Mary Lynn Haasch

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United States Environmental Protection Agency (EPA)
MED
Molecular and Cellular Mechanisms Research
ORD
Senior ScientistAppointed: 2005

Mailing Address

USEPA, MED
NRC Research Associate Senior Scientist
6201 Congdon Blvd.
Duluth, Minnesota 55804
United States

Contact Information

Phone: (218) 529-5172
Fax: (218) 529-5003
Haasch.Mary@epa.gov

Qualifications

Ph.D., University of Wisconsin-Milwaukee, Biological Sciences, 1989.
B.S., University of Wisconsin-Oshkosh, Microbiology and Public Health, 1976.

Expertise and Research Interests

Environmental toxicology
Aquatic toxicology
Endocrine disruption
Nanotoxicology
Developmental toxicology
Physiological and biochemical adaptation to anthropogenic stress
Biotransformation
Lower vertebrate and invertebrate models of human disease
Regulation of gene expression
Biomarkers of xenobiotic exposure

Keywords

COS Keywords:

Biological Sciences, Biomarkers, Disease Model, Environmental Sciences, Environmental Toxicology, Gene Expression, Gene Regulation, Microbiology, Pharmaceuticals, Pharmacology, Public Health, Toxicology, Xenobiotics.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Association for the Advancement of Science
Society of Environmental Toxicology and Chemistry
Society of Toxicology

Honors and Awards

2005-2008, Research Associate Fellowship, National Research Council (NRC) - USA, USEPA, Biomarkers of Endocrine Disruption
1992, Victor Drill Award for Meritorius Research in Toxicology, ASPET/SOT
1990, Molecular Biology Section Student Award, SOT-Molecular Biology Section
1989, Student Travel Award, SOT

Previous Positions

2001-2005, Research Associate Professor, University of Mississippi, School of Pharmacy, Research Institute of Pharmaceutical Sciences, National Center for Natural Products Research, Environmental Toxicology Research Program
2001-2005, Associate Professor, University of Mississippi, School of Pharmacy, Pharmacology
1994-2001, Assistant Professor, University of Maryland College Park, Center for Environmental Science
1990-1994, Research Assistant Professor, Medical College of Wisconsin, Pharmacology & Toxicology

