Dr. Mark A. Haidekker

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University of Georgia
Faculty of Engineering
Associate ProfessorAppointed: 2007
Professional Headshot of Mark A. Haidekker

Mailing Address

University of Georgia
Faculty of Enigneering
Driftmier Engineering Center
Athens, Georgia 30602
United States

Contact Information

Phone: (706) 542-1653
Fax: (706) 542-8806
mhaidekk @at@ uga .dot. edu
http://photonics.engr.uga.edu

Qualifications

Postdoctoral, University of California, San Diego, Bioengineering, 1999.
Ph.D., University of Bremen, Computer Science, 1998.
M.Sc., University of Hannover, Electrical Engineering, 1990.

Expertise and Research Interests

Computer Aided Radiology:
Dr. Haidekker develops image analysis methods based on modern imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Specific areas include: Classification of structural properties in CT/MRI images of cancellous bone, a diagnostic tool for the diagnosis of osteoporosis and the assessment of the individual fracture risk; Quantitative analysis and comparison of the sulcal structure in MRI scans of the human brain, a method ("Laplacian Brainprint") that can be used for the research of neurodegenrative diseases, and the quantitative assessment of lung emphysema.

Cell signaling pathways:
The second field of research involves cell signaling pathways, particularly the mechanosensing capabilities. Dr. Haidekker conducts experiments to elucidate effects of fluid shear stress and hydrostatic pressure on the membrane of endothelial cells by means of fluorescence. This also involves the design and synthesis of fluorescent compounds that act as viscosity probes in hydrophobic environments.

Other Expertise

Advanced programming capabilities (C, C++, Pascal, x86 and microcontroller Assembler; Windows and Linux)
System administration and networking (Linux)
Digital control and automation, embedded systems

Future Research

Continuation of the project 'Bone Structure in the Computer Aided Diagnosis of Osteoporosis'
Continuation of the project 'Molecular Viscometers in Biology and Medicine'
Continuation of the project 'Novel Methods for the Quantitative Analysisof Brain Surface Morphology'
Planned project 'Nondestructive Methods for the Quality Assessment in Tissue Engineering'

Industrial Relevance

Bone structure in osteoporosis:
Algorithms may be integrated in CT workstations to allow more accurate determination of the individual fracture risk, allow better monitoring of the progress of the disease, and allow the determination of drug efficacy

Molecular viscometers:
Fluorescence-based real-time low-volume measurement of viscosity in various fields

Keywords

COS Keywords:

Bioengineering, Bioinstrumentation, Biological Engineering, Computed Tomography, Computer and Information Sciences, Computing Resources, Fluorescence, Lung Diseases, Magnetic Resonance Imaging, Medical Instrumentation, Medical or Diagnostic Imaging, Neurodegenerative Diseases, Neuroimaging, Osteoporosis, Radiography, Radiology.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)
Spanish: (Functional, Functional, Functional)
French: (Functional, Basic, Basic)

Memberships

American Society for Engineering Education
Biomedical Engineering Society
Institute of Biological Engineering
Sigma Xi

Honors and Awards

2007, Sigma Xi Excellence in Research Award, Sigma Xi, University of Missouri-Columbia
2006, Junior Faculty Research Award, College of Engineering, University of Missouri-Columbia
2006, Faculty Fellowship Appointment, College of Engineering, University of Missouri-Columbia
2006, Research Highlight, Nature 439
2005, Sigma Xi Excellence in Graduate Research Mentoring, Sigma Xi
2005, CAFNR Outstanding Teaching Award, CAFNR
2000-2001, National Research Service Award, NIH, National Institutes of Health, Cell membrane fluidity changes under fluid shear stress
1998-1998, ISCD Certificate of Acievement, International Society for Clincal Densitometry, Assessment of the cortical structure of lumbar vertebrae based on HR-CT images
1998, Paper of Interest, Osteop Rev 6(2)
1997-1997, ECR Certificate of Merit European Congress of Radiology, MeVis Workstation for Computer-Aided Diagnosis
1997, Paper of Interest, Osteop Rev 5(3)

