Dr. Michael J. Vandehaar

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Michigan State University
College of Agriculture & Natural Resources
Animal Science
ProfessorAppointed: 1989
Michigan State University
College of Agriculture & Natural Resources
Animal Science
ProfessorAppointed: 1988
Professional Headshot of Michael J. Vandehaar

Mailing Address

2265 Anthony
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 355-8489
Fax: (517) 432-0147
mikevh@msu.edu
http://www.msu.edu/user/mikevh/

Qualifications

Postdoctorate, University of North Carolina at Chapel Hill, Pediatric Endocrinology, 1988.
Ph.D., Iowa State University, Animal Science - Nutritional Physiology, 1987.
M.S., Iowa State University, Animal Science - Nutritional Physiology, 1984.
A.B., Dordt College, Sioux Center, IA, Biology, 1981.

Expertise and Research Interests

My goal is to understand how nutrition impacts the growth and function of mammary tissue. A better understanding of mammary development will be used to increase the efficiency with which ruminants produce protein for human consumption. This work also has potential to reduce the incidence of breast cancer in humans.

Specific objectives are:
1. To determine the effects of energy and protein nutrition of dairy heifers on mammary development
2. To determine effects of leptin and insulin-like growth factor-I on mammary cell proliferation using in vitro and in vivo models and to determine if these regulators mediate effects of nutrition on the mammary gland
3. To identify the major intracellular pathways mediating leptin and IGF-I signaling in mammary tissue
4. To identify the growth rate and breeding size of dairy heifers that optimize subsequent milk production
5. To develop mathematical models of animal nutrition and nutritional efficiency that can be used practically in animal agriculture
6. To determine the effect of diet on the expression of metabolic genes in liver, muscle, and mammary tissues

Industrial Relevance

The raising of dairy heifers accounts for about 20% of the costs involved in dairy farming. How dairy heifers are raised can significantly alter the cost and can have a significant effect on the animals productivity once it becomes a lactating cow. Thus, improved methods to cost effectively raise dairy heifers can have a major impact on dairy farm profitability.

Keywords

COS Keywords:

Agricultural Biotechnology, Animal Nutrition, Animal Science, Cell Culture, Endocrinology, Nutrition Or Dietetics, Recombinant DNA.

Additional Terms:

Animal Experiments, Cell Culture, Endocrinology, Energy and Protein Nutrition, Insulin-like Growth Factors, Leptin, MRNA Abundance, Mammary Development, Microarray.

Languages

(Reading, Writing, Speaking)

English: (Basic, Basic, Basic)

Memberships

American Dairy Science Association
American Society of Animal Science
Council for Agricultural Science and Technology

Honors and Awards

2008, Fulbright Scholar Award, Fulbright Program

Previous Positions

1994-2001, Associate Professor, Michigan State University
1988-1994, Assistant Professor, Michigan State University
1987-1988, Postdoctoral Research Fellow, University of North Carolina at Chapel Hill, School of Medicine, Pediatrics, Pediatric Endocrinology
1996, Centre for Tissue Growth and Repair, Adelaide, South Australia, Visiting Research Fellow

Funding Received

  • United States Department of Agriculture (USDA): The stomal effect: remodeling and the effect of transforming growth factor beta on the mammary gland during the dry period in the dairy cow, $360,000, 2006 to 2009.
  • NNGF: Functional genomics in animal and veterinary science., $252,000, 2006 to 2009.
  • United States Department of Agriculture (USDA): Interaction of leptin and IGF-I in bovine mammary development., $270,000, 2002 to 2005.
  • Michigan Animal Industry Coalition: Final development of Spartan Dairy 3 for Windows using the 2001 Dairy NRC., $66,725, 2002 to 2004.
  • United States Department of Agriculture (USDA): Enhancing management and profitability of small and mid-sized dairy farms., $1,900,000, 2001 to 2005.
  • United States Department of Agriculture (USDA): Leptin regulation of bovine mammary cell proliferation, $142,029, 2000 to 2002.
  • Michigan Corn Marketing Program: Grain intake of calves and milk production potential., $43,740, 1999 to 2001.
  • USDA Section 1433 Formula Funds: Effect of negative energy balance on neutrophil migration into the mammary gland of cattle., $15,000, 1999 to 2000.
  • Michigan Animal Industry Coalition: Effect of negative energy balance on neutrophil migration in dairy cows., $27,030, 1999 to 2001.

