Dr. Mohamed E. H. El-Sayed |
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University of Michigan Engineering Biomedical Engineering Assistant ProfessorAppointed: 2007 |  |
Mailing AddressUniversity of Michigan Department of Biomedical Engineering 1101 Beal Avenue Ann & Robert Lurie Biomedical Engineering Building, Room 2150 Ann Arbor, Michigan 48109-2099United States | Contact Information |
Qualifications
Postdoc Training, University of Washington, Bioengineering, Biomaterials, 2006.
Ph.D., University of Maryland at Baltimore, Pharmaceutical Sciences, 2002.
B.S., Cairo University, Pharmacy, 1994.
Expertise and Research Interests
1. Rational design and synthesis of biomaterials for drug delivery and gene therapy applications
2. Evaluation of epithelial and endothelial transport of macromolecules
3. Molecular engineering of oral "biomimetic" drug delivery systems
4. Development of "smart" polymer therapeutics
5. Applications of nanotechnology in biology and medicine
2. Evaluation of epithelial and endothelial transport of macromolecules
3. Molecular engineering of oral "biomimetic" drug delivery systems
4. Development of "smart" polymer therapeutics
5. Applications of nanotechnology in biology and medicine
Future Research
Drug delivery and cellular engineering
Keywords
COS Keywords:
Biochemical Engineering, Bioengineering, Biological Resources, Biomaterials, Biomedical Research Resources, Other, Biotechnology, Blood - Brain Barrier, Brain Tumors, Breast Cancer, Cell Lines, Colorectal Cancer, Cystic Fibrosis, Diabetes, Drug Delivery Systems, Heart Diseases, Inflammatory Bowel Disease, Leukemia, Lung Cancer, Magnetic Resonance Imaging, Methods of Drug Delivery, Opportunistic Infections, Organs, Ovarian Cancer, Pharmaceuticals, Pharmacy, Prostate Cancer, Tissue Culture, Tissue Engineering, Tuberculosis, Tumor Immunology, Tumors, Urogenital Diseases.Additional Terms:
"Smart" Polymers, Bio-Nanotechnology, Biomaterials, Biomimetic Drug Delivery Systems, Drug Delivery, Gene Therapy, Oral Absorption of Therapeutic Macromolecules.Languages
(Reading, Writing, Speaking)
Arabic: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
Memberships
Academy of Molecular Imaging
American Association for Cancer Research
American Association of Pharmaceutical Scientists
American Chemical Society
American Society for Engineering Education
Controlled Release Society
General Syndicate of Pharmacists in Egypt
Rho Chi
Society for Biomaterials
Honors and Awards
2005-2008,
The Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship,
The Susan G. Komen Breast Cancer Foundation,
University of Washington,
Breast Cancer Therapy
2005-2008,
Department of Defense Breast Cancer Research Program-Multidisciplinary Postdoctoral Award,
Department of the Army,
University of Washington,
Breast Cancer Therapy
2004-2006,
Postdoctoral Fellowship,
The National Cancer Center,
University of Washington,
'Smart' Polymeric Carriers for Enhanced Antisense Breast Cancer Therapy
2002, Travel Award,
The 4th Intensive Course and Workshop on Cell Culture and Ex-Vivo Models for Drug Absorption and Delivery, Saarbrücken, Germany,
University of Maryland at Baltimore
2001-2002,
School of Pharmacy Merit Award,
University of Maryland,
University of Maryland at Baltimore,
Pharmaceutical Sciences
2001, Travel Award,
The 10th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah,
University of Maryland at Baltimore
2000, Best Podium Presentation Award,
20th Annual Graduate Research Association of Students in Pharmaceutics Conference,
University of Maryland at Baltimore,
Pharmaceutical Sciences
2000, Best Poster Presentation Award,
22nd Annual Graduate Research Conference,
University of Maryland Baltimore County,
Pharmaceutical Sciences
2000, Charles A. Stevens Memorial Award,
7th Annual Student Poster Night–Philadelphia Pharmaceutical Forum,
University of Maryland at Baltimore,
Pharmaceutical Sciences
1999, Best Podium Presentation Award,
2nd annual meeting of the American Association of Pharmaceutical Scientists-Southern Regional Discussion Group,
University of Mississippi
1999, Travel Award,
The 14th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, New Orleans, Louisiana,
University of Maryland at Baltimore
1999, Travel Award,
The 2nd annual meeting of the American Association of Pharmaceutical Scientists-Southern Regional Discussion Group, Monroe, Louisiana,
University of Mississippi
1999, Membership,
The Rho-Chi National Pharmacy Honor Society,
University of Mississippi
Previous Positions
2002-2006, Postdoctoral Fellow,
University of Washington,
College of Engineering,
Bioengineering
2000-2002, Visiting Research Scientist,
Guilford Phrmaceuticals, Inc.,
Exploratory Pharmaceutics
1999-2000, Graduate Research Assistant,
University of Maryland at Baltimore,
Pharmacy,
Pharmaceutical Sciences,
Drug Delivery/Metabolism/Pharmacokinetics
1997-1999, Graduate Research Assistant,
University of Mississippi,
School of Pharmacy,
Pharmaceutics
1995-1997, Teaching & Research Assistant,
Al-Azhar University,
Faculty of Pharmacy,
Pharmaceutics & Industrial Pharmacy
Funding Received
- Department of the Army: Department of Defense Breast Cancer Research Program-Multidisciplinary Postdoctoral Award, $435,000, 2005 to 2008.
