Michael W. Orth

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Michigan State University
College of Agriculture & Natural Resources
Animal Science
Growth and Musculoskeletal Biology
Associate ProfessorAppointed: 2002
Michigan State University
College of Agriculture & Natural Resources
Animal Science
Associate ChairAppointed: 2006
Michigan State University
College of Agriculture & Natural Resources
Food Science and Human Nutrition
Adjunct Associate ProfessorAppointed: 1999

Mailing Address

2209F Anthony Hall
Department of Animal Science
Michigan State University
East Lansing, Michigan 48824-1225
United States

Contact Information

Phone: (517) 432-1816
Fax: (517) 432-0190
Mobile: (517) 203-8815
orthm@msu.edu

Qualifications

Ph.D., University of Wisconsin-Madison, Nutritional Science, 1993.
B.S., University of Iowa, Biochemistry, 1986.

Expertise and Research Interests

1. To explore the use of biological fluid markers to monitor skeletal metabolism in livestock.
2. To understand the mechanisms involved in articular cartilage degradation and how it can be prevented. The goal is to help prevent or minimize the deleterious effects of arthritis.
3. To develop strategies for preventing or minimizing cartilage and bone degradation in both humans and animals.
4. To elucidate the mechanisms of action of nutritional supplements with purported chondroprotective properties.

Keywords

COS Keywords:

Arthritis, Biological Markers, Bone, Livestock, Nutrition or Dietetics, Osteoarthritis, Prostaglandins, Sports Medicine.

Additional Terms:

Bone, Nutraceuticals, Prostaglandins, Sports Medicine.

Memberships

American Society of Animal Science
Osteoarthritis Research Society International

Previous Positions

1996-2002, Assistant Professor, Michigan State University, College of Agriculture & Natural Resources, Animal Science
1993-1996, Postdoctoral Fellow, Rush University Medical Center, Rush Medical College, Biochemistry