Publications

  • Aitken SL, Karcher EL, Rezamand P, Gandy JC, VandeHaar MJ, Capuco AV, Sordillo LM (Feb 2009) Evaluation of antioxidant and proinflammatory gene expression in bovine mammary tissue during the periparturient period., Journal of dairy science, 92 (2), 589-98 Abstract
  • Silva LF, Etchebarne BE, Nielsen MS, Liesman JS, Kiupel M, VandeHaar MJ (Aug 2008) Intramammary infusion of leptin decreases proliferation of mammary epithelial cells in prepubertal heifers., Journal of dairy science, 91 (8), 3034-44 Abstract
  • Davis Rincker LE, Weber Nielsen MS, Chapin LT, Liesman JS, VandeHaar MJ (May 2008) Effects of feeding prepubertal heifers a high-energy diet for three, six, or twelve weeks on feed intake, body growth, and fat deposition., Journal of dairy science, 91 (5), 1913-25 Abstract
  • Davis Rincker LE, Weber Nielsen MS, Chapin LT, Liesman JS, Daniels KM, Akers RM, Vandehaar MJ (May 2008) Effects of feeding prepubertal heifers a high-energy diet for three, six, or twelve weeks on mammary growth and composition., Journal of dairy science, 91 (5), 1926-35 Abstract
  • Bartlett KS, McKeith FK, VandeHaar MJ, Dahl GE, Drackley JK (Jun 2006) Growth and body composition of dairy calves fed milk replacers containing different amounts of protein at two feeding rates., Journal of animal science, 84 (6), 1454-67 Abstract
  • Schlegel ML, Bergen WG, Schroeder AL, VandeHaar MJ, Rust SR (May 2006) Use of bovine somatotropin for increased skeletal and lean tissue growth of Holstein steers., Journal of animal science, 84 (5), 1176-87 Abstract
  • VandeHaar MJ, St-Pierre N (Apr 2006) Major advances in nutrition: relevance to the sustainability of the dairy industry., Journal of dairy science, 89 (4), 1280-91 Abstract
  • Silva LF, Liesman JS, Etchebarne BE, Nielsen MS, Vandehaar MJ (Aug 2005) Short communication: intramammary infusion of IGF-I increases bromodeoxyuridine labeling in mammary epithelial cells of prepubertal heifers., Journal of dairy science, 88 (8), 2771-3 Abstract
  • Brown EG, Vandehaar MJ, Daniels KM, Liesman JS, Chapin LT, Forrest JW, Akers RM, Pearson RE, Nielsen MS (Feb 2005) Effect of increasing energy and protein intake on mammary development in heifer calves., 88 (2), 595-603 Abstract
  • Brown EG, Vandehaar MJ, Daniels KM, Liesman JS, Chapin LT, Keisler DH, Nielsen MS (Feb 2005) Effect of increasing energy and protein intake on body growth and carcass composition of heifer calves., 88 (2), 585-94 Abstract
  • Radcliff RP, VandeHaar MJ, Kobayashi Y, Sharma BK, Tucker HA, Lucy MC, Effect of dietary energy and somatotropin on components of the somatotropic axis in Holstein heifers, Journal of Dairy Science, 87(5), 1229-35, May 2004 Abstract
  • Radcliff RP, VandeHaar MJ, Kobayashi Y, Sharma BK, Tucker HA, Lucy MC (May 2004) Effect of dietary energy and somatotropin on components of the somatotropic axis in Holstein heifers., Journal of dairy science, 87 (5), 1229-35 Abstract
  • Suchyta SP, Sipkovsky S, Halgren RG, Kruska R, Elftman M, Weber-Nielsen M, Vandehaar MJ, Xiao L, Tempelman RJ, Coussens PM, Bovine mammary gene expression profiling using a cDNA microarray enhanced for mammary-specific transcripts, Physiological Genomics, 16(1), 8-18, December 2003 Abstract
  • Suchyta SP, Sipkovsky S, Halgren RG, Kruska R, Elftman M, Weber-Nielsen M, Vandehaar MJ, Xiao L, Tempelman RJ, Coussens PM (Dec 2003) Bovine mammary gene expression profiling using a cDNA microarray enhanced for mammary-specific transcripts., Physiological genomics, 16 (1), 8-18 Abstract
  • Silva LF, VandeHaar MJ, Weber Nielsen MS, Smith GW, Evidence for a local effect of leptin in bovine mammary gland, Journal of Dairy Science, 85(12), 3277-86, December 2002 Abstract
  • Silva LF, VandeHaar MJ, Weber Nielsen MS, Smith GW (Dec 2002) Evidence for a local effect of leptin in bovine mammary gland., Journal of dairy science, 85 (12), 3277-86 Abstract
