning SC, Cunningham ML, Perkins JA (January 2006) Lymphocytopenia in children with lymphatic malformation, Archives of Otolaryngology : Head and Neck Surgery, 132 (1), 93-97
  • Ruiz-Correa S, Shapiro LG, Meila M, Berson G, Cunningham ML, Sze RW (January 2006) Symbolic signatures for deformable shapes, IEEE Transactions on Pattern Analysis and Machine Intelligence, 28 (1), 75-90
  • Heike CL, Cunningham ML, Steiner RD, Wenkert D, Hornung RL, Gruss JS, Gannon FH, McAlister WH, Mumm S, Whyte MP (December 2005) Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis?, American Journal of Medical Genetics Part A, 139 (2), 67-77
  • Pollack PS, Shields KE, Burnett DM, Osborne MJ, Cunningham ML, Stepanavage ME (November 2005) Pregnancy outcomes after maternal exposure to simvastatin and lovastatin, Birth Defects Research Part A: Clinical and Molecular Teratology, 73 (11), 888-896
  • Sze RW, Hopper RA, Ghioni V, Gruss JS, Ellenbogen RG, King D, Hing AV, Cunningham ML (November 2005) MDCT diagnosis of the child with posterior plagiocephaly, American Journal of Roentgenology, 185 (5), 1342-1346
  • Lin HJ, Ruiz-Correa S, Sze RW, Cunningham ML, Speltz ML, Hing AV, Shapiro LG (October 2005) Efficient symbolic signatures for classifying craniosynostosis skull deformities, Computer Science, 3765, 302-313
  • Lin HJ, Ruiz-Correa S, Shapiro LG, Cunningham ML, Sze RW (October 2005) A symbolic shaped-based retrieval of skull images, AMIA Annual Symposium Proceedings, 1030
  • Collett B, Breiger D, King D, Cunningham M, Speltz M (Oct 2005) Neurodevelopmental implications of "deformational" plagiocephaly, Journal of Developmental and Behavioral Pediatrics, 26 (5), 379-89
  • Kapp-Simon KA, Leroux B, Cunningham M, Speltz ML (Jul 2005) Multisite study of infants with single-suture craniosynostosis: preliminary report of presurgery development, The Cleft Palate-Craniofacial Journal, 42 (4), 377-84
  • Collett B, Breiger D, King D, Cunningham ML, Speltz ML (May 2005) Neurodevelopmental implications of "deformational" plagiocephaly, Journal of Developmental and Behavioral Pediatrics, 26 (5), 379-389
  • Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM (April 2005) Surgical site infections following pediatric intracranial surgery for craniofacial malformations: frequency and risk factors, Neurosurgery, 56 (4), 733-739
  • Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM (Apr 2005) Surgical site infections after pediatric intracranial surgery for craniofacial malformations: frequency and risk factors, Neurosurgery, 56 (4), 733-9; discussion 73
  • Ratisoontorn C, Seto ML, Broughton KM, Cunningham ML (Apr 2005) In vitro differentiation profile of osteoblasts derived from patients with Saethre-Chotzen syndrome, Bone, 36 (4), 627-34
  • Speltz ML, Kapp-Simon KA, Cunningham ML, Marsh J, Dawson G (December 2004) Single-suture craniosynostosis: a review of neurobehavioral research and theory, Journal of Pediatric Psychology, 29 (8), 651-68
  • Hing AV, Syed N, Cunningham ML (August 2004) Familial acromelic frontonasal dysostosis: autosomal dominant inheritance with reduced penetrance, American Journal of Medical Genetics Part A, 128 (4), 374-82
  • Hu S, Michels DA, Fazal MA, Ratisoontorn C, Cunningham ML, Dovichi NJ (July 2004) Capillary sieving electrophoresis/micellar electrokinetic capillary chromatography for two-dimensional protein fingerprinting of single mammalian cells, Analytical Chemistry, 76 (14), 4044-9
  • Ngo AV, Sze RW, Parisi MT, Sidhu M, Paladin AM, Weinberger E, Seidel KD, Cunningham ML (July 2004) Cranial suture simulator for ultrasound diagnosis of craniosynostosis, Pediatric Radiology, 34 (7), 535-40
  • Connolly JP, Gruss J, Seto ML, Whelan MF, Ellenbogen R, Weiss A, Buchman SR, Cunningham ML (April 2004) Progressive postnatal craniosynostosis and increased intracranial pressure, Plastic and Reconstructive Surgery, 113 (5), 1313-23
