Dr. Matthew L. Fero

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Fred Hutchinson Cancer Research Center
Clinical Research Division
Associate MemberAppointed: 2000
University of Washington
School of Medicine
Medicine
Oncology
Associate ProfessorAppointed: 2000
Professional Headshot of Matthew L. Fero

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-5065
Fax: (206) 667-1494
mfero@fhcrc.org
http://www.fhcrc.org/labs/fero/index.html

Qualifications

Diplomate, American Board of Internal Medicine, Medical Oncology, 1996.
Diplomate, American Board of Internal Medicine, Internal Medicine, 1993.
M.D., University of California, Irvine, 1990.
B.A., University of California, Berkeley, Microbiology, 1984.

Expertise and Research Interests

The additional layers of regulation and functional redundancy of cell cycle proteins in mammals may reflect the need for alternative, tissue specific, growth control pathways. Mouse models have challanged our understanding the biochemical mechanisms of CDK regulation in mammals and have demonstrated both generalized and tissue specific patterns of cellular growth control. Targeted disruption of the CKI genes, p27Kip1 and p18ink4c in knockout mice lead both to generalized animal overgrowth and to tissue specific increases in cell proliferation, tumor susceptibility, and CDK activation. In the cases of the CKI, p27Kip1, both growth and tumor suppression is haploid insufficient, i.e. growth and tumorigenesis is increased even when a single intact gene copy present. Through the study of genetic mosaics we have demonstrated that some of the mechanisms of growth suppression by p27Kip1 are cell non-autonomous, meaning that they are driven by extracellular signals in the context of a knockout animal.

Other Expertise

Hematopoietic stem cell transplantation

Future Research

The Fero lab is highly interactive and has collaborative interactions with local and international groups. Our current research projects include the following:
* Inducible and tissue specific mutation of the p27Kip1 CDK inhibitor.
* Genetic and pathophysiologic basis of lymphoma
* DNA copy number changes in acute leukemia and myelodysplastic syndrome

Keywords

COS Keywords:

Animal Models, Biochemistry, Cancer or Carcinogenesis, Cell Cycle, Clinical Research Or Studies, Hematology, Medical Genetics, Oncology.

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American Society of Hematology
Puget Sound Oncology Consortium

Patents

Compositions and methods for mediating cell cycle progression, Patent Number: 5958769, 1999, Institution-owned, United States.

Publications

  • Chien WM, Rabin S, Macias E, Miliani de Marval P, Garrison K, Orthel J, Rodriguez-Puebla M, Fero ML (2006) Genetic mosaics reveal both cell-autonomous and nonautonomous function of murine p27Kip1, Proceedings of the National Academy of Sciences (USA), 103 (11), 4122-7
  • Walkley CR, Fero ML, Chien WM, Purton LE, McArthur GA (2005) Negative cell-cycle regulators cooperatively control self-renewal and differentiation of hematopoietic stem cells, Nature Cell Biology, 7 (2), 172-8
  • Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE, Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis, Proceedings of the National Academy of Sciences (USA), 99(17), 11293-8, Aug 2002 Abstract
  • McArthur GA, Foley KP, Fero ML, Walkley CR, Deans AJ, Roberts JM, Eisenman RN, MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity, Molecular and Cellular Biology, 22(9), 3014-23, May 2002 Abstract
  • Fero ML, Kemp CJ (2002) p27 (Kip1), The Encyclopedia of Molecular Medicine., New York, John Wiley & Sons, Inc., 2363-6 pages (bookchapter)
  • Beier R, Burgin A, Kiermaier A, Fero M, Karsunky H, Saffrich R, Moroy T, Ansorge W, Roberts J, Eilers M, Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events, The Embo Journal, 19(21), 5813-23, November 2000 Abstract
  • Levine EM, Close J, Fero M, Ostrovsky A, Reh TA, p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina, Developmental Biology, 219(2), 299-314, 2000 Abstract
  • Lowenheim H, Furness DN, Kil J, Zinn C, Gultig K, Fero ML, Frost D, Gummer AW, Roberts JM, Rubel EW, Hackney CM, Zenner HP, Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti, Proceedings of the National Academy of Sciences (USA), 96(7), 4084-8, 1999 Abstract
  • Hiromura K, Pippin JW, Fero ML, Roberts JM, Shankland SJ, Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1), Journal of Clinical Investigation, 103(5), 597-604, March 1999 Abstract
  • Coats S, Whyte P, Fero ML, Lacy S, Chung G, Randel E, Firpo E, Roberts JM, A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells, Current Biology, 9(4), 163-73, 1999 Abstract
  • Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ, The murine gene p27Kip1 is haplo-insufficient for tumour suppression, Nature, 396(6707), 177-80, 1998 Abstract
  • Ophascharoensuk V, Fero ML, Hughes J, Roberts JM, Shankland SJ, The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury, Nature Medicine, 4(5), 575-80, May 1998 Abstract
  • Durand B, Fero ML, Roberts JM, Raff MC, p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation, Current Biology, 8(8), 431-40, 1998 Abstract
  • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM, A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice, Cell, 85(5), 733-44, May 1996 Abstract
  • Morgan WF, Fero ML, Land MC, Winegar RA, Inducible expression and cytogenetic effects of the EcoRI restriction endonuclease in Chinese hamster ovary cells, Molecular and Cellular Biology, 8(10), 4204-11, October 1988 Abstract
  • Morgan WF, Bodycote J, Doida Y, Fero ML, Hahn P, Kapp LN, Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis [published erratum appears in Mutagenesis 1988 May, Mutagenesis, 1(6), 453-9, November 1986 Abstract
  • Morgan WF, Bodycote J, Fero ML, Hahn PJ, Kapp LN, Pantelias GE, Painter RB, A cytogenetic investigation of DNA rereplication after hydroxyurea treatment: implications for gene amplification, Chromosoma, 93(3), 191-6, 1986 Abstract

Profile Details

Last Updated: 1/11/2008

COS Expertise ID #872746
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