Previous Positions

2006, Member, US Army Medical Research and Materiel Command (PRMRP 064563)
2005, Ad-hoc Reviewer, ASME Journal of Dynamic Systems
2005, Ad-hoc Reviewer, Applied Engineering in Agriculture
2004-2007, Adjunct Professor, University of Missouri-Columbia, Engineering
2003, Member, NIH Review Board (ZRG1 SSS-M Tissue Engineering)
2003, Ad-hoc Reviewer, Microvascular Research
2003, Ad-hoc Book Reviewer, E. Haake et al., Magnetic Resonance Imaging, Wiley-Liss
2002-2003, Ad-hoc Reviewer, Nanotechnology
2002-2007, Assistant Professor, University of Missouri-Columbia, Engineering
2001, Ad-hoc Book Reviewer, CRC Bone Biomechanics Handbook, Chapter 12, CRC Press
2000-2002, Assistant Research Scientist, University of California, San Diego, Jacobs School of Engineering, Bioengineering
1999-2000, Postdoctoral Fellow, University of California, San Diego, Bioengineering
1994-1999, Graduate Student, University of Bremen, Computer Science
1990-1994, Founder and CEO, InfOrg GmbH, Information Systems Organization
1984-1990, Research Assistant, University of Hannover (Germany), (with Dr. U. Sparboom)

Patents

Novel Proximity Sensors for Non-Invasive Real-Time Monitoring of Cattle Body Temperature, Patent Number: Pending, 2006, United States of America.
Local Shear Stress Sensor Based on Molecular Rotors, Patent Number: , 2004, United States of America.
Supported Molecular Biofluid Viscosity Sensors for in Vitro and in Vivo Use, Patent Number: , 2003, United States of America.
Molecular Rotor Derivatives and Methods of Use, Patent Number: WO 02/086472 A1, 2002, Institution-owned, United States.

Funding Received

  • National Institutes of Health (NIH): Investigation of Cell Membrane Fluidity Changes Under Fluid Shear Stress (NRSA 1F32GM20476), $32,000, May 1, 2000 to Apr 30, 2001.
  • National Institutes of Health (NIH): Development of a fluorescence-based viscometer (1R21 RR018399-01), $662,185, Aug 1, 2002 to 2007.
  • Manchot Foundation: Noninvasive Imaging for Quality Control in Tissue Engineering, apx. $50,000, 2006 to 2007.
  • National Institutes of Health (NIH): Noninvasive Imaging of Tissue-Engineered Blood Vessels (NIH 1R21 HL 081308-01), $377,349, 2006 to 2008.
  • MU Research Council: Confocal Imaging of Engineered Tissue Sheets, $2,992, 2005 to 2006.
  • MU Research Board: Laser Optical Tomography for Cardiovascular Research, $29,580, 2004 to 2005.
  • MU Research Council: Use of untrasound technology to determine cooking doneness in meat, $7,271, 2004 to 2005.
  • National Institutes of Health (NIH): From clinic to bench & back - clinical biodetective training (NIH 1T90 DK70105), $886,864, 2004 to 2009.
  • MU Teaching Enhancement: A Linux-Based Computer Lab for High-Performance Image Analysis, $14,000, 2003 to 2003.
  • MU Research Council: Noninvasive Cattle Body Temperature Monitor, $4,992, 2003 to 2003.
  • National Science Foundation (NSF): REU SITE - Summer Research Projects in Biosystems Modeling and Analysis (NSF REU EEC-0244045), $330,877, 2003 to 2006.
  • National Institutes of Health (NIH): Molecular Pathopphysiology of Cystic Fibrosis (NIH 2R01 DK055835), $1,239,750, 2003 to 2008.
  • National Institutes of Health (NIH): Interstitial Fluid Flow in Bone Remodeling (NIH R01 AR/AG46797), $1,494,000, 2001 to 2005.
  • National Institutes of Health (NIH): Shear Stress Activation of Endothelial Cell Membrane Function (NIH 1 R01 Hl40696), $1,500,000, 2000 to 2005.