  • Ehret FW, Whelan MF, Ellenbogen RG, Cunningham ML, Gruss JS (January 2004) Differential diagnosis of the trapezoid-shaped head, The Cleft Palate-Craniofacial Journal, 41 (1), 13-9
  • Cai J, Goodman BK, Patel AS, Mulliken JB, Van Maldergem L, Hoganson GE, Paznekas WA, Ben-Neriah Z, Sheffer R, Cunningham ML, Daentl DL, Jabs EW (December 2003) Increased risk for developmental delay in Saethre-Chotzen syndrome is associated with TWIST deletions: an improved strategy for TWIST mutation screening, Human Genetics, 114 (1), 68-76
  • Sze RW, Parisi MT, Sidhu M, Paladin AM, Ngo AV, Seidel KD, Weinberger E, Ellenbogen RG, Gruss JS, Cunningham ML (September 2003) Ultrasound screening of the lambdoid suture in the child with posterior plagiocephaly, Pediatric Radiology, 33 (9), 630-6
  • Cunningham ML, Perry RJ, Eby PR, Gibson RL, Opheim KE, Manning SC (August 2003) Primary pulmonary dysgenesis in velocardiofacial syndrome: a second patient, American Journal of Medical Genetics, 121A (2), 177-9
  • Jaeger A, Kapur R, Whelan M, Leung E, Cunningham ML (June 2003) Cleft-palate lateral synechia syndrome: insight into the phenotypic spectrum of Fryns syndrome?, Birth Defects Research Part A: Clinical and Molecular Teratology, 67 (6), 460-6
  • Simon GE, Cunningham ML, Davis RL (December 2002) Outcomes of prenatal antidepressant exposure, The American Journal of Psychiatry, 159 (12), 2055-61
  • Conway K, Gibson R, Perkins J, Cunningham ML (November 2002) Pulmonary agenesis: expansion of the VCFS phenotype, American Journal of Medical Genetics, 113 (1), 89-92
  • Bonadio J, Cunningham ML (June 2002) Genetic approaches to craniofacial tissue repair, Annals of the New York Academy of Sciences, 961, 48-57
  • Sze RW, Paladin AM, Lee S, Cunningham ML (June 2002) Hemifacial microsomia in pediatric patients: asymmetric abnormal development of the first and second branchial arches, American Journal of Roentgenology, 178 (6), 1523-30
  • Lee S, Seto ML, Sie KC, Cunningham ML (January 2002) A child with Saethre-Chotzen syndrome, sensorineural hearing loss, and a TWIST mutation, The Cleft Palate-Craniofacial Journal, 39 (1), 110-4
  • Seto ML, Lee SJ, Sze RW, Cunningham ML (December 2001) Another TWIST on Baller-Gerold syndrome, American Journal of Medical Genetics, 104 (4), 323-30
  • Lee S, Sze RW, Murakami C, Gruss JS, Cunningham ML (November 2001) Hemifacial myohyperplasia: description of a new syndrome, American Journal of Medical Genetics, 103 (4), 326-33
  • Koo SH, Cunningham ML, Arabshahi B, Gruss JS, Grant JH (September 2001) The transforming growth factor-beta 3 knock-out mouse: an animal model for cleft palate, Plastic and Reconstructive Surgery, 108 (4), 938-48; discussion 9
  • Sze RW, Gruss JS, Cunningham ML (August 2001) Unilateral aplasia of the middle cranial fossa floor in atypical hemifacial microsomia, Ajnr. American Journal of Neuroradiology, 22 (7), 1434-7
  • Heike C, Seto M, Hing AV, Palidin A, Hu FZ, Preston RA, Ehrlich GD, Cunningham ML (May 2001) Century of Jackson-Weiss syndrome: further definition of clinical and radiographic findings in 'lost' descendants of the original kindred, American Journal of Medical Genetics, 100 (4), 315-24
  • Nurnberg P, Thiele H, Chandler D, Hohne W, Cunningham ML, Ritter H, Leschik G, Uhlmann K, Mischung C, Harrop K, Goldblatt J, Borochowitz ZU, Kotzot D, Westermann F, Mundlos S, Braun HS, Laing N, Tinschert S (May 2001) Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia, Nature Genetics, 28 (1), 37-41
  • Williams G, King J, Cunningham ML, Stephan M, Kerr B, Hersh JH (March 2001) Fetal valproate syndrome and autism: additional evidence of an association, Developmental Medicine and Child Neurology, 43 (3), 202-6
