Mensur Dlakic

powered by
COS Expertise®
Montana State University
College of Letters and Science
Microbiology
Assistant ProfessorAppointed: 2004

Mailing Address

P.O. Box 173520
109 Lewis Hall
Department of Microbiology
Montana State University
Bozeman, Montana 59717-3520
United States

Contact Information

Phone: (406) 994-6576
Fax: (406) 994-4926
mdlakic@montana.edu

Qualifications

Ph.D., University of Nevada, Reno, Biochemistry, 1997.
B.Sc., Belgrade University, Molecular Biology, 1991.

Expertise and Research Interests

Ribosome synthesis in budding yeast
Fold recognition (threading) and comparative modeling of proteins
Structural polymorphism of DNA
Studies of DNA bending by gel phasing analysis and cyclization
Computer modeling of DNA structure and macromolecular graphics
The analysis of protein-DNA interactions using fluorescence resonance energy transfer (FRET) and Scanning Probe Microscopy
Probabilistic models (Hidden Markov Models) of proteins
Iterative profile searches for detecting remote protein homology
Protein evolution
Comparative genomics
Genomic search for DNA regulatory elements (protein binding sites)

Keywords

COS Keywords:

Biochemistry, Biophysics, Cell Biology, Computer Modeling, Genetic Engineering, Genomics, Leukemia, Lymphoma, Microbiology, Molecular Biology, Mutagenesis, Protein Folding, Structural Biology.

Additional Terms:

Molecular Biology, Molecular Modeling, Protein Evolution.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Serbo-Croatian: (Fluent, Fluent, Fluent)

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American Chemical Society
Biophysical Society

Honors and Awards

2000-2003, Special Fellowship, Leukemia and Lymphoma Society, University of Michigan
1999-2000, Postdoctoral Fellowship, AACR - Sydney Kimmel Foundation for Cancer Research, University of Michigan
1999, Postdoctoral Fellowship, Rackham Interdisciplinary Institute, University of Michigan

Previous Positions

1999-2003, Special Fellow, University of Michigan, Medical School, Biological Chemistry, Leukemia and Lymphoma Society
1997-1999, Research Associate, Howard Hughes Medical Institute
1993-1997, Graduate Research Assistant, University of Nevada, Reno, Medical School, Biochemistry
1991-1992, Research Fellow, Institute of Molecular Genetics and Genetic Engineering

Funding Received

  • Leukemia and Lymphoma Society: Special Fellowship, 2000 to 2003.
  • AACR-Sidney Kimmel Foundation for Cancer Research: Postdoctoral Fellowship, 1999 to 2000.
  • Open Society Institute, New York: Supplementary Grant, 1994 to 1998.