Publications

  • Pearson W, Orth MW, Karrow NA, Lindinger MI (Dec 2008) Effects of simulated digests of Biota orientalis and a dietary nutraceutical on interleukin-1- induced inflammatory responses in cartilage explants., American journal of veterinary research, 69 (12), 1560-8 Abstract
  • Turner KK, Nielsen BD, O'Connor-Robison CI, Nielsen FH, Orth MW (Feb 2008) Tissue response to a supplement high in aluminum and silicon., Biological trace element research, 121 (2), 134-48 Abstract
  • Turner KK, Nielsen BD, O'Connor-Robison CI, Rosenstein DS, Marks BP, Nielsen FH, Orth MW (Feb 2008) Sodium zeolite a supplementation and its impact on the skeleton of dairy calves., Biological trace element research, 121 (2), 149-59 Abstract
  • Pearson W, Orth MW, Lindinger MI (Dec 2007) Differential anti-inflammatory and chondroprotective effects of simulated digests of indomethacin and an herbal composite (Mobility(TM)) in a cartilage explant model of articular inflammation., Journal of veterinary pharmacology and therapeutics, 30 (6), 523-33 Abstract
  • Pearson W, Orth MW, Karrow NA, Maclusky NJ, Lindinger MI (Aug 2007) Anti-inflammatory and chondroprotective effects of nutraceuticals from Sasha's Blend in a cartilage explant model of inflammation., Molecular nutrition & food research, 51 (8), 1020-30 Abstract
  • Chan PS, Caron JP, Orth MW (Jul 2007) Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions., American journal of veterinary research, 68 (7), 709-15 Abstract
  • Chan PS, Caron JP, Orth MW (Jul 2006) Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate., The Journal of rheumatology, 33 (7), 1329-40 Abstract
  • Shaw DT, Rozeboom DW, Hill GM, Orth MW, Rosenstein DS, Link JE (May 2006) Impact of supplement withdrawal and wheat middling inclusion on bone metabolism, bone strength, and the incidence of bone fractures occurring at slaughter in pigs., Journal of animal science, 84 (5), 1138-46 Abstract
  • Neil KM, Orth MW, Coussens PM, Chan PS, Caron JP (Nov 2005) Effects of glucosamine and chondroitin sulfate on mediators of osteoarthritis in cultured equine chondrocytes stimulated by use of recombinant equine interleukin-1beta., American journal of veterinary research, 66 (11), 1861-9 Abstract
  • Chan PS, Caron JP, Orth MW (Nov 2005) Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants., American journal of veterinary research, 66 (11), 1870-6 Abstract
  • Peterson AB, Orth MW, Goff JP, Beede DK (Oct 2005) Periparturient responses of multiparous Holstein cows fed different dietary phosphorus concentrations prepartum., Journal of Dairy Science, 88 (10), 3582-94 Abstract
  • Chan PS, Schlueter AE, Coussens PM, Rosa GJ, Haut RC, Orth MW (Sep 2005) Gene expression profile of mechanically impacted bovine articular cartilage explants., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society., 23 (5), 1146-51 Abstract
  • Roberson KD, Klunzinger MW, Charbeneau RA, Orth MW (Aug 2005) Evaluation of phytase concentration needed for growing-finishing commercial turkey toms., British Poultry Science, 46 (4), 470-7 Abstract
  • Botolin S, Faugere MC, Malluche H, Orth M, Meyer R, McCabe LR (Aug 2005) Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice., Endocrinology, 146 (8), 3622-31 Abstract
  • Chan PS, Caron JP, Rosa GJM, and Orth MW, Glucosamine and Chondroitin Sulfate Regulate Gene Expression and Synthesis of Nitric Oxide and Prostaglandin E(2) in Articular Cartilage Explants, Osteoarthritis and Cartilage, 13(5), 387-393, May 2005
  • Neil KM, Caron JP, Orth MW (Apr 2005) The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals., Journal of the American Veterinary Medical Association, 226 (7), 1079-88 Abstract
  • Schlueter AE, Orth MW (Nov 2004) Further studies on the ability of glucosamine and chondroitin sulphate to regulate catabolic mediators in vitro., Equine Veterinary Journal, 36 (7), 634-6 Abstract
  • Byron CR, Orth MW, Venta PJ, Lloyd JW, Caron JP, Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes, American Journal of Veterinary Research, 64(6), 666-71, 2003 Abstract
  • Krueger JA, Thisse P, Ewers BJ, Dvoracek-Driksna D, Orth MW, Haut RC, The extent and distribution of cell death and matrix damage in impacted chondral explants varies with the presence of underlying bone, Journal of Biomechanical Engineering, 125(1), 114-9, 2003 Abstract
  • Kyparos A, Orth MW, Vailas AC, Martinez DA, Growth and maturational changes in dense fibrous connective tissue following 14 days of rhGH supplementation in the dwarf rat, Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society., 12(5), 367-73, 2002 Abstract
  • Orth MW, Peters TL, Hawkins JN, Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate, Equine Veterinary Journal. Supplement, 224-9, 2002 Abstract
  • Fenton JI, Chlebek-Brown KA, Caron JP, Orth MW, Effect of glucosamine on interleukin-1-conditioned articular cartilage, Equine Veterinary Journal. Supplement, 219-23, 2002 Abstract