- The Susan G. Komen Breast Cancer Foundation: The Susan G. Komen Breast Cancer Foundation-Postdoctoral Fellowship, $135,000, 2005 to 2008.
- The National Cancer Center: Postdoctoral Fellowship, $70,000, 2004 to 2006.
- National Science Foundation: CAREER: Development of Enzyme-Activated, Nano-Conjugates for Targeted Drug Delivery, UM ID# 08-0185, 09/01/2008 to 08/31/2013.
- Smart Polymeric Carriers for Enhanced Antisense Breast Cancer Therapy: Defense, Department of-Army, Department of the, UM ID# 07-3025, 05/11/2007 to 05/30/2009.
Publications
- Scott M. Henry, Mohamed E.H. El-Sayed, Christopher M. Pirie, Allan S. Hoffman, and Patrick S. Stayton (2006) pH-responsive poly(styrene-alt-maleic anhydride) alkylamide copolymers for intracellular drug delivery, Biomacromolecules, 7 (8), 2407-2414
- M. E.H. El-Sayed, E. M. Bulger, A. S. Hoffman, and P. S. Stayton (2006) Development and evaluation of "smart" polymer-nucleic acid complexes, The Society for Biomaterials Annual Meeting
- Kelly Kitchens, Mohamed El-Sayed, and Hamidreza Ghandehari, Transepithelial and -endothelial transport of poly(amidoamine) dendrimers, Advanced Drug Delivery Reviews, 57(15), 2163, 2005
- Mohamed E.H. El-Sayed, Allan S. Hoffman, and Patrick S. Stayton, Rational design of composition and activity correlations for pH-sensitive and glutathione-reactive polymer therapeutics, Journal of Controlled Release, 101(1-3), 47-58, 2005
- Mohamed E.H. El-Sayed, Allan S. Hoffman, and Patrick Stayton, Smart polymeric carriers for enhanced intracellular drug delivery of therapeutic macromolecules, Expert Opinion on Biological Therapy, 5(1), 23-32, 2005
- Patrick S. Stayton, Allan S. Hoffman, Mohamed E.H. El-Sayed, Samarth Kulkarni, Tsuyoshi Shimoboji, Niren Murthy, Volga Bulmus, and Chantal Lackey, Intelligent biohybrid materials for therapeutic and imaging agent delivery, Proceeding of the IEEE (Institute of Electrical and Electronics Engineers), 93(4), 726, 2005
- Patrick S. Stayton, Mohamed E.H. El-Sayed, Niren Murthy, Volga Bulmus, Chantal Lackey, Charles Cheung, and Allan S. Hoffman, Smart delivery systems for biomolecular therapeutics, Orthodontics & Craniofacial Research, 8(3), 219, 2005
- M. El-Sayed, A. S. Hoffman, and P. S. Stayton (2005) Rational design and activity of pH-responsive, membrane-destabilizing, and glutathione-reactive polymers for intracellular drug delivery, 12th International Symposium On Recent Advances In Drug Delivery Systems
- M. El-Sayed, A. S. Hoffman, and P. S. Stayton (2005) Development of pH-responsive, endosomal membrane-disruptive, and glutathione-reactive polymeric carriers for enhanced intracellular delivery of therapeutic molecules, 32nd Annual Meeting and Exposition of the Controlled Release of Bioactive Materials
- M. El-Sayed, M. Ginski, C. A. Rhodes, K. Kitchens, and H. Ghandehari (2004) Poly (amidoamine) (PAMAM) dendrimers as oral drug carriers: influence of molecular architecture on transepithelial transport and cytotoxicity, 31st Annual Meeting and Exposition of the Controlled Release of Bioactive Materials
- Mohamed El-Sayed, Mark Ginski, Christopher Rhodes, and Hamidreza Ghandehari, Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers, International Journal of Pharmaceutics, 265(1-2), 151-157, 2003
- Mohamed El-Sayed, Mark Ginski, Christopher Rhodes, and Hamidreza Ghandehari, Influence of surface chemistry of poly (amidoamine) dendrimers on Caco-2 cell monolayers, Journal of Bioactive and Compatible Polymers, 18(1), 7-22, 1 2003
- R. E. Johns, M. El-Sayed, A. S. Hoffman, and P. S. Stayton (2003) Gene expression analysis of THP-1 cells treated with antisense IRAK delivered with a pH-sensitive, membrane-disruptive polymer, University of Washington Engineered Biomaterials (UWEB) Research Center Research Day