Publications

  • Zhu S, King SC, Haasch ML (May 2008) Biomarker induction in tropical fish species on the Northwest Shelf of Australia by produced formation water., Marine environmental research, 65 (4), 315-24 Abstract
  • Zhu S, King SC, Haasch ML (2006) Environmental induction of CYP1A-, CYP2M1- and CYP2K1-like proteins in tropical fish species by produced formation water on the northwest shelf of Australia., Marine Environmental Research, 62 Suppl, S322-6 Abstract
  • Zhu S, Oberdörster E, Haasch ML (2006) Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow., Marine Environmental Research, 62 Suppl, S5-9 Abstract
  • Oberdörster, Eva, Zhu, Shiqian, Blickley, T. Michelle, McClellan-Green, Patricia, Haasch, Mary L. (2006) Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms, Carbon <doi:10.1016/j.carbon.2005.11.008 >, 44 (6), 1112-1120
  • Wang X, Williams E, Haasch ML, Dasmahapatra AK (2006) Japanese medaka (Oryzias latipes): developmental model for the study of alcohol teratology., Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 77 (1), 29-39 Abstract
  • King SC, Johnson JE, Haasch ML, Ryan DA, Ahokas JT, Burns KA (2005) Summary results from a pilot study conducted around an oil production platform on the Northwest Shelf of Australia., Marine Pollution Bulletin, 50 (11), 1163-72 Abstract
  • Dasmahapatra AK, Wang X, Haasch ML (2005) Expression of Adh8 mRNA is developmentally regulated in Japanese medaka (Oryzias latipes)., Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 140 (4), 657-64 Abstract
  • Haasch, M.L., McClellan-Green, P., Oberdörster, E. (2005) Consideration of the toxicity of manufactured nanoparticles, XIX International Winterschool/Euroconference on Electronic Properties of Novel Materials/Electronic Properties of Synthetic Nanostructures, American Institute of Physics, Melville, New York, AIP Conference Proceedings Vol 786, 586-590 pages
  • Haasch ML, Ford AW (2004) Combined effects of ethanol and cinnamaldehyde in the Japanese medaka embryo-larval assay (MELA)., Marine Environmental Research, 58 (2-5), 175-9 Abstract
  • Haasch ML (2002) Effects of vehicle, diet and gender on the expression of PMP70- and CYP2K1/2M1-like proteins in the mummichog., Marine Environmental Research, 54 (3-5), 297-301 Abstract
  • Ackers JT, Johnston MF, Haasch ML (2000) Immunodetection of hepatic peroxisomal PMP70 as an indicator of peroxisomal proliferation in the mummichog, Fundulus heteroclitus., Marine Environmental Research, 50 (1-5), 361-5 Abstract
  • Haasch ML, Henderson MC, Buhler DR (1998) Induction of lauric acid hydroxylase activity in catfish and bluegill by peroxisome proliferating agents., Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology, 121 (1-3), 297-303 Abstract
  • Haasch, M.L, Book Review: Techniques in aquatic toxicology, Aquatic Toxicology, 41, 355-356, 1998
  • Haasch, M.L., M.C. Henderson, and D.R. Buhler (1998) Induction of CYP2M1 and CYP2K1 lauric acid hydroxylase activities by peroxisome proliferating agents in certain fish species: Possible implications, Marine Environmental Research <doi:10.1016/S0141-1136(97)00109-8>, 46 (1-5), 37-40
  • Haasch, M.L (1996) Induction of anti-trout lauric acid hydroxylase immunoreactive proteins by peroxisome proliferators in bluegill and catfish, Marine Environmental Research <doi:10.1016/0141-1136(95)00032-1>, 42 (1-4), 287-291
  • Haasch ML, Graf WK, Quardokus EM, Mayer RT, Lech JJ (1994) Use of 7-alkoxyphenoxazones, 7-alkoxycoumarins and 7-alkoxyquinolines as fluorescent substrates for rainbow trout hepatic microsomes after treatment with various inducers., Biochemical Pharmacology, 47 (5), 893-903 Abstract
  • Lee PC, Yoon HI, Haasch ML, Lech JJ (1993) Negative control of cytochrome P450 1A1 (CYP1A1) by glucocorticoids in rainbow trout liver., Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology, 104 (3), 457-61 Abstract
  • Myers, C.R., L.A. Sutherland, M.L. Haasch, and J.J. Lech (1993) Antibodies to a synthetic peptide that react specifically with rainbow trout hepatic cytochrome P450 1A1, Environmental Toxicology and Chemistry, 12, 1619-1626
  • Haasch, M.L., R. Prince, P.J. Wejksnora, K.R. Cooper, and J.J. Lech (1993) Caged and wild fish: Induction of hepatic cytochrome P450 (CYP1A1) as an environmental biomonitor, Environmental Toxicology and Chemistry, 12, 885-895
  • Haasch ML, Quardokus EM, Sutherland LA, Goodrich MS, Lech JJ (1993) Hepatic CYP1A1 induction in rainbow trout by continuous flowthrough exposure to beta-naphthoflavone., Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 20 (1), 72-82 Abstract
  • Haasch ML, Sutherland LA, Wejksnora PJ, Lech JJ (Jun 1992) Effect of acrylamide monomer on hepatic CYP1A1 monooxygenase induction in rainbow trout., Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology., 102 (2), 281-6 Abstract
  • Haasch, M.L., E.M. Quardokus, L.A. Sutherland, M.S. Goodrich, R. Prince, K.R. Cooper, and J.J. Lech (1992) CYP1A1 protein and mRNA in teleosts as an environmental bioindicator: Laboratory and environmental studies, Marine Environmental Research <doi:10.1016/0141-1136(92)90098-7>, 34, 139-145
  • Kleinow KM, Haasch ML, Williams DE, Lech JJ (1990) A comparison of hepatic P450 induction in rat and trout (Oncorhynchus mykiss): delineation of the site of resistance of fish to phenobarbital-type inducers., Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology, 96 (2), 259-70 Abstract
  • Haasch ML, Wejksnora PJ, Stegeman JJ, Lech JJ (1989) Cloned rainbow trout liver P(1)450 complementary DNA as a potential environmental monitor., Toxicology and Applied Pharmacology, 98 (2), 362-8 Abstract
  • Haasch ML, Kleinow KM, Lech JJ (1988) Induction of cytochrome P-450 mRNA in rainbow trout: in vitro translation and immunodetection., Toxicology and Applied Pharmacology, 94 (2), 246-53 Abstract
  • Kleinow, K.M., M.L. Haasch, and J.J. Lech, The effect of tricaine anesthesia upon induction of select P-450 dependent monooxygenase activities in rainbow trout (Salmo gairdneri), Aquatic Toxicology, 8, 231-241, 1986
  • Gray RW, Haasch ML, Brown CE (1983) Regulation of plasma 1,25-(OH)2-D3 by phosphate: evidence against a role for total or acid-soluble renal phosphate content., Calcified Tissue International, 35 (6), 773-7 Abstract
  • Spencer, Hattie, Wahome, Joseph, Haasch, Mary L., Toxicity evaluation of acrylamide on the early life stages of the zebrafish (Danio rerio) embryos, Archives of Environmental Contamination and Toxicology, Submitted

Profile Details

Last Verified: 5/28/2008

COS Expertise ID #1138873
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