Dr. Marco Mielcarek

(Reading, Writing, Speaking)

Dana Foundation: The Role of Dendritic Cells in Graft-versus-Host Disease, 2006 to 2009.
National Institutes of Health (NIH): Cell Therapy for Transient Hematopoietic Recovery, 2005 to 2010.
National Institutes of Health (NIH): Optimizing Nonmyeloablative Stem Cell Transplantation, 2003 to 2008.

• Mielcarek M, Storer BE, Boeckh MJ, Carpenter PA, McDonald GB, Deeg HJ, Nash RA, Flowers ME, Doney K, Lee S, Marr KA, Furlong T, Storb R, Appelbaum FR, Martin PJ (Nov 2008) Initial therapy of acute graft-versus-host disease with "low-dose" prednisone does not compromise patient outcomes., Blood
• Furlong T, Kiem HP, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Flowers ME, Mielcarek M, Nash RA, Storb R, Martin PJ (May 2008) Sirolimus in combination with cyclosporine or tacrolimus plus methotrexate for prevention of graft-versus-host disease following hematopoietic cell transplantation from unrelated donors., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 14 (5), 531-7
• Sorror ML, Leisenring W, Mielcarek M, Baron F, Diaconescu R, Hogan WJ, Graves SS, Storb R (Apr 2008) Intensified postgrafting immunosuppression failed to assure long-term engraftment of dog leukocyte antigen-identical canine marrow grafts after 1 gray total body irradiation., Transplantation, 85 (7), 1023-9
• Mielcarek M, Storer BE, Sandmaier BM, Sorror ML, Maloney DG, Petersdorf E, Martin PJ, Storb R (Dec 2007) Comparable outcomes after nonmyeloablative hematopoietic cell transplantation with unrelated and related donors., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 13 (12), 1499-507
• Mielcarek M, Kucera KA, Nash R, Torok-Storb B, McKenna HJ (Nov 2007) Identification and characterization of canine dendritic cells generated in vivo., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 13 (11), 1286-93
• Mielcarek M, Storer BE, Flowers ME, Storb R, Sandmaier BM, Martin PJ (Oct 2007) Outcomes among patients with recurrent high-risk hematologic malignancies after allogeneic hematopoietic cell transplantation., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 13 (10), 1160-8
• Kahl C, Storer BE, Sandmaier BM, Mielcarek M, Maris MB, Blume KG, Niederwieser D, Chauncey TR, Forman SJ, Agura E, Leis JF, Bruno B, Langston A, Pulsipher MA, McSweeney PA, Wade JC, Epner E, Bo Petersen F, Bethge WA, Maloney DG, Storb R (Oct 2007) Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning., Blood, 110 (7), 2744-8
• Georges GE, Maris MB, Maloney DG, Sandmaier BM, Sorror ML, Shizuru JA, Lange T, Agura ED, Bruno B, McSweeney PA, Pulsipher MA, Chauncey TR, Mielcarek M, Storer BE, Storb R (Apr 2007) Nonmyeloablative unrelated donor hematopoietic cell transplantation to treat patients with poor-risk, relapsed, or refractory multiple myeloma., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 13 (4), 423-32
• Mielcarek M, Georges GE, Storb R (Sep 2006) Denileukin diftitox as prophylaxis against graft-versus-host disease in the canine hematopoietic cell transplantation model., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 (9), 899-904
• Burroughs L, Mielcarek M, Leisenring W, Sandmaier BM, Maloney DG, Baron F, Martin PJ, Flowers ME, Forman SJ, Chauncey TR, Bruno B, Storb R (Mar 2006) Extending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation., Transplantation, 81 (6), 818-25
• Mielcarek M, Bryant E, Loken M, Zaucha JM, Torok-Storb B, Storb R (Feb 2006) Long-term engraftment and clonal dominance of donor-derived del(20q) hematopoietic cells after allogeneic stem cell transplantation., Blood, 107 (4), 1732-3
• Burroughs L, Mielcarek M, Little MT, Bridger G, Macfarland R, Fricker S, Labrecque J, Sandmaier BM, Storb R (2005) Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral blood mononuclear cells in a canine transplantation model, Blood, 106 (12), 4002-8
• Mielcarek M, Storb R (Sep 2005) Graft-vs-host disease after non-myeloablative hematopoietic cell transplantation, Leuk Lymphoma, 46 (9), 1251-60
• Mielcarek M, Burroughs L, Leisenring W, Diaconescu R, Martin PJ, Sandmaier BM, Maloney DG, Maris MB, Chauncey TR, Shizuru JA, Blume KG, Hegenbart U, Niederwieser D, Forman S, Bruno B, Woolfrey A, Storb R (May 2005) Prognostic relevance of 'early-onset' graft-versus-host disease following non-myeloablative haematopoietic cell transplantation, Br J Haematol, 129 (3), 381-91
• Mielcarek M, Gooley T, Martin PJ, Chauncey TR, Young BA, Storb R, Torok-Storb B (Mar 2005) Effects of race on survival after stem cell transplantation, Biol Blood Marrow Transplant, 11 (3), 231-9
• Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R, Woolfrey AE, Chauncey TR, Flowers ME, Mielcarek M, Maloney DG, Storb R (Mar 2005) Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning, J Clin Oncol, 23 (9), 1993-2003
