Prof. Marc D. Binder

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University of Washington
School of Medicine
Physiology and Biophysics
ProfessorAppointed: 1978

Mailing Address

Department of Physiology and Biophysics
University of Washington
School of Medicine
Box 357290
Seattle, Washington 98195-7290
United States

Contact Information

Phone: (206) 543-2509
Fax: (206) 685-0619
mdbinder@u.washington.edu
http://depts.washington.edu/pbiopage/faculty/binder.html

Expertise and Research Interests

Neurophysiology

Keywords

COS Keywords:

Brain, Central Nervous System, Nervous System, Neurobiology, Neurophysiology, Neuroscience.

Additional Terms:

Brain, Central Nervous System, Motor, Muscle Physiology, Nervous System, Neurobiology, Peripheral Nervous System.

Memberships

American Association for the Advancement of Science
American Physiological Society
International Brain Research Organization
Sigma Xi, The Scientific Research Society
Society for Neuroscience

Honors and Awards

Jacob K. Javits Neuroscience Investigator Award, National Institutes of Health

Previous Positions

1982-1983, Visiting Associate Professor, Harvard University
1981-1986, Associate Professor, University of Washington
1978-1981, Assistant Professor, University of Washington
1978-1981, Visiting Assistant Professor, University of Arizona
1975, University of California, Davis, Instructor

Funding Received

  • National Institutes of Health (NIH): Effective Synaptic Currents in Motoneurons, Jul 1988 to Jun 2005.
  • National Science Foundation (NSF): Nonlinear Systems Analysis of Spike Encoding in Motoneurons, Aug 2000 to Jun 2003.
  • National Institutes of Health (NIH): Input-Output Behavior of Real and Model Motoneurons, Aug 1994 to Jun 2004.
  • National Institutes of Health (NIH): Institutional Grant for Neurobiology, 2005 to 2010.
  • National Institutes of Health (NIH): Course Development in the Neurobiology of Disease, 2005 to 2007.