  • Dry GM, Yasinskaya YI, Williams JK, Ehrlich GD, Preston RA, Hu FZ, Gruss JS, Ellenbogen RG, Cunningham ML (February 2001) Inhibition of apoptosis: a potential mechanism for syndromic craniosynostosis, Plastic and Reconstructive Surgery, 107 (2), 425-32
  • Erlich MS, Cunningham ML, Hudgins L (27 November 2000) Transmission of the dysgnathia complex from mother to daughter, American Journal of Medical Genetics, 95 (3), 269-74
  • Ponzio GM, Cunningham ML (May 2000) Clavicular hypoplasia, zygomatic arch hypoplasia, and micrognathia: a newly defined syndrome, American Journal of Medical Genetics, 92 (3), 200-5
  • Ellenbogen RG, Gruss JS, Cunningham ML (January 2000) Update on craniofacial surgery: the differential diagnosis of lambdoid synostosis/posterior plagiocephaly, Clinical Neurosurgery, 47, 303-18
  • Biesecker LG, Peters KF, Darling TN, Choyke P, Hill S, Schimke N, Cunningham ML, Meltzer P, Cohen MM (October 1998) Clinical differentiation between Proteus syndrome and hemihyperplasia: description of a distinct form of hemihyperplasia, American Journal of Medical Genetics, 79 (4), 311-8
  • Paznekas WA, Cunningham ML, Howard TD, Korf BR, Lipson MH, Grix AW, Feingold M, Goldberg R, Borochowitz Z, Aleck K, Mulliken J, Yin M, Jabs EW (June 1998) Genetic heterogeneity of Saethre-Chotzen syndrome, due to TWIST and FGFR mutations, American Journal of Human Genetics, 62 (6), 1370-80
  • Nagahama SI, Cunningham ML, Lee MY, Byers MR (January 1998) Normal development of dental innervation and nerve/tissue interactions in the colony-stimulating factor-1 deficient osteopetrotic mouse, Developmental Dynamics, 211 (1), 52-9
  • Vargas FR, Roessler E, Gaudenz K, Belloni E, Whitehead AS, Kirke PN, Mills JL, Hooper G, Stevenson RE, Cordeiro I, Correia P, Felix T, Gereige R, Cunningham ML, Canun S, Antonarakis SE, Strachan T, Tsui LC, Scherer SW, Muenke M (January 1998) Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly, Human Genetics, 102 (4), 387-92
  • Cunningham ML, Jerome JT (November 1997) Linear growth characteristics of children with cleft lip and palate, Journal of Pediatrics, 131 (5), 707-11
  • Seto ML, Nunes ME, MacArthur CA, Cunningham ML (October 1997) Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant cell death of the apical ectodermal ridge., Teratology, 56 (4), 262-70
  • Mirkes PE, Cornel LM, Park HW, Cunningham ML (September 1997) Induction of thermotolerance in early postimplantation rat embryos is associated with increased resistance to hyperthermia-induced apoptosis, Teratology, 56 (3), 210-9
  • Cunningham ML, Mann N (June 1997) Pulmonary agenesis: a predictor of ipsilateral malformations, American Journal of Medical Genetics, 70 (4), 391-8
  • Blunt AG, Lawshe A, Cunningham ML, Seto ML, Ornitz DM, MacArthur CA (February 1997) Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands, Journal of Biological Chemistry, 272 (6), 3733-8
  • Grant JH, Maggio-Price L, Reutebuch J, Cunningham ML (Winter 1997) Retinoic acid exposure of the mouse on embryonic day 9 selectively spares derivatives of the frontonasal neural crest, Journal of Craniofacial Genetics and Developmental Biology, 17 (1), 1-8
  • Huang MH, Gruss JS, Clarren SK, Mouradian WE, Cunningham ML, Roberts TS, Loeser JD, Cornell CJ (October 1996) The differential diagnosis of posterior plagiocephaly: true lambdoid synostosis versus positional molding, Plastic and Reconstructive Surgery, 98 (5), 765-74
  • Ellegala DB, Tassone JC, Avellino AM, Pekow CA, Cunningham ML, Kliot M (February 1996) Dorsal laminectomy in the adult mouse: a model for nervous system research, Laboratory Animal Science, 46 (1), 86-9
  • Cunningham ML, Mac Auley A, Mirkes PE (July 1994) From gastrulation to neurulation: transition in retinoic acid sensitivity identifies distinct stages of neural patterning in the rat, Developmental Dynamics, 200 (3), 227-41

Profile Details

Last Updated: 7/27/2007

COS Expertise ID #533151
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