Laura M. Ment

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Yale University
School of Medicine
Neurology
Yale University
School of Medicine
Pediatrics
Professor

Mailing Address

333 Cedar Street
Yale University
New Haven, Connecticut
United States

Contact Information

Phone: (203) 785-5708
laura.ment@yale.edu

Qualifications

M.D., Massachusetts General Hospital, 1973.
A.B., Massachusetts General Hospital, 1970.
Residency, Massachusetts General Hospital, Pediatrics/Neurology.

Expertise and Research Interests

Intraventricular hemorrhage (IVH), or hemorrhage into the germinal matrix tissues of the developing brain, remains a major problem of preterm neonates. Over 30% of preterm infants of < 1250 g birth weight suffer IVH and are at greater risk for hydrocephalus, seizures, neurodevelopmental handicaps and death than their peers without hemorrhage. Clinical studies during the past 15 years have studied the incidence and timing of hemorrhage, the changes in cerebral blood flow associated with IVH, prevention ofhemorrhage, and the long-term neurodevelopmental sequelae of this insult. Laboratory studies with Drs. Joseph Madri and William Stewart currently include studies of the pathogenesis and prevention of IVH both in vivo and in vitro.

CORE section of our application is composed of three components: Administration, Education and Model Development. The Administrativecomponent will be led by Dr Ment and will include Program, InternalAdvisory and External Review Committees. The Center Core is ModelDevelopmentand Validation. Although there are many models currently in use neonatal cerebral insult, non of them appears to be entirely adequate to describe the conditionsfollowing IVH. Our clinical studies have indicated no gross changesobservable by sophisticatedneuroimaging techniques and thus models thatresult in unilateral or bilateral destructive lesions are not appropriatefor our needs. Our goal in developing and implementing models of bothhypoxia and ischemia in neonatal rats will be to adjust the severityofinsult so as to not produce large infarcts or wide spread loss ofcortical neurons. We hypothesize that much of the damage done by theevents that lead to IVH and result from its occurrence may not be causedby widespread neuronal death but by sublethal disturbances of the normalsequence of cerebral development. Some of these disturbances may includealterations in cerebral metabolism, abnormal expression of membranechannels and abnormal intracortical connectivity and synaptogenesis.

Other Expertise

I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.

Keywords

COS Keywords:

Blood Flow, Brain Injury, Developmental Neurobiology, Nervous System, Neurological Disorders, Neurology, Pediatrics, Stroke.

Additional Terms:

Autoradiography, Biological Model, Biomedical Facility, Blood Flow, Brain Injury, Cerebral Endothelial Cell, Cerebral Hemorrhage, Cerebral Ischemia Hypoxia, Co-cultures, Controlled Environment Chamber, Developmental Neurobiology, Differential Screen, Histopathology, Intraventricular Hemorrhage, Laboratory Rat, Model Design Development, Newborn Animal, Newborn Beagle Pup, Oxygen Tension, Preterm Infant.

Funding Received

  • National Institutes of Health (NIH), 5 P20 NS32578-03 SUB: 9001, BASIC MECHANISMS OF CORTICAL INJURY--RELEVANCE TO IVH: CORE--MODEL DEVELOPMENT, $96070, 1995