Publications

  • Moritz AT, Newkirk G, Powers RK, Binder MD (Aug 2007) Facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons., Journal of neurophysiology, 98 (2), 1042-7 Abstract
  • RK Powers, A Fairhall, MD Binder (2005) The effects of spike activity on measures of neural coding, Physiology News, 61
  • Zeng J, Powers RK, Newkirk G, Yonkers M, Binder MD, Contribution of Persistent Sodium Currents to Spike-frequency Adaptation in Rat Hypoglossal Motoneurons., Journal of Neurophysiology, 93(2), 1035-41, Feb 2005 Abstract
  • Powers RK, Dai Y, Bell BM, Percival DB, Binder MD, Contributions of the Input Signal and Prior Activation History to The Discharge Behaviour of Rat Motoneurones., The Journal of Physiology, 562(Pt 3), 707-24, Feb 2005 Abstract
  • Binder MD, Intrinsic dendritic currents make a major contribution to the control of motoneurone discharge, Journal of Physiology, 552(Pt 3), 665, November 2003 Abstract
  • Powers RK, Binder MD, Persistent sodium and calcium currents in rat hypoglossal motoneurons, Journal of Neurophysiology, 89(1), 615-24, January 2003 Abstract
  • Binder MD, Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons, Brain Research. Brain Research Reviews, 40(1-3), 1-8, October 2002 Abstract
  • Binder MD, Experiments and evidence, Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons., 60(6), 723, June 2002 Abstract
  • Powers RK, Turker KS, Binder MD, What can be learned about motoneurone properties from studying firing patterns?, Advances in Experimental Medicine and Biology, 508, 199-205, 2002 Abstract
  • Binder MD, Heckman CJ, Powers RK, Relative strengths and distributions of different sources of synaptic input to the motoneurone pool: implications for motor unit recruitment, Advances in Experimental Medicine and Biology, 508, 207-12, 2002 Abstract
  • Powers RK, Binder MD, Input-output functions of mammalian motoneurons, Reviews of Physiology Biochemistry and Pharmacology, 143, 137-263, 2001 Abstract
  • Powers RK, Binder MD, Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons, Journal of Neurophysiology, 83(1), 483-500, Jan 2000 Abstract
  • Binder, MD, Comparison of effective synaptic currents generated in spinal motoneurons by activating different input systems, Biomechanics and Neural Control of Posture and Movement, 74-81, 2000
  • Powers, RK, Binder MD, Relationship between the time course of the afterhyperpolarization and discharge variability in cat spinal motoneurones, Journal of Physiology (London), 528(1), 131-150, 2000
  • Powers RK, Sawczuk A, Musick JR, Binder MD, Multiple mechanisms of spike-frequency adaptation in motoneurones., Journal of Physiology (Paris), 93(1-2), 101-14, Jan 1999 Abstract
  • Binder MD, Poliakov AV, Powers RK, Functional identification of the input-output transforms of mammalian motoneurones., Journal of Physiology (Paris), 93(1-2), 29-42, Jan 1999 Abstract
  • Binder MD, Powers RK, Synaptic integration in spinal motoneurones., Journal of Physiology (Paris), 93(1-2), 71-9, Jan 1999 Abstract
  • Powers RK, Binder MD, Models of spike encoding and their use in the interpretation of motor unit recordings in man, Progress in Brain Research, 123, 83-98, 1999 Abstract
  • Binder, MD, Peripheral and Spinal Mechanisms in the Neural Control of Movement, Progress in Brain Research, 123, 482, 1999
  • Powers RK, Binder MD, Models of spike encoding and their use in the interpretation of motor unit recordings in man., Prog Brain Res, 123, 83-98, 1999 Abstract
  • Binder M D, Robinson F R, Powers R K, Distribution of effective synaptic currents in cat triceps surae motoneurons. VI. Contralateral pyramidal tract., Journal of Neurophysiology, 80(1), 241-8, July 1998 Abstract
  • Sawczuk A, Powers R K, Binder M D, Contribution of outward currents to spike-frequency adaptation in hypoglossal motoneurons of the rat., Journal of Neurophysiology, 78(5), 2246-53, November 1997 Abstract
  • Poliakov A V, Powers R K, Binder M D, Functional identification of the input-output transforms of motoneurones in the rat and cat., Journal of Physiology, 504 ( Pt 2), 401-24, 15 Oct 1997 Abstract
  • Poliakov AV, Powers RK, Binder MD, Functional identification of the input-output transforms of motoneurones in the rat and cat., Journal of Physiology (London), 504 \( Pt 2\), 401-24, 15 Oct 1997 Abstract
  • Poliakov A V, Powers R K, Sawczuk A, Binder M D, Effects of background noise on the response of rat and cat motoneurones to excitatory current transients., Journal of Physiology, 495 ( Pt 1), 143-57, 15 Aug 1996 Abstract
  • Powers R K, Binder M D, Experimental evaluation of input-output models of motoneuron discharge., Journal of Neurophysiology, 75(1), 367-79, January 1996 Abstract
  • Powers R K, Binder M D, Effective synaptic current and motoneuron firing rate modulation., Journal of Neurophysiology, 74(2), 793-801, August 1995 Abstract
  • Sawczuk A, Powers R K, Binder M D, Spike frequency adaptation studied in hypoglossal motoneurons of the rat., Journal of Neurophysiology, 73(5), 1799-810, May 1995 Abstract
  • Sawczuk A, Powers R K, Binder M D, Intrinsic properties of motoneurons. Implications for muscle fatigue., Advances In Experimental Medicine and Biology, 384, 123-34, 1995 Abstract
  • Westcott S L, Powers R K, Robinson F R, Binder M D, Distribution of vestibulospinal synaptic input to cat triceps surae motoneurons., Experimental Brain Research, 107(1), 1-8, 1995 Abstract
  • Binder M D, Heckman C J, Powers R K, How different afferent inputs control motoneuron discharge and the output of the motoneuron pool., Current Opinion In Neurobiology, 3(6), 1028-34, December 1993 Abstract
  • Heckman C J, Binder M D, Computer simulations of the effects of different synaptic input systems on motor unit recruitment., Journal of Neurophysiology, 70(5), 1827-40, November 1993 Abstract
  • Powers R K, Robinson F R, Konodi M A, Binder M D, Distribution of rubrospinal synaptic input to cat triceps surae motoneurons., Journal of Neurophysiology, 70(4), 1460-8, October 1993 Abstract
  • Heckman C J, Binder M D, Computer simulations of motoneuron firing rate modulation., Journal of Neurophysiology, 69(4), 1005-8, April 1993 Abstract