  • Silva LF, VandeHaar MJ, Whitlock BK, Radcliff RP, Tucker HA, Short communication: relationship between body growth and mammary development in dairy heifers, Journal of Dairy Science, 85(10), 2600-2, October 2002 Abstract
  • Silva LF, VandeHaar MJ, Whitlock BK, Radcliff RP, Tucker HA (Oct 2002) Short communication: relationship between body growth and mammary development in dairy heifers., Journal of dairy science, 85 (10), 2600-2 Abstract
  • Perkins KH, VandeHaar MJ, Burton JL, Liesman JS, Erskine RJ, Elsasser TH, Clinical responses to intramammary endotoxin infusion in dairy cows subjected to feed restriction, Journal of Dairy Science, 85(7), 1724-31, July 2002 Abstract
  • Park AF, Shirley JE, Titgemeyer EC, Meyer MJ, VanBaale MJ, VandeHaar MJ, Effect of protein level in prepartum diets on metabolism and performance of dairy cows, Journal of Dairy Science, 85(7), 1815-28, July 2002 Abstract
  • Perkins KH, VandeHaar MJ, Burton JL, Liesman JS, Erskine RJ, Elsasser TH (Jul 2002) Clinical responses to intramammary endotoxin infusion in dairy cows subjected to feed restriction., Journal of dairy science, 85 (7), 1724-31 Abstract
  • Park AF, Shirley JE, Titgemeyer EC, Meyer MJ, VanBaale MJ, VandeHaar MJ (Jul 2002) Effect of protein level in prepartum diets on metabolism and performance of dairy cows., Journal of dairy science, 85 (7), 1815-28 Abstract
  • Whitlock BK, VandeHaar MJ, Silva LF, Tucker HA, Effect of dietary protein on prepubertal mammary development in rapidly growing dairy heifers, Journal of Dairy Science, 85(6), 1516-25, June 2002 Abstract
  • Whitlock BK, VandeHaar MJ, Silva LF, Tucker HA (Jun 2002) Effect of dietary protein on prepubertal mammary development in rapidly growing dairy heifers., Journal of dairy science, 85 (6), 1516-25 Abstract
  • Perkins KH, VandeHaar MJ, Tempelman RJ, Burton JL, Negative energy balance does not decrease expression of leukocyte adhesion or antigen-presenting molecules in cattle, Journal of Dairy Science, 84(2), 421-8, February 2001 Abstract
  • Perkins KH, VandeHaar MJ, Tempelman RJ, Burton JL (Feb 2001) Negative energy balance does not decrease expression of leukocyte adhesion or antigen-presenting molecules in cattle., Journal of dairy science, 84 (2), 421-8 Abstract
  • Moore SJ, VandeHaar MJ, Sharma BK, Pilbeam TE, Beede DK, Bucholtz HF, Liesman JS, Horst RL, Goff JP, Effects of altering dietary cation-anion difference on calcium and energy metabolism in peripartum cows, Journal of Dairy Science, 83(9), 2095-104, September 2000 Abstract
  • Moore SJ, VandeHaar MJ, Sharma BK, Pilbeam TE, Beede DK, Bucholtz HF, Liesman JS, Horst RL, Goff JP (Sep 2000) Effects of altering dietary cation-anion difference on calcium and energy metabolism in peripartum cows., Journal of dairy science, 83 (9), 2095-104 Abstract
  • Vleurick L, Renaville R, VandeHaar M, Hornick JL, Istasse L, Parmentier I, Bertozzi C, Van Eenaeme C, Portetelle D (Mar 2000) A homologous radioimmunoassay for quantification of insulin-like growth factor-binding protein-2 in blood from cattle., Journal of dairy science, 83 (3), 452-8 Abstract
  • Radcliff RP, Vandehaar MJ, Chapin LT, Pilbeam TE, Beede DK, Stanisiewski EP, Tucker HA, Effects of diet and injection of bovine somatotropin on prepubertal growth and first-lactation milk yields of Holstein cows., Journal of Dairy Science, 83(1), 23-9, 2000 Abstract
  • Radcliff RP, Vandehaar MJ, Chapin LT, Pilbeam TE, Beede DK, Stanisiewski EP, Tucker HA (Jan 2000) Effects of diet and injection of bovine somatotropin on prepubertal growth and first-lactation milk yields of Holstein cows., Journal of dairy science, 83 (1), 23-9 Abstract
  • Kobayashi Y, Vandehaar MJ, Tucker HA, Sharma BK, Lucy MC, Expression of growth hormone receptor 1A messenger ribonucleic acid in liver of dairy cows during lactation and after administration of recombinant bovine somatotropin, Journal of Dairy Science, 82(9), 1910-6, September 1999 Abstract