Publications

  • Haidekker MA, Theodorakis EA (Jun 2007) Molecular rotors--fluorescent biosensors for viscosity and flow., Organic & biomolecular chemistry, 5 (11), 1669-78 Abstract
  • Fischer D, Theodorakis EA, Haidekker MA (2007) Synthesis and use of an in-solution ratiometric fluorescent viscosity sensor., Nature protocols, 2 (1), 227-36 Abstract
  • L.W. Boettcher, A. Viehmann, M.A. Haidekker and S.A. Grant, Production of a Type 1 Collagen Crosslinked Matrix Using Functionalized Gold Nanoparticles to Provide Improved Biocompatibility to Implantable Biosensors, Mar 2006
  • M.A. Haidekker, S.A. Grant, L.W. Boettcher, J.D. Suter, R.Rone, A. Viehmann, Quantification of Collagen Fibril Morphology in the Presence of Gold Nanoparticles, Tucson, AZ, Proceedings of the Annual Meeting of the Institute of Biological Engineering, Mar 2006
  • J.T. LaCroix, M.A. Haidekker, Confocal Scanner for Quality Control of Tissue-Engineered Sheets, Tucson, AZ, Proceedings of the Annual Meeting of the Institute of Biological Engineering, Mar 2006
  • M.A. Haidekker, W. Akers, D. Fischer, E.A. Theodorakis (2006) A fiberoptic-based fluorescent viscosity sensor, Optics Letters, 31 (17), 2529-31
  • M.A. Haidekker, A. Bidesi, S. Radmer, R. Andresen (2006) Texturparameter zur Bestimmung osteoporotisch bedingter Strukturveränderungen im CT-Bild der Wirbelkörperspongiosa - eine (Texture parameters to quantify osteoporosis-related structural changes in CT, Osteologie, 15 (2), 120-30
  • M.A. Haidekker, L.W. Boettcher, J.D. Suter, R. Rone, S.A. Grant. (2006) Influence of gold nanoparticles on collagen fibril morphology quantified using transmission electron microscopy and image analysis, Biomed Central - Medical Imaging, 6, 4
  • M.A. Haidekker, T.P. Brady, D. Lichlyter, E.A. Theodorakis (2006) A ratiometric fluorescent viscosity sensor, JACS, 128, 398-99
  • Yao G, Haidekker MA (Jul 2005) Transillumination optical tomography of tissue-engineered blood vessels: a Monte Carlo simulation., Applied Optics, 44 (20), 4265-71 Abstract
  • Gladish JC, Yao G, L'Heureux N, Haidekker MA (Mar 2005) Optical transillumination tomography for imaging of tissue-engineered blood vessels., Annals of Biomedical Engineering, 33 (3), 323-7 Abstract
  • C.R. White (2005) Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells, Am J Physiol Heart Circ Physiol, 289
  • J.D. Benson, M.A. Haidekker, C.M. Benson, J.K. Critser (2005) Mercury free operation of the coulter counter multisizer II sampling stand, Cryobiology, 51, 344-47
  • M.A. Haidekker, T.P. Brady, D. Lichlyter, E.A. Theodorakis (2005) Effects of solvent polarity and solvent viscosity on the fluorescent properties of molecular rotors and related probes, Bioorganic Chemistry, 33, 415-25
  • G. Yao, M.A. Haidekker (2005) Transillumination optical tomography of tissue-engineered blood vessels: A Monte Carlo simulation, Applied Optics, 4, 4265-71
  • W. Akers, M.A. Haidekker (2005) Precision Assessment of Biofluid Viscosity Measurements Using Molecular Rotors, Journal of Biomechanical Engineering, 127, 450-54
  • W. Akers, J. Cupps, M.A. Haidekker (2005) Interaction of fluorescent molecular rotors with blood plasma proteins, Biorheology, 42, 335-44
  • K. Milich, W. Akers, M.A. Haidekker (2005) A Ratiometric Fluorophotometer for Fluorescence-Based Viscosity Measurement with Molecular Rotors, Sensor Letters, 3, 237-43
  • M.A. Haidekker, W. Akers, D. Lichlyter, T.P. Brady, E.A. Theodorakis (2005) Sensing of Flow and Shear Stress Using Fluorescent Molecular Rotors, Sensor Letters, 3 (1), 42-8