- M. El-Sayed, M. Ginski, C. A. Rhodes, and H. Ghandehari (2002) Influence of charge of poly (amidoamine) dendrimers on Caco-2 cell monolayers, 17th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists
- Mohamed El-Sayed, Mark Ginski, Christopher Rhodes, and Hamidreza Ghandehari, Transepithelial transport of poly (amidoamine) dendrimers across Caco-2 cell monolayers, Journal of Controlled Release, 81(3), 355-365, 17 2002
- M. El-Sayed, M. Ginski, C. A. Rhodes, and H. Ghandehari (2002) Transport of poly (amidoamine) dendrimers across Caco-2 cell monolayers, 4th Intensive Course and Workshop on Cell Culture and Ex-Vivo Models for Drug Absorption and Delivery
- H. Ghandehari, M. El-Sayed, M. Ginski, C. A. Rhodes, and M. Kiani (2002) Transport of Poly (Amidoamine) Dendrimers Across Epithelial and Endothelial Barriers, 5th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice
- A. A. Dinerman, J. Cappello, M. El-Sayed, S. W. Hoag, and H. Ghandehari (2002) Influence of solute charge and hydrophobicity on partitioning and diffusion in silk-elastinlike protein polymer hydrogels, 17th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2002) Transport of poly amidoamine (PAMAM) dendrimers across Caco-2 cell monolayers, University of Maryland School of Pharmacy Research Day
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Transport of Poly amidoamine (PAMAM) Dendrimers Across Caco-2 Cell Monolayers, 16th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists
- Farhad Tajarobi, Mohamed El-Sayed, Bhagwant Rege, James Polli, and Hamidreza Ghandehari, Transepithelial transport of poly (amidoamine) (PAMAM) dendrimers across Madin-Darby Canine Kidney (MDCK) cells, International Journal of Pharmaceutics, 215(1-2), 263-267, 14 2001
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Transport of cationic Poly amidoamine (PAMAM) dendrimers across Caco-2 cell monolayers, 10th International Symposium On Recent Advances In Drug Delivery Systems
- Mohamed El-Sayed, Mohammad F. Kiani, Mike D. Naimark, Ahmed H. Hikal, and Hamidreza Ghandehari, Extravasation of poly (amidoamine) (PAMAM) dendrimers across microvascular network endothelium, Pharmaceutical Research, 18(1), 23-28, 1 2001
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Permeability and Absorption Enhancing Properties of Cationic Poly Amidoamine (PAMAM) Dendrimers Across Caco-2 Cell Monolayers, 8th Annual Student Poster Night - Philadelphia Pharmaceutical Forum
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Potential of Poly amidoamine (PAMAM) dendrimers as oral drug delivery systems, 23rd Annual Graduate Research Conference
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Transepithelial transport of Poly amidoamine (PAMAM) dendrimers, University of Maryland School of Pharmacy Research Day
- M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari (2001) Transport of poly amidoamine (PAMAM) dendrimers across Caco-2 cell monolayers, 21st Annual Graduate Research Association of Students in Pharmacy Conference
- H. Ghandehari, M. F. Kiani, M. Naimark, M. El-Sayed, F. Tajarobi, J. Polli, and B. Rege (2000) Trans-endothelial and -epithelial transport of poly (amidoamine) (PAMAM) dendrimers, Annual Fall Meeting of the Biomedical Engineering Society
- H. Ghandehari, M. El-Sayed, M. Haider, A. Nagarsekar, A. Nan, and F. Tajarobi (2000) Intelligent Biomaterials: Constructs For The Next Generation Of Drug Delivery Systems, First International Conference for Pharmaceutical Industry