  • Caron JP, Peters TL, Hauptman JG, Eberhart SW, Orth MW, Serum concentrations of keratan sulfate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to standardbred horses during race training, American Journal of Veterinary Research, 63(8), 1106-10, 2002 Abstract
  • Fenton JI, Wolff MS, Orth MW, Hord NG, Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype, Carcinogenesis, 23(6), 1065-70, June 2002 Abstract
  • Tung JT, Fenton JI, Arnold C, Alexander L, Yuzbasiyan-Gurkan V, Venta PJ, Peters TL, Orth MW, Richardson DW, Caron JP, Recombinant equine interleukin-1beta induces putative mediators of articular cartilage degradation in equine chondrocytes, Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire., 66(1), 19-25, January 2002 Abstract
  • Peters TL, Fulton RM, Roberson KD, Orth MW, Effect of antibiotics on in vitro and in vivo avian cartilage degradation, Avian Diseases, 46(1), 75-86, 2002 Abstract
  • Lang KJ, Nielsen BD, Waite KL, Hill GM, Orth MW, Supplemental silicon increases plasma and milk silicon concentrations in horses, Journal of Animal Science, 79(10), 2627-33, October 2001 Abstract
  • Ewers BJ, Dvoracek-Driksna D, Orth MW, Haut RC, The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading, Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 19(5), 779-84, September 2001 Abstract
  • Fenton JI, Chlebek-Brown KA, Peters TL, Caron JP, Orth MW, The effects of glucosamine derivatives on equine articular cartilage degradation in explant culture, Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society, 8(6), 444-51, November 2000 Abstract
  • Orth MW, Peters TL, Chlebek-Brown KA, Cartilage turnover in embryonic chick tibial explant cultures, Poultry Science, 79(7), 990-3, July 2000 Abstract
  • Fenton JI, Chlebek-Brown KA, Peters TL, Caron JP, Orth MW, Glucosamine HCl reduces equine articular cartilage degradation in explant culture, Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society, 8(4), 258-65, July 2000 Abstract
  • Orth MW, Fenton JI, Chlebek-Brown KA, Biochemical characterization of cartilage degradation in embryonic chick tibial explant cultures, Poultry Science, 78(11), 1596-600, November 1999 Abstract
  • Fenton JI, Orth MW, Chlebek-Brown KA, Nielsen BD, Corn CD, Waite KS, Caron JP, Effect of longeing and glucosamine supplementation on serum markers of bone and joint metabolism in yearling quarter horses, Canadian Journal of Veterinary Research, 63(4), 288-91, October 1999 Abstract
  • Hoekstra KE, Nielsen BD, Orth MW, Rosenstein DS, Schott HC 2nd, Shelle JE, Comparison of bone mineral content and biochemical markers of bone metabolism in stall- vs. pasture-reared horses., Equine Veterinary Journal. Supplement, 30, 601-4, 1999 Abstract
  • DA Martinez, M.W. Orth, R. Vanderby, Jr., M. Vasques, R.E. Grindeland, A.C. Vailas, Cortical bone responses to acute 2G hypergravity in growing rats, Aviation Space and Environmental Medicine, 69(6), A17-A22, 1998
  • Orth M W, Chlebek K A, Cole A A, Schmid T M, Tetracycline derivatives inhibit cartilage degradation in cultured embryonic chick tibiae., Research In Veterinary Science, 63(1), 11-4, July 1997 Abstract
  • Orth M W, Luchene L J, Schmid T M, Type X collagen isolated from the hypertrophic cartilage of embryonic chick tibiae contains both hydroxylysyl- and lysylpyridinoline cross-links., Biochemical and Biophysical Research Communications, 219(2), 301-5, 15 Feb 1996 Abstract
  • Cole A A, Chubinskaya S, Luchene L J, Chlebek K, Orth M W, Greenwald R A, Kuettner K E, Schmid T M, Doxycycline disrupts chondrocyte differentiation and inhibits cartilage matrix degradation., Arthritis and Rheumatism, 37(12), 1727-34, December 1994 Abstract
  • Orth MW, Cook ME (Jul 1994) Avian tibial dyschondroplasia: a morphological and biochemical review of the growth plate lesion and its causes., Veterinary pathology, 31 (4), 403-4 Abstract
  • Cook ME, Bai Y, Orth MW (Jun 1994) Factors influencing growth plate cartilage turnover., Poultry science, 73 (6), 889-96 Abstract
  • Orth MW, Leach RM, Vailas AC, Cook ME (Jan 1994) Non-reducible collagen cross-linking in cartilage from broiler chickens with tibial dyschondroplasia., Avian diseases, 38 (1), 44-9 Abstract
  • Orth MW, Martinez DA, Cook ME, Vailas AC (Jul 1993) The presence of lysylpyridinoline in the hypertrophic cartilage of newly hatched chicks., Biochimica et biophysica acta, 1157 (3), 229-32 Abstract
  • Orth MW, Bai Y, Zeytun IH, Cook ME (Mar 1992) Excess levels of cysteine and homocysteine induce tibial dyschondroplasia in broiler chicks., The Journal of nutrition, 122 (3), 482-7 Abstract
  • Orth MW, Martinez DA, Cook ME, Vailas AC (Sep 1991) Nonreducible crosslink formation in tibial dyschondroplastic growth plate cartilage from broiler chicks fed homocysteine., Biochemical and biophysical research communications, 179 (3), 1582-6 Abstract

Profile Details

Last Updated: 3/4/2009

COS Expertise ID #148995
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