  • Powers R K, Robinson F R, Konodi M A, Binder M D, Effective synaptic current can be estimated from measurements of neuronal discharge., Journal of Neurophysiology, 68(3), 964-8, September 1992 Abstract
  • Powers R K, Binder M D, Summation of motor unit tensions in the tibialis posterior muscle of the cat under isometric and nonisometric conditions., Journal of Neurophysiology, 66(6), 1838-46, December 1991 Abstract
  • Heckman C J, Binder M D, Analysis of Ia-inhibitory synaptic input to cat spinal motoneurons evoked by vibration of antagonist muscles., Journal of Neurophysiology, 66(6), 1888-93, December 1991 Abstract
  • Powers R K, Binder M D, Effects of low-frequency stimulation on the tension-frequency relations of fast-twitch motor units in the cat., Journal of Neurophysiology, 66(3), 905-18, September 1991 Abstract
  • Heckman C J, Binder M D, Computer simulation of the steady-state input-output function of the cat medial gastrocnemius motoneuron pool., Journal of Neurophysiology, 65(4), 952-67, April 1991 Abstract
  • Lindsay A D, Binder M D, Distribution of effective synaptic currents underlying recurrent inhibition in cat triceps surae motoneurons., Journal of Neurophysiology, 65(2), 168-77, February 1991 Abstract
  • Heckman CJ, Binder MD, Analysis of effective synaptic currents generated by homonymous Ia afferent fibers in motoneurons of the cat, Journal of Neurophysiology, 60(6), 1946-66, December 1988 Abstract
  • Osborn CE, Binder MD, Correlation analysis of muscle receptor discharge during active contractions of the cat medial gastrocnemius muscle, Journal of Neurophysiology, 57(2), 343-56, February 1987 Abstract
  • Lucas SM, Ruff RL, Binder MD, Specific tension measurements in single soleus and medial gastrocnemius muscle fibers of the cat, Experimental Neurology, 95(1), 142-54, January 1987 Abstract
  • Binder MD, Changing perspectives on the functional organization of the segmental motor system, Canadian Journal of Physiology and Pharmacology, 64(4), 495-8, April 1986 Abstract
  • Binder MD, Osborn CE, Interactions between motor units and Golgi tendon organs in the tibialis posterior muscle of the cat, Journal of Physiology, 364, 199-215, July 1985 Abstract
  • Powers RK, Binder MD, Determination of afferent fibers mediating oligosynaptic group I input to cat medial gastrocnemius motoneurons, Journal of Neurophysiology, 53(2), 518-29, February 1985 Abstract
  • Powers RK, Binder MD, Distribution of oligosynaptic group I input to the cat medial gastrocnemius motoneuron pool, Journal of Neurophysiology, 53(2), 497-517, February 1985 Abstract
  • Berger AJ, Cameron WE, Averill DB, Kramis RC, Binder MD, Spatial distributions of phrenic and medial gastrocnemius motoneurons in the cat spinal cord, Experimental Neurology, 86(3), 559-75, December 1984 Abstract
  • Bawa P, Binder MD, Ruenzel P, Henneman E, Recruitment order of motoneurons in stretch reflexes is highly correlated with their axonal conduction velocity, Journal of Neurophysiology, 52(3), 410-20, September 1984 Abstract
  • Lucas SM, Binder MD, Topographic factors in distribution of homonymous group Ia-afferent input to cat medial gastrocnemius motoneurons, Journal of Neurophysiology, 51(1), 50-63, January 1984 Abstract
  • Lucas SM, Cope TC, Binder MD, Analysis of individual Ia-afferent EPSPs in a homonymous motoneuron pool with respect to muscle topography, Journal of Neurophysiology, 51(1), 64-74, January 1984 Abstract
  • Fuchs AF, Binder MD, Fatigue resistance of human extraocular muscles, Journal of Neurophysiology, 49(1), 28-34, January 1983 Abstract
  • Binder MD, Houk JC, Nichols TR, Rymer WZ, Stuart DG, Properties and segmental actions of mammalian muscle receptors: an update, Federation Proceedings, 41(13), 2907-18, November 1982 Abstract
  • Cameron WE, Binder MD, Botterman BR, Reinking RM, Stuart DG, 'Sensory partitioning' of cat medial gastrocnemius muscle by its muscle spindles and tendon organs, Journal of Neurophysiology, 46(1), 32-47, July 1981 Abstract
  • Binder MD, Further evidence that the Golgi tendon organ monitors the activity of a discrete set of motor units within a muscle, Experimental Brain Research, 43(2), 186-92, 1981 Abstract
  • Binder MD, Topographic organization of monosynaptic reflexes in the cat spinal cord, Neuroscience Letters, 20(2), 121-4, November 1980 Abstract
  • McDonagh JC, Binder MD, Reinking RM, Stuart DG, A commentary on muscle unit properties in cat hindlimb muscles, Journal of Morphology, 166(2), 217-30, November 1980 Abstract
  • McDonagh JC, Binder MD, Reinking RM, Stuart DG, Tetrapartite classification of motor units of cat tibialis posterior, Journal of Neurophysiology, 44(4), 696-712, October 1980 Abstract
  • Cameron WE, Binder MD, Botterman BR, Reinking RM, Stuart DG, Motor unit--muscle spindle interactions in active muscles of decerebrate cats, Neuroscience Letters, 19(1), 55-60, August 1980 Abstract
  • Binder MD, Stuart DG, Responses of Ia and spindle group II afferents to single motor-unit contractions, Journal of Neurophysiology, 43(3), 621-9, March 1980 Abstract
  • Binder MD, Cameron WE, Stuart DG, Speed-force relations in the motor units of the cat tibialis posterior muscle, American Journal of Physical Medicine, 57(2), 57-65, April 1978 Abstract
  • Binder MD, Kroin JS, Moore GP, Stuart DG, The response of Golgi tendon organs to single motor unit contractions, Journal of Physiology, 271(2), 337-49, October 1977 Abstract
  • Binder MD, Kroin JS, Moore GP, Stauffer EK, Stuart DG, Correlation analysis of muscle spindle responses to single motor unit contractions, Journal of Physiology, 257(2), 325-36, May 1976 Abstract
  • Binder MD, Rosenberg JR, McWilliams PN, Moore GP, Correlation analysis of neuromuscular spike trains, Brain Research, 72(2), 300-4, June 1974 Abstract
  • Binder, M.D., Heckman, C.J., and Powers, R.K. The Physiological Control of Motoneuron Activity. In: Handbook of Phyiology. Section 12, Exercise: Regulation and Integration of Multiple Systems. L.B. Rowell and J.T. Sheperd (eds). American Physiological Society, New York: Oxford, pp. 3-53, 1996

Profile Details

Last Updated: 2/14/2008

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