Publications

  • Dez C, Dlakic M, Tollervey D (Sep 2007) Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation., RNA (New York, N.Y.), 13 (9), 1516-27 Abstract
  • Colmenares SU, Buker SM, Buhler M, Dlakic M, Moazed D (Aug 2007) Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi., Molecular cell, 27 (3), 449-61 Abstract
  • Shenker BJ, Dlakic M, Walker LP, Besack D, Jaffe E, LaBelle E, Boesze-Battaglia K (Apr 2007) A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity., Journal of immunology (Baltimore, Md. : 1950), 178 (8), 5099-108 Abstract
  • Dlakic M (Nov 2006) DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold., Bioinformatics (Oxford, England), 22 (22), 2711-4 Abstract
  • Maaty WS, Ortmann AC, Dlakic M, Schulstad K, Hilmer JK, Liepold L, Weidenheft B, Khayat R, Douglas T, Young MJ, Bothner B (Aug 2006) Characterization of the archaeal thermophile Sulfolobus turreted icosahedral virus validates an evolutionary link among double-stranded DNA viruses from all domains of life., Journal of virology, 80 (15), 7625-35 Abstract
  • Douthit SA, Dlakic M, Ohman DE, Franklin MJ (Jul 2005) Epimerase active domain of Pseudomonas aeruginosa AlgG, a protein that contains a right-handed beta-helix., Journal of bacteriology, 187 (13), 4573-83 Abstract
  • Gioia U, Laneve P, Dlakic M, Arceci M, Bozzoni I, Caffarelli E (May 2005) Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis., The Journal of biological chemistry, 280 (19), 18996-9002 Abstract
  • Dlakic M (Feb 2005) 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p., RNA (New York, N.Y.), 11 (2), 123-7 Abstract
  • Dlakic M, Ussery DW, Brunak S (2005) DNA bendability and nucleosomal positioning in transcriptional regulation, In DNA conformation and transcription, 1st Edition, Landes Biosciences, 189-202 pages (bookchapter)
  • Dlakic M (2005) The ribosomal subunit assembly line., Genome biology, 6 (10), 234 Abstract
  • Fatica A, Tollervey D, Dlakic M, PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA, RNA, 10, 1698-701, Nov 2004 Abstract
  • Dlakic M, Tollervey D, The Noc proteins involved in ribosome synthesis and export contain, RNA, 10, 351-4, 01 Mar 2004 Abstract
  • Oeffinger M, Dlakic M, Tollervey D, A pre-ribosome-associated HEAT-repeat protein is required for export of, Genes & Development, 18, 196-209, 01 Jan 2004 Abstract
  • Katz JE, Dlakic M, Clarke S, Automated identification of putative methyltransferases from genomic open, Molecular & Cellular Proteomics, 2, 525-40, 01 Aug 2003 Abstract
  • Fatica A, Oeffinger M, Dlakic M, Tollervey D, Nob1p is required for cleavage of the 3' end of 18S rRNA, Molecular and Cellular Biology, 23, 1798-807, 01 Mar 2003 Abstract
  • Fatica A, Dlakic M, Tollervey D, Naf1 p is a box H/ACA snoRNP assembly factor, RNA, 8, 1502-14, 01 Dec 2002 Abstract
  • Dlakic M, A model of the replication fork blocking protein Fob1p based on the, Protein Science, 11, 1274-7, 01 May 2002 Abstract
  • Dlakic M, A new family of putative insulin receptor-like proteins in C. elegans, Current Biology, 12, R155-7, 01 Mar 2002 Abstract
  • Fatica A, Cronshaw AD, Dlakic M, Tollervey D, Ssf1p prevents premature processing of an early pre-60S ribosomal, Molecular Cell, 9, 341-51, 01 Feb 2002 Abstract
  • Dlakic M, Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold, Trends in Biochemical Sciences, 26, 405-7, 01 Jul 2001 Abstract
  • Dlakic M, Grinberg AV, Leonard DA, Kerppola TK, DNA sequence-dependent folding determines the divergence in binding specificities between Maf and other bZIP proteins, EMBO Journal, 20, 828-40, 15 Feb 2001 Abstract
  • Heaton JH, Dlakic WM, Dlakic M, Gelehrter TD, Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA, Journal of Biological Chemistry, 276, 3341-7, 02 Feb 2001 Abstract
  • Dlakic M, Is CdtB a nuclease or a phosphatase?, Science, 291, 547, 26 Jan 2001 Abstract
  • Dlakic M, Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases, Trends in Biochemical Sciences, 25, 272-3, 01 Jun 2000 Abstract
  • Dlakic M, Harrington RE, Unconventional helical phasing of repetitive DNA motifs reveals their relative bending contributions, Nucleic Acids Research, 26, 4274-9, 01 Sep 1998 Abstract
  • Dlakic M, Harrington RE, DIAMOD: display and modeling of DNA bending, Bioinformatics, 14, 326-31, 01 Jan 1998 Abstract
  • Han W, Dlakic M, Zhu YJ, Lindsay SM, Harrington RE, Strained DNA is kinked by low concentrations of Zn2, Proceedings of the National Academy of Sciences USA, 94, 10565-70, 01 Sep 1997 Abstract
  • Han W, Lindsay SM, Dlakic M, Harrington RE, Kinked DNA, Nature, 386, 563, 01 Apr 1997 Abstract
  • Dlakic M, Park K, Griffith JD, Harvey SC, Harrington RE, The organic crystallizing agent 2-methyl-2,4-pentanediol reduces DNA curvature by means of structural changes in A-tracts, Journal of Biological Chemistry, 271, 17911-9, 01 Jul 1996 Abstract
  • Dlakic M, Harrington RE, The effects of sequence context on DNA curvature [published erratum appears in Proc Natl Acad Sci U S A 1996 Aug 6, Proceedings of the National Academy of Sciences USA, 93, 3847-52, 01 Apr 1996 Abstract
  • Dlakic M, Harrington RE, Bending and torsional flexibility of G/C-rich sequences as determined by cyclization assays, Journal of Biological Chemistry, 270, 29945-52, 01 Dec 1995 Abstract
  • Harvey SC, Dlakic M, Griffith J, Harrington R, Park K, Sprous D, Zacharias W, What is the basis of sequence-directed curvature in DNAs containing A tracts?, Journal of Biomolecular Structure and Dynamics, 13, 301-7, 01 Oct 1995 Abstract
  • Brukner I, Susic S, Dlakic M, Savic A, Pongor S, Physiological concentration of magnesium ions induces a strong macroscopic curvature in GGGCCC-containing DNA, Journal of Molecular Biology, 236, 26-32, 01 Feb 1994 Abstract
  • Brukner I, Dlakic M, Savic A, Susic S, Pongor S, Suck D, Evidence for opposite groove-directed curvature of GGGCCC and AAAAA sequence elements [published erratum appears in Nucleic Acids Res 1993 Mar 11, Nucleic Acids Research, 21, 1025-9, 01 Feb 1993 Abstract
  • Douthit SA, Dlakic M, Ohman DE, Franklin MJ (Jul 2005) Epimerase active domain of Pseudomonas aeruginosa AlgG, a protein that contains a right-handed beta-helix., 187 (13), 4573-83 Abstract
  • Dlakic M (2005) The ribosomal subunit assembly line., Genome Biology, 6 (10), 234 Abstract

Profile Details

Last Updated: 5/3/2008

COS Expertise ID #1245627
Reference this profile directly: http://myprofile.cos.com/mensur