  • Kobayashi Y, Vandehaar MJ, Tucker HA, Sharma BK, Lucy MC (Sep 1999) Expression of growth hormone receptor 1A messenger ribonucleic acid in liver of dairy cows during lactation and after administration of recombinant bovine somatotropin., Journal of dairy science, 82 (9), 1910-6 Abstract
  • Vandehaar MJ, Yousif G, Sharma BK, Herdt TH, Emery RS, Allen MS, Liesman JS, Effect of energy and protein density of prepartum diets on fat and protein metabolism of dairy cattle in the periparturient period., Journal of Dairy Science, 82(6), 1282-95, June 1999 Abstract
  • Vandehaar MJ, Yousif G, Sharma BK, Herdt TH, Emery RS, Allen MS, Liesman JS (Jun 1999) Effect of energy and protein density of prepartum diets on fat and protein metabolism of dairy cattle in the periparturient period., Journal of dairy science, 82 (6), 1282-95 Abstract
  • Vandehaar M J, Efficiency of nutrient use and relationship to profitability on dairy farms., Journal of Dairy Science, 81(1), 272-82, Jan 1998 Abstract
  • Cameron R E, Dyk P B, Herdt T H, Kaneene J B, Miller R, Bucholtz H F, Liesman J S, Vandehaar M J, Emery R S, Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds., Journal of Dairy Science, 81(1), 132-9, Jan 1998 Abstract
  • Cameron RE, Dyk PB, Herdt TH, Kaneene JB, Miller R, Bucholtz HF, Liesman JS, Vandehaar MJ, Emery RS (Jan 1998) Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds., Journal of dairy science, 81 (1), 132-9 Abstract
  • Vandehaar MJ (Jan 1998) Efficiency of nutrient use and relationship to profitability on dairy farms., Journal of dairy science, 81 (1), 272-82 Abstract
  • Radcliff R P, VandeHaar M J, Skidmore A L, Chapin L T, Radke B R, Lloyd J W, Stanisiewski E P, Tucker H A, Effects of diet and bovine somatotropin on heifer growth and mammary development., Journal of Dairy Science, 80(9), 1996-2003, September 1997 Abstract
  • Radcliff RP, VandeHaar MJ, Skidmore AL, Chapin LT, Radke BR, Lloyd JW, Stanisiewski EP, Tucker HA (Sep 1997) Effects of diet and bovine somatotropin on heifer growth and mammary development., Journal of dairy science, 80 (9), 1996-2003 Abstract
  • Yung M C, VandeHaar M J, Fogwell R L, Sharma B K, Effect of energy balance and somatotropin on insulin-like growth factor I in serum and on weight and progesterone of corpus luteum in heifers., Journal of Animal Science, 74(9), 2239-44, September 1996 Abstract
  • Yung MC, VandeHaar MJ, Fogwell RL, Sharma BK (Sep 1996) Effect of energy balance and somatotropin on insulin-like growth factor I in serum and on weight and progesterone of corpus luteum in heifers., Journal of animal science, 74 (9), 2239-44 Abstract
  • Vanderkooi W K, Vandehaar M J, Sharma B K, Binelli M, Tucker H A, Akers R M, Moseley W M, Comparison of growth hormone-releasing factor and somatotropin: the somatotropic axis in lactating primiparous cows., Journal of Dairy Science, 78(10), 2140-9, October 1995 Abstract
  • Binelli M, Vanderkooi W K, Chapin L T, Vandehaar M J, Turner J D, Moseley W M, Tucker H A, Comparison of growth hormone-releasing factor and somatotropin: body growth and lactation of primiparous cows., Journal of Dairy Science, 78(10), 2129-39, October 1995 Abstract
  • Binelli M, Vanderkooi WK, Chapin LT, Vandehaar MJ, Turner JD, Moseley WM, Tucker HA (Oct 1995) Comparison of growth hormone-releasing factor and somatotropin: body growth and lactation of primiparous cows., Journal of dairy science, 78 (10), 2129-39 Abstract
  • Vanderkooi WK, Vandehaar MJ, Sharma BK, Binelli M, Tucker HA, Akers RM, Moseley WM (Oct 1995) Comparison of growth hormone-releasing factor and somatotropin: the somatotropic axis in lactating primiparous cows., Journal of dairy science, 78 (10), 2140-9 Abstract