  • M.A. Haidekker (2005) A hands-on model computed tomography scanner for teaching biomedical, International Journal of Engineering Education, 21 (2), 327-34
  • Akers W, Haidekker MA (Jun 2004) A molecular rotor as viscosity sensor in aqueous colloid solutions., Journal of Biomechanical Engineering, 126 (3), 340-5 Abstract
  • Haidekker MA, Stevens HY, Frangos JA, Cell membrane fluidity changes and membrane undulations observed using a laser scattering technique, Annals of Biomedical Engineering, 32(4), 531-6, 2004 Abstract
  • Haidekker MA, White CR, Stevens HY, Frangos JA (shared first authorship), Extracellular signal-regulated kinase activation and endothelin-1 production in human endothelial cells exposed to vibration, The Journal of Physiology, 555(Pt 2), 565-72, March 2004 Abstract
  • Haidekker MA, Bergula AP, Huang W, Stevens HY, Frangos JA (shared first authorship), Venous ligation-mediated bone adaptation is NOS 3 dependent, Bone, 34(3), 562-9, March 2004 Abstract
  • Haidekker MA, Stevens HY, Frangos JA, Computerized methods for X-ray-based small bone densitometry, Computer Methods and Programs in Biomedicine, 73(1), 35-42, 2004 Abstract
  • M.A. Haidekker, T. Brady, W. Akers, D. Lichlyter, E. Theodorakis (2004) Hydrophilic molecular rotors - synthesis and characterization, Bioorganic Chemistry, 32, 531-36
  • M.A. Haidekker (2004) A molecular rotor as viscosity sensor in aqueous colloid solutions, Journal of Biomechanical Engineering, 126, 565-72
  • M.A. Haidekker, C. White1 , H.Y. Stevens, J.A. Frangos (2004) ERK1/2 activation and endothelin-1 production in human endothelial cells exposed to vibration, Journal of Physiology, 126, 240-345
  • Haidekker MA, Brady T, Wen K, Okada C, Stevens HY, Snell JM, Frangos JA, Theodorakis EA, Phospholipid-bound molecular rotors: Synthesis and characterization, Bioorganic & Medicinal Chemistry, 10(11), 3627-36, November 2002
  • Haidekker MA, Mallipattu SK, Von Dassow P, Latz MI, Frangos JA (shared first authorship), Evidence for shear-induced increase in membrane fluidity in the dinoflagellate Lingulodinium polyedrum, 188(5), 409-16, June 2002
  • Haidekker MA, Tsai AG, Brady T, Stevens HY, Frangos JA, Theodorakis E, Intaglietta M, A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors, American Journal of Physiology. Heart and Circulatory Physiology, 282(5), H1609-14, 2002 Abstract
  • Haidekker MA, White CR, Frangos JA, Analysis of Temporal Shear Stress Gradients During the Onset Phase of Flow over a Backward-Facing Step, Journal of Biomechanical Engineering, 123, 455-463, October 2001
  • Haidekker MA, White CR, Bao X, Frangos JA (shared first authorship), Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation, Circulation, 103(20), 2508-2513, May 2001
  • Haidekker MA, Ling T, Anglo M, Stevens HY, Frangos JA, Theodorakis EA, New fluorescent probes for the measurement of cell membrane viscosity, Chemistry and Biology, 8(2), 123-31, February 2001 Abstract
  • Haidekker MA, L'Heureux N, Frangos JA, Fluid shear stress increases membrane fluidity in endothelial cells: A study with DCVJ fluorescence, American Journal of Physiology. Heart and Circulatory Physiology, 278(4), H1401-6, April 2000
  • Haidekker MA, Andresen R, Evertsz CJ, Banzer D, Peitgen HO, Issues of threshold selection when determining the fractal dimension in HRCT slices of lumbar vertebrae, British Journal of Radiology, 73(865), 69-72, Jan 2000 Abstract