Publications

  • Ment LR, Vohr B, Allan W, Westerveld M, Katz KH, Schneider KC, Makuch RW, The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infants., Pediatrics, 104(2 Pt 1), 243-8, August 1999 Abstract
  • Vohr B, Allan WC, Scott DT, Katz KH, Schneider KC, Makuch RW, Ment LR, Early-onset intraventricular hemorrhage in preterm neonates: incidence of neurodevelopmental handicap., Seminars In Perinatology, 23(3), 212-7, June 1999 Abstract
  • Ment LR, Schwartz M, Makuch RW, Stewart WB, Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain., Brain Research. Developmental Brain Research, 111(2), 197-203, 7 Dec 1998 Abstract
  • Svatek M, Stevens S, Ment LR, Caudal appendage in a full-term infant., Curr Opin Pediatr, 10(6), 635-9, December 1998 Abstract
  • Varelas P N, Sleight B J, Rinder H M, Sze G, Ment L R, Stroke in a neonate heterozygous for factor V Leiden., Pediatric Neurology, 18(3), 262-4, March 1998 Abstract
  • Ment L R, Stewart W B, Scaramuzzino D, Madri J A, An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation., In Vitro Cellular and Developmental biology. Animal, 33(9), 684-91, October 1997 Abstract
  • Stewart W B, Ment L R, Schwartz M, Chronic postnatal hypoxia increases the numbers of cortical neurons., Brain Research, 760(1-2), 17-21, 20 Jun 1997 Abstract
  • Allan W C, Vohr B, Makuch R W, Katz K H, Ment L R, Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage., Archives of Pediatrics and Adolescent Medicine, 151(6), 580-5, June 1997 Abstract
  • Ment L R, Stewart W B, Fronc R, Seashore C, Mahooti S, Scaramuzzino D, Madri J A, Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain., Brain research. Developmental Brain Research, 100(1), 52-61, 20 May 1997 Abstract
  • Allan WC, Vohr B, Makuch RW, Katz KH, Ment LR, Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage, Archives of Pediatrics and Adolescent Medicine, 151(6), 580-5, 1997 Abstract
  • Mari G, Abuhamad A Z, Keller M, Verpairojkit B, Ment L, Copel J A, Is the fetal brain-sparing effect a risk factor for the development of intraventricular hemorrhage in the preterm infant? [see comments], Ultrasound In Obstetrics and Gynecology, 8(5), 329-32, November 1996 Abstract
  • Ment L R, Vohr B, Oh W, Scott D T, Allan W C, Westerveld M, Duncan C C, Ehrenkranz R A, Katz K H, Schneider K C, Makuch R W, Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial [see comments], Pediatrics, 98(4 Pt 1), 714-8, October 1996 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Allan W C, Antenatal exposure to steroids and the additional prophylaxis effect of indomethacin to prevent intraventricular hemorrhage [letter], Pediatrics, 97(4), 601, April 1996 Abstract
  • Vohr B, Ment L R, Intraventricular hemorrhage in the preterm infant [published erratum appears in Early Hum Dev 1996 Jul 5;45(1-2):169], Early Human Development, 44(1), 1-16, 5 Jan 1996 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Philip A G, Duncan C C, Makuch R W, Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants., American Journal of Obstetrics and Gynecology, 172(3), 795-800, March 1995 Abstract
  • Ment L R, Stewart W B, Ardito T A, Madri J A, Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage., Brain research. Developmental Brain Research, 84(1), 142-9, 14 Jan 1995 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Phillip A G, Vohr B, Allan W, Makuch R W, Taylor K J, Schneider K C, Katz K H, et al, Low-dose indomethacin therapy and extension of intraventricular hemorrhage: a multicenter randomized trial., Journal of Pediatrics, 124(6), 951-5, June 1994 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Philip A G, Vohr B, Allan W, Duncan C C, Scott D T, Taylor K J, Katz K H, et al, Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial, Pediatrics, 93(4), 543-50, April 1994 Abstract
  • Ment L R, Oh W, Ehrenkranz R A, Philip A G, Schneider K, Katz K H, Taylor K J, Duncan C C, Makuch R W, Risk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age., Seminars In Perinatology, 17(5), 338-41, October 1993 Abstract
  • Duncan C C, Ment L R, Intraventricular hemorrhage and prematurity., Neurosurgery Clinics of North America, 4(4), 727-34, October 1993 Abstract
  • Ment L R, Schneider K, Intraventricular hemorrhage of the preterm infant., Seminars In Neurology, 13(1), 40-7, March 1993 Abstract
  • Ment L R, Oh W, Philip A G, Ehrenkranz R A, Duncan C C, Allan W, Taylor K J, Schneider K, Katz K H, Makuch R W, Risk factors for early intraventricular hemorrhage in low birth weight infants., Journal of Pediatrics, 121(5 Pt 1), 776-83, November 1992 Abstract
  • Ment L R, Stewart W B, Ardito T A, Huang E, Madri J A, Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup., Stroke, 23(8), 1132-7, August 1992 Abstract
  • Ment L R, Stewart W B, Ardito T A, Madri J A, Beagle pup germinal matrix maturation studies., Stroke, 22(3), 390-5, March 1991 Abstract
  • Ment L R, Stewart W B, Petroff O A, Duncan C C, Montoya D, Beagle puppy model of perinatal asphyxia: blockade of excitatory neurotransmitters., Pediatric Neurology, 5(5), 281-6, September 1989 Abstract
  • Ment LR, Steward WB, Ardito TA, Huang E, Madri JA: Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 23:1132-37, 19
  • Ment LR, Oh W, Philip AGS, Ehrenkranz RA, et al: Risk factors for early intraventricular hemorrhage in low birth weight infants. J. Pediatr 121:776-783, 1992

Profile Details

Last Updated: 10/27/2000

COS Expertise ID #917063
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