  • Tucker H A, Terhune A L, Chapin L T, VandeHaar M J, Sharma B K, Moseley W M, Long-term somatotropic and galactopoietic effects of a (1-30) ethyl amide analog of growth hormone-releasing factor., Journal of Dairy Science, 78(7), 1489-97, July 1995 Abstract
  • Tucker HA, Terhune AL, Chapin LT, VandeHaar MJ, Sharma BK, Moseley WM, Long-term somatotropic and galactopoietic effects of a \(1-30\) ethyl amide analog of growth hormone-releasing factor., Journal of Dairy Science, 78(7), 1489-97, 1995 Abstract
  • Tucker HA, Terhune AL, Chapin LT, VandeHaar MJ, Sharma BK, Moseley WM (Jul 1995) Long-term somatotropic and galactopoietic effects of a (1-30) ethyl amide analog of growth hormone-releasing factor., Journal of dairy science, 78 (7), 1489-97 Abstract
  • Vandehaar M J, Sharma B K, Fogwell R L, Effect of dietary energy restriction on the expression of insulin-like growth factor-I in liver and corpus luteum of heifers., Journal of Dairy Science, 78(4), 832-41, April 1995 Abstract
  • Vandehaar MJ, Sharma BK, Fogwell RL (Apr 1995) Effect of dietary energy restriction on the expression of insulin-like growth factor-I in liver and corpus luteum of heifers., Journal of dairy science, 78 (4), 832-41 Abstract
  • Sharma B K, Vandehaar M J, Ames N K, Expression of insulin-like growth factor-I in cows at different stages of lactation and in late lactation cows treated with somatotropin., Journal of Dairy Science, 77(8), 2232-41, August 1994 Abstract
  • Sharma BK, Vandehaar MJ, Ames NK (Aug 1994) Expression of insulin-like growth factor-I in cows at different stages of lactation and in late lactation cows treated with somatotropin., Journal of dairy science, 77 (8), 2232-41 Abstract
  • Simmons C R, Bergen W G, Vandehaar M J, Sprecher D J, Sniffen C J, Stanisiewski E P, Tucker H A, Protein and fat metabolism in cows given somavubove before parturition., Journal of Dairy Science, 77(7), 1835-47, July 1994 Abstract
  • Simmons CR, Bergen WG, Vandehaar MJ, Sprecher DJ, Sniffen CJ, Stanisiewski EP, Tucker HA (Jul 1994) Protein and fat metabolism in cows given somavubove before parturition., Journal of dairy science, 77 (7), 1835-47 Abstract
  • VandeHaar M J, Moats-Staats B M, Davenport M L, Walker J L, Ketelslegers J M, Sharma B K, Underwood L E, Reduced serum concentrations of insulin-like growth factor-I (IGF-I) in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle., Journal of Endocrinology, 130(2), 305-12, August 1991 Abstract
  • VandeHaar MJ, Moats-Staats BM, Davenport ML, Walker JL, Ketelslegers JM, Sharma BK, Underwood LE (Aug 1991) Reduced serum concentrations of insulin-like growth factor-I (IGF-I) in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle., The Journal of endocrinology, 130 (2), 305-12 Abstract
  • VandeHaar M J, Black J R, Ration formulation using linear programming., Veterinary Clinics of North america. Food Animal Practice, 7(2), 541-56, July 1991 Abstract
  • VandeHaar MJ, Black JR (Jul 1991) Ration formulation using linear programming., The Veterinary clinics of North America. Food animal practice, 7 (2), 541-56 Abstract
  • Flakoll PJ, VandeHaar MJ, Kuhlman G, Nissen S (Apr 1991) Influence of alpha-ketoisocaproate on lamb growth, feed conversion, and carcass composition., Journal of animal science, 69 (4), 1461-7 Abstract
  • Kuhlman G, Roth JA, Flakoll PJ, Vandehaar MJ, Nissen S (Dec 1988) Effects of dietary leucine, alpha-ketoisocaproate and isovalerate on antibody production and lymphocyte blastogenesis in growing lambs., The Journal of nutrition, 118 (12), 1564-9 Abstract
  • Vandehaar MJ, Flakoll PJ, Beitz DC, Nissen S (Dec 1988) Milk production and composition in cows and goats fed alpha-ketoisocaproate., Journal of dairy science, 71 (12), 3352-61 Abstract

Profile Details

Last Updated: 3/2/2009

COS Expertise ID #413509
Reference this profile directly: http://myprofile.cos.com/mikevh