  • Haidekker MA, Frangos JA, A fluorescent molecular rotor for the study of membrane fluidity in endothelial cells under fluid shear stress, Proc SPIE, 3921, 101-112, 2000
  • M.A. Haidekker, J. A. Frangos (2000) A fluorescent molecular rotor for the study of membrane fluidity in endothelial cells under fluid shear stress, Optical fluidity in endothelial cells under fluid shear stress, 101-112
  • Andresen R, Haidekker MA, Radmer S, Banzer D, Computerized analysis of gray-value profiles in spongy and cortical bone. Clinical experience, Investigative Radiology, 34(9), 572-8, September 1999 Abstract
  • Andresen R, Haidekker MA, Radmer S, Banzer D, CT determination of bone mineral density and structural investigations on the axial skeleton for estimating the osteoporosis-related fracture risk by means of a risk score, British Journal of Radiology, 72(858), 569-78, June 1999 Abstract
  • Haidekker MA, Andresen R, Werner HJ, Relationship between structural parameters, bone mineral density and fracture load in lumbar vertebrae, based on high-resolution computed tomography, quantitative computed tomography and compression t, Osteoporosis International, 9(5), 433-40, 1999 Abstract
  • R. Andresen, S. Radmer, M. Sparmann, and M.A. Haidekker (1999) Imaging of Hamate Bone Fractures in Conventional X-Rays and HR-CT: An in-vitro study, Acta Radiologica, 34 (1), 46-50
  • M.A. Haidekker (1999) Automatische Strukturklassifizierung in Computertomogrammen bei der Diagnose der Osteoporose und in der Zwillingshirnforschung (Automated structural classification of computed tomography images in the diagnosis of osteoporosis and in twin brain research), Vol. VDI 17, Fortschritt-Berichte, 181 pages, ISBN=3-18-318117-7
  • Haidekker MA, Evertsz CJ, Fitzek C, Boor S, Andresen R, Falkai P, Stoeter P, Peitgen HO, Projecting the sulcal pattern of human brains onto a 2D plane--a new approach using potential theory and MRI, Psychiatry Research, 83(2), 75-84, August 1998 Abstract
  • Zang A, Wagner C, Stanchits S, Dresen G, Andresen R, Haidekker MA, Source analysis of acoustic emissions in aue granite cores under symmetric and asymmetric compressive loads, Geophysical Journal International, 135, 1113-1130, 1998
  • Haidekker MA, Andresen R, Evertsz CJ, Banzer D, Peitgen HO, Evaluation of the cortical structure in high resolution CT images of lumbar vertebrae by analysing low bone mineral density clusters and cortical profiles, British Journal of Radiology, 70(840), 1222-8, December 1997 Abstract
  • Haidekker MA, Andresen R, Evertsz CJ, Banzer D, Peitgen HO, Assessing the degree of osteoporosis in the axial skeleton using the dependence of the fractal dimension on the grey level threshold, British Journal of Radiology, 70(834), 586-93, June 1997 Abstract
  • D. Zhu, C. Hu, Y. Lai, P.B. Shelat, M.A. Haidekker, G.Y. Sun, J.C-M. Lee, Role of Cytosolic Phospholipase A2 in Plasma Membrane Phase Alterations Induced by Oxidative Stress in Astrocytes, Biochemical Journal, Submitted
  • M.A. Haidekker, D. Lichlyter, M. Ben Johny, C.A. Grimes, Probing polymerization dynamics with Fluorescent Molecular Rotors and Magnetoelastic Sensors, Sensor Letters, Unpublished
  • M.A. Haidekker, Optical transillumination tomography with tolerance against refraction, Computer Methods and Programs in Biomedicine, 80, 225-35

Profile Details

Last Updated: 1/22/2008

COS Expertise ID #942944
Reference this profile directly: http://myprofile.cos.com/mhaidekk