- M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (2000) Transport of macromolecular drug carriers across microvascular beds, 220th American Chemical Society National Meeting
- M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (2000) Influence of size, molecular weight and geometry on the extravasation of polymeric drug carriers across the microvascular endothelium, 27th International Symposium on Controlled Release of Bioactive Materials
- F. Tajarobi, M. El-Sayed, B. Rege, J. Polli and H. Ghandehari (2000) Transport of poly (amidoamine) (PAMAM) dendrimers across Madin Darby Canine Kidney (MDCK) cell lines, 59th Prague Meeting on Macromolecules
- 5. M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (2000) Influence of polymeric structural features of Poly (amidoamine) (PAMAM) dendrimers on their transport across biological barriers, 59th Prague Meeting on Macromolecules
- M. El-Sayed, M. F. Kiani, M. Naimark, A. H. Hikal, and H. Ghandehari (2000) Extravasation of poly (amidoamine) dendrimers across the microvascular network endothelium, Gordon Research Conference: Drug Carriers in Medicine and Biology
- M. El-Sayed, M. F. Kiani, M. Naimark, A. H. Hikal, and H. Ghandehari (2000) Extravasation of poly (amidoamine) dendrimers across the microvascular network endothelium, 7th Annual Student Poster Night - Philadelphia Pharmaceutical Forum
- M. El-Sayed, M. F. Kiani, M. Naimark, A. H. Hikal, and H. Ghandehari (2000) Influence of size, molecular weight and geometry on the extravasation of polymeric drug carriers across the microvascular endothelium, 22nd Annual Graduate Research Conference
- M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (2000) Extravasation of Poly amidoamine (PAMAM) dendrimers across microvascular network endothelium, University of Maryland, School of Pharmacy research day
- M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (2000) Extravasation of poly (amidoamine) (PAMAM) dendrimers across microvascular network endothelium, 20th Annual Graduate Research Association of Students in Pharmaceutics Conference
- M. El-Sayed, M. F. Kiani, M. Naimark, and H. Ghandehari (1999) Extravasation of poly (amidoamine) dendrimers across the microvascular network endothelium, 14th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists
- M. El-Sayed, M. F. Kiani, M. Naimark, A. H. Hikal, and H. Ghandehari (1999) Extravasation of poly (amidoamine) dendrimers across the microvascular network endothelium, 2nd Annual meeting of the American Association of Pharmaceutical Scientists - Southern Regional Discussion Group
- Mohamed E.H. El-Sayed, Eileen M. Bulger, Allan S. Hoffman, and Patrick S. Stayton, In vivo evaluation of biodistribution and compatibility of "smart" polymer-antisense oligodeoxynucleotides complexes, Submitted
- Rachel Johns, Mohamed E.H. El-Sayed, Joseph Cuschieri, Ronald Maier, Allan S. Hoffman, and Patrick S. Stayton, Gene expression analysis of LPS-stimulated THP-1 cells pretreated with pH sensitive, membrane-destabilizing polymer carrying anti-IRAK-1 oligodeoxynucleotides, Submitted
- Mohamed E.H. El-Sayed, Allan S. Hoffman, and Patrick S. Stayton, In vitro evaluation of new pH-sensitive, membrane-destabilizing, and glutathione-reactive polymeric carriers for enhancing the cytoplasmic delivery of therapeutic antisense oligodeoxynucleotides, Submitted
- Adam A. Dinerman, Joseph Cappello, Mohamed El-Sayed, Stephen W. Hoag, and Hamidreza Ghandehari, Influence of solute charge and hydrophobicity on partitioning and diffusion in silk-elastinlike protein polymer hydrogels, Submitted
Profile Details
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