• Kahl C, Mielcarek M, Iwata M, Harkey MA, Storer B, Torok-Storb B (Dec 2004) Radiation dose determines the degree of myeloid engraftment after nonmyeloablative stem cell transplantation, Biol Blood Marrow Transplant, 10 (12), 826-33
• Mielcarek M, Martin PJ, Heimfeld S, Storb R, Torok-Storb B (Jan 2004) CD34 cell dose and chronic graft-versus-host disease after human leukocyte antigen-matched sibling hematopoietic stem cell transplantation, Leuk Lymphoma, 45 (1), 27-34
• Mielcarek M, Storb R (Aug 2003) Non-myeloablative hematopoietic cell transplantation as immunotherapy for hematologic malignancies, Cancer Treat Rev, 29 (4), 283-90
• Mielcarek M, Martin PJ, Leisenring W, Flowers ME, Maloney DG, Sandmaier BM, Maris MB, Storb R (Jul 2003) Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation, Blood, 102 (2), 756-62
• Mielcarek M, Torok-Storb B, Storb R, Is alloantigen expression by host epithelium required for acute graft-versus-host disease?, Nature Medicine, 9(2), 150-1; author reply, Feb 2003
• Maciej Zaucha J, Mielcarek M, Takatu A, Little MT, Gooley T, Baker J, Maloney DG, Sandmaier BM, Maris M, Chauncey T, Storb R, Torok-Storb B (Dec 2002) Engraftment of early erythroid progenitors is not delayed after non-myeloablative major ABO-incompatible haematopoietic stem cell transplantation, Br J Haematol, 119 (3), 740-50
• Mielcarek M, Sandmaier BM, Maloney DG, Maris M, McSweeney PA, Woolfrey A, Chauncey T, Feinstein L, Niederwieser D, Blume KG, Forman S, Torok-Storb B, Storb R (Mar 2002) Nonmyeloablative hematopoietic cell transplantation: status quo and future perspectives, J Clin Immunol, 22 (2), 70-4
• Mielcarek M, Zaucha JM, Sandmaier B, Maloney D, Butrynski J, Maris M, Feinstein L, Torok-Storb B, Storb R, Type of post-grafting immunosuppression after non-myeloablative blood cell transplantation may influence risk of delayed haemolysis due to minor ABO incompatibility., British Journal of Haematology, 116(2), 500-1, Feb 2002
• Awaya N, Baerlocher GM, Manley TJ, Sanders JE, Mielcarek M, Torok-Storb B, Lansdorp PM (2002) Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure?, Biol Blood Marrow Transplant, 8 (11), 597-600
• Mielcarek M, Leisenring W, Torok-Storb B, Storb R (Aug 2000) Graft-versus-host disease and donor-directed hemagglutinin titers after ABO-mismatched related and unrelated marrow allografts: evidence for a graft-versus-plasma cell effect, Blood, 96 (3), 1150-6
• Mielcarek M, Bryant E, Loken M, Torok-Storb B, Storb R (May 1999) Haemopoietic reconstitution by donor-derived myelodysplastic progenitor cells after haemopoietic stem cell transplantation, Br J Haematol, 105 (2), 361-5
• Mielcarek M, Graf L, Johnson G, Torok-Storb B (Jul 1998) Production of interleukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation, Blood, 92 (1), 215-22
• Purton LE, Mielcarek M, Torok-Storb B, Monocytes are the likely candidate 'stromal' cell in G-CSF-mobilized peripheral blood., Bone Marrow Transplantation, 21(10), 1075-6, May 1998
• Tanaka J, Mielcarek M, Torok-Storb B (Jan 1998) Impaired induction of the CD28-responsive complex in granulocyte colony-stimulating factor mobilized CD4 T cells, Blood, 91 (1), 347-52
• Reems JA, Mielcarek M, Torok-Storb B (Aug 1997) Differential modulation of adhesion markers with ex vivo expansion of human umbilical CD34+ progenitor cells, Biol Blood Marrow Transplant, 3 (3), 133-41
• Mielcarek M, Torok-Storb B (May 1997) Phenotype and engraftment potential of cytokine-mobilized peripheral blood mononuclear cells, Curr Opinion Hematol, 4 (3), 176-82
• Mielcarek M, Martin PJ, Torok-Storb B (Mar 1997) Suppression of alloantigen-induced T-cell proliferation by CD14+ cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells, Blood, 89 (5), 1629-34
• Mielcarek M, Sperling C, Schrappe M, Meyer U, Riehm H, Ludwig WD (Feb 1997) Expression of intercellular adhesion molecule 1 (ICAM-1) in childhood acute lymphoblastic leukaemia: correlation with clinical features and outcome, Br J Haematol, 96 (2), 301-7
• Mielcarek M, Reems J, Torok-Storb B (1997) Extrinsic control of stem cell fate: practical considerations, Stem Cells, 15 Suppl 1, 229-32; discussion 2
• Mielcarek M, Purton LE, Torok-Storb B, Accessory cell function may be retained in CD34-selected G-CSF mobilized peripheral blood mononuclear cells., British Journal of Haematology, 93(2), 495-7, May 1996
• Mielcarek M, Roecklein BA, Torok-Storb B (Jan 1996) CD14+ cells in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow stroma, Blood, 87 (2), 574-80
• Sperling C, Buchner T, Creutzig U, Ritter J, Harbott J, Fonatsch C, Sauerland C, Mielcarek M, Maschmeyer G, Loffler H, Et Al. (May 1995) Clinical, morphologic, cytogenetic and prognostic implications of CD34 expression in childhood and adult de novo AML, Leuk Lymphoma, 17 (5-6), 417-26